DRUG BINDING INTERFACES MAPPED TO 'L1'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1OPJ_A_STIA3 | 1opj | STI DB00619(Imatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 17 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337LEU A 389ALA A 399ASP A 400 | STI A 3 |
1OPJ_B_STIB4 | 1opj | STI DB00619(Imatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340ARG B 381ALA B 399ASP B 400 | STI B 4 |
2B9E_A_SAMA1201 | 2b9e | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | NOL1/NOP2/SUN DOMAINFAMILY, MEMBER 5ISOFORM 2 | PF01189(Methyltr_RsmB-F) | 14 | CYS A 234PRO A 237GLY A 238ASN A 239LYS A 240ASP A 258LEU A 259ASP A 260ARG A 263ASP A 285PHE A 286ASP A 305SER A 307PHE A 337 | SAM A1201 |
2GQG_A_1N1A501 | 2gqg | 1N1 DB01254(Dasatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 14 | LEU A 248TYR A 253ALA A 269LYS A 271GLU A 286MET A 290VAL A 299ILE A 313THR A 315PHE A 317MET A 318GLY A 321LEU A 370ALA A 380 | 1N1 A 501 |
2GQG_B_1N1B502 | 2gqg | 1N1 DB01254(Dasatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 14 | LEU B 248VAL B 256ALA B 269LYS B 271GLU B 286MET B 290VAL B 299ILE B 313THR B 315MET B 318TYR B 320GLY B 321LEU B 370ALA B 380 | 1N1 B 502 |
2HYY_A_STIA600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293VAL A 299ILE A 313THR A 315PHE A 317GLY A 321ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 600 |
2HYY_B_STIB600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321LEU B 370ALA B 380ASP B 381 | STI B 600 |
2HYY_C_STIC600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU C 248TYR C 253VAL C 256ALA C 269LYS C 271GLU C 286VAL C 289MET C 290ILE C 293VAL C 299ILE C 313THR C 315PHE C 317MET C 318GLY C 321LEU C 370ALA C 380ASP C 381 | STI C 600 |
2HYY_D_STID600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 16 | LEU D 248TYR D 253VAL D 256ALA D 269LYS D 271GLU D 286MET D 290ILE D 293VAL D 299ILE D 313THR D 315PHE D 317MET D 318LEU D 370ALA D 380ASP D 381 | STI D 600 |
2NXE_A_SAMA302 | 2nxe | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | PF06325(PrmA) | 15 | PHE A 99GLY A 100THR A 107ASP A 126LEU A 127GLY A 128GLY A 130LEU A 134ASP A 149ILE A 150ASP A 151SER A 175ASN A 191LEU A 192LEU A 196 | SAM A 302 |
2NXE_B_SAMB303 | 2nxe | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | None | 15 | PHE B 99GLY B 100THR B 107ASP B 126LEU B 127GLY B 128GLY B 130LEU B 134ASP B 149ILE B 150ASP B 151SER B 175ASN B 191LEU B 192LEU B 196 | SAM B 303 |
2ZBP_A_SAMA300 | 2zbp | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | PF06325(PrmA) | 14 | PHE A 99GLY A 100THR A 107LEU A 127GLY A 128GLY A 130LEU A 134ASP A 149ILE A 150ASP A 151SER A 175ASN A 191LEU A 192LEU A 196 | SAM A 300 |
3CJT_C_SAMC302 | 3cjt | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | None | 14 | HIS C 103THR C 107ASP C 126LEU C 127GLY C 128VAL C 133LEU C 134ASP C 149ILE C 150ASP C 151SER C 175ASN C 191LEU C 192LEU C 196 | SAM C 302 |
3CJT_G_SAMG302 | 3cjt | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | None | 14 | HIS G 103LEU G 127GLY G 128GLY G 130SER G 131VAL G 133LEU G 134ASP G 149ILE G 150ASP G 151SER G 175ASN G 191LEU G 192LEU G 196 | SAM G 302 |
3CJT_K_SAMK302 | 3cjt | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | None | 13 | HIS K 103LEU K 127GLY K 128SER K 131VAL K 133LEU K 134ASP K 149ILE K 150ASP K 151SER K 175ASN K 191LEU K 192LEU K 196 | SAM K 302 |
3CJT_O_SAMO302 | 3cjt | SAM DB00118(S-Adenosylmethionine) | Thermusthermophilus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE | None | 14 | HIS O 103LEU O 127GLY O 128GLY O 130SER O 131VAL O 133LEU O 134ASP O 149ILE O 150ASP O 151SER O 175ASN O 191LEU O 192LEU O 196 | SAM O 302 |
3CS9_A_NILA600 | 3cs9 | NIL DB04868(Nilotinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 22 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271LYS A 285GLU A 286VAL A 289MET A 290ILE A 293LEU A 298VAL A 299ILE A 313THR A 315PHE A 317GLY A 321PHE A 359HIS A 361LEU A 370VAL A 379ALA A 380ASP A 381 | NIL A 600 |
3CS9_B_NILB600 | 3cs9 | NIL DB04868(Nilotinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 21 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293LEU B 298VAL B 299ILE B 313THR B 315GLY B 321PHE B 359HIS B 361LEU B 370VAL B 379ALA B 380ASP B 381PHE B 382 | NIL B 600 |
3CS9_C_NILC600 | 3cs9 | NIL DB04868(Nilotinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 21 | LEU C 248TYR C 253VAL C 256ALA C 269LYS C 271GLU C 286VAL C 289MET C 290ILE C 293LEU C 298VAL C 299ILE C 313THR C 315PHE C 317MET C 318PHE C 359HIS C 361VAL C 379ALA C 380ASP C 381PHE C 382 | NIL C 600 |
3CS9_D_NILD600 | 3cs9 | NIL DB04868(Nilotinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU D 248TYR D 253VAL D 256ALA D 269LYS D 271GLU D 286VAL D 289MET D 290ILE D 293LEU D 298THR D 315PHE D 317GLY D 321PHE D 359HIS D 361LEU D 370ALA D 380ASP D 381 | NIL D 600 |
3H5G_A_LEIA16 | 3h5g | LEI DB00859(Penicillamine) | - | COIL SER L16D-PEN | None | 6 | LYS C 15LYS A 15GLN A 17LEU C 19LEU A 19GLU A 20 | LEI A 16 |
3H5G_B_LEIB16 | 3h5g | LEI DB00859(Penicillamine) | - | COIL SER L16D-PEN | None | 5 | LYS B 15GLN B 17LEU A 19LEU B 19GLU B 20 | LEI B 16 |
3H5G_C_LEIC16 | 3h5g | LEI DB00859(Penicillamine) | - | COIL SER L16D-PEN | None | 6 | LYS B 15LYS C 15GLN C 17LEU B 19LEU C 19GLU C 20 | LEI C 16 |
3IK3_A_0LIA1 | 3ik3 | 0LI DB08901(Ponatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 19 | LEU A 248TYR A 253ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293LEU A 298VAL A 299ILE A 313ILE A 315MET A 318HIS A 361ARG A 362LEU A 370ALA A 380ASP A 381PHE A 382 | 0LI A 1 |
3IK3_B_0LIB2 | 3ik3 | 0LI DB08901(Ponatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 19 | LEU B 248TYR B 253ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293LEU B 298VAL B 299ILE B 313ILE B 315MET B 318HIS B 361ARG B 362LEU B 370ALA B 380ASP B 381PHE B 382 | 0LI B 2 |
3K5V_A_STIA2 | 3k5v | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400 | STI A 2 |
3K5V_B_STIB2 | 3k5v | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340LEU B 389ALA B 399ASP B 400 | STI B 2 |
3MS9_A_STIA1 | 3ms9 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293VAL A 299ILE A 313THR A 315PHE A 317MET A 318ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 1 |
3MS9_B_STIB1 | 3ms9 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 19 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321ARG B 362LEU B 370ALA B 380ASP B 381 | STI B 1 |
3MSS_A_STIA1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293VAL A 299ILE A 313THR A 315PHE A 317MET A 318ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 1 |
3MSS_B_STIB1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 19 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321ARG B 362LEU B 370ALA B 380ASP B 381 | STI B 1 |
3MSS_C_STIC1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU C 248TYR C 253VAL C 256ALA C 269LYS C 271GLU C 286VAL C 289MET C 290ILE C 293VAL C 299ILE C 313THR C 315PHE C 317MET C 318ARG C 362LEU C 370ALA C 380ASP C 381 | STI C 1 |
3MSS_D_STID1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU D 248TYR D 253VAL D 256ALA D 269LYS D 271GLU D 286VAL D 289MET D 290ILE D 293VAL D 299ILE D 313THR D 315PHE D 317MET D 318GLY D 321LEU D 370ALA D 380ASP D 381 | STI D 1 |
3OXZ_A_0LIA1 | 3oxz | 0LI DB08901(Ponatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 21 | LEU A 248TYR A 253ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293LEU A 298VAL A 299ILE A 313THR A 315MET A 318GLY A 321HIS A 361ARG A 362LEU A 370VAL A 379ALA A 380ASP A 381PHE A 382 | 0LI A 1 |
3UE4_A_DB8A601 | 3ue4 | DB8 DB06616(Bosutinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 12 | LEU A 248ALA A 269LYS A 271GLU A 286VAL A 299ILE A 313THR A 315PHE A 317MET A 318GLY A 321LEU A 370PHE A 382 | DB8 A 601 |
3UE4_B_DB8B601 | 3ue4 | DB8 DB06616(Bosutinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | no annotation | 14 | LEU B 248VAL B 256ALA B 269LYS B 271GLU B 286MET B 290VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321LEU B 370PHE B 382 | DB8 B 601 |
4TWP_A_AXIA601 | 4twp | AXI DB06626(Axitinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 12 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271PHE A 317MET A 318GLY A 321ASN A 368LEU A 370ALA A 380ASP A 381 | AXI A 601 |
4TWP_B_AXIB601 | 4twp | AXI DB06626(Axitinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | no annotation | 12 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271PHE B 317MET B 318GLY B 321ASN B 368LEU B 370ALA B 380ASP B 381 | AXI B 601 |
4WA9_A_AXIA9000 | 4wa9 | AXI DB06626(Axitinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 11 | LEU A 248TYR A 253ALA A 269LYS A 271THR A 315MET A 318GLY A 321ASN A 368LEU A 370ALA A 380PHE A 382 | AXI A9000 |
4WA9_B_AXIB9000 | 4wa9 | AXI DB06626(Axitinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | no annotation | 12 | TYR B 253VAL B 256ALA B 269LYS B 271THR B 315PHE B 317MET B 318GLY B 321ASN B 368LEU B 370ALA B 380PHE B 382 | AXI B9000 |
4XEY_A_1N1A601 | 4xey | 1N1 DB01254(Dasatinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 15 | LEU A 267VAL A 275ALA A 288LYS A 290MET A 309VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400PHE A 401 | 1N1 A 601 |
4XEY_B_1N1B601 | 4xey | 1N1 DB01254(Dasatinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | no annotation | 15 | LEU B 267VAL B 275ALA B 288LYS B 290MET B 309VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340LEU B 389ALA B 399ASP B 400PHE B 401 | 1N1 B 601 |
5FA8_A_SAMA301 | 5fa8 | SAM DB00118(S-Adenosylmethionine) | Sulfolobusislandicus | RIBOSOMAL PROTEINL11METHYLTRANSFERASE,PUTATIVE | PF13847(Methyltransf_31) | 15 | PRO A 11THR A 12ASP A 34GLY A 36GLY A 38ARG A 41ILE A 42GLU A 59ILE A 60ASN A 61ARG A 64ASN A 87PHE A 88PHE A 102LEU A 104 | SAM A 301 |
5L6E_B_ACTB401 | 5l6e | ACT DB03166(Aceticacid) | Homo sapiens | N6-ADENOSINE-METHYLTRANSFERASE 70 KDASUBUNIT;N6-ADENOSINE-METHYLTRANSFERASE SUBUNITMETTL14 | PF05063(MT-A70) | 6 | ARG B 245LEU B 248ARG B 249ARG B 254ARG B 255GLU A 438 | ACT B 401 |
5MO4_A_NILA601 | 5mo4 | NIL DB04868(Nilotinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL1 | PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 22 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312LEU A 317VAL A 318ILE A 332ILE A 334PHE A 336MET A 337GLY A 340PHE A 378HIS A 380LEU A 389ALA A 399ASP A 400PHE A 401 | NIL A 601 |
5UMD_K_YMZK301 | 5umd | YMZ DB00358(Mefloquine) | Plasmodiumfalciparum | 60S RIBOSOMALPROTEIN L13,PUTATIVE | PF00572(Ribosomal_L13) | 11 | LEU K 15ILE K 42ASN K 49LYS K 52TYR K 53GLU K 55PHE K 56LEU K 59ILE K 78ARG K 81LEU K 140 | YMZ K 301 |
6AZ3_1_PAR11801 | 6az3 | PAR DB01421(Paromomycin) | Leishmaniadonovani | RIBOSOMAL PROTEINEL18;RRNA ALPHA | no annotation | 4 | ARG P 66ARG P 149GLY P 152ARG P 157 | PAR 11801 |
6AZ3_1_PAR11802 | 6az3 | PAR DB01421(Paromomycin) | Leishmaniadonovani | RIBOSOMAL PROTEINEL15;RIBOSOMAL PROTEINUL15;RIBOSOMAL PROTEINUL4;RRNA ALPHA | no annotation | 3 | LYS L 6ARG C 109ARG M 204 | PAR 11802 |
6AZ3_1_PAR11803 | 6az3 | PAR DB01421(Paromomycin) | Leishmaniadonovani | RIBOSOMAL PROTEINEL18;RRNA ALPHA | no annotation | 3 | SER P 9LYS P 10SER P 12 | PAR 11803 |
6HD4_A_STIA604 | 6hd4 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 17 | TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400 | STI A 604 |
6HD4_B_STIB602 | 6hd4 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | None | 18 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340LEU B 389ALA B 399ASP B 400 | STI B 602 |
6HD6_A_STIA603 | 6hd6 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 17 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400 | STI A 603 |
6HD6_B_STIB601 | 6hd6 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | None | 19 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340ARG B 381LEU B 389ALA B 399ASP B 400 | STI B 601 |