DRUG BINDING INTERFACES MAPPED TO 'SMOOTHENED'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)| DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
|---|---|---|---|---|---|---|---|---|
| 5L7I_A_VISA1202 | 5l7i | VIS DB08828(Vismodegib) | Escherichia coli;Homo sapiens | SMOOTHENEDHOMOLOG,SOLUBLECYTOCHROMEB562,SMOOTHENEDHOMOLOG | PF01392(Fz)PF01534(Frizzled)PF07361(Cytochrom_B562) | 14 | ASN A 219LEU A 221TRP A 281ASP A 384VAL A 386SER A 387TYR A 394ARG A 400GLN A 477PHE A 484GLU A 518ASN A 521LEU A 522MET A 525 | VIS A1202 |
| 5L7I_B_VISB1202 | 5l7i | VIS DB08828(Vismodegib) | Escherichia coli;Homo sapiens | SMOOTHENEDHOMOLOG,SOLUBLECYTOCHROMEB562,SMOOTHENEDHOMOLOG | no annotation | 14 | LEU B 221TRP B 281ASP B 384SER B 387TYR B 394ARG B 400ASP B 473GLN B 477TRP B 480PRO B 513GLU B 518ASN B 521LEU B 522MET B 525 | VIS B1202 |