DRUG BINDING INTERFACES MAPPED TO 'RNA POLYMERASE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1I6V_C_RFPC1640 1i6v RFP

DB01045
(Rifampicin) 		Thermus aquaticus DNA-DIRECTED RNA
POLYMERASE 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 ARG C 134
GLN C 390
LEU C 391
GLN C 393
PHE C 394
ASP C 396
ARG C 405
HIS C 406
ARG C 409
SER C 411
GLU C 445
ILE C 452
 RFP C1640
1YNN_C_RFPC1120 1ynn RFP

DB01045
(Rifampicin) 		Thermus aquaticus DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 ARG C 134
GLN C 390
GLN C 393
PHE C 394
ASP C 396
ARG C 405
HIS C 406
ARG C 409
SER C 411
LEU C 413
PRO C 444
ILE C 452
 RFP C1120
2A68_C_RBTC8001 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RBT C8001
2A68_M_RBTM8002 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 13 ARG M 134
ASP P 323
LYS P 325
GLN M 390
GLN M 393
PHE M 394
ASP M 396
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
 RBT M8002
2A69_C_RPTC8001 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RPT C8001
2A69_M_RPTM8002 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN 		no annotation 14 ARG M 134
GLN M 390
GLN M 393
PHE M 394
ASP M 396
ARG M 405
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
MET M1000
GLU M1002
 RPT M8002
2PXC_A_SAMA500 2pxc SAM

DB00118
(S-
Adenosylmethionine) 		Murray Valley
encephalitis
virus 		GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN);
ENVELOPE PROTEIN M
(MATRIX PROTEIN);
MAJOR ENVELOPE
PROTEIN E;
NON-STRUCTURAL
PROTEIN 1 (NS1);
NON-STRUCTURAL
PROTEIN 2A (NS2A);
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT;
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT;
NON-STRUCTURAL
PROTEIN 4A (NS4A);
NON-STRUCTURAL
PROTEIN 4B (NS4B);
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)] 		PF01728
(FtsJ) 		14 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM A 500
3NAI_A_URFA521 3nai URF

DB00544
(Fluorouracil) 		Norwalk virus RNA DEPENDENT RNA
POLYMERASE 		PF00680
(RdRP_1) 		5 ARG A 185
ASP A 245
ASP A 346
ASP A 347
ARG A 395
 URF A 521
3NAI_B_URFB521 3nai URF

DB00544
(Fluorouracil) 		Norwalk virus RNA DEPENDENT RNA
POLYMERASE 		no annotation 4 ARG B 185
ASP B 245
ASP B 346
ASP B 347
 URF B 521
3NAI_C_URFC521 3nai URF

DB00544
(Fluorouracil) 		Norwalk virus RNA DEPENDENT RNA
POLYMERASE 		no annotation 5 ARG C 185
ASP C 245
ASP C 346
ASP C 347
ARG C 395
 URF C 521
3PGL_A_RZXA257 3pgl RZX

DB01129
(Rabeprazole) 		Homo sapiens CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1 		PF03031
(NIF) 		7 ASP A  98
PHE A 106
VAL A 118
ILE A 120
SER A 154
TYR A 158
ARG A 178
 RZX A 257
3SFU_A_RBVA601 3sfu RBV

DB00811
(Ribavirin) 		Norwalk virus RNA POLYMERASE PF00680
(RdRP_1) 		9 ASP A 250
SER A 303
THR A 308
THR A 309
ASN A 312
TYR A 344
GLY A 345
ASP A 346
ASP A 347
 RBV A 601
3SFU_B_RBVB601 3sfu RBV

DB00811
(Ribavirin) 		Norwalk virus RNA POLYMERASE no annotation 9 ASP B 250
THR B 309
ASN B 312
TYR B 344
GLY B 345
ASP B 346
ASP B 347
LEU B 394
ARG B 395
 RBV B 601
3SFU_C_RBVC601 3sfu RBV

DB00811
(Ribavirin) 		Norwalk virus RNA POLYMERASE no annotation 11 LYS C 169
ARG C 185
LEU C 187
ASP C 250
LEU C 301
SER C 303
THR C 308
THR C 309
ASN C 312
GLY C 345
ASP C 346
 RBV C 601
3UR0_B_SVRB516 3ur0 SVR

DB04786
(Suramin) 		Norwalk virus RNA-DEPENDENT RNA
POLYMERASE 		no annotation 7 PRO B  38
GLY B  40
ALA B  41
TRP B  42
ALA B 409
ASP B 412
ARG B 413
 SVR B 516
3UR0_C_SVRC516 3ur0 SVR

DB04786
(Suramin) 		Norwalk virus RNA-DEPENDENT RNA
POLYMERASE 		no annotation 9 PRO C  38
GLY C  40
ALA C  41
TRP C  42
LYS C 171
ALA C 409
ASP C 412
ARG C 413
LEU C 416
 SVR C 516
3UR0_C_SVRC517 3ur0 SVR

DB04786
(Suramin) 		Norwalk virus RNA-DEPENDENT RNA
POLYMERASE 		no annotation 11 TRP C  42
GLN C  66
LYS C  68
GLU C 168
VAL C 170
LYS C 171
LYS C 174
LYS C 180
ARG C 182
ARG C 245
ARG C 392
 SVR C 517
4K4Y_A_ACTA502 4k4y ACT

DB03166
(Acetic
acid) 		Enterovirus B RNA-DEPENDENT RNA
POLYMERASE 		PF00680
(RdRP_1) 		5 LYS A  96
LEU A  97
GLU A  98
LEU A 138
LYS A 142
 ACT A 502
4K4Y_E_ACTE503 4k4y ACT

DB03166
(Acetic
acid) 		Enterovirus B RNA-DEPENDENT RNA
POLYMERASE 		None 4 LYS E  96
LEU E  97
GLU E  98
LEU E 138
 ACT E 503
4K4Y_I_ACTI503 4k4y ACT

DB03166
(Acetic
acid) 		Enterovirus B RNA-DEPENDENT RNA
POLYMERASE 		None 5 LYS I  96
LEU I  97
GLU I  98
LEU I 138
LYS I 142
 ACT I 503
4K50_A_ACTA502 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		PF00680
(RdRP_1) 		3 ARG A 163
LYS A 164
LYS A 167
 ACT A 502
4K50_A_ACTA503 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		PF00680
(RdRP_1) 		4 LYS A 336
ASP A 338
MET A 339
PHE A 362
 ACT A 503
4K50_A_ACTA505 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		PF00680
(RdRP_1) 		3 CYS A  68
ASN A  71
LYS A 348
 ACT A 505
4K50_A_ACTA506 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		PF00680
(RdRP_1) 		3 VAL A 121
GLY A 124
LYS A 126
 ACT A 506
4K50_B_ACTB701 4k50 ACT

DB03166
(Acetic
acid) 		;
Rhinovirus A 		RNA (33-MER);
RNA POLYMERASE
3D-POL 		None
PF00680
(RdRP_1) 		3 HIS A 199
GLY A 291
ILE A 294
 ACT B 701
4K50_E_ACTE501 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 4 CYS E 212
THR E 216
PHE E 217
LYS E 220
 ACT E 501
4K50_E_ACTE502 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 3 ARG E 163
LYS E 164
LYS E 167
 ACT E 502
4K50_E_ACTE503 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 4 MET E 154
SER E 179
LEU E 267
CYS E 289
 ACT E 503
4K50_E_ACTE504 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 3 VAL E 121
GLY E 124
LYS E 126
 ACT E 504
4K50_F_ACTF701 4k50 ACT

DB03166
(Acetic
acid) 		;
Rhinovirus A 		RNA (33-MER);
RNA POLYMERASE
3D-POL 		None 4 PHE E 195
HIS E 199
GLY E 291
ILE E 294
 ACT F 701
4K50_I_ACTI501 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 4 LYS I 336
ASP I 338
MET I 339
PHE I 362
 ACT I 501
4K50_I_ACTI504 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 3 VAL I 121
GLY I 124
LYS I 126
 ACT I 504
4K50_I_ACTI506 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 3 ARG I 163
LYS I 164
LYS I 167
 ACT I 506
4K50_I_ACTI507 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 3 LYS I 405
PRO I 406
SER I 407
 ACT I 507
4K50_J_ACTJ701 4k50 ACT

DB03166
(Acetic
acid) 		;
Rhinovirus A 		RNA (33-MER);
RNA POLYMERASE
3D-POL 		None 3 HIS I 199
GLY I 291
ILE I 294
 ACT J 701
4K50_M_ACTM501 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 4 MET M 154
SER M 179
LEU M 267
CYS M 289
 ACT M 501
4K50_M_ACTM502 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 4 CYS M 212
THR M 216
PHE M 217
LYS M 220
 ACT M 502
4K50_M_ACTM503 4k50 ACT

DB03166
(Acetic
acid) 		Rhinovirus A RNA POLYMERASE
3D-POL 		None 4 PHE M 195
HIS M 199
GLY M 291
ILE M 294
 ACT M 503
4KMU_C_RFPC1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		14 GLN C 510
LEU C 511
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ASN C 568
ILE C 572
ARG C 687
 RFP C1401
4KMU_H_RFPH1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 14 GLN H 510
GLN H 513
ASP Y 514
PHE H 514
ASP H 516
HIS H 526
ARG H 529
SER H 531
LEU H 533
ARG H 540
PRO H 564
ASN H 568
ILE H 572
ARG H 687
 RFP H1401
4M6T_A_SAMA201 4m6t SAM

DB00118
(S-
Adenosylmethionine) 		Homo sapiens RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1 		PF03985
(Leo1)
PF04004
(Paf1) 		4 ILE A  30
VAL A  42
VAL A  44
ARG A 169
 SAM A 201
4UCI_A_ADNA2414 4uci ADN

DB00640
(Adenosine) 		Human
metapneumovirus 		RNA-DIRECTED RNA
POLYMERASE L 		no annotation 6 GLU A1781
PHE A1782
ARG A1785
PHE A1788
TYR A1818
HIS A1819
 ADN A2414
4UCI_A_SAMA2409 4uci SAM

DB00118
(S-
Adenosylmethionine) 		Human
metapneumovirus 		RNA-DIRECTED RNA
POLYMERASE L 		None 16 SER A1668
THR A1670
GLY A1696
GLU A1697
GLY A1698
GLY A1700
ASN A1701
TRP A1702
SER A1719
LEU A1720
ASP A1725
ASP A1755
ALA A1756
ASP A1779
ALA A1780
LYS A1817
 SAM A2409
4UCI_B_ADNB2415 4uci ADN

DB00640
(Adenosine) 		Human
metapneumovirus 		RNA-DIRECTED RNA
POLYMERASE L 		no annotation 7 GLU B1781
PHE B1782
ARG B1785
PHE B1788
LYS B1817
TYR B1818
HIS B1819
 ADN B2415
4UCI_B_SAMB2409 4uci SAM

DB00118
(S-
Adenosylmethionine) 		Human
metapneumovirus 		RNA-DIRECTED RNA
POLYMERASE L 		None 16 SER B1668
THR B1670
GLY B1696
GLU B1697
GLY B1698
GLY B1700
ASN B1701
TRP B1702
SER B1719
LEU B1720
ASP B1725
ASP B1755
ALA B1756
ASP B1779
ALA B1780
LYS B1817
 SAM B2409
4UCK_A_SAMA2409 4uck SAM

DB00118
(S-
Adenosylmethionine) 		Human
metapneumovirus 		RNA-DIRECTED RNA
POLYMERASE L 		None 15 SER A1668
THR A1670
GLY A1696
GLU A1697
GLY A1698
GLY A1700
ASN A1701
TRP A1702
SER A1719
LEU A1720
ASP A1755
ALA A1756
THR A1757
ASP A1779
ALA A1780
 SAM A2409
4UCK_B_SAMB2409 4uck SAM

DB00118
(S-
Adenosylmethionine) 		Human
metapneumovirus 		RNA-DIRECTED RNA
POLYMERASE L 		None 18 SER B1668
THR B1670
GLY B1696
GLU B1697
GLY B1698
GLY B1700
ASN B1701
TRP B1702
SER B1719
LEU B1720
ASP B1722
ASP B1725
ASP B1755
ALA B1756
THR B1757
ASP B1779
ALA B1780
LYS B1817
 SAM B2409
4WZM_A_ACTA503 4wzm ACT

DB03166
(Acetic
acid) 		Foot-and-mouth
disease virus 		RNA DEPENDENT RNA
POLYMERASE 		PF00680
(RdRP_1) 		4 ASP A 238
ASP A 240
ASP A 339
ALA A 367
 ACT A 503
5EHG_A_SAMA301 5ehg SAM

DB00118
(S-
Adenosylmethionine) 		Dengue virus RNA-DIRECTED RNA
POLYMERASE NS5 		PF01728
(FtsJ) 		14 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM A 301
5EHG_C_SAMC4001 5ehg SAM

DB00118
(S-
Adenosylmethionine) 		Dengue virus RNA-DIRECTED RNA
POLYMERASE NS5 		None 14 SER C  56
GLY C  58
GLY C  81
GLY C  83
GLY C  86
TRP C  87
THR C 104
LYS C 105
HIS C 110
GLU C 111
ASP C 131
VAL C 132
ASP C 146
ILE C 147
 SAM C4001
5UAC_C_RFPC3001 5uac RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 GLN C 510
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ILE C 572
ARG C 687
 RFP C3001
5UAH_C_RFPC3001 5uah RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		13 ARG C 143
GLN C 510
LEU C 511
GLN C 513
PHE C 514
VAL C 516
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ILE C 572
ARG C 687
 RFP C3001
5UAL_C_RFPC3001 5ual RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 GLN C 510
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
LEU C 531
PRO C 564
ILE C 572
ARG C 687
GLN C 761
 RFP C3001
5UH6_C_RFPC1201 5uh6 RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ARG C 173
ASP F 429
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHB_C_RFPC1201 5uhb RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		15 GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHC_C_RFPC1201 5uhc RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ASP F 429
GLU F 430
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHD_C_RFPC1201 5uhd RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		16 ARG C 173
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHG_C_RFPC1201 5uhg RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		16 ARG C 173
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
6BZO_C_FI8C1201 6bzo FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_5)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_2)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		28 ARG J  10
VAL J  14
ARG D  84
LYS D  86
ARG D  89
GLU D 323
LEU D 324
PRO D 326
SER D 338
ARG D 412
GLN D 415
LEU F 423
ASP F 424
GLN F 434
VAL F 445
MET C1051
ILE C1052
THR C1053
GLN C1054
ASP C1094
THR C1096
VAL C1097
VAL C1100
LYS C1101
GLU C1119
SER C1120
VAL C1123
GLU C1127
 FI8 C1201
6C06_D_FI8D1404 6c06 FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_2)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		13 ARG J  10
ARG D  84
LYS D  86
ARG D 412
GLN F 434
ILE C1052
THR C1053
GLN C1054
THR C1096
ARG C1099
LYS C1101
GLU C1119
SER C1120
 FI8 D1404
6FBV_D_FI8D1904 6fbv FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_45)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_5)
PF04998
(RNA_pol_Rpb1_4)
PF05000
(RNA_pol_Rpb1_1) 		18 ASP D  57
ARG D  84
LYS D  86
ARG D  89
GLU D 323
VAL D 328
ARG D 412
GLN D 415
LEU F 423
ASP F 424
MET C1051
ILE C1052
GLN C1054
THR C1096
VAL C1097
LYS C1101
GLU C1119
SER C1120
 FI8 D1904