DRUG BINDING INTERFACES MAPPED TO 'METHYLTRANSFERASE 1'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
3AV6_A_SAMA1 | 3av6 | SAM DB00118(S-Adenosylmethionine) | Mus musculus | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 | PF00145(BAH)PF01426(zf-CXXC)PF02008(BAH)PF12047(DNMT1-RFD) | 14 | PHE A1148GLY A1150GLY A1153LEU A1154GLU A1171MET A1172TRP A1173ASP A1193CYS A1194PRO A1228LEU A1250ASN A1580ALA A1581VAL A1582 | SAM A 1 |
3O7W_A_SAMA801 | 3o7w | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | LEUCINE CARBOXYLMETHYLTRANSFERASE 1 | PF04072(LCM) | 15 | ALA A 33LYS A 37ARG A 73GLY A 98GLY A 100ASP A 122PHE A 123ILE A 126ASP A 171LEU A 172ARG A 173GLU A 198CYS A 199VAL A 200TYR A 203 | SAM A 801 |
4N48_A_SAMA601 | 4n48 | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 | PF01728(FtsJ) | 17 | ASN A 234ALA A 236CYS A 277GLY A 279PRO A 280GLY A 281GLY A 282PHE A 283THR A 301LEU A 302ASN A 306ASP A 335ILE A 336THR A 337ASP A 364GLY A 365LEU A 383 | SAM A 601 |
4N48_B_SAMB601 | 4n48 | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 | None | 17 | ASN B 234ALA B 236CYS B 277GLY B 279PRO B 280GLY B 281GLY B 282PHE B 283THR B 301LEU B 302ASN B 306ASP B 335ILE B 336THR B 337ASP B 364GLY B 365LEU B 383 | SAM B 601 |
4N49_A_SAMA601 | 4n49 | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 | PF01728(FtsJ) | 16 | ASN A 234ALA A 236CYS A 277GLY A 279PRO A 280GLY A 281GLY A 282PHE A 283THR A 301LEU A 302ASN A 306ASP A 335ILE A 336THR A 337ASP A 364LEU A 383 | SAM A 601 |
4RFQ_A_SAMA401 | 4rfq | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | HISTIDINE PROTEINMETHYLTRANSFERASE 1HOMOLOG | PF13489(Methyltransf_23) | 16 | PRO A 78GLU A 89PRO A 90ILE A 168TRP A 169THR A 172GLY A 195GLN A 216ASP A 217TYR A 218GLU A 269TRP A 270SER A 293THR A 295TYR A 297TYR A 301 | SAM A 401 |
5DPD_A_SAMA601 | 5dpd | SAM DB00118(S-Adenosylmethionine) | Rickettsiaprowazekii | PROTEIN LYSINEMETHYLTRANSFERASE 1 | PF10119(Methyltransf_31)PF13847(MethyTransf_Reg) | 13 | TYR A 48GLU A 77GLY A 79ASP A 102LEU A 103SER A 104GLN A 107SER A 129ILE A 130HIS A 146VAL A 148VAL A 152VAL A 156 | SAM A 601 |
5DPD_B_SAMB601 | 5dpd | SAM DB00118(S-Adenosylmethionine) | Rickettsiaprowazekii | PROTEIN LYSINEMETHYLTRANSFERASE 1 | None | 12 | TYR B 48GLY B 79ASP B 102LEU B 103SER B 104GLN B 107SER B 129ILE B 130VAL B 148TRP B 151VAL B 152VAL B 156 | SAM B 601 |
5UBB_A_SAMA301 | 5ubb | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | ALPHA N-TERMINALPROTEINMETHYLTRANSFERASE 1B | PF05891(Methyltransf_PK) | 17 | TYR A 76MET A 86GLY A 124GLY A 126ARG A 129VAL A 130ASP A 146MET A 147MET A 148SER A 173LEU A 174GLN A 175GLN A 190TRP A 191VAL A 192HIS A 195LEU A 196 | SAM A 301 |
6B3A_A_SAMA701 | 6b3a | SAM DB00118(S-Adenosylmethionine) | Moorea bouillonii | APRAMETHYLTRANSFERASE 1 | PF16864(Dimerisation2) | 14 | HIS A 249PHE A 253MET A 279GLY A 280GLY A 282ASP A 315TYR A 316ASN A 317ALA A 320ASP A 339ILE A 340SER A 365LEU A 367PRO A 372 | SAM A 701 |
6B3B_A_SAMA701 | 6b3b | SAM DB00118(S-Adenosylmethionine) | Moorea bouillonii | APRAMETHYLTRANSFERASE 1 | PF16864(Dimerisation2) | 14 | HIS A 249PHE A 253MET A 279GLY A 280GLY A 282ASP A 315TYR A 316ASN A 317ALA A 320ASP A 339ILE A 340SER A 365LEU A 367PRO A 372 | SAM A 701 |
6I5Z_D_SAMD401 | 6i5z | SAM DB00118(S-Adenosylmethionine) | Papaversomniferum | O-METHYLTRANSFERASE1 | None | 11 | SER D 211GLY D 235GLY D 237ASP D 258LEU D 259VAL D 262ASP D 278MET D 279LYS D 292TRP D 293ASP D 297 | SAM D 401 |