DRUG BINDING INTERFACES MAPPED TO 'RNA-DIRECTED RNA POLYMERASE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
2PXC_A_SAMA500 2pxc SAM

DB00118
(S-
Adenosylmethionine)
Murray Valley
encephalitis
virus
GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN);
ENVELOPE PROTEIN M
(MATRIX PROTEIN);
MAJOR ENVELOPE
PROTEIN E;
NON-STRUCTURAL
PROTEIN 1 (NS1);
NON-STRUCTURAL
PROTEIN 2A (NS2A);
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT;
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT;
NON-STRUCTURAL
PROTEIN 4A (NS4A);
NON-STRUCTURAL
PROTEIN 4B (NS4B);
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]
PF01728
(FtsJ)
14 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
SAM A 500
4UCI_A_ADNA2414 4uci ADN

DB00640
(Adenosine)
Human
metapneumovirus
RNA-DIRECTED RNA
POLYMERASE L
no annotation 6 GLU A1781
PHE A1782
ARG A1785
PHE A1788
TYR A1818
HIS A1819
ADN A2414
4UCI_A_SAMA2409 4uci SAM

DB00118
(S-
Adenosylmethionine)
Human
metapneumovirus
RNA-DIRECTED RNA
POLYMERASE L
None 16 SER A1668
THR A1670
GLY A1696
GLU A1697
GLY A1698
GLY A1700
ASN A1701
TRP A1702
SER A1719
LEU A1720
ASP A1725
ASP A1755
ALA A1756
ASP A1779
ALA A1780
LYS A1817
SAM A2409
4UCI_B_ADNB2415 4uci ADN

DB00640
(Adenosine)
Human
metapneumovirus
RNA-DIRECTED RNA
POLYMERASE L
no annotation 7 GLU B1781
PHE B1782
ARG B1785
PHE B1788
LYS B1817
TYR B1818
HIS B1819
ADN B2415
4UCI_B_SAMB2409 4uci SAM

DB00118
(S-
Adenosylmethionine)
Human
metapneumovirus
RNA-DIRECTED RNA
POLYMERASE L
None 16 SER B1668
THR B1670
GLY B1696
GLU B1697
GLY B1698
GLY B1700
ASN B1701
TRP B1702
SER B1719
LEU B1720
ASP B1725
ASP B1755
ALA B1756
ASP B1779
ALA B1780
LYS B1817
SAM B2409
4UCK_A_SAMA2409 4uck SAM

DB00118
(S-
Adenosylmethionine)
Human
metapneumovirus
RNA-DIRECTED RNA
POLYMERASE L
None 15 SER A1668
THR A1670
GLY A1696
GLU A1697
GLY A1698
GLY A1700
ASN A1701
TRP A1702
SER A1719
LEU A1720
ASP A1755
ALA A1756
THR A1757
ASP A1779
ALA A1780
SAM A2409
4UCK_B_SAMB2409 4uck SAM

DB00118
(S-
Adenosylmethionine)
Human
metapneumovirus
RNA-DIRECTED RNA
POLYMERASE L
None 18 SER B1668
THR B1670
GLY B1696
GLU B1697
GLY B1698
GLY B1700
ASN B1701
TRP B1702
SER B1719
LEU B1720
ASP B1722
ASP B1725
ASP B1755
ALA B1756
THR B1757
ASP B1779
ALA B1780
LYS B1817
SAM B2409
5EHG_A_SAMA301 5ehg SAM

DB00118
(S-
Adenosylmethionine)
Dengue virus RNA-DIRECTED RNA
POLYMERASE NS5
PF01728
(FtsJ)
14 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
SAM A 301
5EHG_C_SAMC4001 5ehg SAM

DB00118
(S-
Adenosylmethionine)
Dengue virus RNA-DIRECTED RNA
POLYMERASE NS5
None 14 SER C  56
GLY C  58
GLY C  81
GLY C  83
GLY C  86
TRP C  87
THR C 104
LYS C 105
HIS C 110
GLU C 111
ASP C 131
VAL C 132
ASP C 146
ILE C 147
SAM C4001