DRUG BINDING INTERFACES MAPPED TO 'RNA-DIRECTED RNA POLYMERASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
2PXC_A_SAMA500 | 2pxc | SAM DB00118(S-Adenosylmethionine) | Murray Valleyencephalitisvirus | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN); ENVELOPE PROTEIN M(MATRIX PROTEIN); MAJOR ENVELOPEPROTEIN E; NON-STRUCTURALPROTEIN 1 (NS1); NON-STRUCTURALPROTEIN 2A (NS2A); FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT; FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT; NON-STRUCTURALPROTEIN 4A (NS4A); NON-STRUCTURALPROTEIN 4B (NS4B); RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 500 |
4UCI_A_ADNA2414 | 4uci | ADN DB00640(Adenosine) | Humanmetapneumovirus | RNA-DIRECTED RNAPOLYMERASE L | no annotation | 6 | GLU A1781PHE A1782ARG A1785PHE A1788TYR A1818HIS A1819 | ADN A2414 |
4UCI_A_SAMA2409 | 4uci | SAM DB00118(S-Adenosylmethionine) | Humanmetapneumovirus | RNA-DIRECTED RNAPOLYMERASE L | None | 16 | SER A1668THR A1670GLY A1696GLU A1697GLY A1698GLY A1700ASN A1701TRP A1702SER A1719LEU A1720ASP A1725ASP A1755ALA A1756ASP A1779ALA A1780LYS A1817 | SAM A2409 |
4UCI_B_ADNB2415 | 4uci | ADN DB00640(Adenosine) | Humanmetapneumovirus | RNA-DIRECTED RNAPOLYMERASE L | no annotation | 7 | GLU B1781PHE B1782ARG B1785PHE B1788LYS B1817TYR B1818HIS B1819 | ADN B2415 |
4UCI_B_SAMB2409 | 4uci | SAM DB00118(S-Adenosylmethionine) | Humanmetapneumovirus | RNA-DIRECTED RNAPOLYMERASE L | None | 16 | SER B1668THR B1670GLY B1696GLU B1697GLY B1698GLY B1700ASN B1701TRP B1702SER B1719LEU B1720ASP B1725ASP B1755ALA B1756ASP B1779ALA B1780LYS B1817 | SAM B2409 |
4UCK_A_SAMA2409 | 4uck | SAM DB00118(S-Adenosylmethionine) | Humanmetapneumovirus | RNA-DIRECTED RNAPOLYMERASE L | None | 15 | SER A1668THR A1670GLY A1696GLU A1697GLY A1698GLY A1700ASN A1701TRP A1702SER A1719LEU A1720ASP A1755ALA A1756THR A1757ASP A1779ALA A1780 | SAM A2409 |
4UCK_B_SAMB2409 | 4uck | SAM DB00118(S-Adenosylmethionine) | Humanmetapneumovirus | RNA-DIRECTED RNAPOLYMERASE L | None | 18 | SER B1668THR B1670GLY B1696GLU B1697GLY B1698GLY B1700ASN B1701TRP B1702SER B1719LEU B1720ASP B1722ASP B1725ASP B1755ALA B1756THR B1757ASP B1779ALA B1780LYS B1817 | SAM B2409 |
5EHG_A_SAMA301 | 5ehg | SAM DB00118(S-Adenosylmethionine) | Dengue virus | RNA-DIRECTED RNAPOLYMERASE NS5 | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 |
5EHG_C_SAMC4001 | 5ehg | SAM DB00118(S-Adenosylmethionine) | Dengue virus | RNA-DIRECTED RNAPOLYMERASE NS5 | None | 14 | SER C 56GLY C 58GLY C 81GLY C 83GLY C 86TRP C 87THR C 104LYS C 105HIS C 110GLU C 111ASP C 131VAL C 132ASP C 146ILE C 147 | SAM C4001 |