DRUG BINDING INTERFACES MAPPED TO 'IGM'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
2A68_C_RBTC8001 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RBT C8001
2A68_M_RBTM8002 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 13 ARG M 134
ASP P 323
LYS P 325
GLN M 390
GLN M 393
PHE M 394
ASP M 396
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
 RBT M8002
2A69_C_RPTC8001 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RPT C8001
2WB9_A_CYSA301 2wb9 CYS

DB00151
(L-
Cysteine) 		Fasciola hepatica GLUTATHIONE
TRANSFERASE SIGMA
CLASS 		PF14497
(GST_C_3) 		5 TYR A  10
GLY A  15
ARG A  16
TYR A 106
TYR A 110
 CYS A 301
3O14_A_NIOA300 3o14 NIO

DB00627
(Niacin) 		Marinobacter
hydrocarbonoclast
icus 		ANTI-ECFSIGMA
FACTOR, CHRR 		PF12973
(Cupin_7) 		7 ARG A  30
ARG A  35
ALA A  43
SER A  45
VAL A  47
VAL A 106
LEU A 108
 NIO A 300
4KMU_H_RFPH1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 14 GLN H 510
GLN H 513
ASP Y 514
PHE H 514
ASP H 516
HIS H 526
ARG H 529
SER H 531
LEU H 533
ARG H 540
PRO H 564
ASN H 568
ILE H 572
ARG H 687
 RFP H1401
5UH6_C_RFPC1201 5uh6 RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ARG C 173
ASP F 429
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHC_C_RFPC1201 5uhc RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ASP F 429
GLU F 430
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
6BZO_C_FI8C1201 6bzo FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_5)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_2)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		28 ARG J  10
VAL J  14
ARG D  84
LYS D  86
ARG D  89
GLU D 323
LEU D 324
PRO D 326
SER D 338
ARG D 412
GLN D 415
LEU F 423
ASP F 424
GLN F 434
VAL F 445
MET C1051
ILE C1052
THR C1053
GLN C1054
ASP C1094
THR C1096
VAL C1097
VAL C1100
LYS C1101
GLU C1119
SER C1120
VAL C1123
GLU C1127
 FI8 C1201
6C06_D_FI8D1404 6c06 FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_2)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		13 ARG J  10
ARG D  84
LYS D  86
ARG D 412
GLN F 434
ILE C1052
THR C1053
GLN C1054
THR C1096
ARG C1099
LYS C1101
GLU C1119
SER C1120
 FI8 D1404
6DJZ_A_GMJA301 6djz GMJ

DB00502
(Haloperidol) 		Homo sapiens SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1 		PF04622
(ERG2_Sigma1R) 		18 MET A  93
TYR A 103
LEU A 105
SER A 117
TYR A 120
ILE A 124
ASP A 126
PHE A 133
GLN A 135
VAL A 152
HIS A 154
THR A 160
VAL A 162
GLU A 172
THR A 181
LEU A 182
ALA A 185
TYR A 206
 GMJ A 301
6DJZ_B_GMJB301 6djz GMJ

DB00502
(Haloperidol) 		Homo sapiens SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1 		None 18 TRP B  89
TYR B 103
LEU B 105
SER B 117
TYR B 120
ILE B 124
ASP B 126
PHE B 133
GLN B 135
VAL B 152
HIS B 154
THR B 160
VAL B 162
TRP B 164
GLU B 172
THR B 181
LEU B 182
ALA B 185
 GMJ B 301
6DJZ_C_GMJC301 6djz GMJ

DB00502
(Haloperidol) 		Homo sapiens SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1 		None 18 TRP C  89
MET C  93
LEU C  95
ALA C  98
LEU C 105
SER C 117
TYR C 120
ASP C 126
PHE C 133
GLN C 135
VAL C 152
HIS C 154
VAL C 162
GLU C 172
THR C 181
LEU C 182
ALA C 185
TYR C 206
 GMJ C 301
6DK1_A_GM4A301 6dk1 GM4

DB00652
(Pentazocine) 		Homo sapiens SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1 		PF04622
(ERG2_Sigma1R) 		11 VAL A  84
ALA A  86
TRP A  89
MET A  93
TYR A 103
LEU A 105
TYR A 120
ASP A 126
TRP A 164
GLU A 172
ALA A 185
 GM4 A 301
6DK1_B_GM4B301 6dk1 GM4

DB00652
(Pentazocine) 		Homo sapiens SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1 		None 11 VAL B  84
ALA B  86
TRP B  89
TYR B 103
LEU B 105
TYR B 120
ASP B 126
TRP B 164
GLU B 172
ALA B 185
LEU B 186
 GM4 B 301
6DK1_C_GM4C301 6dk1 GM4

DB00652
(Pentazocine) 		Homo sapiens SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1 		None 11 VAL C  84
ALA C  86
TRP C  89
TYR C 103
LEU C 105
TYR C 120
ASP C 126
TRP C 164
GLU C 172
THR C 181
ALA C 185
 GM4 C 301
6FBV_D_FI8D1904 6fbv FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_45)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_5)
PF04998
(RNA_pol_Rpb1_4)
PF05000
(RNA_pol_Rpb1_1) 		18 ASP D  57
ARG D  84
LYS D  86
ARG D  89
GLU D 323
VAL D 328
ARG D 412
GLN D 415
LEU F 423
ASP F 424
MET C1051
ILE C1052
GLN C1054
THR C1096
VAL C1097
LYS C1101
GLU C1119
SER C1120
 FI8 D1904
6FI4_B_DVAB8 6fi4 DVA

DB00161
(L-
Valine) 		Homo sapiens 14-3-3 PROTEIN
SIGMA;
PRO-SEP-LEU-PRO-DVA 		None
PF00244
(14-3-3) 		5 PRO B   7
SER A  45
VAL A  46
LYS A  49
ASN A  50
 DVA B   8