DRUG BINDING INTERFACES MAPPED TO 'METHIONINE SYNTHASE'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
1MSK_A_ACTA1302
1msk
ACT
DB03166(Aceticacid)
Escherichia coli
COBALAMIN-DEPENDENTMETHIONINE SYNTHASE
PF02965(Met_synt_B12)
4
GLN A 932VAL A 934ARG A1106TYR A1111
ACT A1302
1MSK_A_SAMA1301
1msk
SAM
DB00118(S-Adenosylmethionine)
Escherichia coli
COBALAMIN-DEPENDENTMETHIONINE SYNTHASE
PF02965(Met_synt_B12)
10
ASP A 946ARG A1094GLU A1097ARG A1134PRO A1135ALA A1136TYR A1139PRO A1140ALA A1141TYR A1189
SAM A1301
4K0B_B_SAMB504
4k0b
SAM
DB00118(S-Adenosylmethionine)
Saccharolobussolfataricus
S-ADENOSYLMETHIONINESYNTHASE
NonePF01941(AdoMet_Synthase)
16
HIS B 29PRO B 30HIS A 58ASN A 60ARG A 91ASP A 144LEU A 145ASN A 159ASP A 160ASP B 199LYS B 201ALA B 216TYR B 270SER B 277ASP B 282ILE A 349
SAM B 504
4KTT_A_SAMA405
4ktt
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
NonePF00438(S-AdoMet_synt_M)PF02772(S-AdoMet_synt_C)PF02773(S-AdoMet_synt_N)
16
HIS A 29PRO A 30ALA B 55GLU B 70GLN B 113ASP B 116ILE B 117ASP B 134ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258LYS B 289ILE B 322
SAM A 405
4KTT_C_SAMC404
4ktt
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
None
16
HIS C 29PRO C 30ALA D 55GLU D 70GLN D 113ASP D 116ILE D 117ASP D 134ASP C 179LYS C 181SER C 206SER C 247PHE C 250ASP C 258LYS D 289ILE D 322
SAM C 404
4KTV_A_ADNA403
4ktv
ADN
DB00640(Adenosine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)no annotation
12
HIS A 29PRO A 30ASP B 116ILE B 117ASP B 134ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258ILE B 322
ADN A 403
4KTV_C_ADNC403
4ktv
ADN
DB00640(Adenosine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
no annotation
11
HIS C 29PRO C 30ASP D 116ILE D 117ASP D 134ASP C 179LYS C 181SER C 247PHE C 250ASP C 258ILE D 322
ADN C 403
4L7I_B_SAMB501
4l7i
SAM
DB00118(S-Adenosylmethionine)
Saccharolobussolfataricus
S-ADENOSYLMETHIONINESYNTHASE
NonePF01941(AdoMet_Synthase)
16
HIS B 29PRO B 30HIS A 58ASN A 60ARG A 91ASP A 144LEU A 145ASN A 159ASP A 160ASP B 199LYS B 201ALA B 216TYR B 270SER B 277ASP B 282ILE A 349
SAM B 501
4NDN_A_SAMA407
4ndn
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
NonePF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)
16
HIS A 29PRO A 30ALA B 55GLU B 70GLN B 113ASP B 116ILE B 117ASP B 134ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258LYS B 289ILE B 322
SAM A 407
4NDN_C_SAMC405
4ndn
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
None
15
HIS C 29PRO C 30ALA D 55GLU D 70GLN D 113ASP D 116ILE D 117ASP D 134ASP C 179LYS C 181SER C 247PHE C 250ASP C 258LYS D 289ILE D 322
SAM C 405
4ODJ_A_SAMA500
4odj
SAM
DB00118(S-Adenosylmethionine)
Cryptosporidiumhominis
S-ADENOSYLMETHIONINESYNTHASE
PF00438(S-AdoMet_synt_M)PF02772(S-AdoMet_synt_C)PF02773(S-AdoMet_synt_N)
7
HIS A 34PRO A 35ASP A 187LYS A 189SER A 255PHE A 258ASP A 266
SAM A 500
5A1I_A_ADNA407
5a1i
ADN
DB00640(Adenosine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)
8
HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258
ADN A 407
5A1I_A_SAMA405
5a1i
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)
7
HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258
SAM A 405
5T8S_B_SAMB402
5t8s
SAM
DB00118(S-Adenosylmethionine)
Neisseriagonorrhoeae
S-ADENOSYLMETHIONINESYNTHASE
NonePF00438(S-AdoMet_synt_M)PF02772(S-AdoMet_synt_C)PF02773(S-AdoMet_synt_N)
16
HIS B 15PRO B 16ALA A 41GLU A 56GLN A 99ASP A 102ILE A 103ASP A 121ASP B 166LYS B 168SER B 191THR B 232PHE B 235ASP B 243LYS A 274ILE A 307
SAM B 402
6BM5_A_SAMA1301
6bm5
SAM
DB00118(S-Adenosylmethionine)
Escherichia coli
METHIONINE SYNTHASE
PF02965(Met_synt_B12)
11
ASP A 946PRO A 949ARG A1094GLU A1097ARG A1134PRO A1135ALA A1136TYR A1139PRO A1140ALA A1141TYR A1189
SAM A1301
6FBN_B_SAMB401
6fbn
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
NonePF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)
15
HIS B 29PRO B 30ALA A 55GLU A 70ASP A 116ILE A 117ASP A 134ASP B 179LYS B 181SER B 206SER B 247PHE B 250ASP B 258LYS A 289ILE A 322
SAM B 401
6FBO_A_ADNA406
6fbo
ADN
DB00640(Adenosine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_C)PF02772(S-AdoMet_synt_N)PF02773(S-AdoMet_synt_M)
8
HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258
ADN A 406
6FBP_B_ADNB404
6fbp
ADN
DB00640(Adenosine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
NonePF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)
12
HIS B 29PRO B 30ASP A 116ILE A 117ASP A 134ASP B 179LYS B 181SER B 206SER B 247PHE B 250ASP B 258ILE A 322
ADN B 404
6FCB_A_SAMA405
6fcb
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_M)PF02772(S-AdoMet_synt_C)PF02773(S-AdoMet_synt_N)
8
HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258
SAM A 405
6FCD_A_ADNA405
6fcd
ADN
DB00640(Adenosine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C)
8
HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258
ADN A 405
6G6R_A_SAMA406
6g6r
SAM
DB00118(S-Adenosylmethionine)
Homo sapiens
S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2
PF00438(S-AdoMet_synt_M)PF02772(S-AdoMet_synt_C)PF02773(S-AdoMet_synt_N)
7
HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258
SAM A 406
[["1MSK_A_ACTA1302","1msk","ACT","DB03166(Acetic acid)","Escherichia coli","COBALAMIN-DEPENDENT METHIONINE SYNTHASE","PF02965(Met_synt_B12)",4,"GLN A 932;VAL A 934;ARG A1106;TYR A1111","ACT A1302\r"],["1MSK_A_SAMA1301","1msk","SAM","DB00118(S-Adenosylmethionine)","Escherichia coli","COBALAMIN-DEPENDENT METHIONINE SYNTHASE","PF02965(Met_synt_B12)",10,"ASP A 946;ARG A1094;GLU A1097;ARG A1134;PRO A1135;ALA A1136;TYR A1139;PRO A1140;ALA A1141;TYR A1189","SAM A1301\r"],["4K0B_B_SAMB504","4k0b","SAM","DB00118(S-Adenosylmethionine)","Saccharolobus solfataricus","S-ADENOSYLMETHIONINE SYNTHASE","None;PF01941(AdoMet_Synthase)",16,"HIS B 29;PRO B 30;HIS A 58;ASN A 60;ARG A 91;ASP A 144;LEU A 145;ASN A 159;ASP A 160;ASP B 199;LYS B 201;ALA B 216;TYR B 270;SER B 277;ASP B 282;ILE A 349","SAM B 504\r"],["4KTT_A_SAMA405","4ktt","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","None;PF00438(S-AdoMet_synt_M);PF02772(S-AdoMet_synt_C);PF02773(S-AdoMet_synt_N)",16,"HIS A 29;PRO A 30;ALA B 55;GLU B 70;GLN B 113;ASP B 116;ILE B 117;ASP B 134;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258;LYS B 289;ILE B 322","SAM A 405\r"],["4KTT_C_SAMC404","4ktt","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","None",16,"HIS C 29;PRO C 30;ALA D 55;GLU D 70;GLN D 113;ASP D 116;ILE D 117;ASP D 134;ASP C 179;LYS C 181;SER C 206;SER C 247;PHE C 250;ASP C 258;LYS D 289;ILE D 322","SAM C 404\r"],["4KTV_A_ADNA403","4ktv","ADN","DB00640(Adenosine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C);no annotation",12,"HIS A 29;PRO A 30;ASP B 116;ILE B 117;ASP B 134;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258;ILE B 322","ADN A 403\r"],["4KTV_C_ADNC403","4ktv","ADN","DB00640(Adenosine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","no annotation",11,"HIS C 29;PRO C 30;ASP D 116;ILE D 117;ASP D 134;ASP C 179;LYS C 181;SER C 247;PHE C 250;ASP C 258;ILE D 322","ADN C 403\r"],["4L7I_B_SAMB501","4l7i","SAM","DB00118(S-Adenosylmethionine)","Saccharolobus solfataricus","S-ADENOSYLMETHIONINE SYNTHASE","None;PF01941(AdoMet_Synthase)",16,"HIS B 29;PRO B 30;HIS A 58;ASN A 60;ARG A 91;ASP A 144;LEU A 145;ASN A 159;ASP A 160;ASP B 199;LYS B 201;ALA B 216;TYR B 270;SER B 277;ASP B 282;ILE A 349","SAM B 501\r"],["4NDN_A_SAMA407","4ndn","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","None;PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",16,"HIS A 29;PRO A 30;ALA B 55;GLU B 70;GLN B 113;ASP B 116;ILE B 117;ASP B 134;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258;LYS B 289;ILE B 322","SAM A 407\r"],["4NDN_C_SAMC405","4ndn","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","None",15,"HIS C 29;PRO C 30;ALA D 55;GLU D 70;GLN D 113;ASP D 116;ILE D 117;ASP D 134;ASP C 179;LYS C 181;SER C 247;PHE C 250;ASP C 258;LYS D 289;ILE D 322","SAM C 405\r"],["4ODJ_A_SAMA500","4odj","SAM","DB00118(S-Adenosylmethionine)","Cryptosporidium hominis","S-ADENOSYLMETHIONINE SYNTHASE","PF00438(S-AdoMet_synt_M);PF02772(S-AdoMet_synt_C);PF02773(S-AdoMet_synt_N)",7,"HIS A 34;PRO A 35;ASP A 187;LYS A 189;SER A 255;PHE A 258;ASP A 266","SAM A 500\r"],["5A1I_A_ADNA407","5a1i","ADN","DB00640(Adenosine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",8,"HIS A 29;PRO A 30;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258","ADN A 407\r"],["5A1I_A_SAMA405","5a1i","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",7,"HIS A 29;PRO A 30;ASP A 179;LYS A 181;SER A 247;PHE A 250;ASP A 258","SAM A 405\r"],["5T8S_B_SAMB402","5t8s","SAM","DB00118(S-Adenosylmethionine)","Neisseria gonorrhoeae","S-ADENOSYLMETHIONINE SYNTHASE","None;PF00438(S-AdoMet_synt_M);PF02772(S-AdoMet_synt_C);PF02773(S-AdoMet_synt_N)",16,"HIS B 15;PRO B 16;ALA A 41;GLU A 56;GLN A 99;ASP A 102;ILE A 103;ASP A 121;ASP B 166;LYS B 168;SER B 191;THR B 232;PHE B 235;ASP B 243;LYS A 274;ILE A 307","SAM B 402\r"],["6BM5_A_SAMA1301","6bm5","SAM","DB00118(S-Adenosylmethionine)","Escherichia coli","METHIONINE SYNTHASE","PF02965(Met_synt_B12)",11,"ASP A 946;PRO A 949;ARG A1094;GLU A1097;ARG A1134;PRO A1135;ALA A1136;TYR A1139;PRO A1140;ALA A1141;TYR A1189","SAM A1301\r"],["6FBN_B_SAMB401","6fbn","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","None;PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",15,"HIS B 29;PRO B 30;ALA A 55;GLU A 70;ASP A 116;ILE A 117;ASP A 134;ASP B 179;LYS B 181;SER B 206;SER B 247;PHE B 250;ASP B 258;LYS A 289;ILE A 322","SAM B 401\r"],["6FBO_A_ADNA406","6fbo","ADN","DB00640(Adenosine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_C);PF02772(S-AdoMet_synt_N);PF02773(S-AdoMet_synt_M)",8,"HIS A 29;PRO A 30;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258","ADN A 406\r"],["6FBP_B_ADNB404","6fbp","ADN","DB00640(Adenosine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","None;PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",12,"HIS B 29;PRO B 30;ASP A 116;ILE A 117;ASP A 134;ASP B 179;LYS B 181;SER B 206;SER B 247;PHE B 250;ASP B 258;ILE A 322","ADN B 404\r"],["6FCB_A_SAMA405","6fcb","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_M);PF02772(S-AdoMet_synt_C);PF02773(S-AdoMet_synt_N)",8,"HIS A 29;PRO A 30;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258","SAM A 405\r"],["6FCD_A_ADNA405","6fcd","ADN","DB00640(Adenosine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",8,"HIS A 29;PRO A 30;ASP A 179;LYS A 181;SER A 206;SER A 247;PHE A 250;ASP A 258","ADN A 405\r"],["6G6R_A_SAMA406","6g6r","SAM","DB00118(S-Adenosylmethionine)","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","PF00438(S-AdoMet_synt_M);PF02772(S-AdoMet_synt_C);PF02773(S-AdoMet_synt_N)",7,"HIS A 29;PRO A 30;ASP A 179;LYS A 181;SER A 247;PHE A 250;ASP A 258","SAM A 406\r"]]