DRUG BINDING INTERFACES MAPPED TO 'PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
2XKW_A_P1BA1478 | 2xkw | P1B DB01132(Pioglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 19 | LEU A 255GLU A 259ILE A 281PHE A 282CYS A 285GLN A 286ARG A 288SER A 289ALA A 292HIS A 323ILE A 326TYR A 327LEU A 330ILE A 341MET A 348MET A 364HIS A 449LEU A 469TYR A 473 | P1B A1478 |
2XKW_B_P1BB1475 | 2xkw | P1B DB01132(Pioglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 18 | ILE B 249LEU B 255GLU B 259PHE B 264HIS B 266ARG B 280ILE B 281CYS B 285ARG B 288SER B 289ALA B 292ILE B 326MET B 329LEU B 330LEU B 333ILE B 341MET B 348MET B 364 | P1B B1475 |
3ADS_A_IMNA1 | 3ads | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 10 | GLU A 259ARG A 280ILE A 281GLY A 284CYS A 285ARG A 288LEU A 330ILE A 341MET A 348MET A 364 | IMN A 1 |
3ADS_A_IMNA2 | 3ads | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 18 | ILE A 281PHE A 282CYS A 285SER A 289HIS A 323ILE A 326TYR A 327LEU A 330LEU A 353LEU A 356PHE A 360PHE A 363MET A 364LYS A 367HIS A 449LEU A 453LEU A 469TYR A 473 | IMN A 2 |
3ADS_B_IMNB3 | 3ads | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 12 | ILE B 281GLY B 284CYS B 285ARG B 288SER B 289ALA B 292ILE B 326LEU B 330LEU B 333VAL B 339ILE B 341MET B 364 | IMN B 3 |
3ADX_A_IMNA2 | 3adx | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 19 | ILE A 281PHE A 282CYS A 285GLN A 286SER A 289HIS A 323ILE A 326TYR A 327LEU A 330LEU A 353LEU A 356PHE A 360PHE A 363MET A 364LYS A 367HIS A 449LEU A 453LEU A 469TYR A 473 | IMN A 2 |
3ADX_B_IMNB3 | 3adx | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 13 | LEU B 228ILE B 281GLY B 284CYS B 285ARG B 288SER B 289ALA B 292ILE B 326LEU B 330LEU B 333VAL B 339ILE B 341MET B 364 | IMN B 3 |
3CS8_A_BRLA503 | 3cs8 | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 14 | GLY A 284CYS A 285GLN A 286SER A 289HIS A 323ILE A 326LEU A 330ILE A 341MET A 364LYS A 367HIS A 449LEU A 453LEU A 469TYR A 473 | BRL A 503 |
3DZY_D_BRLD478 | 3dzy | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep)PF00105(zf-C4) | 16 | ILE D 281PHE D 282CYS D 285GLN D 286ARG D 288SER D 289HIS D 323TYR D 327LEU D 330VAL D 339ILE D 341LEU D 353MET D 364HIS D 449LEU D 453TYR D 473 | BRL D 478 |
3G9E_A_RO7A1 | 3g9e | RO7 DB08915(Aleglitazar) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 13 | GLY A 284CYS A 285SER A 289HIS A 323TYR A 327LEU A 330VAL A 339ILE A 341MET A 364LYS A 367HIS A 449LEU A 469TYR A 473 | RO7 A 1 |
3QT0_A_486A4 | 3qt0 | 486 DB00834(Mifepristone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 16 | LYS A 265CYS A 285GLN A 286ARG A 288SER A 289ALA A 292ILE A 326TYR A 327LEU A 330LEU A 333ILE A 341MET A 348PHE A 363MET A 364LYS A 367HIS A 449 | 486 A 4 |
3VN2_A_TLSA501 | 3vn2 | TLS DB00966(Telmisartan) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 20 | PHE A 282CYS A 285GLN A 286ARG A 288SER A 289HIS A 323ILE A 326TYR A 327LEU A 330VAL A 339ILE A 341LEU A 353LEU A 356PHE A 363MET A 364HIS A 449LEU A 453LEU A 465LEU A 469TYR A 473 | TLS A 501 |
4EMA_A_BRLA601 | 4ema | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 15 | PHE A 282GLY A 284CYS A 285SER A 289HIS A 323TYR A 327LEU A 330VAL A 339ILE A 341MET A 348MET A 364HIS A 449LEU A 453LEU A 469TYR A 473 | BRL A 601 |
4O8F_A_BRLA501 | 4o8f | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 17 | PHE A 282GLY A 284CYS A 285ARG A 288SER A 289HIS A 323TYR A 327LEU A 330VAL A 339ILE A 341MET A 348LEU A 353MET A 364HIS A 449LEU A 453LEU A 469TYR A 473 | BRL A 501 |
4O8F_B_BRLB501 | 4o8f | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 18 | ILE B 281PHE B 282GLY B 284CYS B 285SER B 289HIS B 323ILE B 326LEU B 330VAL B 339ILE B 341MET B 348LEU B 353PHE B 363MET B 364HIS B 449LEU B 453LEU B 469TYR B 473 | BRL B 501 |
4OJ4_A_DIFA501 | 4oj4 | DIF DB00586(Diclofenac) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 8 | CYS A 285ARG A 288SER A 289LEU A 330LEU A 333VAL A 339ILE A 341MET A 364 | DIF A 501 |
4XLD_A_BRLA502 | 4xld | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 13 | PHE A 282GLY A 284CYS A 285SER A 289HIS A 323TYR A 327LEU A 330ILE A 341PHE A 363MET A 364HIS A 449LEU A 469TYR A 473 | BRL A 502 |
4XTA_A_DIFA501 | 4xta | DIF DB00586(Diclofenac) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 9 | CYS A 285ARG A 288SER A 289ALA A 292GLU A 295MET A 329LEU A 330LEU A 333ILE A 341 | DIF A 501 |
4XTA_B_DIFB501 | 4xta | DIF DB00586(Diclofenac) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 8 | ILE B 281CYS B 285ARG B 288SER B 289LEU B 330LEU B 333ILE B 341MET B 364 | DIF B 501 |
4XUM_A_IMNA501 | 4xum | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 13 | PHE A 282CYS A 285SER A 289HIS A 323ILE A 326LEU A 356PHE A 363MET A 364HIS A 449LEU A 453LEU A 465LEU A 469TYR A 473 | IMN A 501 |
4XUM_A_IMNA502 | 4xum | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 7 | GLU A 259ILE A 281CYS A 285ARG A 288LEU A 330ILE A 341MET A 348 | IMN A 502 |
4XUM_B_IMNB501 | 4xum | IMN DB00328(Indomethacin) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 11 | GLY B 284CYS B 285ARG B 288SER B 289ALA B 292ILE B 326MET B 329LEU B 330LEU B 333ILE B 341MET B 348 | IMN B 501 |
5JI0_D_BRLD501 | 5ji0 | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 14 | PHE D 282GLY D 284CYS D 285GLN D 286SER D 289HIS D 323TYR D 327LEU D 330VAL D 339ILE D 341MET D 364HIS D 449LEU D 453TYR D 473 | BRL D 501 |
5Y2O_A_8N6A501 | 5y2o | 8N6 DB01132(Pioglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | no annotation | 14 | PHE A 282CYS A 285SER A 289HIS A 323ILE A 326TYR A 327LEU A 330ILE A 341PHE A 363MET A 364HIS A 449LEU A 453LEU A 469TYR A 473 | 8N6 A 501 |
5Y2T_A_8LXA501 | 5y2t | 8LX DB09198(Lobeglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 15 | LEU A 255PHE A 282GLY A 284CYS A 285GLN A 286SER A 289HIS A 323TYR A 327LEU A 330ILE A 341MET A 348MET A 364HIS A 449LEU A 453TYR A 473 | 8LX A 501 |
5Y2T_B_8LXB501 | 5y2t | 8LX DB09198(Lobeglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | None | 20 | LEU B 255GLU B 259PHE B 264HIS B 266ARG B 280ILE B 281PHE B 282CYS B 285GLN B 286SER B 289HIS B 323ILE B 326TYR B 327LEU B 330ILE B 341MET B 348PHE B 363MET B 364HIS B 449LEU B 453 | 8LX B 501 |
5YCN_A_8LXA501 | 5ycn | 8LX DB09198(Lobeglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 18 | LEU A 255ARG A 280ILE A 281PHE A 282GLY A 284CYS A 285SER A 289HIS A 323TYR A 327LEU A 330VAL A 339ILE A 341MET A 348MET A 364HIS A 449LEU A 453LEU A 469TYR A 473 | 8LX A 501 |
5YCP_A_BRLA501 | 5ycp | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 15 | PHE A 282GLY A 284CYS A 285SER A 289HIS A 323TYR A 327LEU A 330VAL A 339ILE A 341MET A 348MET A 364HIS A 449LEU A 453LEU A 469TYR A 473 | BRL A 501 |
6MD4_A_BRLA501 | 6md4 | BRL DB00412(Rosiglitazone) | Homo sapiens | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA | PF00104(Hormone_recep) | 12 | PHE A 282GLY A 284CYS A 285GLN A 286SER A 289HIS A 323TYR A 327LEU A 330ILE A 341MET A 364HIS A 449TYR A 473 | BRL A 501 |