DRUG BINDING INTERFACES MAPPED TO 'RIBONUCLEASE H'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
2HND_A_NVPA999
2hnd
NVP
DB00238(Nevirapine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
10
LEU A 100LYS A 103VAL A 106VAL A 179TYR A 181TYR A 188GLY A 190TRP A 229LEU A 234TYR A 318
NVP A 999
2HNY_A_NVPA999
2hny
NVP
DB00238(Nevirapine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
10
LEU A 100LYS A 103VAL A 106VAL A 179TYR A 181TYR A 188GLY A 190TRP A 229LEU A 234TYR A 318
NVP A 999
2ZD1_A_T27A557
2zd1
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 101LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234TYR A 318
T27 A 557
2ZE2_A_T27A556
2ze2
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
10
PRO A 95ILE A 100ASN A 103VAL A 179TYR A 181TYR A 188PRO A 225TRP A 229LEU A 234TYR A 318
T27 A 556
3BGR_A_T27A556
3bgr
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
11
LEU A 100ASN A 103GLU B 138VAL A 179CYS A 181TYR A 183TYR A 188PHE A 227TRP A 229LEU A 234TYR A 318
T27 A 556
3LP0_A_NVPA701
3lp0
NVP
DB00238(Nevirapine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
9
LEU A 100VAL A 106VAL A 179TYR A 181TYR A 188GLY A 190TRP A 229LEU A 234TYR A 318
NVP A 701
3LP1_A_NVPA701
3lp1
NVP
DB00238(Nevirapine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
10
LEU A 100ASN A 103VAL A 106VAL A 179TYR A 181TYR A 188GLY A 190TRP A 229LEU A 234TYR A 318
NVP A 701
3M8P_A_65BA562
3m8p
65B
DB06414(Etravirine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H;P51 RT
PF00075(RNase_H)PF00078(RVT_thumb)PF06815(RVT_1)PF06817(RVT_connect)PF00078(RVT_thumb)PF06815(RVT_1)PF06817(RVT_connect)
11
LEU A 100LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PHE A 227TRP A 229LEU A 234TYR A 318
65B A 562
3QLH_A_T27A555
3qlh
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
12
PRO A 95LEU A 100LYS A 101LYS A 103VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229PRO A 236TYR A 318
T27 A 555
4B3O_A_EFZA1557
4b3o
EFZ
DB00625(Efavirenz)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
9
LEU A 100LYS A 101LYS A 103VAL A 106TYR A 181TYR A 188GLY A 190LEU A 234TYR A 318
EFZ A1557
4B3Q_A_NVPA999
4b3q
NVP
DB00238(Nevirapine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
7
LEU A 100LYS A 103VAL A 106TYR A 181TYR A 188LEU A 234TYR A 318
NVP A 999
4G1Q_A_T27A601
4g1q
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
15
PRO A 95LEU A 100LYS A 101LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234PRO A 236TYR A 318
T27 A 601
4ICL_A_T27A601
4icl
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 101LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234TYR A 318
T27 A 601
4ID5_A_T27A601
4id5
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234PRO A 236TYR A 318
T27 A 601
4IDK_A_T27A601
4idk
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 101LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234TYR A 318
T27 A 601
4IFV_A_T27A601
4ifv
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
EXORIBONUCLEASE H,P66 RT;GAG-POL POLYPROTEIN
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234PRO A 236TYR A 318
T27 A 601
4IFY_A_T27A601
4ify
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234PRO A 236TYR A 318
T27 A 601
4IG3_A_T27A601
4ig3
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234PRO A 236TYR A 318
T27 A 601
4KFB_A_T27A607
4kfb
T27
DB08864(Rilpivirine)
Humanimmunodeficiencyvirus 1
P51 RT;REVERSETRANSCRIPTASE/RIBONUCLEASE H,EXORIBONUCLEA P66 RT
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
14
PRO A 95LEU A 100LYS A 103VAL A 106GLU B 138VAL A 179TYR A 181TYR A 188PRO A 225PHE A 227TRP A 229LEU A 234PRO A 236TYR A 318
T27 A 607
5HBM_A_NVPA601
5hbm
NVP
DB00238(Nevirapine)
Humanimmunodeficiencyvirus 1
REVERSETRANSCRIPTASE/RIBONUCLEASE H
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb)
11
PRO A 95LEU A 100LYS A 103VAL A 106VAL A 179TYR A 181TYR A 188GLY A 190TRP A 229LEU A 234TYR A 318
NVP A 601
[["2HND_A_NVPA999","2hnd","NVP","DB00238(Nevirapine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",10,"LEU A 100;LYS A 103;VAL A 106;VAL A 179;TYR A 181;TYR A 188;GLY A 190;TRP A 229;LEU A 234;TYR A 318","NVP A 999\r"],["2HNY_A_NVPA999","2hny","NVP","DB00238(Nevirapine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",10,"LEU A 100;LYS A 103;VAL A 106;VAL A 179;TYR A 181;TYR A 188;GLY A 190;TRP A 229;LEU A 234;TYR A 318","NVP A 999\r"],["2ZD1_A_T27A557","2zd1","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 101;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;TYR A 318","T27 A 557\r"],["2ZE2_A_T27A556","2ze2","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",10,"PRO A 95;ILE A 100;ASN A 103;VAL A 179;TYR A 181;TYR A 188;PRO A 225;TRP A 229;LEU A 234;TYR A 318","T27 A 556\r"],["3BGR_A_T27A556","3bgr","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",11,"LEU A 100;ASN A 103;GLU B 138;VAL A 179;CYS A 181;TYR A 183;TYR A 188;PHE A 227;TRP A 229;LEU A 234;TYR A 318","T27 A 556\r"],["3LP0_A_NVPA701","3lp0","NVP","DB00238(Nevirapine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",9,"LEU A 100;VAL A 106;VAL A 179;TYR A 181;TYR A 188;GLY A 190;TRP A 229;LEU A 234;TYR A 318","NVP A 701\r"],["3LP1_A_NVPA701","3lp1","NVP","DB00238(Nevirapine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",10,"LEU A 100;ASN A 103;VAL A 106;VAL A 179;TYR A 181;TYR A 188;GLY A 190;TRP A 229;LEU A 234;TYR A 318","NVP A 701\r"],["3M8P_A_65BA562","3m8p","65B","DB06414(Etravirine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H;P51 RT","PF00075(RNase_H);PF00078(RVT_thumb);PF06815(RVT_1);PF06817(RVT_connect);PF00078(RVT_thumb);PF06815(RVT_1);PF06817(RVT_connect)",11,"LEU A 100;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PHE A 227;TRP A 229;LEU A 234;TYR A 318","65B A 562\r"],["3QLH_A_T27A555","3qlh","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",12,"PRO A 95;LEU A 100;LYS A 101;LYS A 103;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;PRO A 236;TYR A 318","T27 A 555\r"],["4B3O_A_EFZA1557","4b3o","EFZ","DB00625(Efavirenz)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",9,"LEU A 100;LYS A 101;LYS A 103;VAL A 106;TYR A 181;TYR A 188;GLY A 190;LEU A 234;TYR A 318","EFZ A1557\r"],["4B3Q_A_NVPA999","4b3q","NVP","DB00238(Nevirapine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",7,"LEU A 100;LYS A 103;VAL A 106;TYR A 181;TYR A 188;LEU A 234;TYR A 318","NVP A 999\r"],["4G1Q_A_T27A601","4g1q","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",15,"PRO A 95;LEU A 100;LYS A 101;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;PRO A 236;TYR A 318","T27 A 601\r"],["4ICL_A_T27A601","4icl","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 101;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;TYR A 318","T27 A 601\r"],["4ID5_A_T27A601","4id5","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;PRO A 236;TYR A 318","T27 A 601\r"],["4IDK_A_T27A601","4idk","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 101;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;TYR A 318","T27 A 601\r"],["4IFV_A_T27A601","4ifv","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","EXORIBONUCLEASE H, P66 RT;GAG-POL POLYPROTEIN","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;PRO A 236;TYR A 318","T27 A 601\r"],["4IFY_A_T27A601","4ify","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;PRO A 236;TYR A 318","T27 A 601\r"],["4IG3_A_T27A601","4ig3","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;PRO A 236;TYR A 318","T27 A 601\r"],["4KFB_A_T27A607","4kfb","T27","DB08864(Rilpivirine)","Human immunodeficiency virus 1","P51 RT;REVERSE TRANSCRIPTASE\/RIBONUCLEASE H, EXORIBONUCLEA P66 RT","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",14,"PRO A 95;LEU A 100;LYS A 103;VAL A 106;GLU B 138;VAL A 179;TYR A 181;TYR A 188;PRO A 225;PHE A 227;TRP A 229;LEU A 234;PRO A 236;TYR A 318","T27 A 607\r"],["5HBM_A_NVPA601","5hbm","NVP","DB00238(Nevirapine)","Human immunodeficiency virus 1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","PF00075(RNase_H);PF00078(RVT_1);PF06815(RVT_connect);PF06817(RVT_thumb)",11,"PRO A 95;LEU A 100;LYS A 103;VAL A 106;VAL A 179;TYR A 181;TYR A 188;GLY A 190;TRP A 229;LEU A 234;TYR A 318","NVP A 601\r"]]