DRUG BINDING INTERFACES MAPPED TO 'PROTEIN L'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
2BYO_A_LNLA1216
2byo
LNL
DB00132(Alpha-LinolenicAcid)
Mycobacteriumtuberculosis
LIPOPROTEIN LPPX
PF07161(LppX_LprAFG)
5
LEU A 69ILE A 106LEU A 109SER A 110ARG A 113
LNL A1216
2BYO_A_LNLA1217
2byo
LNL
DB00132(Alpha-LinolenicAcid)
Mycobacteriumtuberculosis
LIPOPROTEIN LPPX
PF07161(LppX_LprAFG)
4
VAL A 87LEU A 159ILE A 193LEU A 195
LNL A1217
2F8L_A_SAMA400
2f8l
SAM
DB00118(S-Adenosylmethionine)
Listeriamonocytogenes
HYPOTHETICAL PROTEINLMO1582
PF02384(N6_Mtase)
16
HIS A 95THR A 98ALA A 126GLY A 128THR A 129ASN A 131LEU A 132ASP A 154VAL A 155ASP A 156LEU A 159ASP A 180GLY A 181ASP A 196PRO A 198PHE A 226
SAM A 400
2NXE_A_SAMA302
2nxe
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
PF06325(PrmA)
15
PHE A 99GLY A 100THR A 107ASP A 126LEU A 127GLY A 128GLY A 130LEU A 134ASP A 149ILE A 150ASP A 151SER A 175ASN A 191LEU A 192LEU A 196
SAM A 302
2NXE_B_SAMB303
2nxe
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
None
15
PHE B 99GLY B 100THR B 107ASP B 126LEU B 127GLY B 128GLY B 130LEU B 134ASP B 149ILE B 150ASP B 151SER B 175ASN B 191LEU B 192LEU B 196
SAM B 303
2ZBP_A_SAMA300
2zbp
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
PF06325(PrmA)
14
PHE A 99GLY A 100THR A 107LEU A 127GLY A 128GLY A 130LEU A 134ASP A 149ILE A 150ASP A 151SER A 175ASN A 191LEU A 192LEU A 196
SAM A 300
3CJT_C_SAMC302
3cjt
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
None
14
HIS C 103THR C 107ASP C 126LEU C 127GLY C 128VAL C 133LEU C 134ASP C 149ILE C 150ASP C 151SER C 175ASN C 191LEU C 192LEU C 196
SAM C 302
3CJT_G_SAMG302
3cjt
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
None
14
HIS G 103LEU G 127GLY G 128GLY G 130SER G 131VAL G 133LEU G 134ASP G 149ILE G 150ASP G 151SER G 175ASN G 191LEU G 192LEU G 196
SAM G 302
3CJT_K_SAMK302
3cjt
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
None
13
HIS K 103LEU K 127GLY K 128SER K 131VAL K 133LEU K 134ASP K 149ILE K 150ASP K 151SER K 175ASN K 191LEU K 192LEU K 196
SAM K 302
3CJT_O_SAMO302
3cjt
SAM
DB00118(S-Adenosylmethionine)
Thermusthermophilus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE
None
14
HIS O 103LEU O 127GLY O 128GLY O 130SER O 131VAL O 133LEU O 134ASP O 149ILE O 150ASP O 151SER O 175ASN O 191LEU O 192LEU O 196
SAM O 302
3J7Z_A_ERYA9000
3j7z
ERY
DB00199(Erythromycin)
Escherichia coli;Staphylococcusaureus
23S RRNA;50S RIBOSOMALPROTEIN L22;ERMCL NASCENT CHAIN
PF00237(Ribosomal_L22)PF08253(Leader_Erm)
3
ILE a 81PHE a 82LYS S 90
ERY A9000
3TPX_C_ACTC207
3tpx
ACT
DB03166(Aceticacid)
Homo sapiens
E3 UBIQUITIN-PROTEINLIGASE MDM2
None
4
LYS C 31PRO C 32LEU C 33ASN C 106
ACT C 207
3TPX_E_ACTE204
3tpx
ACT
DB03166(Aceticacid)
Homo sapiens
E3 UBIQUITIN-PROTEINLIGASE MDM2
None
3
LYS E 31PRO E 32LEU E 33
ACT E 204
4M6T_A_SAMA201
4m6t
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
RNA POLYMERASEII-ASSOCIATED FACTOR1 HOMOLOG, LINKER,RNAPOLYMERASE-ASSOCIATED PROTEIN LEO1
PF03985(Leo1)PF04004(Paf1)
4
ILE A 30VAL A 42VAL A 44ARG A 169
SAM A 201
5DPD_A_SAMA601
5dpd
SAM
DB00118(S-Adenosylmethionine)
Rickettsiaprowazekii
PROTEIN LYSINEMETHYLTRANSFERASE 1
PF10119(Methyltransf_31)PF13847(MethyTransf_Reg)
13
TYR A 48GLU A 77GLY A 79ASP A 102LEU A 103SER A 104GLN A 107SER A 129ILE A 130HIS A 146VAL A 148VAL A 152VAL A 156
SAM A 601
5DPD_B_SAMB601
5dpd
SAM
DB00118(S-Adenosylmethionine)
Rickettsiaprowazekii
PROTEIN LYSINEMETHYLTRANSFERASE 1
None
12
TYR B 48GLY B 79ASP B 102LEU B 103SER B 104GLN B 107SER B 129ILE B 130VAL B 148TRP B 151VAL B 152VAL B 156
SAM B 601
5FA8_A_SAMA301
5fa8
SAM
DB00118(S-Adenosylmethionine)
Sulfolobusislandicus
RIBOSOMAL PROTEINL11METHYLTRANSFERASE,PUTATIVE
PF13847(Methyltransf_31)
15
PRO A 11THR A 12ASP A 34GLY A 36GLY A 38ARG A 41ILE A 42GLU A 59ILE A 60ASN A 61ARG A 64ASN A 87PHE A 88PHE A 102LEU A 104
SAM A 301
5UMD_A_YMZA3801
5umd
YMZ
DB00358(Mefloquine)
Plasmodiumfalciparum
28S RIBOSOMAL RNA;60S RIBOSOMALPROTEIN L28;60S RIBOSOMALPROTEIN L4
PF00573(Ribosomal_L4)PF01778(Ribosomal_L28e)PF14374(Ribos_L4_asso_C)no annotation
6
ASN 2 6ALA 2 7PRO 2 44VAL 2 50ASP F 288TYR F 290
YMZ A3801
5UMD_K_YMZK301
5umd
YMZ
DB00358(Mefloquine)
Plasmodiumfalciparum
60S RIBOSOMALPROTEIN L13,PUTATIVE
PF00572(Ribosomal_L13)
11
LEU K 15ILE K 42ASN K 49LYS K 52TYR K 53GLU K 55PHE K 56LEU K 59ILE K 78ARG K 81LEU K 140
YMZ K 301
6B89_A_NOVA403
6b89
NOV
DB01051(Novobiocin)
Escherichia coli
LIPOPOLYSACCHARIDEEXPORT SYSTEMATP-BINDING PROTEINLPTB
no annotation
16
LEU A 72HIS A 73ALA A 76TYR A 82PRO A 84GLU A 86SER A 88PHE A 90PHE B 90ARG B 91ARG B 92LEU B 93ALA B 101VAL A 102GLN B 136ARG A 150
NOV A 403
6B89_B_NOVB403
6b89
NOV
DB01051(Novobiocin)
Escherichia coli
LIPOPOLYSACCHARIDEEXPORT SYSTEMATP-BINDING PROTEINLPTB
no annotation
17
LEU B 72HIS B 73ALA B 76TYR B 82PRO B 84GLU B 86SER B 88PHE A 90PHE B 90ARG A 91ARG A 92LEU A 93ALA A 101VAL B 102GLN A 104GLN A 136ARG B 150
NOV B 403
[["2BYO_A_LNLA1216","2byo","LNL","DB00132(Alpha-Linolenic Acid)","Mycobacterium tuberculosis","LIPOPROTEIN LPPX","PF07161(LppX_LprAFG)",5,"LEU A 69;ILE A 106;LEU A 109;SER A 110;ARG A 113","LNL A1216\r"],["2BYO_A_LNLA1217","2byo","LNL","DB00132(Alpha-Linolenic Acid)","Mycobacterium tuberculosis","LIPOPROTEIN LPPX","PF07161(LppX_LprAFG)",4,"VAL A 87;LEU A 159;ILE A 193;LEU A 195","LNL A1217\r"],["2F8L_A_SAMA400","2f8l","SAM","DB00118(S-Adenosylmethionine)","Listeria monocytogenes","HYPOTHETICAL PROTEIN LMO1582","PF02384(N6_Mtase)",16,"HIS A 95;THR A 98;ALA A 126;GLY A 128;THR A 129;ASN A 131;LEU A 132;ASP A 154;VAL A 155;ASP A 156;LEU A 159;ASP A 180;GLY A 181;ASP A 196;PRO A 198;PHE A 226","SAM A 400\r"],["2NXE_A_SAMA302","2nxe","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","PF06325(PrmA)",15,"PHE A 99;GLY A 100;THR A 107;ASP A 126;LEU A 127;GLY A 128;GLY A 130;LEU A 134;ASP A 149;ILE A 150;ASP A 151;SER A 175;ASN A 191;LEU A 192;LEU A 196","SAM A 302\r"],["2NXE_B_SAMB303","2nxe","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","None",15,"PHE B 99;GLY B 100;THR B 107;ASP B 126;LEU B 127;GLY B 128;GLY B 130;LEU B 134;ASP B 149;ILE B 150;ASP B 151;SER B 175;ASN B 191;LEU B 192;LEU B 196","SAM B 303\r"],["2ZBP_A_SAMA300","2zbp","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","PF06325(PrmA)",14,"PHE A 99;GLY A 100;THR A 107;LEU A 127;GLY A 128;GLY A 130;LEU A 134;ASP A 149;ILE A 150;ASP A 151;SER A 175;ASN A 191;LEU A 192;LEU A 196","SAM A 300\r"],["3CJT_C_SAMC302","3cjt","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","None",14,"HIS C 103;THR C 107;ASP C 126;LEU C 127;GLY C 128;VAL C 133;LEU C 134;ASP C 149;ILE C 150;ASP C 151;SER C 175;ASN C 191;LEU C 192;LEU C 196","SAM C 302\r"],["3CJT_G_SAMG302","3cjt","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","None",14,"HIS G 103;LEU G 127;GLY G 128;GLY G 130;SER G 131;VAL G 133;LEU G 134;ASP G 149;ILE G 150;ASP G 151;SER G 175;ASN G 191;LEU G 192;LEU G 196","SAM G 302\r"],["3CJT_K_SAMK302","3cjt","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","None",13,"HIS K 103;LEU K 127;GLY K 128;SER K 131;VAL K 133;LEU K 134;ASP K 149;ILE K 150;ASP K 151;SER K 175;ASN K 191;LEU K 192;LEU K 196","SAM K 302\r"],["3CJT_O_SAMO302","3cjt","SAM","DB00118(S-Adenosylmethionine)","Thermus thermophilus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","None",14,"HIS O 103;LEU O 127;GLY O 128;GLY O 130;SER O 131;VAL O 133;LEU O 134;ASP O 149;ILE O 150;ASP O 151;SER O 175;ASN O 191;LEU O 192;LEU O 196","SAM O 302\r"],["3J7Z_A_ERYA9000","3j7z","ERY","DB00199(Erythromycin)","Escherichia coli;Staphylococcus aureus","23S RRNA;50S RIBOSOMAL PROTEIN L22;ERMCL NASCENT CHAIN","PF00237(Ribosomal_L22);PF08253(Leader_Erm)",3,"ILE a 81;PHE a 82;LYS S 90","ERY A9000\r"],["3TPX_C_ACTC207","3tpx","ACT","DB03166(Acetic acid)","Homo sapiens","E3 UBIQUITIN-PROTEIN LIGASE MDM2","None",4,"LYS C 31;PRO C 32;LEU C 33;ASN C 106","ACT C 207\r"],["3TPX_E_ACTE204","3tpx","ACT","DB03166(Acetic acid)","Homo sapiens","E3 UBIQUITIN-PROTEIN LIGASE MDM2","None",3,"LYS E 31;PRO E 32;LEU E 33","ACT E 204\r"],["4M6T_A_SAMA201","4m6t","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG, LINKER, RNA POLYMERASE-ASSOCIATED PROTEIN LEO1","PF03985(Leo1);PF04004(Paf1)",4,"ILE A 30;VAL A 42;VAL A 44;ARG A 169","SAM A 201\r"],["5DPD_A_SAMA601","5dpd","SAM","DB00118(S-Adenosylmethionine)","Rickettsia prowazekii","PROTEIN LYSINE METHYLTRANSFERASE 1","PF10119(Methyltransf_31);PF13847(MethyTransf_Reg)",13,"TYR A 48;GLU A 77;GLY A 79;ASP A 102;LEU A 103;SER A 104;GLN A 107;SER A 129;ILE A 130;HIS A 146;VAL A 148;VAL A 152;VAL A 156","SAM A 601\r"],["5DPD_B_SAMB601","5dpd","SAM","DB00118(S-Adenosylmethionine)","Rickettsia prowazekii","PROTEIN LYSINE METHYLTRANSFERASE 1","None",12,"TYR B 48;GLY B 79;ASP B 102;LEU B 103;SER B 104;GLN B 107;SER B 129;ILE B 130;VAL B 148;TRP B 151;VAL B 152;VAL B 156","SAM B 601\r"],["5FA8_A_SAMA301","5fa8","SAM","DB00118(S-Adenosylmethionine)","Sulfolobus islandicus","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE","PF13847(Methyltransf_31)",15,"PRO A 11;THR A 12;ASP A 34;GLY A 36;GLY A 38;ARG A 41;ILE A 42;GLU A 59;ILE A 60;ASN A 61;ARG A 64;ASN A 87;PHE A 88;PHE A 102;LEU A 104","SAM A 301\r"],["5UMD_A_YMZA3801","5umd","YMZ","DB00358(Mefloquine)","Plasmodium falciparum","28S RIBOSOMAL RNA;60S RIBOSOMAL PROTEIN L28;60S RIBOSOMAL PROTEIN L4","PF00573(Ribosomal_L4);PF01778(Ribosomal_L28e);PF14374(Ribos_L4_asso_C);no annotation",6,"ASN 2 6;ALA 2 7;PRO 2 44;VAL 2 50;ASP F 288;TYR F 290","YMZ A3801\r"],["5UMD_K_YMZK301","5umd","YMZ","DB00358(Mefloquine)","Plasmodium falciparum","60S RIBOSOMAL PROTEIN L13, PUTATIVE","PF00572(Ribosomal_L13)",11,"LEU K 15;ILE K 42;ASN K 49;LYS K 52;TYR K 53;GLU K 55;PHE K 56;LEU K 59;ILE K 78;ARG K 81;LEU K 140","YMZ K 301\r"],["6B89_A_NOVA403","6b89","NOV","DB01051(Novobiocin)","Escherichia coli","LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB","no annotation",16,"LEU A 72;HIS A 73;ALA A 76;TYR A 82;PRO A 84;GLU A 86;SER A 88;PHE A 90;PHE B 90;ARG B 91;ARG B 92;LEU B 93;ALA B 101;VAL A 102;GLN B 136;ARG A 150","NOV A 403\r"],["6B89_B_NOVB403","6b89","NOV","DB01051(Novobiocin)","Escherichia coli","LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB","no annotation",17,"LEU B 72;HIS B 73;ALA B 76;TYR B 82;PRO B 84;GLU B 86;SER B 88;PHE A 90;PHE B 90;ARG A 91;ARG A 92;LEU A 93;ALA A 101;VAL B 102;GLN A 104;GLN A 136;ARG B 150","NOV B 403\r"]]