DRUG BINDING INTERFACES MAPPED TO 'LIPASE A'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1OXR_A_AINA141 | 1oxr | AIN DB00945(Acetylsalicylicacid) | Naja sagittifera | PHOSPHOLIPASE A2ISOFORM 3 | PF00068(Phospholip_A2_1) | 4 | LEU A 2GLY A 30ASP A 49TYR A 64 | AIN A 141 |
1SV9_A_DIFA701 | 1sv9 | DIF DB00586(Diclofenac) | Daboia russelii | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1) | 8 | LEU A 2ALA A 18ILE A 19CYS A 29GLY A 30CYS A 45HIS A 48PHE A 106 | DIF A 701 |
1TD7_A_NFLA2001 | 1td7 | NFL DB04552(NiflumicAcid) | Naja sagittifera | PHOSPHOLIPASE A2ISOFORM 3 | PF00068(Phospholip_A2_1) | 9 | LEU A 2LYS A 6ILE A 9TRP A 19PHE A 22GLY A 30CYS A 45TYR A 64PHE A 101 | NFL A2001 |
1TGM_A_AINA202 | 1tgm | AIN DB00945(Acetylsalicylicacid) | Daboia russelii | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1) | 3 | LEU A 2ALA A 18ILE A 19 | AIN A 202 |
1TH6_A_OINA401 | 1th6 | OIN DB00424(Hyoscyamine)DB00572(Atropine) | Daboia russelii | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1) | 7 | GLY A 30TRP A 31HIS A 48ASP A 49TYR A 52PRO A 68LYS A 69 | OIN A 401 |
1Y4L_B_SVRB301 | 1y4l | SVR DB04786(Suramin) | Bothrops asper | PHOSPHOLIPASE A2HOMOLOG 2 | PF00068(Phospholip_A2_1)no annotation | 24 | LEU B 2LEU A 2LEU B 5GLY A 23GLY A 30VAL B 31VAL A 31LEU A 32GLY A 33GLY B 33ARG B 34ARG A 34HIS B 48LYS B 49LYS A 49TYR A 52TYR B 52LYS A 53LYS B 53PRO A 68LYS B 69LYS A 69LYS A 70LYS B 70 | SVR B 301 |
1ZWP_A_NIMA401 | 1zwp | NIM DB04743(Nimesulide) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 5 | LEU A 2GLY A 30TRP A 31ASP A 49LYS A 69 | NIM A 401 |
2ARM_A_OINA401 | 2arm | OIN DB00424(Hyoscyamine)DB00572(Atropine) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 7 | GLY A 30TRP A 31HIS A 48ASP A 49TYR A 52PRO A 68LYS A 69 | OIN A 401 |
2AZY_A_CHDA237 | 2azy | CHD DB02659(CholicAcid) | Sus scrofa | PHOSPHOLIPASE A2,MAJOR ISOENZYME | PF00068(Phospholip_A2_1) | 11 | ARG A 6ILE A 9ILE A 13HIS A 17MET A 20ASP A 21TYR A 25GLY A 30LEU A 41PHE A 106TYR A 111 | CHD A 237 |
2B17_A_DIFA701 | 2b17 | DIF DB00586(Diclofenac) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 10 | LEU A 2ALA A 18ILE A 19CYS A 29GLY A 30CYS A 45HIS A 48ASP A 49LYS A 69PHE A 106 | DIF A 701 |
2DPZ_A_TYLA2001 | 2dpz | TYL DB00316(Acetaminophen) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 6 | LEU A 2ALA A 18HIS A 48ASP A 49TYR A 52LYS A 69 | TYL A2001 |
2OTF_A_2TNA201 | 2otf | 2TN DB00335(Atenolol) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 5 | LEU A 2ILE A 19SER A 23GLY A 30HIS A 48 | 2TN A 201 |
2OTH_A_IMNA301 | 2oth | IMN DB00328(Indomethacin) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 3 | ASP A 49TYR A 52LYS A 69 | IMN A 301 |
2OTH_A_NIMA300 | 2oth | NIM DB04743(Nimesulide) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 5 | LEU A 2ALA A 18ILE A 19SER A 23LYS A 69 | NIM A 300 |
2OUB_A_2TNA134 | 2oub | 2TN DB00335(Atenolol) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 4 | LEU A 2ILE A 19HIS A 48LYS A 69 | 2TN A 134 |
2PWS_A_IBPA3960 | 2pws | IBP DB01050(Ibuprofen) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 4 | LEU A 2ILE A 19TRP A 31LYS A 69 | IBP A3960 |
2WQ5_A_MIYA1120 | 2wq5 | MIY DB01017(Minocycline) | Naja naja | PHOSPHOLIPASE A2,ACIDIC | PF00068(Phospholip_A2_1) | 7 | LEU A 2TRP A 18ALA A 22GLY A 29ARG A 30PHE A 63PHE A 64 | MIY A1120 |
3BJW_A_SVRA508 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1)no annotation | 17 | VAL G 2VAL G 3VAL E 3GLY G 6LYS G 7GLN E 11PRO G 18PHE E 19THR G 23GLY G 30PRO A 36LYS G 69ARG E 72ARG G 72ARG E 77PHE A 124PHE H 124 | SVR A 508 |
3BJW_B_SVRB501 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1)no annotation | 20 | VAL B 2LEU B 5GLY B 6ILE B 10LYS B 16SER A 17SER B 17PRO B 18PRO A 18PHE A 19PRO B 20PRO A 20SER B 21THR B 23LYS B 115LYS G 116LYS F 116ASN F 122PHE F 124TRP F 125 | SVR B 501 |
3BJW_B_SVRB512 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1)no annotation | 21 | VAL A 2VAL B 3VAL A 3LYS B 7ILE B 10GLN B 11GLY B 14LYS G 16THR A 23THR A 70ARG A 72ARG B 107LEU B 110TYR G 113ASN G 114LYS G 115LYS G 116TYR G 117PRO G 121PHE G 124TRP G 125 | SVR B 512 |
3BJW_C_SVRC505 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | no annotation | 18 | VAL D 2VAL H 2VAL D 3VAL H 3GLU D 4GLY D 6LYS D 7GLN H 11PRO D 18PHE H 19THR D 23PRO C 36LYS D 69ARG D 72LYS D 74ARG H 77PHE E 124TRP E 125 | SVR C 505 |
3BJW_C_SVRC507 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | no annotation | 17 | VAL F 2VAL C 2VAL F 3VAL C 3GLY C 6GLN F 11PRO C 18PHE F 19PRO D 36LYS C 69ARG F 72ARG C 72LYS C 74ARG F 77PHE D 124PHE B 124TRP B 125 | SVR C 507 |
3BJW_E_SVRE503 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1)no annotation | 20 | VAL E 2LEU E 5GLY E 6ILE E 10LYS E 16SER E 17SER G 17PRO E 18PRO G 18PHE G 19PRO E 20PRO G 20SER E 21THR E 23LYS E 115LYS H 116LYS A 116ASN H 122PHE H 124TRP H 125 | SVR E 503 |
3BJW_E_SVRE510 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1)no annotation | 20 | VAL G 2VAL E 3VAL G 3LYS E 7GLN E 11GLY E 14LYS A 16THR G 23THR G 70ARG G 72ARG E 107LEU E 110TYR A 113ASN A 114LYS A 115LYS A 116TYR A 117PRO A 121PHE A 124TRP A 125 | SVR E 510 |
3BJW_F_SVRF502 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | no annotation | 22 | VAL F 2LEU F 5GLY F 6ILE F 10ILE C 10LYS F 16SER F 17SER C 17PRO F 18PRO C 18PHE F 19PHE C 19PRO F 20PRO C 20SER F 21THR F 23LYS F 115LYS B 116LYS D 116ASN B 122PHE B 124TRP B 125 | SVR F 502 |
3BJW_F_SVRF509 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | no annotation | 20 | VAL C 2VAL F 3VAL C 3LYS F 7ILE F 10GLN F 11GLY F 14LYS D 16THR C 23THR C 70ARG C 72ARG F 107LEU F 110TYR D 113ASN D 114LYS D 115LYS D 116PRO D 121PHE D 124TRP D 125 | SVR F 509 |
3BJW_G_SVRG506 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | PF00068(Phospholip_A2_1)no annotation | 18 | VAL B 2VAL A 2VAL B 3VAL A 3GLY A 6LYS A 7GLN B 11PRO A 18PHE B 19PRO G 36LYS A 69ARG A 72LYS A 74ARG B 77PHE G 124PHE F 124TRP F 125LYS G 127 | SVR G 506 |
3BJW_H_SVRH504 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | no annotation | 20 | VAL H 2LEU H 5GLY H 6ILE H 10LYS H 16SER D 17SER H 17PRO D 18PRO H 18PHE D 19PRO H 20PRO D 20SER H 21THR H 23LYS H 115LYS C 116PRO E 121ASN E 122PHE E 124TRP E 125 | SVR H 504 |
3BJW_H_SVRH511 | 3bjw | SVR DB04786(Suramin) | Echis carinatus | PHOSPHOLIPASE A2 | no annotation | 21 | VAL D 2VAL D 3VAL H 3LYS H 7ILE H 10GLN H 11GLY H 14LYS C 16THR D 23THR D 70ARG D 72ARG H 107LEU H 110TYR C 113ASN C 114LYS C 115LYS C 116TYR C 117PRO C 121PHE C 124TRP C 125 | SVR H 511 |
3FO7_A_IMNA301 | 3fo7 | IMN DB00328(Indomethacin) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 5 | HIS A 48ASP A 49TYR A 52PRO A 68LYS A 69 | IMN A 301 |
3H1X_A_IMNA301 | 3h1x | IMN DB00328(Indomethacin) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 5 | HIS A 48ASP A 49TYR A 52PRO A 68LYS A 69 | IMN A 301 |
3OSH_A_OINA5811 | 3osh | OIN DB00424(Hyoscyamine)DB00572(Atropine) | Naja sagittifera | PHOSPHOLIPASE A2ISOFORM 3 | PF00068(Phospholip_A2_1) | 9 | LEU A 2PHE A 5ILE A 9TRP A 19PHE A 22GLY A 30LYS A 31HIS A 48TYR A 64 | OIN A5811 |
3R0L_D_ACTD127 | 3r0l | ACT DB03166(Aceticacid) | Crotalus durissus | PHOSPHOLIPASE A2 CB | PF00068(Phospholip_A2_1) | 5 | PHE D 5ILE D 9GLY D 29CYS D 44HIS D 47 | ACT D 127 |
4EIX_A_NIMA201 | 4eix | NIM DB04743(Nimesulide) | Daboia russelii | PHOSPHOLIPASE A2VRV-PL-VIIIA | PF00068(Phospholip_A2_1) | 4 | LEU A 2ALA A 18ILE A 19LYS A 69 | NIM A 201 |
4NTX_A_AMRA509 | 4ntx | AMR DB00594(Amiloride) | Gallus gallus;Micrurus tener | ACID-SENSING IONCHANNEL 1;BASIC PHOSPHOLIPASEA2 HOMOLOG TX-BETA | PF00068(Phospholip_A2_1)PF00858(ASC) | 6 | ASN C 83ARG C 87GLU A 236ASP A 238ASP A 350GLU A 354 | AMR A 509 |
4YV5_A_SVRA205 | 4yv5 | SVR DB04786(Suramin) | Bothrops moojeni | BASIC PHOSPHOLIPASEA2 HOMOLOG 2 | PF00068(Phospholip_A2_1)no annotation | 13 | PHE B 3LYS B 7LEU B 10ASN B 17PRO B 18ARG B 72ASN A 114LYS A 115LYS A 116TYR A 119TYR A 121LEU A 122PHE A 126 | SVR A 205 |
4YV5_B_SVRB207 | 4yv5 | SVR DB04786(Suramin) | Bothrops moojeni | BASIC PHOSPHOLIPASEA2 HOMOLOG 2 | PF00068(Phospholip_A2_1)no annotation | 13 | PHE A 3LYS A 7LEU A 10ASN A 17PRO A 18ARG A 72ASN B 114LYS B 115LYS B 116TYR B 119TYR B 121LEU B 122PHE B 126 | SVR B 207 |