DRUG BINDING INTERFACES MAPPED TO 'RNA POLYMERASE SIGMA FACTOR'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
2A68_C_RBTC8001 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RBT C8001
2A68_M_RBTM8002 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 13 ARG M 134
ASP P 323
LYS P 325
GLN M 390
GLN M 393
PHE M 394
ASP M 396
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
 RBT M8002
2A69_C_RPTC8001 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RPT C8001
4KMU_H_RFPH1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 14 GLN H 510
GLN H 513
ASP Y 514
PHE H 514
ASP H 516
HIS H 526
ARG H 529
SER H 531
LEU H 533
ARG H 540
PRO H 564
ASN H 568
ILE H 572
ARG H 687
 RFP H1401
5UH6_C_RFPC1201 5uh6 RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ARG C 173
ASP F 429
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHC_C_RFPC1201 5uhc RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ASP F 429
GLU F 430
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
6BZO_C_FI8C1201 6bzo FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_5)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_2)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		28 ARG J  10
VAL J  14
ARG D  84
LYS D  86
ARG D  89
GLU D 323
LEU D 324
PRO D 326
SER D 338
ARG D 412
GLN D 415
LEU F 423
ASP F 424
GLN F 434
VAL F 445
MET C1051
ILE C1052
THR C1053
GLN C1054
ASP C1094
THR C1096
VAL C1097
VAL C1100
LYS C1101
GLU C1119
SER C1120
VAL C1123
GLU C1127
 FI8 C1201
6C06_D_FI8D1404 6c06 FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_2)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		13 ARG J  10
ARG D  84
LYS D  86
ARG D 412
GLN F 434
ILE C1052
THR C1053
GLN C1054
THR C1096
ARG C1099
LYS C1101
GLU C1119
SER C1120
 FI8 D1404
6FBV_D_FI8D1904 6fbv FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_45)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_5)
PF04998
(RNA_pol_Rpb1_4)
PF05000
(RNA_pol_Rpb1_1) 		18 ASP D  57
ARG D  84
LYS D  86
ARG D  89
GLU D 323
VAL D 328
ARG D 412
GLN D 415
LEU F 423
ASP F 424
MET C1051
ILE C1052
GLN C1054
THR C1096
VAL C1097
LYS C1101
GLU C1119
SER C1120
 FI8 D1904