DRUG BINDING INTERFACES MAPPED TO 'PROLINE--TRNA LIGASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
4HVC_A_HFGA1602 | 4hvc | HFG DB04866(Halofuginone) | Homo sapiens | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE | PF00587(HGTP_anticodon)PF03129(ProRS-C_1)PF09180(tRNA-synt_2b) | 16 | HIS A1093PHE A1097GLU A1100VAL A1101PRO A1120THR A1121GLU A1123ARG A1152TRP A1169GLU A1171HIS A1173PHE A1216THR A1240HIS A1242SER A1272GLY A1274 | HFG A1602 |
4HVC_B_HFGB1602 | 4hvc | HFG DB04866(Halofuginone) | Homo sapiens | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE | None | 17 | LEU B1087HIS B1093PHE B1097GLU B1100VAL B1101PRO B1120THR B1121GLU B1123ARG B1152TRP B1169GLU B1171HIS B1173PHE B1216THR B1240HIS B1242SER B1272GLY B1274 | HFG B1602 |
4K87_A_ADNA602 | 4k87 | ADN DB00640(Adenosine) | Homo sapiens | PROLINE--TRNA LIGASE | PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 8 | ARG A 152ARG A 163PHE A 167GLN A 237GLY A 239THR A 240THR A 276ARG A 278 | ADN A 602 |
4K88_A_HFGA602 | 4k88 | HFG DB04866(Halofuginone) | Homo sapiens | PROLINE--TRNA LIGASE | PF00587(ProRS-C_1)PF03129(tRNA-synt_2b)PF09180(HGTP_anticodon) | 12 | PHE A 97GLU A 100VAL A 101PRO A 120THR A 121GLU A 123ARG A 152TRP A 169GLU A 171PHE A 216HIS A 242SER A 272 | HFG A 602 |
4OLF_A_HFGA802 | 4olf | HFG DB04866(Halofuginone) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 16 | PHE A 335GLU A 338VAL A 339PRO A 358THR A 359GLU A 361ARG A 390TRP A 407GLU A 409HIS A 411PHE A 454THR A 478HIS A 480SER A 508TRP A 509GLY A 510 | HFG A 802 |
4Q15_A_HFGA803 | 4q15 | HFG DB04866(Halofuginone) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | PF00587(HGTP_anticodon)PF03129(ProRS-C_1)PF09180(tRNA-synt_2b) | 15 | LEU A 325PHE A 335GLU A 338VAL A 339PRO A 358THR A 359GLU A 361ARG A 390TRP A 407HIS A 411PHE A 454THR A 478HIS A 480SER A 508GLY A 510 | HFG A 803 |
4Q15_B_HFGB803 | 4q15 | HFG DB04866(Halofuginone) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | None | 15 | LEU B 325PHE B 335GLU B 338VAL B 339PRO B 358THR B 359GLU B 361ARG B 390TRP B 407GLU B 409PHE B 454THR B 478HIS B 480SER B 508GLY B 510 | HFG B 803 |
4YDQ_A_HFGA802 | 4ydq | HFG DB04866(Halofuginone) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | PF00587(ProRS-C_1)PF03129(tRNA-synt_2b)PF09180(HGTP_anticodon) | 16 | LEU A 325PHE A 335GLU A 338VAL A 339PRO A 358THR A 359GLU A 361ARG A 390TRP A 407GLU A 409HIS A 411PHE A 454THR A 478HIS A 480SER A 508GLY A 510 | HFG A 802 |
4YDQ_B_HFGB802 | 4ydq | HFG DB04866(Halofuginone) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | None | 15 | PHE B 335GLU B 338VAL B 339PRO B 358THR B 359GLU B 361ARG B 390TRP B 407GLU B 409HIS B 411PHE B 454THR B 478HIS B 480SER B 508GLY B 510 | HFG B 802 |
5IFU_A_GBMA801 | 5ifu | GBM DB01016(Glyburide) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 13 | PHE A 262TYR A 266ILE A 276TYR A 285LEU A 287GLU A 404THR A 513ARG A 514ILE A 516GLY A 517ILE A 520MET A 521TYR A 746 | GBM A 801 |
5IFU_B_GBMB801 | 5ifu | GBM DB01016(Glyburide) | Plasmodiumfalciparum | PROLINE--TRNA LIGASE | no annotation | 9 | TYR B 266ILE B 276TYR B 285LEU B 287GLU B 404THR B 513ARG B 514ILE B 516GLY B 517 | GBM B 801 |