DRUG BINDING INTERFACES MAPPED TO 'RNA METHYLTRANSFERASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1X7P_A_SAMA301 | 1x7p | SAM DB00118(S-Adenosylmethionine) | Streptomycesviridochromogenes | RRNAMETHYLTRANSFERASE | NonePF00588(SpoU_methylase) | 11 | ARG B 145THR A 210GLU A 212GLY A 232GLY A 237ILE A 252MET A 254SER A 260LEU A 261ALA A 263ALA A 266 | SAM A 301 |
1X7P_B_SAMB302 | 1x7p | SAM DB00118(S-Adenosylmethionine) | Streptomycesviridochromogenes | RRNAMETHYLTRANSFERASE | NonePF00588(SpoU_methylase) | 10 | ARG A 145THR B 210ASP B 211GLU B 212GLY B 232GLY B 237ILE B 252MET B 254LEU B 261ALA B 266 | SAM B 302 |
2EJT_A_SAMA501 | 2ejt | SAM DB00118(S-Adenosylmethionine) | Pyrococcushorikoshii | N(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASE | PF02005(TRM) | 15 | ARG A 36ASP A 53LEU A 55ALA A 57ILE A 60ARG A 61ASN A 77ASP A 78ILE A 79SER A 80ASP A 120ALA A 121ASP A 138PHE A 140PHE A 146 | SAM A 501 |
2NYU_A_SAMA201 | 2nyu | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 | PF01728(FtsJ) | 16 | SER A 6GLY A 30ALA A 32PRO A 33GLY A 34ALA A 35TRP A 36ASP A 62LEU A 63LEU A 64ASP A 79VAL A 80ASP A 104MET A 105LEU A 123LYS A 144 | SAM A 201 |
2NYU_B_SAMB201 | 2nyu | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 | None | 17 | SER B 6GLY B 30ALA B 32PRO B 33GLY B 34ALA B 35TRP B 36ASP B 62LEU B 63LEU B 64ASP B 79VAL B 80THR B 81ASP B 104MET B 105LEU B 123LYS B 144 | SAM B 201 |
2PLW_A_SAMA203 | 2plw | SAM DB00118(S-Adenosylmethionine) | Plasmodiumfalciparum | RIBOSOMAL RNAMETHYLTRANSFERASE,PUTATIVE | PF01728(FtsJ) | 15 | ALA A 6GLY A 30TYR A 32PRO A 33GLY A 34SER A 35TRP A 36ASP A 55LYS A 56LYS A 57GLU A 71ILE A 72ASP A 113ALA A 114LEU A 132 | SAM A 203 |
3AXT_A_SAMA397 | 3axt | SAM DB00118(S-Adenosylmethionine) | Aquifex aeolicus | PROBABLEN(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASETRM1 | PF02005(TRM) | 12 | ARG A 36LEU A 60ALA A 62ILE A 65ARG A 66ASP A 84ILE A 85SER A 86GLU A 113ALA A 114ASP A 132PHE A 134 | SAM A 397 |
3KW2_A_ADNA300 | 3kw2 | ADN DB00640(Adenosine) | Porphyromonasgingivalis | PROBABLE R-RNAMETHYLTRANSFERASE | PF04452(Methyltrans_RNA) | 11 | ALA A 164VAL A 166ARG A 178ILE A 195GLY A 196ASP A 200SER A 218LEU A 219LEU A 224THR A 226ALA A 229 | ADN A 300 |
3KW2_B_ADNB300 | 3kw2 | ADN DB00640(Adenosine) | Porphyromonasgingivalis | PROBABLE R-RNAMETHYLTRANSFERASE | no annotation | 11 | ALA B 164VAL B 166ARG B 178ILE B 195GLY B 196ASP B 200SER B 218LEU B 219LEU B 224THR B 226ALA B 229 | ADN B 300 |
3NK7_A_SAMA770 | 3nk7 | SAM DB00118(S-Adenosylmethionine) | Streptomycesactuosus | 23S RRNAMETHYLTRANSFERASE | NonePF00588(SpoU_methylase)PF04705(TSNR_N) | 14 | ASN A 129ARG B 135ARG B 165LEU A 195THR A 197GLY A 218GLU A 220GLY A 223ILE A 238MET A 240SER A 246ASN A 248VAL A 249SER A 252 | SAM A 770 |
3NK7_B_SAMB770 | 3nk7 | SAM DB00118(S-Adenosylmethionine) | Streptomycesactuosus | 23S RRNAMETHYLTRANSFERASE | NonePF00588(SpoU_methylase)PF04705(TSNR_N) | 15 | ASN B 129ARG A 135ARG A 165LEU B 195PHE B 217GLY B 218GLU B 220GLY B 223ILE B 238MET B 240SER B 246LEU B 247ASN B 248VAL B 249SER B 252 | SAM B 770 |
4PL1_A_SAMA401 | 4pl1 | SAM DB00118(S-Adenosylmethionine) | Escherichia coli | DUAL-SPECIFICITY RNAMETHYLTRANSFERASERLMN | PF04055(Radical_SAM) | 11 | PHE A 131MET A 176GLU A 180PRO A 181SER A 211SER A 233HIS A 235GLU A 278ILE A 309TRP A 311ASN A 312 | SAM A 401 |
4PL1_B_SAMB401 | 4pl1 | SAM DB00118(S-Adenosylmethionine) | Escherichia coli | DUAL-SPECIFICITY RNAMETHYLTRANSFERASERLMN | None | 10 | CYS B 132MET B 176GLU B 180PRO B 181SER B 211SER B 233HIS B 235GLU B 278TRP B 311ASN B 312 | SAM B 401 |
5E72_A_SAMA400 | 5e72 | SAM DB00118(S-Adenosylmethionine) | Thermococcuskodakarensis | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE | PF01170(THUMP)PF02926(UPF0020) | 16 | ILE A 163ASP A 185PHE A 187GLY A 189GLY A 192ILE A 193ASP A 208ILE A 209ARG A 210MET A 213ASP A 235ALA A 236THR A 253ASP A 254PRO A 256LEU A 271 | SAM A 400 |
5L0Z_A_SAMA304 | 5l0z | SAM DB00118(S-Adenosylmethionine) | Sinorhizobiummeliloti | PROBABLE RNAMETHYLTRANSFERASE,TRMH FAMILY | PF00588(SpoU_sub_bind)PF08032(SpoU_methylase) | 12 | THR A 212LEU A 214GLY A 235GLY A 240ARG A 254ILE A 255GLN A 257ASP A 262SER A 263LEU A 264LEU A 266ALA A 269 | SAM A 304 |
5L0Z_B_SAMB304 | 5l0z | SAM DB00118(S-Adenosylmethionine) | Sinorhizobiummeliloti | PROBABLE RNAMETHYLTRANSFERASE,TRMH FAMILY | None | 10 | THR B 212LEU B 214GLY B 235GLY B 240ILE B 255GLN B 257SER B 263LEU B 264LEU B 266ALA B 269 | SAM B 304 |