DRUG BINDING INTERFACES MAPPED TO 'HISTONE-LYSINE N-METHYLTRANSFERASE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
2R3A_A_SAMA304 2r3a SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
PF00856
(Pre-SET)
PF05033
(SET)
13 ARG A 150
GLY A 151
TRP A 152
LYS A 189
THR A 192
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYS A 287
LYS A 288
CYS A 289
LEU A 298
SAM A 304
3OOI_A_SAMA237 3ooi SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
PF00856
(SET)
13 ARG A 101
GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
HIS A 170
TYR A 207
ASN A 214
CYS A 219
LYS A 220
CYS A 221
LEU A 230
SAM A 237
3OPE_A_SAMA7 3ope SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(SET)
12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
ILE A2279
SAM A   7
3OPE_B_SAMB8 3ope SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 9 LYS B2150
GLY B2151
TRP B2152
ASP B2192
TYR B2194
ASN B2217
TYR B2255
GLN B2266
ILE B2279
SAM B   8
3QOW_A_SAMA417 3qow SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
PF08123
(DOT1)
15 TYR A 136
GLY A 137
GLU A 138
THR A 139
ASP A 161
GLY A 163
GLN A 168
VAL A 169
GLU A 186
LYS A 187
ALA A 188
ASP A 222
PHE A 223
ASN A 241
PHE A 245
SAM A 417
3RQ4_A_SAMA500 3rq4 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2
PF00856
(SET)
13 HIS A  32
TYR A 114
MET A 116
GLU A 117
GLY A 120
SER A 161
ASN A 182
HIS A 183
TYR A 217
PHE A 222
CYS A 229
GLU A 230
CYS A 231
SAM A 500
3S8P_A_SAMA500 3s8p SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1
PF00856
(SET)
15 HIS A  98
TYR A 203
SER A 205
GLU A 206
GLY A 209
ALA A 210
PHE A 250
SER A 251
ASN A 272
HIS A 273
TYR A 307
PHE A 312
CYS A 319
GLU A 320
CYS A 321
SAM A 500
3S8P_B_SAMB500 3s8p SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1
None
PF00856
(SET)
16 HIS B  98
TYR B 203
SER B 205
GLU B 206
GLY B 209
ALA B 210
PHE B 250
SER B 251
ARG A 257
ASN B 272
HIS B 273
TYR B 307
PHE B 312
CYS B 319
GLU B 320
CYS B 321
SAM B 500
3SMT_A_ACTA1001 3smt ACT

DB03166
(Acetic
acid)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3
PF00856
(Rubis-subs-bind)
PF09273
(SET)
5 LEU A 340
GLY A 341
PHE A 387
PHE A 428
ARG A 432
ACT A1001
3SMT_A_ACTA500 3smt ACT

DB03166
(Acetic
acid)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3
PF00856
(Rubis-subs-bind)
PF09273
(SET)
3 PHE A 367
SER A 377
GLN A 379
ACT A 500
3SMT_A_SAMA1000 3smt SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3
PF00856
(Rubis-subs-bind)
PF09273
(SET)
10 ARG A  74
GLU A 103
PHE A 105
PRO A 179
THR A 252
ARG A 253
ASN A 277
HIS A 278
TYR A 312
PHE A 326
SAM A1000
4BUP_A_SAMA500 4bup SAM

DB00118
(S-
Adenosylmethionine)
Mus musculus HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1
PF00856
(SET)
14 HIS A  90
TYR A 195
SER A 197
GLU A 198
GLY A 201
ALA A 202
SER A 243
ASN A 264
HIS A 265
TYR A 299
PHE A 304
CYS A 311
GLU A 312
CYS A 313
SAM A 500
4BUP_B_SAMB500 4bup SAM

DB00118
(S-
Adenosylmethionine)
Mus musculus HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1
None 15 HIS B  90
TYR B 195
SER B 197
GLU B 198
GLY B 201
ALA B 202
PHE B 242
SER B 243
ASN B 264
HIS B 265
TYR B 299
PHE B 304
CYS B 311
GLU B 312
CYS B 313
SAM B 500
4E47_A_SAMA401 4e47 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
PF00856
(SET)
11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
SAM A 401
4E47_B_SAMB800 4e47 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 11 ILE B 223
ALA B 226
GLY B 227
GLU B 228
GLY B 264
ASN B 265
LYS B 294
ASN B 296
HIS B 297
TYR B 335
TRP B 352
SAM B 800
4E47_C_SAMC800 4e47 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 11 ILE C 223
ALA C 226
GLY C 227
GLU C 228
GLY C 264
ASN C 265
LYS C 294
ASN C 296
HIS C 297
TYR C 335
TRP C 352
SAM C 800
4E47_D_SAMD800 4e47 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 10 ILE D 223
ALA D 226
GLU D 228
GLY D 264
ASN D 265
LYS D 294
ASN D 296
HIS D 297
TYR D 335
TRP D 352
SAM D 800
4J83_A_SAMA401 4j83 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
PF00856
(SET)
11 ILE A 223
ALA A 226
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
GLU A 356
SAM A 401
4JDS_A_SAMA401 4jds SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
PF00856
(SET)
11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
SAM A 401
4JDS_B_SAMB401 4jds SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 11 ILE B 223
ALA B 226
GLY B 227
GLU B 228
GLY B 264
ASN B 265
LYS B 294
ASN B 296
HIS B 297
TYR B 335
TRP B 352
SAM B 401
4JDS_C_SAMC401 4jds SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 11 ILE C 223
ALA C 226
GLY C 227
GLU C 228
GLY C 264
ASN C 265
LYS C 294
ASN C 296
HIS C 297
TYR C 335
TRP C 352
SAM C 401
4JDS_D_SAMD401 4jds SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 11 ILE D 223
ALA D 226
GLU D 228
GLY D 264
ASN D 265
LYS D 294
ASN D 296
HIS D 297
TYR D 335
TRP D 352
GLU D 356
SAM D 401
4JLG_A_SAMA401 4jlg SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
PF00856
(SET)
12 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
GLU A 356
SAM A 401
4JLG_B_SAMB401 4jlg SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
None 11 ILE B 223
ALA B 226
GLU B 228
GLY B 264
ASN B 265
LYS B 294
ASN B 296
HIS B 297
TYR B 335
TRP B 352
GLU B 356
SAM B 401
4YNM_A_SAMA2304 4ynm SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(SET)
13 LYS A2150
GLY A2151
TRP A2152
ASP A2192
HIS A2193
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
ILE A2279
SAM A2304
4YNM_B_SAMB2304 4ynm SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 12 GLY B2151
TRP B2152
ASP B2192
HIS B2193
TYR B2194
ASN B2217
HIS B2218
TYR B2255
GLN B2266
CYS B2268
LYS B2269
ILE B2279
SAM B2304
4YNP_A_SAMA2304 4ynp SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(SET)
14 LYS A2150
GLY A2151
TRP A2152
ASP A2192
HIS A2193
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
CYS A2270
ILE A2279
SAM A2304
4YNP_B_SAMB2304 4ynp SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 10 GLY B2151
TRP B2152
ASP B2192
TYR B2194
ASN B2217
HIS B2218
TYR B2255
GLN B2266
CYS B2268
ILE B2279
SAM B2304
4YPA_A_SAMA3004 4ypa SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(SET)
12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
ILE A2279
SAM A3004
4YPA_B_SAMB2304 4ypa SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 13 LYS B2150
GLY B2151
TRP B2152
ASP B2192
HIS B2193
TYR B2194
ASN B2217
HIS B2218
TYR B2255
GLN B2266
CYS B2268
LYS B2269
ILE B2279
SAM B2304
4YPA_C_SAMC2304 4ypa SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 13 LYS C2150
GLY C2151
TRP C2152
ASP C2192
HIS C2193
TYR C2194
ASN C2217
HIS C2218
TYR C2255
GLN C2266
CYS C2268
LYS C2269
ILE C2279
SAM C2304
4YPA_D_SAMD2304 4ypa SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 13 LYS D2150
GLY D2151
TRP D2152
ASP D2192
HIS D2193
TYR D2194
ASN D2217
HIS D2218
TYR D2255
GLN D2266
CYS D2268
LYS D2269
ILE D2279
SAM D2304
4YPE_A_SAMA2304 4ype SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(SET)
12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
ILE A2279
SAM A2304
4YPE_B_SAMB2304 4ype SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 11 LYS B2150
GLY B2151
TRP B2152
ASP B2192
TYR B2194
ASN B2217
HIS B2218
TYR B2255
CYS B2268
LYS B2269
ILE B2279
SAM B2304
4YPU_A_SAMA2304 4ypu SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(SET)
12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
HIS A2193
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
SAM A2304
4YPU_B_SAMB2304 4ypu SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
None 11 LYS B2150
GLY B2151
TRP B2152
ASP B2192
HIS B2193
TYR B2194
ASN B2217
HIS B2218
TYR B2255
GLN B2266
LYS B2269
SAM B2304
5AYF_A_C7HA402 5ayf C7H

DB00434
(Cyproheptadine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
PF00856
(SET)
5 TYR A 245
GLY A 264
TYR A 305
TYR A 335
GLY A 336
C7H A 402
5AYF_A_SAMA401 5ayf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
PF00856
(SET)
11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
SAM A 401
5CCL_A_SAMA504 5ccl SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3
PF00856
(SET)
13 ARG A  14
GLY A  15
ASN A  16
TYR A 124
GLU A 130
ASN A 132
CYS A 180
ASN A 181
ASN A 205
HIS A 206
TYR A 239
TYR A 257
PHE A 259
SAM A 504
5CCM_A_SAMA504 5ccm SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3
PF00856
(SET)
12 ARG A  14
GLY A  15
ASN A  16
TYR A 124
GLU A 130
ASN A 132
ASN A 181
ASN A 205
HIS A 206
TYR A 239
TYR A 257
PHE A 259
SAM A 504
5CPR_B_SAMB402 5cpr SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1
PF00856
(SET)
15 HIS B  98
TYR B 203
SER B 205
GLU B 206
GLY B 209
ALA B 210
PHE B 250
SER B 251
ASN B 272
HIS B 273
TYR B 307
PHE B 312
CYS B 319
GLU B 320
CYS B 321
SAM B 402
5JHN_A_SAMA1205 5jhn SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYS A1168
SAM A1205
5JHN_B_SAMB1205 5jhn SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
GLN B1169
SAM B1205
5JIN_A_SAMA1205 5jin SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE H3.1 PEPTIDE
WITH K9M MUTATION;
HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None
PF00856
(SET)
PF05033
(Pre-SET)
14 MET F   9
MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYS A1168
GLN A1169
SAM A1205
5JIN_B_SAMB1205 5jin SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
LYS B1162
PHE B1166
CYS B1168
GLN B1169
SAM B1205
5JIY_A_SAMA1205 5jiy SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYS A1168
SAM A1205
5JIY_B_SAMB1205 5jiy SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
LYS B1162
PHE B1166
CYS B1168
SAM B1205
5JJ0_A_SAMA1205 5jj0 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE H3K9M MUTANT
PEPTIDE;
HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None
PF00856
(Pre-SET)
PF05033
(SET)
14 MET F   9
MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYS A1168
GLN A1169
SAM A1205
5JJ0_B_SAMB1205 5jj0 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 13 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
LYS B1162
PHE B1166
CYS B1168
GLN B1169
SAM B1205
5LSU_A_SAMA1304 5lsu SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
PF00856
(SET)
14 ARG A1073
GLY A1074
TRP A1075
HIS A1116
TYR A1118
ASN A1141
HIS A1142
TYR A1179
ASN A1186
THR A1189
CYS A1191
ARG A1192
CYS A1193
LEU A1202
SAM A1304
5LSU_B_SAMB1304 5lsu SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
None 15 ARG B1073
GLY B1074
TRP B1075
HIS B1116
PHE B1117
TYR B1118
ASN B1141
HIS B1142
TYR B1179
ASN B1186
THR B1189
CYS B1191
ARG B1192
CYS B1193
LEU B1202
SAM B1304
5MVS_A_ADNA401 5mvs ADN

DB00640
(Adenosine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
PF08123
(DOT1)
7 GLY A 163
GLU A 186
LYS A 187
ALA A 188
ASP A 222
PHE A 223
ASN A 241
ADN A 401
5MVS_B_ADNB401 5mvs ADN

DB00640
(Adenosine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
no annotation 8 GLY B 163
GLU B 186
LYS B 187
ALA B 188
ASP B 222
PHE B 223
ASN B 241
PHE B 245
ADN B 401
5T0K_A_SAMA1304 5t0k SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYS A1168
GLN A1169
SAM A1304
5T0K_B_SAMB1304 5t0k SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 13 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
LYS B1162
PHE B1166
CYS B1168
GLN B1169
SAM B1304
5T0M_A_SAMA1205 5t0m SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYS A1168
GLN A1169
SAM A1205
5T0M_B_SAMB1205 5t0m SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
GLN B1169
SAM B1205
5TQR_B_SAMB8009 5tqr SAM

DB00118
(S-
Adenosylmethionine)
Chaetomium
thermophilum
HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12
PF00856
(VEFS-Box)
PF09733
(SET)
10 LEU B 804
CYS B 807
GLY B 808
TYR B 809
VAL B 853
TYR B 855
TYR B 878
ASN B 880
HIS B 881
TYR B 918
SAM B8009
5TTF_A_SAMA1505 5ttf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(Pre-SET)
PF05033
(SET)
11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYS A1168
SAM A1505
5TTF_B_SAMB1505 5ttf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
GLN B1169
SAM B1505
5TTF_C_SAMC1505 5ttf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 13 MET C1048
GLY C1049
TRP C1050
SER C1084
TYR C1085
ASN C1112
HIS C1113
TYR C1154
PHE C1158
TRP C1159
PHE C1166
CYS C1168
GLN C1169
SAM C1505
5TTF_D_SAMD1505 5ttf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 11 MET D1048
GLY D1049
TRP D1050
SER D1084
TYR D1085
ASN D1112
HIS D1113
TYR D1154
PHE D1158
PHE D1166
CYS D1168
SAM D1505
5TTG_A_SAMA1301 5ttg SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYS A1256
ARG A1257
SAM A1301
5TTG_B_SAMB1301 5ttg SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
None 11 MET B1136
GLY B1137
TRP B1138
SER B1172
TYR B1173
ASN B1200
HIS B1201
TYR B1242
PHE B1246
PHE B1254
CYS B1256
SAM B1301
5TUY_A_SAMA1505 5tuy SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYS A1168
GLN A1169
SAM A1505
5TUY_B_SAMB1505 5tuy SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
GLN B1169
SAM B1505
5TUZ_A_SAMA3001 5tuz SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
PF00856
(Pre-SET)
PF05033
(SET)
13 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYS A1256
ARG A1257
CYS A1258
SAM A3001
5TUZ_B_SAMB3001 5tuz SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
None 12 MET B1136
GLY B1137
TRP B1138
SER B1172
TYR B1173
ASN B1200
HIS B1201
TYR B1242
PHE B1246
PHE B1254
CYS B1256
ARG B1257
SAM B3001
5UPD_A_SAMA1301 5upd SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3
PF00856
(SET)
11 ARG A1155
GLY A1156
TRP A1157
ASN A1198
TYR A1200
ASN A1223
HIS A1224
TYR A1261
CYS A1273
CYS A1275
LEU A1284
SAM A1301
5V21_A_SAMA1804 5v21 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
PF00856
(SET)
12 LYS A1560
GLY A1561
TRP A1562
HIS A1603
TYR A1604
TYR A1605
ASN A1628
HIS A1629
TYR A1666
GLN A1676
CYS A1678
LEU A1689
SAM A1804
5V37_A_SAMA504 5v37 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3
PF00856
(SET)
13 ARG A  14
GLY A  15
ASN A  16
TYR A 124
GLU A 130
ASN A 132
CYS A 180
ASN A 181
ASN A 205
HIS A 206
TYR A 239
TYR A 257
PHE A 259
SAM A 504
5V9I_A_SAMA1505 5v9i SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYS A1168
GLN A1169
SAM A1505
5V9I_B_SAMB1505 5v9i SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 11 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
SAM B1505
5V9I_C_SAMC1505 5v9i SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 11 MET C1048
GLY C1049
TRP C1050
SER C1084
TYR C1085
ASN C1112
HIS C1113
TYR C1154
PHE C1158
PHE C1166
CYS C1168
SAM C1505
5V9I_D_SAMD1505 5v9i SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 13 MET D1048
GLY D1049
TRP D1050
SER D1084
TYR D1085
ASN D1112
HIS D1113
TYR D1154
PHE D1158
TRP D1159
PHE D1166
CYS D1168
GLN D1169
SAM D1505
5V9J_A_SAMA1301 5v9j SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
PHE A1254
CYS A1256
ARG A1257
SAM A1301
5V9J_B_SAMB1301 5v9j SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
None 12 MET B1136
GLY B1137
TRP B1138
SER B1172
TYR B1173
ASN B1200
HIS B1201
TYR B1242
PHE B1246
PHE B1254
CYS B1256
ARG B1257
SAM B1301
5VSC_A_SAMA1505 5vsc SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYS A1168
GLN A1169
SAM A1505
5VSC_B_SAMB1505 5vsc SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
GLN B1169
SAM B1505
5VSD_A_SAMA3001 5vsd SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
PF00856
(Pre-SET)
PF05033
(SET)
13 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
TRP A1247
PHE A1254
CYS A1256
ARG A1257
SAM A3001
5VSD_B_SAMB3001 5vsd SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
None 12 MET B1136
GLY B1137
TRP B1138
SER B1172
TYR B1173
ASN B1200
HIS B1201
TYR B1242
PHE B1246
PHE B1254
CYS B1256
ARG B1257
SAM B3001
5VSE_A_SAMA1505 5vse SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
PF00856
(SET)
PF05033
(Pre-SET)
12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYS A1168
GLN A1169
SAM A1505
5VSE_B_SAMB1505 5vse SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
None 12 MET B1048
GLY B1049
TRP B1050
SER B1084
TYR B1085
ASN B1112
HIS B1113
TYR B1154
PHE B1158
PHE B1166
CYS B1168
GLN B1169
SAM B1505
5VSF_A_SAMA3001 5vsf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
PF00856
(Pre-SET)
PF05033
(SET)
13 MET A1136
GLY A1137
TRP A1138
SER A1172
TYR A1173
ASN A1200
HIS A1201
TYR A1242
PHE A1246
TRP A1247
PHE A1254
CYS A1256
ARG A1257
SAM A3001
5VSF_B_SAMB3001 5vsf SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
None 12 MET B1136
GLY B1137
TRP B1138
SER B1172
TYR B1173
ASN B1200
HIS B1201
TYR B1242
PHE B1246
PHE B1254
CYS B1256
ARG B1257
SAM B3001
5WBV_A_SAMA402 5wbv SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B
PF00856
(SET)
15 HIS A  98
TYR A 203
SER A 205
GLU A 206
GLY A 209
ALA A 210
PHE A 250
SER A 251
ASN A 272
HIS A 273
TYR A 307
PHE A 312
CYS A 319
GLU A 320
CYS A 321
SAM A 402
5WBV_B_SAMB402 5wbv SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B
None
PF00856
(SET)
16 HIS B  98
TYR B 203
SER B 205
GLU B 206
GLY B 209
ALA B 210
PHE B 250
SER B 251
ARG A 257
ASN B 272
HIS B 273
TYR B 307
PHE B 312
CYS B 319
GLU B 320
CYS B 321
SAM B 402
5YJO_A_SAMA505 5yjo SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3
PF00856
(SET)
13 ARG A  14
GLY A  15
ASN A  16
TYR A 124
GLU A 130
ASN A 132
CYS A 180
ASN A 181
ASN A 205
HIS A 206
TYR A 239
TYR A 257
PHE A 259
SAM A 505
6A5K_A_SAMA805 6a5k SAM

DB00118
(S-
Adenosylmethionine)
Arabidopsis
thaliana
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6
PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET)
13 ARG A 626
GLY A 627
TRP A 628
GLU A 663
TYR A 664
ASN A 717
HIS A 718
TYR A 759
LYS A 776
CYS A 778
PHE A 779
CYS A 780
LEU A 789
SAM A 805
6A5M_A_SAMA805 6a5m SAM

DB00118
(S-
Adenosylmethionine)
Arabidopsis
thaliana
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6
PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET)
13 ARG A 626
GLY A 627
TRP A 628
GLU A 663
TYR A 664
ASN A 717
HIS A 718
TYR A 759
LYS A 776
CYS A 778
PHE A 779
CYS A 780
LEU A 789
SAM A 805
6AGO_A_SAMA2301 6ago SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(AWS)
PF17907
(SET)
11 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYS A2268
CYS A2270
ILE A2279
SAM A2301
6BP4_A_SAMA505 6bp4 SAM

DB00118
(S-
Adenosylmethionine)
Schizosaccharomyc
es pombe
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
PF00856
(SET)
PF05033
(Pre-SET)
15 LYS A 338
GLY A 339
TRP A 340
ILE A 379
THR A 380
TYR A 381
ARG A 406
ASN A 409
HIS A 410
TYR A 451
ARG A 475
CYS A 477
LYS A 478
CYS A 479
LEU A 488
SAM A 505
6BP4_B_SAMB505 6bp4 SAM

DB00118
(S-
Adenosylmethionine)
Schizosaccharomyc
es pombe
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
None 13 LYS B 338
GLY B 339
TRP B 340
ILE B 379
TYR B 381
ASN B 409
HIS B 410
TYR B 451
ARG B 475
CYS B 477
CYS B 479
LEU B 488
GLY B 490
SAM B 505
6CEN_A_SAMA1301 6cen SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3
PF00856
(SET)
11 ARG A1155
GLY A1156
TRP A1157
ASN A1198
TYR A1200
ASN A1223
HIS A1224
TYR A1261
CYS A1273
CYS A1275
LEU A1284
SAM A1301
6CHG_C_SAMC1101 6chg SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens;
Kluyveromyces
lactis
H3;
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC
None
PF00856
(SET)
14 MET J   4
ILE C 867
HIS C 868
ASN C 869
TRP C 870
SER C 911
SER C 912
TYR C 913
PHE C 934
ASN C 936
HIS C 937
TYR C 974
LEU C 989
LEU C 999
SAM C1101
6INE_A_SAMA2304 6ine SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
PF00856
(AWS)
PF17907
(SET)
13 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYS A2268
LYS A2269
CYS A2270
ILE A2279
SAM A2304
6NJ9_K_SAMK500 6nj9 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
PF08123
(DOT1)
15 PRO K 133
GLY K 137
THR K 139
ASP K 161
GLY K 163
GLY K 165
GLN K 168
VAL K 169
GLU K 186
LYS K 187
ALA K 188
ASP K 222
PHE K 223
PHE K 239
ASN K 241
SAM K 500
6NM4_A_SAMA402 6nm4 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9
PF00856
(SET)
7 ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
CYS A 321
SAM A 402
6NM4_B_SAMB402 6nm4 SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9
None 9 ILE B 253
ALA B 256
GLY B 257
LEU B 258
GLY B 290
TYR B 291
ASN B 320
CYS B 321
ARG B 323
SAM B 402
6NQA_K_SAMK500 6nqa SAM

DB00118
(S-
Adenosylmethionine)
Homo sapiens HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
PF08123
(DOT1)
10 THR K 139
ASP K 161
GLY K 163
GLY K 165
GLN K 168
VAL K 169
GLU K 186
LYS K 187
ASN K 241
PHE K 245
SAM K 500