DRUG BINDING INTERFACES MAPPED TO 'Pyrococcus horikoshii'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
1VE3_A_SAMA302
1ve3
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0226
PF13649(Methyltransf_25)
16
TYR A 7TYR A 13TYR A 21ARG A 24ALA A 46GLY A 48ASP A 67ILE A 68SER A 69ASP A 93ALA A 94ARG A 95ILE A 110SER A 112HIS A 115PHE A 116
SAM A 302
1VE3_B_SAMB301
1ve3
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0226
None
16
TYR B 7TYR B 13TYR B 21ARG B 24ALA B 46GLY B 48ASP B 67ILE B 68SER B 69ASP B 93ALA B 94ARG B 95ILE B 110SER B 112HIS B 115PHE B 116
SAM B 301
1WU8_A_ADNA500
1wu8
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0463
PF01887(SAM_adeno_trans)no annotation
9
ASP A 7ARG A 40HIS A 41ASP A 68VAL A 71PHE B 181ASN B 183TYR B 212ASN B 235
ADN A 500
1WU8_B_ADNB501
1wu8
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0463
no annotation
11
ASP B 7ARG B 40HIS B 41ILE B 67ASP B 68PRO B 69VAL B 71PHE C 181ASN C 183TYR C 212ASN C 235
ADN B 501
1WU8_C_ADNC502
1wu8
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0463
PF01887(SAM_adeno_trans)no annotation
7
ARG C 40HIS C 41VAL C 71PHE A 181ASN A 183TYR A 212ASN A 235
ADN C 502
2DTT_A_H4BA1003
2dtt
H4B
DB00360(Sapropterin)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0634
PF01242(PTPS)no annotation
10
HIS A 15HIS A 27HIS A 29TYR C 45ASP C 48PHE C 49THR A 76THR A 77GLU A 78GLU A 105
H4B A1003
2DTT_B_H4BB1001
2dtt
H4B
DB00360(Sapropterin)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0634
PF01242(PTPS)no annotation
10
ILE A 5GLU B 24HIS B 27TYR A 45ASP A 48PHE A 49THR B 76THR B 77GLU B 78GLU B 105
H4B B1001
2DTT_C_H4BC1002
2dtt
H4B
DB00360(Sapropterin)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0634
no annotation
6
TYR B 45ASP B 48PHE B 49THR C 77GLU C 78GLU C 105
H4B C1002
2DTT_D_H4BD1006
2dtt
H4B
DB00360(Sapropterin)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0634
no annotation
10
HIS D 15HIS D 27HIS D 29TYR F 45ASP F 48PHE F 49THR D 76THR D 77GLU D 78GLU D 105
H4B D1006
2DTT_E_H4BE1004
2dtt
H4B
DB00360(Sapropterin)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0634
no annotation
11
HIS E 15VAL E 17HIS E 27HIS E 29TYR D 45PHE D 49LEU D 50THR E 76THR E 77GLU E 78GLU E 105
H4B E1004
2DTT_F_H4BF1005
2dtt
H4B
DB00360(Sapropterin)
Pyrococcushorikoshii
HYPOTHETICAL PROTEINPH0634
no annotation
9
ILE E 5HIS F 29TYR E 45ASP E 48PHE E 49THR F 76THR F 77GLU F 78GLU F 105
H4B F1005
2EJF_A_ADNA2001
2ejf
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
235AA LONGHYPOTHETICALBIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE
PF02237(BPL_C)PF03099(BPL_LplA_LipB)
7
ARG A 51TRP A 53GLU A 54ALA A 111ASN A 131PRO A 137ALA A 140
ADN A2001
2EJF_B_ADNB2002
2ejf
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
235AA LONGHYPOTHETICALBIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE
no annotation
6
ARG B 51TRP B 53GLU B 54ASN B 131PRO B 137ALA B 140
ADN B2002
2EJG_A_ADNA1501
2ejg
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
235AA LONGHYPOTHETICALBIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE
PF02237(BPL_C)PF03099(BPL_LplA_LipB)
7
ARG A 51TRP A 53GLU A 54LYS A 111ASN A 131PRO A 137ALA A 140
ADN A1501
2EJG_B_ADNB1502
2ejg
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
235AA LONGHYPOTHETICALBIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE
no annotation
7
ARG B 51TRP B 53GLU B 54LYS B 111ASN B 131PRO B 137ALA B 140
ADN B1502
2EJT_A_SAMA501
2ejt
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
N(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASE
PF02005(TRM)
15
ARG A 36ASP A 53LEU A 55ALA A 57ILE A 60ARG A 61ASN A 77ASP A 78ILE A 79SER A 80ASP A 120ALA A 121ASP A 138PHE A 140PHE A 146
SAM A 501
2R6V_A_NCAA174
2r6v
NCA
DB02701(Nicotinamide)
Pyrococcushorikoshii
UNCHARACTERIZEDPROTEIN PH0856
PF01613(Flavin_Reduct)
6
HIS A -7TYR A 8ASP A 29TRP A 30ARG A 49HIS A 124
NCA A 174
2YY8_B_SAMB500
2yy8
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
UPF0106 PROTEINPH0461
NonePF01994(Trm56)
11
HIS A 20LEU B 80MET B 82VAL B 108GLY B 109LYS B 112VAL B 113ILE B 127HIS B 132GLU B 134ALA B 137
SAM B 500
2YZQ_A_SAMA6075
2yzq
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
PUTATIVEUNCHARACTERIZEDPROTEIN PH1780
PF00571(CBS)
13
MET A 158ILE A 172ASP A 174THR A 176ASP A 177ARG A 180THR A 228VAL A 231ILE A 232ILE A 252GLU A 253GLN A 254PRO A 256
SAM A6075
2ZGW_A_ADNA1301
2zgw
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE
PF02237(BPL_C)PF03099(BPL_LplA_LipB)
7
ARG A 51TRP A 53GLU A 54ALA A 111ASN A 131PRO A 137ALA A 140
ADN A1301
2ZGW_B_ADNB1302
2zgw
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE
no annotation
6
TRP B 53GLU B 54ALA B 111ASN B 131PRO B 137ALA B 140
ADN B1302
3A25_A_SAMA279
3a25
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
UNCHARACTERIZEDPROTEIN PH0793
PF02475(Met_10)
15
MET A 107SER A 109ASN A 112ARG A 116PHE A 133GLY A 135HIS A 138ILE A 154GLU A 155LYS A 156ASP A 157THR A 160ASP A 183ASN A 184PHE A 207
SAM A 279
3ZOD_A_HQEA1173
3zod
HQE
DB09526(Hydroquinone)
Pyrococcushorikoshii
FMN-BINDING PROTEIN
PF01613(Flavin_Reduct)
7
HIS A -7TYR A 8ASP A 29TRP A 30ARG A 49HIS A 124HIS A 155
HQE A1173
4O8J_A_ADNA401
4o8j
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
RNA 3'-TERMINALPHOSPHATE CYCLASE
PF01137(RTC)PF05189(RTC_insert)
12
GLN A 14ARG A 17LEU A 97GLN A 100PRO A 127PRO A 128TYR A 131ASP A 250PHE A 283ASP A 286GLN A 287HIS A 307
ADN A 401
4O8J_B_ADNB401
4o8j
ADN
DB00640(Adenosine)
Pyrococcushorikoshii
RNA 3'-TERMINALPHOSPHATE CYCLASE
no annotation
12
GLN B 14ARG B 17LEU B 97GLN B 100PRO B 127PRO B 128TYR B 131ASP B 250PHE B 283ASP B 286GLN B 287HIS B 307
ADN B 401
5ZVG_A_SAMA401
5zvg
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
389AA LONGHYPOTHETICALNUCLEOLAR PROTEIN
PF01189(PUA)PF01472(Methyltr_RsmB-F)
15
ALA A 209PRO A 212GLY A 214LYS A 215ASP A 233LYS A 234SER A 235ARG A 238ASP A 260ALA A 261ARG A 262ASP A 277PRO A 279TYR A 304PHE A 308
SAM A 401
5ZVG_B_SAMB401
5zvg
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
389AA LONGHYPOTHETICALNUCLEOLAR PROTEIN
None
15
ALA B 209PRO B 212GLY B 214LYS B 215ASP B 233LYS B 234SER B 235ARG B 238ASP B 260ALA B 261ARG B 262ASP B 277PRO B 279TYR B 304PHE B 308
SAM B 401
6BXL_A_SAMA401
6bxl
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINESYNTHASE
PF01866(Diphthamide_syn)
12
TYR A 56LEU A 161GLY A 162HIS A 184SER A 236LYS A 238GLN A 241ASP A 268CYS A 287ARG A 289VAL A 290ASP A 293
SAM A 401
6BXL_B_SAMB401
6bxl
SAM
DB00118(S-Adenosylmethionine)
Pyrococcushorikoshii
2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINESYNTHASE
None
12
TYR B 56LEU B 161GLY B 162HIS B 184SER B 236LYS B 238GLN B 241VAL B 269CYS B 287ARG B 289VAL B 290ASP B 293
SAM B 401
[["1VE3_A_SAMA302","1ve3","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0226","PF13649(Methyltransf_25)",16,"TYR A 7;TYR A 13;TYR A 21;ARG A 24;ALA A 46;GLY A 48;ASP A 67;ILE A 68;SER A 69;ASP A 93;ALA A 94;ARG A 95;ILE A 110;SER A 112;HIS A 115;PHE A 116","SAM A 302\r"],["1VE3_B_SAMB301","1ve3","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0226","None",16,"TYR B 7;TYR B 13;TYR B 21;ARG B 24;ALA B 46;GLY B 48;ASP B 67;ILE B 68;SER B 69;ASP B 93;ALA B 94;ARG B 95;ILE B 110;SER B 112;HIS B 115;PHE B 116","SAM B 301\r"],["1WU8_A_ADNA500","1wu8","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0463","PF01887(SAM_adeno_trans);no annotation",9,"ASP A 7;ARG A 40;HIS A 41;ASP A 68;VAL A 71;PHE B 181;ASN B 183;TYR B 212;ASN B 235","ADN A 500\r"],["1WU8_B_ADNB501","1wu8","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0463","no annotation",11,"ASP B 7;ARG B 40;HIS B 41;ILE B 67;ASP B 68;PRO B 69;VAL B 71;PHE C 181;ASN C 183;TYR C 212;ASN C 235","ADN B 501\r"],["1WU8_C_ADNC502","1wu8","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0463","PF01887(SAM_adeno_trans);no annotation",7,"ARG C 40;HIS C 41;VAL C 71;PHE A 181;ASN A 183;TYR A 212;ASN A 235","ADN C 502\r"],["2DTT_A_H4BA1003","2dtt","H4B","DB00360(Sapropterin)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0634","PF01242(PTPS);no annotation",10,"HIS A 15;HIS A 27;HIS A 29;TYR C 45;ASP C 48;PHE C 49;THR A 76;THR A 77;GLU A 78;GLU A 105","H4B A1003\r"],["2DTT_B_H4BB1001","2dtt","H4B","DB00360(Sapropterin)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0634","PF01242(PTPS);no annotation",10,"ILE A 5;GLU B 24;HIS B 27;TYR A 45;ASP A 48;PHE A 49;THR B 76;THR B 77;GLU B 78;GLU B 105","H4B B1001\r"],["2DTT_C_H4BC1002","2dtt","H4B","DB00360(Sapropterin)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0634","no annotation",6,"TYR B 45;ASP B 48;PHE B 49;THR C 77;GLU C 78;GLU C 105","H4B C1002\r"],["2DTT_D_H4BD1006","2dtt","H4B","DB00360(Sapropterin)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0634","no annotation",10,"HIS D 15;HIS D 27;HIS D 29;TYR F 45;ASP F 48;PHE F 49;THR D 76;THR D 77;GLU D 78;GLU D 105","H4B D1006\r"],["2DTT_E_H4BE1004","2dtt","H4B","DB00360(Sapropterin)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0634","no annotation",11,"HIS E 15;VAL E 17;HIS E 27;HIS E 29;TYR D 45;PHE D 49;LEU D 50;THR E 76;THR E 77;GLU E 78;GLU E 105","H4B E1004\r"],["2DTT_F_H4BF1005","2dtt","H4B","DB00360(Sapropterin)","Pyrococcus horikoshii","HYPOTHETICAL PROTEIN PH0634","no annotation",9,"ILE E 5;HIS F 29;TYR E 45;ASP E 48;PHE E 49;THR F 76;THR F 77;GLU F 78;GLU F 105","H4B F1005\r"],["2EJF_A_ADNA2001","2ejf","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","PF02237(BPL_C);PF03099(BPL_LplA_LipB)",7,"ARG A 51;TRP A 53;GLU A 54;ALA A 111;ASN A 131;PRO A 137;ALA A 140","ADN A2001\r"],["2EJF_B_ADNB2002","2ejf","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","no annotation",6,"ARG B 51;TRP B 53;GLU B 54;ASN B 131;PRO B 137;ALA B 140","ADN B2002\r"],["2EJG_A_ADNA1501","2ejg","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","PF02237(BPL_C);PF03099(BPL_LplA_LipB)",7,"ARG A 51;TRP A 53;GLU A 54;LYS A 111;ASN A 131;PRO A 137;ALA A 140","ADN A1501\r"],["2EJG_B_ADNB1502","2ejg","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","no annotation",7,"ARG B 51;TRP B 53;GLU B 54;LYS B 111;ASN B 131;PRO B 137;ALA B 140","ADN B1502\r"],["2EJT_A_SAMA501","2ejt","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","PF02005(TRM)",15,"ARG A 36;ASP A 53;LEU A 55;ALA A 57;ILE A 60;ARG A 61;ASN A 77;ASP A 78;ILE A 79;SER A 80;ASP A 120;ALA A 121;ASP A 138;PHE A 140;PHE A 146","SAM A 501\r"],["2R6V_A_NCAA174","2r6v","NCA","DB02701(Nicotinamide)","Pyrococcus horikoshii","UNCHARACTERIZED PROTEIN PH0856","PF01613(Flavin_Reduct)",6,"HIS A -7;TYR A 8;ASP A 29;TRP A 30;ARG A 49;HIS A 124","NCA A 174\r"],["2YY8_B_SAMB500","2yy8","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","UPF0106 PROTEIN PH0461","None;PF01994(Trm56)",11,"HIS A 20;LEU B 80;MET B 82;VAL B 108;GLY B 109;LYS B 112;VAL B 113;ILE B 127;HIS B 132;GLU B 134;ALA B 137","SAM B 500\r"],["2YZQ_A_SAMA6075","2yzq","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","PUTATIVE UNCHARACTERIZED PROTEIN PH1780","PF00571(CBS)",13,"MET A 158;ILE A 172;ASP A 174;THR A 176;ASP A 177;ARG A 180;THR A 228;VAL A 231;ILE A 232;ILE A 252;GLU A 253;GLN A 254;PRO A 256","SAM A6075\r"],["2ZGW_A_ADNA1301","2zgw","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","PF02237(BPL_C);PF03099(BPL_LplA_LipB)",7,"ARG A 51;TRP A 53;GLU A 54;ALA A 111;ASN A 131;PRO A 137;ALA A 140","ADN A1301\r"],["2ZGW_B_ADNB1302","2zgw","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","no annotation",6,"TRP B 53;GLU B 54;ALA B 111;ASN B 131;PRO B 137;ALA B 140","ADN B1302\r"],["3A25_A_SAMA279","3a25","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","UNCHARACTERIZED PROTEIN PH0793","PF02475(Met_10)",15,"MET A 107;SER A 109;ASN A 112;ARG A 116;PHE A 133;GLY A 135;HIS A 138;ILE A 154;GLU A 155;LYS A 156;ASP A 157;THR A 160;ASP A 183;ASN A 184;PHE A 207","SAM A 279\r"],["3ZOD_A_HQEA1173","3zod","HQE","DB09526(Hydroquinone)","Pyrococcus horikoshii","FMN-BINDING PROTEIN","PF01613(Flavin_Reduct)",7,"HIS A -7;TYR A 8;ASP A 29;TRP A 30;ARG A 49;HIS A 124;HIS A 155","HQE A1173\r"],["4O8J_A_ADNA401","4o8j","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","RNA 3'-TERMINAL PHOSPHATE CYCLASE","PF01137(RTC);PF05189(RTC_insert)",12,"GLN A 14;ARG A 17;LEU A 97;GLN A 100;PRO A 127;PRO A 128;TYR A 131;ASP A 250;PHE A 283;ASP A 286;GLN A 287;HIS A 307","ADN A 401\r"],["4O8J_B_ADNB401","4o8j","ADN","DB00640(Adenosine)","Pyrococcus horikoshii","RNA 3'-TERMINAL PHOSPHATE CYCLASE","no annotation",12,"GLN B 14;ARG B 17;LEU B 97;GLN B 100;PRO B 127;PRO B 128;TYR B 131;ASP B 250;PHE B 283;ASP B 286;GLN B 287;HIS B 307","ADN B 401\r"],["5ZVG_A_SAMA401","5zvg","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN","PF01189(PUA);PF01472(Methyltr_RsmB-F)",15,"ALA A 209;PRO A 212;GLY A 214;LYS A 215;ASP A 233;LYS A 234;SER A 235;ARG A 238;ASP A 260;ALA A 261;ARG A 262;ASP A 277;PRO A 279;TYR A 304;PHE A 308","SAM A 401\r"],["5ZVG_B_SAMB401","5zvg","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN","None",15,"ALA B 209;PRO B 212;GLY B 214;LYS B 215;ASP B 233;LYS B 234;SER B 235;ARG B 238;ASP B 260;ALA B 261;ARG B 262;ASP B 277;PRO B 279;TYR B 304;PHE B 308","SAM B 401\r"],["6BXL_A_SAMA401","6bxl","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE","PF01866(Diphthamide_syn)",12,"TYR A 56;LEU A 161;GLY A 162;HIS A 184;SER A 236;LYS A 238;GLN A 241;ASP A 268;CYS A 287;ARG A 289;VAL A 290;ASP A 293","SAM A 401\r"],["6BXL_B_SAMB401","6bxl","SAM","DB00118(S-Adenosylmethionine)","Pyrococcus horikoshii","2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE","None",12,"TYR B 56;LEU B 161;GLY B 162;HIS B 184;SER B 236;LYS B 238;GLN B 241;VAL B 269;CYS B 287;ARG B 289;VAL B 290;ASP B 293","SAM B 401\r"]]