DRUG BINDING INTERFACES MAPPED TO 'NS2'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
2M9P_B_BEZB251 2m9p BEZ

DB03793
(Benzoic
Acid)
;
Dengue virus
SERINE PROTEASE
INHIBITOR;
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
None
PF00949
(Flavi_NS2B)
PF01002
(Peptidase_S7)
3 VAL A 216
SER A 219
GLY A 220
BEZ B 251
2M9Q_B_BEZB251 2m9q BEZ

DB03793
(Benzoic
Acid)
;
Dengue virus
SERINE PROTEASE
INHIBITOR;
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3
None
PF00949
(Flavi_NS2B)
PF01002
(Peptidase_S7)
9 LEU A   6
ILE A  86
ILE A  97
PHE A 107
THR A 109
VAL A 113
THR A 114
ALA A 117
LEU A 119
BEZ B 251
2PXC_A_SAMA500 2pxc SAM

DB00118
(S-
Adenosylmethionine)
Murray Valley
encephalitis
virus
GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN);
ENVELOPE PROTEIN M
(MATRIX PROTEIN);
MAJOR ENVELOPE
PROTEIN E;
NON-STRUCTURAL
PROTEIN 1 (NS1);
NON-STRUCTURAL
PROTEIN 2A (NS2A);
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT;
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT;
NON-STRUCTURAL
PROTEIN 4A (NS4A);
NON-STRUCTURAL
PROTEIN 4B (NS4B);
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]
PF01728
(FtsJ)
14 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
SAM A 500
5ZMQ_I_PACI1 5zmq PAC

DB09269
(Phenylacetic
acid)
Zika virus;
synthetic
construct
SERINE PROTEASE NS3;
SERINE PROTEASE
SUBUNIT NS2B;
PEPTIDE
PAC-DLY-DLY-DAR
None 3 GLU E  66
VAL D 155
TYR D 161
PAC I   1