DRUG BINDING INTERFACES MAPPED TO 'LIGHT CHAIN'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1DBB_H_STRH229 1dbb STR

DB00396
(Progesterone) 		Mus musculus IGG1-KAPPA DB3 FAB
(HEAVY CHAIN);
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN) 		PF07654
(C1-set)
PF07686
(V-set) 		8 HIS L  27
GLY H  33
ASN H  35
TRP H  50
VAL L  94
GLY H  95
TYR H  97
TRP H 100
 STR H 229
1I9J_H_TESH1010 1i9j TES

DB00624
(Testosterone) 		Mus musculus RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN;
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		11 SER H  35
TRP H  47
SER H  50
VAL H  52
TYR H  58
GLU H  98
VAL L  99
PRO L 101
TYR H 102
GLY H 104
LEU H 105
 TES H1010
1IBG_H_OBNH1 1ibg OBN

DB01092
(Ouabain) 		Mus musculus IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN);
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN) 		PF07654
(C1-set)
PF07686
(V-set) 		13 THR L  27
SER L  28
HIS L  32
HIS H  35
LEU H  50
TRP H  52
SER L  91
ARG L  92
TYR L  94
PHE H  95
LEU L  96
TYR H 100
VAL H 100
 OBN H   1
1IGJ_B_DGXB228 1igj DGX

DB00390
(Digoxin) 		Mus musculus IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN);
IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN) 		PF07654
(C1-set)
PF07686
(V-set) 		10 TYR B  33
ASN B  35
TYR A  36
TYR B  47
TYR B  50
THR A  91
SER B  95
PRO A  96
MET B 100
TRP B 100
 DGX B 228
1IGJ_D_DGXD228 1igj DGX

DB00390
(Digoxin) 		Mus musculus IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN);
IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN) 		no annotation 9 TYR D  33
ASN D  35
TYR D  47
TYR D  50
THR C  91
SER D  95
PRO C  96
TRP D 100
MET D 100
 DGX D 228
1MCB_P_DHIP3 1mcb DHI

DB00117
(L-
Histidine) 		;
Homo sapiens 		IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN);
PEPTIDE
N-ACETYL-L-GLN-D-PHE
-L-HIS-D-PRO-OH 		None
PF07654
(C1-set)
PF07686
(V-set) 		5 GLN P   1
TYR A  34
TYR A  51
GLU A  52
TYR B  93
 DHI P   3
1MCL_P_DHIP1 1mcl DHI

DB00117
(L-
Histidine) 		;
Homo sapiens 		IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN);
N-ACETYL-D-HIS-L-PRO
-OH 		None
PF07654
(V-set)
PF07686
(C1-set) 		5 PRO P   2
TYR A  51
GLU A  52
TYR B  93
PHE A  99
 DHI P   1
1MCN_P_DHIP1 1mcn DHI

DB00117
(L-
Histidine) 		;
Homo sapiens 		IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN);
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2 		None
PF07654
(V-set)
PF07686
(C1-set) 		3 PRO P   2
TYR B  34
PHE A  99
 DHI P   1
1Q0Y_H_MOIH401 1q0y MOI

DB00295
(Morphine) 		Mus musculus FAB 9B1, HEAVY
CHAIN;
FAB 9B1, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		7 TRP H  33
GLU H  35
GLU H  50
ILE H  58
TRP L  91
TRP H  95
LEU H  97
 MOI H 401
1Q72_H_COCH401 1q72 COC

DB00907
(Cocaine) 		Mus musculus FAB M82G2, HEAVY
CHAIN;
FAB M82G2, LIGHT
CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		10 HIS L  27
TYR L  32
TRP H  33
ASN H  52
HIS L  91
TYR L  94
VAL H  95
PHE L  96
GLN H  97
GLY H  99
 COC H 401
1RU9_H_ACTH611 1ru9 ACT

DB03166
(Acetic
acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(V-set)
PF07686
(C1-set) 		6 ASN L  34
LEU L  36
TRP L  89
LEU H  95
PHE L  98
TRP H 103
 ACT H 611
1RU9_H_BEZH601 1ru9 BEZ

DB03793
(Benzoic
Acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(V-set)
PF07686
(C1-set) 		9 PHE L  32
ALA H  34
ASN H  35
TYR H  50
TRP L  89
GLY L  91
LEU H  95
TYR L  96
GLY H 100
 BEZ H 601
1RUA_H_BEZH601 1rua BEZ

DB03793
(Benzoic
Acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		10 PHE L  32
ALA H  34
ASN H  35
TRP H  47
TYR H  50
TRP L  89
GLY L  91
LEU H  95
TYR L  96
GLY H 100
 BEZ H 601
1RUA_L_ACTL611 1rua ACT

DB03166
(Acetic
acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN L  34
LEU L  36
TRP L  89
LEU H  95
TRP H 103
 ACT L 611
1RUK_H_BEZH601 1ruk BEZ

DB03793
(Benzoic
Acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		8 ALA H  34
ASN H  35
TRP H  47
TYR H  50
TRP L  89
GLY L  91
LEU H  95
GLY H 100
 BEZ H 601
1RUK_L_ACTL611 1ruk ACT

DB03166
(Acetic
acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		6 ASN L  34
LEU L  36
TRP L  89
LEU H  95
PHE L  98
TRP H 103
 ACT L 611
1RUL_H_BEZH601 1rul BEZ

DB03793
(Benzoic
Acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		9 ALA H  34
ASN H  35
TRP H  47
TYR H  50
TRP L  89
GLY L  91
LEU H  95
TYR L  96
GLY H 100
 BEZ H 601
1RUL_L_ACTL611 1rul ACT

DB03166
(Acetic
acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN L  34
LEU L  36
TRP L  89
LEU H  95
TRP H 103
 ACT L 611
1RUM_H_BEZH1601 1rum BEZ

DB03793
(Benzoic
Acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(V-set)
PF07686
(C1-set) 		9 ALA H  34
ASN H  35
TRP H  47
TYR H  50
TRP L  89
GLY L  91
LEU H  95
TYR L  96
GLY H 100
 BEZ H1601
1RUP_H_BEZH601 1rup BEZ

DB03793
(Benzoic
Acid) 		Mus musculus IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN;
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		9 ALA H  34
ASN H  35
TRP H  47
TYR H  50
TRP L  89
GLY L  91
LEU H  95
TYR L  96
GLY H 100
 BEZ H 601
1VPO_H_TESH1010 1vpo TES

DB00624
(Testosterone) 		Mus musculus ANTI-TESTOSTERONE
(HEAVY CHAIN);
ANTI-TESTOSTERONE
(LIGHT CHAIN) 		PF07654
(C1-set)
PF07686
(V-set) 		12 ARG L  32
SER H  35
TRP H  47
SER H  50
TYR H  58
PHE L  94
ALA H  98
VAL L  99
PRO L 101
TYR H 102
GLY H 104
LEU H 105
 TES H1010
1XZ1_A_HLTA2001 1xz1 HLT

DB01159
(Halothane) 		Equus caballus FERRITIN LIGHT CHAIN PF00210
(Ferritin) 		4 LEU A  24
SER A  27
TYR A  28
LEU A  81
 HLT A2001
1XZ3_A_ICFA201 1xz3 ICF

DB00753
(Isoflurane) 		Equus caballus FERRITIN LIGHT CHAIN PF00210
(Ferritin) 		4 LEU A  24
SER A  27
TYR A  28
LEU A  81
 ICF A 201
2FL5_B_RBFB202 2fl5 RBF

DB00140
(Riboflavin) 		Homo sapiens IMMUNOGLOBULIN IGG1
HEAVY CHAIN;
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		11 TYR B  33
ASN B  50
ARG B  52
GLU B  56
PHE B  58
GLU F  85
TYR A  95
VAL B  95
GLY A  95
PRO A  96
TYR B 100
 RBF B 202
2FL5_D_RBFD228 2fl5 RBF

DB00140
(Riboflavin) 		Homo sapiens IMMUNOGLOBULIN IGG1
HEAVY CHAIN;
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN 		no annotation 9 TYR D  33
ASN D  50
ARG D  52
GLU D  56
PHE D  58
VAL D  95
TYR C  95
PRO C  96
TYR D 100
 RBF D 228
2FL5_F_RBFF204 2fl5 RBF

DB00140
(Riboflavin) 		Homo sapiens IMMUNOGLOBULIN IGG1
HEAVY CHAIN;
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN 		no annotation 8 TYR F  33
ASN F  50
ARG F  52
GLU F  56
PHE F  58
VAL F  95
TYR E  95
TYR F 100
 RBF F 204
2FL5_H_RBFH201 2fl5 RBF

DB00140
(Riboflavin) 		Homo sapiens IMMUNOGLOBULIN IGG1
HEAVY CHAIN;
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN 		no annotation 9 TYR H  33
ASN H  50
ARG H  52
GLU H  56
PHE H  58
GLU D  85
TYR L  95
VAL H  95
TYR H 100
 RBF H 201
2OLD_B_IPHB2001 2old IPH

DB03255
(Phenol) 		Homo sapiens BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN 		None
PF07654
(C1-set)
PF07686
(V-set) 		7 TYR A  38
TYR B  38
HIS A  40
PRO B  46
PRO A  46
TYR A  89
TYR B  89
 IPH B2001
2OMB_A_IPHA2001 2omb IPH

DB03255
(Phenol) 		Homo sapiens BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN 		None
PF07654
(V-set)
PF07686
(C1-set) 		5 TYR B  38
HIS A  40
PRO A  46
PRO B  46
TYR A  89
 IPH A2001
2OMB_D_IPHD2002 2omb IPH

DB03255
(Phenol) 		Homo sapiens BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN 		None 7 TYR C  38
TYR D  38
HIS C  40
HIS D  40
PRO C  46
PRO D  46
TYR D  89
 IPH D2002
2OMN_B_IPHB401 2omn IPH

DB03255
(Phenol) 		Homo sapiens BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN 		None
PF07654
(V-set)
PF07686
(C1-set) 		4 HIS B  40
PRO B  46
PRO A  46
TYR B  89
 IPH B 401
2YK1_H_NCTH300 2yk1 NCT

DB00184
(Nicotine) 		Homo sapiens FAB FRAGMENT, HEAVY
CHAIN;
FAB FRAGMENT, LIGHT
CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		10 ILE H  29
GLY H  31
TYR L  34
TYR L  36
SER H  50
ALA L  89
VAL H  93
TRP H  95
TRP L  96
GLU H 101
 NCT H 300
3F33_A_PFLA2001 3f33 PFL

DB00818
(Propofol) 		Equus caballus FERRITIN LIGHT CHAIN PF00210
(Ferritin) 		6 LEU A  24
SER A  27
TYR A  28
LEU A  31
ARG A  59
LEU A  81
 PFL A2001
3KDM_B_TESB226 3kdm TES

DB00624
(Testosterone) 		Homo sapiens IMMUNOGLOBULIN HEAVY
CHAIN;
IMMUNOGLOBULIN LIGHT
CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		9 TRP B  47
ALA B  50
TYR B  59
PRO A  99
ASP B  99
TYR A 100
TYR B 105
TYR B 107
MET B 109
 TES B 226
3KDM_H_TESH226 3kdm TES

DB00624
(Testosterone) 		Homo sapiens IMMUNOGLOBULIN HEAVY
CHAIN;
IMMUNOGLOBULIN LIGHT
CHAIN 		no annotation 9 SER H  35
TRP H  47
ALA H  50
TYR H  59
PRO L  99
ASP H  99
TYR L 100
TYR H 105
MET H 109
 TES H 226
3LS4_H_TCIH220 3ls4 TCI

DB00470
(Dronabinol) 		Mus musculus HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT;
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT 		PF07654
(C1-set)
PF07686
(V-set) 		15 VAL H  33
VAL H  35
LEU H  37
TYR L  37
TRP H  47
SER H  50
TYR H  58
GLN L  90
ILE L  95
LEU L  97
GLY H  98
PHE L  99
VAL H 102
GLY H 104
TRP H 107
 TCI H 220
3RAV_A_RAVA183 3rav RAV

DB00312
(Pentobarbital) 		Equus caballus FERRITIN LIGHT CHAIN PF00210
(Ferritin) 		6 LEU A  24
SER A  27
TYR A  28
ALA A  55
ARG A  59
LEU A  81
 RAV A 183
3RD0_A_EDPA175 3rd0 EDP

DB00599
(Thiopental) 		Equus caballus FERRITIN LIGHT CHAIN PF00210
(Ferritin) 		6 LEU A  24
SER A  27
TYR A  28
ALA A  55
ARG A  59
LEU A  81
 EDP A 175
4LAR_L_1WEL300 4lar 1WE

DB00182
(Amphetamine)
DB01576
(Dextroamphetamine) 		Mus musculus SINGLE HEAVY CHAIN
VARIABLE FRAGMENT;
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT 		PF07686
(V-set) 		10 TYR H  33
SER H  35
TYR L  36
TYR H  47
TYR H  50
HIS L  89
TRP L  91
PHE H  95
PHE L  96
GLU H 101
 1WE L 300
4M93_B_ACTB303 4m93 ACT

DB03166
(Acetic
acid) 		Mus musculus S25-26 FAB (IGG1K)
HEAVY CHAIN;
S25-26 FAB (IGG1K)
LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B 127
SER B 128
ALA B 129
PHE C 209
GLU C 213
 ACT B 303
4M93_B_ACTB304 4m93 ACT

DB03166
(Acetic
acid) 		Mus musculus S25-26 FAB (IGG1K)
HEAVY CHAIN;
S25-26 FAB (IGG1K)
LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO C 119
GLY B 127
SER B 128
ARG B 213
 ACT B 304
4MA3_L_ACTL301 4ma3 ACT

DB03166
(Acetic
acid) 		Homo sapiens;
Oryctolagus
cuniculus 		C2095 HEAVY CHAIN;
C2095 LIGHT CHAIN 		None 3 PRO H  32
ASN H  34
HIS L 101
 ACT L 301
5ALB_L_TIQL1210 5alb TIQ

DB08816
(Ticagrelor) 		Homo sapiens MEDI2452 HEAVY
CHAIN;
MEDI2452 LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		19 SER H  33
SER L  34
HIS H  35
TYR L  36
TRP H  47
ILE H  52
THR H  56
SER H  58
GLY L  89
TRP L  91
TYR L  93
ALA L  95
GLY L  96
PHE L  98
TYR H  99
ASP H 100
LEU H 100
TRP H 100
PRO H 100
 TIQ L1210
5ALC_L_TIQL1210 5alc TIQ

DB08816
(Ticagrelor) 		Homo sapiens ANTI-TICAGRELOR FAB
72, HEAVY CHAIN;
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		17 SER L  34
HIS H  35
TYR L  36
TRP H  47
ILE H  52
THR H  56
SER H  58
GLY L  89
TRP L  91
ILE L  93
SER L  95
GLY L  96
PHE L  98
TYR H  99
ASP H 100
LEU H 100
PRO H 100
 TIQ L1210
5CP3_A_YTZA301 5cp3 YTZ

DB06147
(Sulfathiazole) 		Mus musculus HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7;
LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7 		PF07654
(C1-set)
PF07686
(V-set) 		11 HIS H  36
ASN H  38
ASN A  39
LEU A  41
ARG A  51
TRP A  94
ALA H  97
TYR H  99
GLY H 101
GLN A 101
TRP H 103
 YTZ A 301
5ICX_E_SC2E1 5icx SC2

DB06151
(Acetylcysteine) 		Homo sapiens;
Mus musculus;
synthetic
construct 		CETUXIMAB FAB LIGHT
CHAIN;
MEDITOPE 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 GLN E   2
VAL A   9
CYS E  12
 SC2 E   1
5ICX_F_SC2F1 5icx SC2

DB06151
(Acetylcysteine) 		Homo sapiens;
Mus musculus;
synthetic
construct 		CETUXIMAB FAB LIGHT
CHAIN;
MEDITOPE 		no annotation 3 GLN F   2
VAL C   9
CYS F  12
 SC2 F   1
5MTH_B_ACTB302 5mth ACT

DB03166
(Acetic
acid) 		Mus musculus ANTIBODY FAB HEAVY
CHAIN;
ANTIBODY FAB LIGHT
CHAIN 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLU A  50
TYR A  59
TYR B  99
TYR A 101
ARG B 101
 ACT B 302
5MTH_H_ACTH304 5mth ACT

DB03166
(Acetic
acid) 		Mus musculus ANTIBODY FAB HEAVY
CHAIN;
ANTIBODY FAB LIGHT
CHAIN 		None 5 GLU H  50
TYR H  59
TYR L  99
TYR H 101
ARG L 101
 ACT H 304
6CJK_C_ACTC301 6cjk ACT

DB03166
(Acetic
acid) 		Oryctolagus
cuniculus 		IMMUNOGLOBULIN FAB
LIGHT CHAIN 		None 4 VAL C  15
GLY C 108
ASP C 109
ASP C 169
 ACT C 301