DRUG BINDING INTERFACES MAPPED TO 'GYRASE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1AJ6_A_NOVA1 1aj6 NOV

DB01051
(Novobiocin)
Escherichia coli GYRASE PF02518
(HATPase_c)
9 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ALA A  90
ILE A  94
THR A 165
NOV A   1
1KIJ_A_NOVA400 1kij NOV

DB01051
(Novobiocin)
Thermus
thermophilus
DNA GYRASE SUBUNIT B PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation
16 ILE B  10
ASN A  45
ASP A  48
GLU A  49
ASP A  72
ARG A  75
ILE A  77
PRO A  78
ASP A  80
ILE A  93
LYS A 102
PHE A 103
LYS A 109
VAL A 117
ARG A 135
THR A 166
NOV A 400
1KIJ_B_NOVB444 1kij NOV

DB01051
(Novobiocin)
Thermus
thermophilus
DNA GYRASE SUBUNIT B PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation
16 ILE A  10
ASN B  45
ASP B  48
GLU B  49
ASP B  72
ARG B  75
ILE B  77
PRO B  78
ASP B  80
ILE B  93
TYR B  94
PHE B 103
VAL B 117
ALA B 119
ARG B 135
THR B 166
NOV B 444
2XCT_G_CPFG1020 2xct CPF

DB00537
(Ciprofloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
3 ARG B 458
GLY B 459
SER B1084
CPF G1020
2XCT_H_CPFH1020 2xct CPF

DB00537
(Ciprofloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A
no annotation 3 ARG D 458
GLU D 477
SER D1084
CPF H1020
2XCT_X_CPFX1020 2xct CPF

DB00537
(Ciprofloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A
no annotation 4 ARG S 458
GLY S 459
GLU S 477
SER U1084
CPF X1020
4URO_A_NOVA2000 4uro NOV

DB01051
(Novobiocin)
Staphylococcus
aureus
DNA GYRASE SUBUNIT B PF02518
(HATPase_c)
no annotation
15 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
GLN A  91
ILE A 102
SER A 128
ARG A 144
THR A 173
ARG D 200
NOV A2000
4URO_B_NOVB2000 4uro NOV

DB01051
(Novobiocin)
Staphylococcus
aureus
DNA GYRASE SUBUNIT B no annotation 13 ASN B  54
SER B  55
ASP B  57
GLU B  58
ASP B  81
ARG B  84
ILE B  86
PRO B  87
ASP B  89
GLN B  91
ILE B 102
SER B 128
ARG B 144
NOV B2000
4URO_C_NOVC2000 4uro NOV

DB01051
(Novobiocin)
Staphylococcus
aureus
DNA GYRASE SUBUNIT B no annotation 14 ASN C  54
ASP C  57
GLU C  58
ASP C  81
ARG C  84
ILE C  86
PRO C  87
ASP C  89
GLN C  91
ALA C  98
ILE C 102
SER C 128
ARG C 144
THR C 173
NOV C2000
4URO_D_NOVD2000 4uro NOV

DB01051
(Novobiocin)
Staphylococcus
aureus
DNA GYRASE SUBUNIT B no annotation 12 ASN D  54
SER D  55
GLU D  58
ASP D  81
ARG D  84
ILE D  86
PRO D  87
ASP D  89
ILE D 102
SER D 128
ARG D 144
THR D 173
NOV D2000
4Z2C_F_MFXF101 4z2c MFX

DB00218
(Moxifloxacin)
Escherichia coli;
Streptococcus
pneumoniae
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
4 SER B  81
ARG C 456
GLY C 457
GLU C 475
MFX F 101
4Z2C_H_MFXH101 4z2c MFX

DB00218
(Moxifloxacin)
Escherichia coli;
Streptococcus
pneumoniae
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA
PF00521
(DNA_topoisoIV)
no annotation
4 SER A  81
ARG D 456
GLY D 457
GLU D 475
MFX H 101
4Z2D_F_LFXF102 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin)
Escherichia coli;
Streptococcus
pneumoniae
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
4 SER B  81
ARG C 456
GLY C 457
GLU C 475
LFX F 102
4Z2D_H_LFXH101 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin)
Escherichia coli;
Streptococcus
pneumoniae
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA
PF00521
(DNA_topoisoIV)
no annotation
4 SER A  81
ARG D 456
GLY D 457
GLU D 475
LFX H 101
4Z2E_F_TR6F101 4z2e TR6

DB00685
(Trovafloxacin)
Escherichia coli;
Streptococcus
pneumoniae
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
5 SER B  81
GLY C 434
ARG C 456
GLY C 457
GLU C 475
TR6 F 101
4Z2E_H_TR6H101 4z2e TR6

DB00685
(Trovafloxacin)
Escherichia coli;
Streptococcus
pneumoniae
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA
PF00521
(DNA_topoisoIV)
no annotation
5 SER A  81
GLY D 434
ARG D 456
GLY D 457
GLU D 475
TR6 H 101
5BS8_G_MFXG101 5bs8 MFX

DB00218
(Moxifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
no annotation
7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
MFX G 101
5BS8_H_MFXH101 5bs8 MFX

DB00218
(Moxifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
7 ALA A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
MFX H 101
5BTA_G_MFXG101 5bta MFX

DB00218
(Moxifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
no annotation
7 SER C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
MFX G 101
5BTA_H_MFXH101 5bta MFX

DB00218
(Moxifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
MFX H 101
5BTC_G_CPFG101 5btc CPF

DB00537
(Ciprofloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
no annotation
6 SER C  90
ARG A 128
ARG D 482
GLY D 483
THR D 500
GLU D 501
CPF G 101
5BTC_G_CPFG102 5btc CPF

DB00537
(Ciprofloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
CPF G 102
5BTD_E_GFNE101 5btd GFN

DB01044
(Gatifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
7 ALA A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
GFN E 101
5BTD_G_GFNG101 5btd GFN

DB01044
(Gatifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
no annotation
7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
GFN G 101
5BTF_F_GFNF101 5btf GFN

DB01044
(Gatifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
7 SER A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
GFN F 101
5BTF_G_GFNG101 5btf GFN

DB01044
(Gatifloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
no annotation
7 SER C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
GFN G 101
5BTG_E_LFXE101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 ALA A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
LFX E 101
5BTG_F_LFXF101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
PF00521
(DNA_topoisoIV)
no annotation
7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
LFX F 101
5BTI_E_LFXE101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
5 SER A  90
ARG B 482
GLY B 483
THR B 500
GLU B 501
LFX E 101
5BTI_F_LFXF101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin)
Mycobacterium
tuberculosis;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC
no annotation 5 SER C  90
ARG D 482
GLY D 483
THR D 500
GLU D 501
LFX F 101
5CDN_G_EVPG2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
EVP G2101
5CDN_N_EVPN2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 6 SER R  84
GLU R  88
GLY S 436
ASP S 437
ARG S 458
GLY S 459
EVP N2101
5CDN_O_EVPO2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 6 SER C  84
GLU C  88
GLY D 436
ASP D 437
ARG D 458
GLY D 459
EVP O2101
5CDN_P_EVPP2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 6 SER T  84
GLU T  88
GLY U 436
ASP U 437
ARG U 458
GLY U 459
EVP P2101
5CDP_H_EVPH2101 5cdp EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT B
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
EVP H2101
5CDQ_E_MFXE2101 5cdq MFX

DB00218
(Moxifloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
5 SER A  84
ARG C 122
ARG B 458
GLY B 459
GLU B 477
MFX E2101
5CDQ_F_MFXF2101 5cdq MFX

DB00218
(Moxifloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
PF00521
(DNA_topoisoIV)
no annotation
6 SER C  84
ARG A 122
ASP D 437
ARG D 458
GLY D 459
GLU D 477
MFX F2101
5CDQ_V_MFXV2101 5cdq MFX

DB00218
(Moxifloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 5 SER R  84
ARG T 122
ARG S 458
GLY S 459
GLU S 477
MFX V2101
5CDQ_W_MFXW2101 5cdq MFX

DB00218
(Moxifloxacin)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 5 SER T  84
ARG R 122
ASP U 437
ARG U 458
GLU U 477
MFX W2101