DRUG BINDING INTERFACES MAPPED TO 'TOPOISOMERASE I'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
1K4T_D_TTCD990
1k4t
TTC
DB01030(Topotecan)
;Homo sapiens
DNA TOPOISOMERASE I
PF01028(Topoisom_I)PF02919(Topoisom_I_N)PF14370(Topo_C_assoc)no annotation
5
GLU A 356ARG A 364LYS A 532ASP A 533THR A 718
TTC D 990
1QZR_B_CDXB901
1qzr
CDX
DB00380(Dexrazoxane)
Saccharomycescerevisiae
DNA TOPOISOMERASE II
PF00204(DNA_gyraseB)PF02518(HATPase_c)no annotation
14
HIS A 20HIS B 20THR B 27THR A 27TYR A 28TYR B 28ASN B 142ASN A 142TYR B 144TYR A 144LEU A 148LEU B 148GLN B 365GLN A 365
CDX B 901
1RFF_A_SPMA700
1rff
SPM
DB00127(Spermine)
;Homo sapiens
TOPOISOMERASEI-DERIVED PEPTIDE;TYROSYL-DNAPHOSPHODIESTERASE 1
PF06087(Tyr-DNA_phospho)no annotation
4
ASN A 591TRP A 605VAL A 606TYR C 724
SPM A 700
1RFI_A_SPMA999
1rfi
SPM
DB00127(Spermine)
;Homo sapiens
TOPOISOMERASEI-DERIVED PEPTIDE;TYROSYL-DNAPHOSPHODIESTERASE 1
PF06087(Tyr-DNA_phospho)no annotation
5
TRP A 590TRP A 605VAL A 606PRO A 607LYS C 724
SPM A 999
1RR8_A_TTCA100
1rr8
TTC
DB01030(Topotecan)
;Homo sapiens
DNA TOPOISOMERASE I
PF01028(Topoisom_I)PF02919(Topoisom_I_N)PF14370(Topo_C_assoc)no annotation
5
GLU C 356ARG C 364LYS C 532ASP C 533THR C 718
TTC A 100
1RRJ_B_TTCB990
1rrj
TTC
DB01030(Topotecan)
;Homo sapiens
DNA TOPOISOMERASE I
PF01028(Topoisom_I)PF02919(Topoisom_I_N)PF14370(Topo_C_assoc)no annotation
5
GLU A 356ARG A 364LYS A 532ASP A 533THR A 718
TTC B 990
1S14_A_NOVA1300
1s14
NOV
DB01051(Novobiocin)
Escherichia coli
TOPOISOMERASE IVSUBUNIT B
PF02518(HATPase_c)
12
ASN A1042SER A1043ASP A1045GLU A1046ASP A1069ARG A1072MET A1074PRO A1075ASP A1077ILE A1090ARG A1132THR A1163
NOV A1300
1S14_B_NOVB2300
1s14
NOV
DB01051(Novobiocin)
Escherichia coli
TOPOISOMERASE IVSUBUNIT B
no annotation
13
ASN B2042SER B2043ASP B2045GLU B2046ASP B2069ARG B2072MET B2074PRO B2075ASP B2077ALA B2086ILE B2090ARG B2132THR B2163
NOV B2300
2XKK_E_MFXE1100
2xkk
MFX
DB00218(Moxifloxacin)
Acinetobacterbaumannii;syntheticconstruct
DNA;TOPOISOMERASE IV
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim)no annotation
3
GLU C 437SER C1084ARG A1123
MFX E1100
3LPS_A_NOVA901
3lps
NOV
DB01051(Novobiocin)
Xanthomonasoryzae
TOPOISOMERASE IVSUBUNIT B
PF00204(DNA_gyraseB)PF02518(HATPase_c)
12
ASN A 86SER A 87ASP A 89GLU A 90ASP A 113ARG A 116MET A 118PRO A 119ASP A 121ILE A 134ARG A 176THR A 207
NOV A 901
4URN_A_NOVA2000
4urn
NOV
DB01051(Novobiocin)
Staphylococcusaureus
DNA TOPOISOMERASEIV, B SUBUNIT
PF02518(HATPase_c)no annotation
14
ASP B 35LYS B 36ASN A 49SER A 50ASP A 52GLU A 53ASP A 76ARG A 79MET A 81PRO A 82ILE A 96ARG A 138THR A 168ASN B 186
NOV A2000
4URN_B_NOVB2000
4urn
NOV
DB01051(Novobiocin)
Staphylococcusaureus
DNA TOPOISOMERASEIV, B SUBUNIT
no annotation
11
ASN B 49SER B 50ASP B 52GLU B 53ASP B 76ARG B 79MET B 81PRO B 82ILE B 96ARG B 138THR B 168
NOV B2000
4URN_C_NOVC2000
4urn
NOV
DB01051(Novobiocin)
Staphylococcusaureus
DNA TOPOISOMERASEIV, B SUBUNIT
no annotation
11
ASN C 49SER C 50ASP C 52GLU C 53ASP C 76ARG C 79MET C 81PRO C 82ILE C 96ARG C 138THR C 168
NOV C2000
[["1K4T_D_TTCD990","1k4t","TTC","DB01030(Topotecan)",";Homo sapiens","DNA TOPOISOMERASE I","PF01028(Topoisom_I);PF02919(Topoisom_I_N);PF14370(Topo_C_assoc);no annotation",5,"GLU A 356;ARG A 364;LYS A 532;ASP A 533;THR A 718","TTC D 990\r"],["1QZR_B_CDXB901","1qzr","CDX","DB00380(Dexrazoxane)","Saccharomyces cerevisiae","DNA TOPOISOMERASE II","PF00204(DNA_gyraseB);PF02518(HATPase_c);no annotation",14,"HIS A 20;HIS B 20;THR B 27;THR A 27;TYR A 28;TYR B 28;ASN B 142;ASN A 142;TYR B 144;TYR A 144;LEU A 148;LEU B 148;GLN B 365;GLN A 365","CDX B 901\r"],["1RFF_A_SPMA700","1rff","SPM","DB00127(Spermine)",";Homo sapiens","TOPOISOMERASE I-DERIVED PEPTIDE;TYROSYL-DNA PHOSPHODIESTERASE 1","PF06087(Tyr-DNA_phospho);no annotation",4,"ASN A 591;TRP A 605;VAL A 606;TYR C 724","SPM A 700\r"],["1RFI_A_SPMA999","1rfi","SPM","DB00127(Spermine)",";Homo sapiens","TOPOISOMERASE I-DERIVED PEPTIDE;TYROSYL-DNA PHOSPHODIESTERASE 1","PF06087(Tyr-DNA_phospho);no annotation",5,"TRP A 590;TRP A 605;VAL A 606;PRO A 607;LYS C 724","SPM A 999\r"],["1RR8_A_TTCA100","1rr8","TTC","DB01030(Topotecan)",";Homo sapiens","DNA TOPOISOMERASE I","PF01028(Topoisom_I);PF02919(Topoisom_I_N);PF14370(Topo_C_assoc);no annotation",5,"GLU C 356;ARG C 364;LYS C 532;ASP C 533;THR C 718","TTC A 100\r"],["1RRJ_B_TTCB990","1rrj","TTC","DB01030(Topotecan)",";Homo sapiens","DNA TOPOISOMERASE I","PF01028(Topoisom_I);PF02919(Topoisom_I_N);PF14370(Topo_C_assoc);no annotation",5,"GLU A 356;ARG A 364;LYS A 532;ASP A 533;THR A 718","TTC B 990\r"],["1S14_A_NOVA1300","1s14","NOV","DB01051(Novobiocin)","Escherichia coli","TOPOISOMERASE IV SUBUNIT B","PF02518(HATPase_c)",12,"ASN A1042;SER A1043;ASP A1045;GLU A1046;ASP A1069;ARG A1072;MET A1074;PRO A1075;ASP A1077;ILE A1090;ARG A1132;THR A1163","NOV A1300\r"],["1S14_B_NOVB2300","1s14","NOV","DB01051(Novobiocin)","Escherichia coli","TOPOISOMERASE IV SUBUNIT B","no annotation",13,"ASN B2042;SER B2043;ASP B2045;GLU B2046;ASP B2069;ARG B2072;MET B2074;PRO B2075;ASP B2077;ALA B2086;ILE B2090;ARG B2132;THR B2163","NOV B2300\r"],["2XKK_E_MFXE1100","2xkk","MFX","DB00218(Moxifloxacin)","Acinetobacter baumannii;synthetic construct","DNA;TOPOISOMERASE IV","PF00521(DNA_topoisoIV);PF00986(DNA_gyraseB_C);PF01751(Toprim);no annotation",3,"GLU C 437;SER C1084;ARG A1123","MFX E1100\r"],["3LPS_A_NOVA901","3lps","NOV","DB01051(Novobiocin)","Xanthomonas oryzae","TOPOISOMERASE IV SUBUNIT B","PF00204(DNA_gyraseB);PF02518(HATPase_c)",12,"ASN A 86;SER A 87;ASP A 89;GLU A 90;ASP A 113;ARG A 116;MET A 118;PRO A 119;ASP A 121;ILE A 134;ARG A 176;THR A 207","NOV A 901\r"],["4URN_A_NOVA2000","4urn","NOV","DB01051(Novobiocin)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","PF02518(HATPase_c);no annotation",14,"ASP B 35;LYS B 36;ASN A 49;SER A 50;ASP A 52;GLU A 53;ASP A 76;ARG A 79;MET A 81;PRO A 82;ILE A 96;ARG A 138;THR A 168;ASN B 186","NOV A2000\r"],["4URN_B_NOVB2000","4urn","NOV","DB01051(Novobiocin)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","no annotation",11,"ASN B 49;SER B 50;ASP B 52;GLU B 53;ASP B 76;ARG B 79;MET B 81;PRO B 82;ILE B 96;ARG B 138;THR B 168","NOV B2000\r"],["4URN_C_NOVC2000","4urn","NOV","DB01051(Novobiocin)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","no annotation",11,"ASN C 49;SER C 50;ASP C 52;GLU C 53;ASP C 76;ARG C 79;MET C 81;PRO C 82;ILE C 96;ARG C 138;THR C 168","NOV C2000\r"]]