DRUG BINDING INTERFACES MAPPED TO 'NS5'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
2PXC_A_SAMA500 | 2pxc | SAM DB00118(S-Adenosylmethionine) | Murray Valleyencephalitisvirus | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN); ENVELOPE PROTEIN M(MATRIX PROTEIN); MAJOR ENVELOPEPROTEIN E; NON-STRUCTURALPROTEIN 1 (NS1); NON-STRUCTURALPROTEIN 2A (NS2A); FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT; FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT; NON-STRUCTURALPROTEIN 4A (NS4A); NON-STRUCTURALPROTEIN 4B (NS4B); RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 500 |
5EHG_A_SAMA301 | 5ehg | SAM DB00118(S-Adenosylmethionine) | Dengue virus | RNA-DIRECTED RNAPOLYMERASE NS5 | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 |
5EHG_C_SAMC4001 | 5ehg | SAM DB00118(S-Adenosylmethionine) | Dengue virus | RNA-DIRECTED RNAPOLYMERASE NS5 | None | 14 | SER C 56GLY C 58GLY C 81GLY C 83GLY C 86TRP C 87THR C 104LYS C 105HIS C 110GLU C 111ASP C 131VAL C 132ASP C 146ILE C 147 | SAM C4001 |
5EHI_A_SAMA4001 | 5ehi | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5METHYLTRANSFERASEDENGUE VIRUS | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A4001 |
5EHI_C_SAMC4000 | 5ehi | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5METHYLTRANSFERASEDENGUE VIRUS | None | 14 | SER C 56GLY C 58GLY C 81GLY C 83GLY C 86TRP C 87THR C 104LYS C 105HIS C 110GLU C 111ASP C 131VAL C 132ASP C 146ILE C 147 | SAM C4000 |
5EIW_A_SAMA301 | 5eiw | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5METHYLTRANSFERASE | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 |
5EIW_C_SAMC4000 | 5eiw | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5METHYLTRANSFERASE | None | 14 | SER C 56GLY C 58GLY C 81GLY C 83GLY C 86TRP C 87THR C 104LYS C 105HIS C 110GLU C 111ASP C 131VAL C 132ASP C 146ILE C 147 | SAM C4000 |
5EKX_A_SAMA301 | 5ekx | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5METHYLTRANSFERASE | PF01728(FtsJ) | 13 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 |
5EKX_B_SAMB4000 | 5ekx | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5METHYLTRANSFERASE | None | 14 | SER B 56GLY B 58GLY B 81GLY B 83GLY B 86TRP B 87THR B 104LYS B 105HIS B 110GLU B 111ASP B 131VAL B 132ASP B 146ILE B 147 | SAM B4000 |
5IKM_A_SAMA311 | 5ikm | SAM DB00118(S-Adenosylmethionine) | Dengue virus | NS5 METHYLTRANSFERASE | PF01728(FtsJ) | 13 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 311 |
5M5B_A_SAMA1001 | 5m5b | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | PF01728(FtsJ) | 14 | SER A 62GLY A 64GLY A 87GLY A 89GLY A 92TRP A 93THR A 110LYS A 111HIS A 116GLU A 117ASP A 137VAL A 138ASP A 152ILE A 153 | SAM A1001 |
5NJV_A_SAMA301 | 5njv | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 | PF01728(FtsJ) | 14 | SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 |
5NJV_B_SAMB301 | 5njv | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 | None | 14 | SER B 56GLY B 58GLY B 81GLY B 83GLY B 86TRP B 87THR B 104LYS B 105HIS B 110GLU B 111ASP B 131VAL B 132ASP B 146ILE B 147 | SAM B 301 |
5NJV_C_SAMC301 | 5njv | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 | None | 14 | SER C 56GLY C 58GLY C 81GLY C 83GLY C 86TRP C 87THR C 104LYS C 105HIS C 110GLU C 111ASP C 131VAL C 132ASP C 146ILE C 147 | SAM C 301 |
5NJV_D_SAMD301 | 5njv | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 | None | 14 | SER D 56GLY D 58GLY D 81GLY D 83GLY D 86TRP D 87THR D 104LYS D 105HIS D 110GLU D 111ASP D 131VAL D 132ASP D 146ILE D 147 | SAM D 301 |
5WZ1_A_SAMA601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | PF01728(FtsJ) | 13 | SER A 58GLY A 60GLY A 83GLY A 88TRP A 89THR A 106LYS A 107HIS A 112GLU A 113ASP A 133VAL A 134ASP A 148ILE A 149 | SAM A 601 |
5WZ1_B_SAMB601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 14 | SER B 58GLY B 60GLY B 83GLY B 85GLY B 88TRP B 89THR B 106LYS B 107HIS B 112GLU B 113ASP B 133VAL B 134ASP B 148ILE B 149 | SAM B 601 |
5WZ1_C_SAMC601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 13 | SER C 58GLY C 60GLY C 83GLY C 88TRP C 89THR C 106LYS C 107HIS C 112GLU C 113ASP C 133VAL C 134ASP C 148ILE C 149 | SAM C 601 |
5WZ1_D_SAMD601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 13 | SER D 58GLY D 60GLY D 83GLY D 88TRP D 89THR D 106LYS D 107HIS D 112GLU D 113ASP D 133VAL D 134ASP D 148ILE D 149 | SAM D 601 |
5WZ1_E_SAME601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 13 | SER E 58GLY E 60GLY E 83GLY E 88TRP E 89THR E 106LYS E 107HIS E 112GLU E 113ASP E 133VAL E 134ASP E 148ILE E 149 | SAM E 601 |
5WZ1_F_SAMF601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 13 | SER F 58GLY F 60GLY F 83GLY F 88TRP F 89THR F 106LYS F 107HIS F 112GLU F 113ASP F 133VAL F 134ASP F 148ILE F 149 | SAM F 601 |
5WZ1_G_SAMG601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 13 | SER G 58GLY G 60GLY G 83GLY G 88TRP G 89THR G 106LYS G 107HIS G 112GLU G 113ASP G 133VAL G 134ASP G 148ILE G 149 | SAM G 601 |
5WZ1_H_SAMH601 | 5wz1 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5METHYLTRANSFERASE | None | 13 | SER H 58GLY H 60GLY H 83GLY H 88TRP H 89THR H 106LYS H 107HIS H 112GLU H 113ASP H 133VAL H 134ASP H 148ILE H 149 | SAM H 601 |
5WZ2_A_SAMA601 | 5wz2 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 MTASE | PF01728(FtsJ) | 14 | SER A 58GLY A 60GLY A 83GLY A 85GLY A 88TRP A 89THR A 106LYS A 107HIS A 112GLU A 113ASP A 133VAL A 134ASP A 148ILE A 149 | SAM A 601 |
5WZ2_B_SAMB601 | 5wz2 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 MTASE | None | 14 | SER B 58GLY B 60GLY B 83GLY B 85GLY B 88TRP B 89THR B 106LYS B 107HIS B 112GLU B 113ASP B 133VAL B 134ASP B 148ILE B 149 | SAM B 601 |
5WZ2_C_SAMC601 | 5wz2 | SAM DB00118(S-Adenosylmethionine) | Zika virus | NS5 MTASE | None | 14 | SER C 58GLY C 60GLY C 83GLY C 85GLY C 88TRP C 89THR C 106LYS C 107HIS C 112GLU C 113ASP C 133VAL C 134ASP C 148ILE C 149 | SAM C 601 |