DRUG BINDING INTERFACES MAPPED TO 'PTERIDINE REDUCTASE 1'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)| DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
|---|---|---|---|---|---|---|---|---|
| 1P33_A_MTXA351 | 1p33 | MTX DB00563(Methotrexate) | Leishmaniatarentolae | PTERIDINE REDUCTASE1 | PF13561(adh_short_C2) | 13 | ARG A 17SER A 111PHE A 113PRO A 115ASP A 181LEU A 188TYR A 191TYR A 194LEU A 226LEU A 229PRO A 230MET A 233TYR A 241 | MTX A 351 |
| 1P33_B_MTXB352 | 1p33 | MTX DB00563(Methotrexate) | Leishmaniatarentolae | PTERIDINE REDUCTASE1 | no annotation | 13 | ARG B 17SER B 111PHE B 113PRO B 115ASP B 181LEU B 188TYR B 191TYR B 194LEU B 226LEU B 229PRO B 230MET B 233TYR B 241 | MTX B 352 |
| 1P33_C_MTXC353 | 1p33 | MTX DB00563(Methotrexate) | Leishmaniatarentolae | PTERIDINE REDUCTASE1 | no annotation | 13 | ARG C 17SER C 111PHE C 113PRO C 115ASP C 181LEU C 188TYR C 191TYR C 194LEU C 226LEU C 229PRO C 230MET C 233TYR C 241 | MTX C 353 |
| 1P33_D_MTXD354 | 1p33 | MTX DB00563(Methotrexate) | Leishmaniatarentolae | PTERIDINE REDUCTASE1 | no annotation | 12 | ARG D 17SER D 111PHE D 113PRO D 115ASP D 181LEU D 188TYR D 191TYR D 194LEU D 229PRO D 230MET D 233TYR D 241 | MTX D 354 |
| 2BFM_A_TOPA1290 | 2bfm | TOP DB00440(Trimethoprim) | Leishmania major | PTERIDINE REDUCTASE1 | PF00106(adh_short)PF13561(adh_short_C2)no annotation | 9 | PHE A 113ASP A 181LEU A 188TYR A 194LEU A 226LEU A 229HIS A 241TYR A 283ARG D 287 | TOP A1290 |
| 2BFM_B_TOPB1290 | 2bfm | TOP DB00440(Trimethoprim) | Leishmania major | PTERIDINE REDUCTASE1 | no annotation | 9 | PHE B 113ASP B 181LEU B 188TYR B 191TYR B 194LEU B 226LEU B 229HIS B 241ARG C 287 | TOP B1290 |
| 2BFP_A_H4BA1290 | 2bfp | H4B DB00360(Sapropterin) | Leishmania major | PTERIDINE REDUCTASE1 | PF00106(adh_short)PF13561(adh_short_C2) | 8 | ARG A 17SER A 111PHE A 113ASP A 181LEU A 188TYR A 194LEU A 226LEU A 229 | H4B A1290 |
| 2BFP_B_H4BB1290 | 2bfp | H4B DB00360(Sapropterin) | Leishmania major | PTERIDINE REDUCTASE1 | no annotation | 8 | ARG B 17SER B 111PHE B 113ASP B 181LEU B 188TYR B 194LEU B 226LEU B 229 | H4B B1290 |
| 2BFP_C_H4BC1290 | 2bfp | H4B DB00360(Sapropterin) | Leishmania major | PTERIDINE REDUCTASE1 | no annotation | 8 | ARG C 17SER C 111PHE C 113ASP C 181LEU C 188TYR C 194LEU C 226LEU C 229 | H4B C1290 |
| 2BFP_D_H4BD1290 | 2bfp | H4B DB00360(Sapropterin) | Leishmania major | PTERIDINE REDUCTASE1 | no annotation | 8 | ARG D 17SER D 111PHE D 113ASP D 181LEU D 188TYR D 194LEU D 226LEU D 229 | H4B D1290 |
| 3JQ7_A_DX2A271 | 3jq7 | DX2 DB00384(Triamterene) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | PF13561(adh_short_C2) | 10 | ARG A 14SER A 95PHE A 97ASP A 161TYR A 174VAL A 206LEU A 209PRO A 210MET A 213TRP A 221 | DX2 A 271 |
| 3JQ7_B_DX2B271 | 3jq7 | DX2 DB00384(Triamterene) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | PF13561(adh_short_C2) | 8 | ARG B 14SER B 95PHE B 97ASP B 161TYR B 174LEU B 209PRO B 210TRP B 221 | DX2 B 271 |
| 3JQ7_C_DX2C270 | 3jq7 | DX2 DB00384(Triamterene) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | no annotation | 8 | ARG C 14SER C 95PHE C 97ASP C 161TYR C 174VAL C 206LEU C 209PRO C 210 | DX2 C 270 |
| 3JQ7_D_DX2D270 | 3jq7 | DX2 DB00384(Triamterene) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | no annotation | 9 | ARG D 14SER D 95PHE D 97ASP D 161TYR D 174LEU D 209PRO D 210MET D 213TRP D 221 | DX2 D 270 |
| 3JQA_A_DX4A270 | 3jqa | DX4 DB00352(Tioguanine) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | PF13561(adh_short_C2) | 6 | ARG A 14SER A 95PHE A 97ASP A 161TYR A 174PRO A 210 | DX4 A 270 |
| 3JQA_B_DX4B270 | 3jqa | DX4 DB00352(Tioguanine) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | PF13561(adh_short_C2) | 6 | ARG B 14SER B 95PHE B 97ASP B 161TYR B 174PRO B 210 | DX4 B 270 |
| 3JQA_C_DX4C270 | 3jqa | DX4 DB00352(Tioguanine) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | None | 6 | ARG C 14SER C 95PHE C 97ASP C 161TYR C 174PRO C 210 | DX4 C 270 |
| 3JQA_D_DX4D270 | 3jqa | DX4 DB00352(Tioguanine) | Trypanosomabrucei | PTERIDINE REDUCTASE1 | PF13561(adh_short_C2) | 6 | ARG D 14SER D 95PHE D 97ASP D 161TYR D 174PRO D 210 | DX4 D 270 |