DRUG BINDING INTERFACES MAPPED TO 'NS2'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
2M9P_B_BEZB251
2m9p
BEZ
DB03793(BenzoicAcid)
;Dengue virus
SERINE PROTEASEINHIBITOR;SERINE PROTEASESUBUNIT NS2B, SERINEPROTEASE NS3
NonePF00949(Flavi_NS2B)PF01002(Peptidase_S7)
3
VAL A 216SER A 219GLY A 220
BEZ B 251
2M9Q_B_BEZB251
2m9q
BEZ
DB03793(BenzoicAcid)
;Dengue virus
SERINE PROTEASEINHIBITOR;SERINE PROTEASESUBUNIT NS2B, SERINEPROTEASE NS3
NonePF00949(Flavi_NS2B)PF01002(Peptidase_S7)
9
LEU A 6ILE A 86ILE A 97PHE A 107THR A 109VAL A 113THR A 114ALA A 117LEU A 119
BEZ B 251
2PXC_A_SAMA500
2pxc
SAM
DB00118(S-Adenosylmethionine)
Murray Valleyencephalitisvirus
GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN); ENVELOPE PROTEIN M(MATRIX PROTEIN); MAJOR ENVELOPEPROTEIN E; NON-STRUCTURALPROTEIN 1 (NS1); NON-STRUCTURALPROTEIN 2A (NS2A); FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT; FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT; NON-STRUCTURALPROTEIN 4A (NS4A); NON-STRUCTURALPROTEIN 4B (NS4B); RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)]
PF01728(FtsJ)
14
SER A 56GLY A 58GLY A 81GLY A 83GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147
SAM A 500
5ZMQ_I_PACI1
5zmq
PAC
DB09269(Phenylaceticacid)
Zika virus;syntheticconstruct
SERINE PROTEASE NS3;SERINE PROTEASESUBUNIT NS2B;PEPTIDEPAC-DLY-DLY-DAR
None
3
GLU E 66VAL D 155TYR D 161
PAC I 1
[["2M9P_B_BEZB251","2m9p","BEZ","DB03793(Benzoic Acid)",";Dengue virus","SERINE PROTEASE INHIBITOR;SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3","None;PF00949(Flavi_NS2B);PF01002(Peptidase_S7)",3,"VAL A 216;SER A 219;GLY A 220","BEZ B 251\r"],["2M9Q_B_BEZB251","2m9q","BEZ","DB03793(Benzoic Acid)",";Dengue virus","SERINE PROTEASE INHIBITOR;SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3","None;PF00949(Flavi_NS2B);PF01002(Peptidase_S7)",9,"LEU A 6;ILE A 86;ILE A 97;PHE A 107;THR A 109;VAL A 113;THR A 114;ALA A 117;LEU A 119","BEZ B 251\r"],["2PXC_A_SAMA500","2pxc","SAM","DB00118(S-Adenosylmethionine)","Murray Valley encephalitis virus","GENOME POLYPROTEIN [CONTAINS: CAPSID PROTEIN C (CORE PROTEIN); ENVELOPE PROTEIN M (MATRIX PROTEIN); MAJOR ENVELOPE PROTEIN E; NON-STRUCTURAL PROTEIN 1 (NS1); NON-STRUCTURAL PROTEIN 2A (NS2A); FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT; FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT; NON-STRUCTURAL PROTEIN 4A (NS4A); NON-STRUCTURAL PROTEIN 4B (NS4B); RNA-DIRECTED RNA POLYMERASE (EC 2.7.7.48) (NS5)]","PF01728(FtsJ)",14,"SER A 56;GLY A 58;GLY A 81;GLY A 83;GLY A 86;TRP A 87;THR A 104;LYS A 105;HIS A 110;GLU A 111;ASP A 131;VAL A 132;ASP A 146;ILE A 147","SAM A 500\r"],["5ZMQ_I_PACI1","5zmq","PAC","DB09269(Phenylacetic acid)","Zika virus;synthetic construct","SERINE PROTEASE NS3;SERINE PROTEASE SUBUNIT NS2B;PEPTIDE PAC-DLY-DLY-DAR","None",3,"GLU E 66;VAL D 155;TYR D 161","PAC I 1\r"]]