DRUG BINDING INTERFACES MAPPED TO 'MITOGEN-ACTIVATED PROTEIN KINASE 1'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
3GCS_A_BAXA401 | 3gcs | BAX DB00398(Sorafenib) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 14 | PF00069(Pkinase) | 18 | VAL A 38ALA A 51ARG A 70GLU A 71LEU A 74LEU A 75MET A 78VAL A 83ILE A 84THR A 106LEU A 108MET A 109ILE A 141ILE A 146HIS A 148ILE A 166LEU A 167ASP A 168 | BAX A 401 |
3GP0_A_NILA1 | 3gp0 | NIL DB04868(Nilotinib) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 11 | PF00069(Pkinase) | 19 | VAL A 38ALA A 51LYS A 53ARG A 67GLU A 71LEU A 74LEU A 75VAL A 83ILE A 84LEU A 104THR A 106LEU A 108MET A 109HIS A 148ALA A 157ILE A 166LEU A 167ASP A 168PHE A 169 | NIL A 1 |
3HEC_A_STIA1 | 3hec | STI DB00619(Imatinib) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 14 | PF00069(Pkinase) | 16 | VAL A 30ALA A 51LYS A 53GLU A 71LEU A 74LEU A 75ILE A 84LEU A 104THR A 106LEU A 108MET A 109ILE A 146ASP A 150LEU A 167ASP A 168PHE A 169 | STI A 1 |
3HEG_A_BAXA1 | 3heg | BAX DB00398(Sorafenib) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 14 | PF00069(Pkinase) | 18 | VAL A 30VAL A 38ALA A 51LYS A 53GLU A 71LEU A 74LEU A 75MET A 78VAL A 83ILE A 84THR A 106MET A 109ILE A 141ILE A 146HIS A 148ILE A 166LEU A 167ASP A 168 | BAX A 1 |
3LFA_A_1N1A361 | 3lfa | 1N1 DB01254(Dasatinib) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 14 | PF00069(Pkinase) | 8 | VAL A 30ALA A 51LYS A 53GLU A 71LEU A 104THR A 106LEU A 108MET A 109 | 1N1 A 361 |
4XOY_A_DX4A401 | 4xoy | DX4 DB00352(Tioguanine) | Rattus norvegicus | MITOGEN-ACTIVATEDPROTEIN KINASE 1 | PF00069(Pkinase) | 6 | ALA A 50LYS A 52GLN A 103LEU A 105MET A 106LEU A 154 | DX4 A 401 |
4XP3_A_DX4A401 | 4xp3 | DX4 DB00352(Tioguanine) | Rattus norvegicus | MITOGEN-ACTIVATEDPROTEIN KINASE 1 | PF00069(Pkinase) | 6 | ALA A 50LYS A 52GLN A 103LEU A 105MET A 106LEU A 154 | DX4 A 401 |
5WP1_A_BEZA403 | 5wp1 | BEZ DB03793(BenzoicAcid) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 1 | PF00069(Pkinase) | 4 | GLY A 182PHE A 183ASN A 257LYS A 259 | BEZ A 403 |