DRUG BINDING INTERFACES MAPPED TO 'SERINE HYDROXYMETHYLTRANSFERASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1DFO_A_FFOA1002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 20 | GLU B 57TYR B 64TYR B 65LEU A 121GLY A 124HIS A 126LEU A 127VAL A 133SER A 175ALA A 176SER D 245GLU D 246GLU D 247PHE B 257PRO B 258ASN A 347SER A 355PRO A 356PHE A 357ARG A 363 | FFO A1002 |
1DFO_B_FFOB2002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 17 | GLU A 57TYR A 64TYR A 65LEU B 121GLY B 124HIS B 126LEU B 127VAL B 133SER B 175ALA B 176PHE A 257PRO A 258ASN B 347SER B 355PRO B 356PHE B 357ARG B 363 | FFO B2002 |
1DFO_C_FFOC3002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 20 | GLU D 57TYR D 64TYR D 65LEU C 121GLY C 124HIS C 126LEU C 127VAL C 133SER C 175ALA C 176SER B 245GLU B 246GLU B 247PHE D 257PRO D 258ASN C 347SER C 355PRO C 356PHE C 357ARG C 363 | FFO C3002 |
1DFO_D_FFOD4002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 17 | GLU C 57TYR C 64TYR C 65LEU D 121GLY D 124HIS D 126LEU D 127VAL D 133SER D 175ALA D 176PHE C 257PRO C 258ASN D 347SER D 355PRO D 356PHE D 357ARG D 363 | FFO D4002 |
1EQB_A_FFOA1293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 18 | GLU B 57TYR B 64LEU A 121GLY A 124HIS A 126LEU A 127VAL A 133SER A 175ALA A 176SER D 245GLU D 246GLU D 247PHE B 257ASN A 347SER A 355PRO A 356PHE A 357ARG A 363 | FFO A1293 |
1EQB_A_GLYA1292 | 1eqb | GLY DB00145(Glycine) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 8 | SER A 35TYR B 55PHE B 65HIS A 126SER A 175HIS A 203LYS A 229ARG A 363 | GLY A1292 |
1EQB_B_FFOB2293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 15 | GLU A 57TYR A 64LEU B 121GLY B 124HIS B 126LEU B 127VAL B 133SER B 175ALA B 176PHE A 257ASN B 347SER B 355PRO B 356PHE B 357ARG B 363 | FFO B2293 |
1EQB_B_GLYB2292 | 1eqb | GLY DB00145(Glycine) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 8 | SER B 35TYR A 55PHE A 65HIS B 126SER B 175HIS B 203LYS B 229ARG B 363 | GLY B2292 |
1EQB_C_FFOC3293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 18 | GLU D 57TYR D 64LEU C 121GLY C 124HIS C 126LEU C 127VAL C 133SER C 175ALA C 176SER B 245GLU B 246GLU B 247PHE D 257ASN C 347SER C 355PRO C 356PHE C 357ARG C 363 | FFO C3293 |
1EQB_C_GLYC3292 | 1eqb | GLY DB00145(Glycine) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 8 | SER C 35TYR D 55PHE D 65HIS C 126SER C 175HIS C 203LYS C 229ARG C 363 | GLY C3292 |
1EQB_D_FFOD4293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 15 | GLU C 57TYR C 64LEU D 121GLY D 124HIS D 126LEU D 127VAL D 133SER D 175ALA D 176PHE C 257ASN D 347SER D 355PRO D 356PHE D 357ARG D 363 | FFO D4293 |
1EQB_D_GLYD4292 | 1eqb | GLY DB00145(Glycine) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 8 | SER D 35TYR C 55PHE C 65HIS D 126SER D 175HIS D 203LYS D 229ARG D 363 | GLY D4292 |
2VMY_A_FFOA505 | 2vmy | FFO DB11596(Levoleucovorin) | Geobacillusstearothermophilus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 18 | GLU A 53TYR A 60TYR A 61LEU B 117GLY B 120HIS B 122LEU B 123VAL B 129SER B 172ALA B 173LYS A 248PHE A 251PRO A 252ASN B 341SER B 349PRO B 350GLY B 351ARG B 357 | FFO A 505 |
2VMY_A_GLYA502 | 2vmy | GLY DB00145(Glycine) | Geobacillusstearothermophilus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 7 | SER A 31TYR B 51TYR B 61HIS A 122HIS A 200LYS A 226ARG A 357 | GLY A 502 |
2VMY_B_FFOB505 | 2vmy | FFO DB11596(Levoleucovorin) | Geobacillusstearothermophilus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 17 | GLU B 53TYR B 60TYR B 61LEU A 117GLY A 120HIS A 122LEU A 123VAL A 129SER A 172ALA A 173PHE B 251ASN A 339ASN A 341SER A 349PRO A 350GLY A 351ARG A 357 | FFO B 505 |
2VMY_B_GLYB502 | 2vmy | GLY DB00145(Glycine) | Geobacillusstearothermophilus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 8 | SER B 31TYR A 51TYR A 61HIS B 122SER B 172HIS B 200LYS B 226ARG B 357 | GLY B 502 |
3PGY_A_GLYA510 | 3pgy | GLY DB00145(Glycine) | Staphylococcusaureus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 6 | GLU A 27ILE A 29GLU A 32PHE A 34ASN B 49ALA A 363 | GLY A 510 |
3PGY_B_GLYB509 | 3pgy | GLY DB00145(Glycine) | Staphylococcusaureus | SERINEHYDROXYMETHYLTRANSFERASE | None | 4 | PHE B 34THR B 366LEU B 410TYR B 411 | GLY B 509 |
3PGY_B_GLYB511 | 3pgy | GLY DB00145(Glycine) | Staphylococcusaureus | SERINEHYDROXYMETHYLTRANSFERASE | None | 5 | SER B 334GLU B 391LEU B 394GLN B 395LYS B 398 | GLY B 511 |