DRUG BINDING INTERFACES MAPPED TO 'DNA-DIRECTED RNA POLYMERASE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1I6V_C_RFPC1640 1i6v RFP

DB01045
(Rifampicin) 		Thermus aquaticus DNA-DIRECTED RNA
POLYMERASE 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 ARG C 134
GLN C 390
LEU C 391
GLN C 393
PHE C 394
ASP C 396
ARG C 405
HIS C 406
ARG C 409
SER C 411
GLU C 445
ILE C 452
 RFP C1640
1YNN_C_RFPC1120 1ynn RFP

DB01045
(Rifampicin) 		Thermus aquaticus DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 ARG C 134
GLN C 390
GLN C 393
PHE C 394
ASP C 396
ARG C 405
HIS C 406
ARG C 409
SER C 411
LEU C 413
PRO C 444
ILE C 452
 RFP C1120
2A68_C_RBTC8001 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RBT C8001
2A68_M_RBTM8002 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 13 ARG M 134
ASP P 323
LYS P 325
GLN M 390
GLN M 393
PHE M 394
ASP M 396
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
 RBT M8002
2A69_C_RPTC8001 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RPT C8001
2A69_M_RPTM8002 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN 		no annotation 14 ARG M 134
GLN M 390
GLN M 393
PHE M 394
ASP M 396
ARG M 405
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
MET M1000
GLU M1002
 RPT M8002
4KMU_C_RFPC1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		14 GLN C 510
LEU C 511
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ASN C 568
ILE C 572
ARG C 687
 RFP C1401
4KMU_H_RFPH1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 14 GLN H 510
GLN H 513
ASP Y 514
PHE H 514
ASP H 516
HIS H 526
ARG H 529
SER H 531
LEU H 533
ARG H 540
PRO H 564
ASN H 568
ILE H 572
ARG H 687
 RFP H1401
5UAC_C_RFPC3001 5uac RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 GLN C 510
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ILE C 572
ARG C 687
 RFP C3001
5UAH_C_RFPC3001 5uah RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		13 ARG C 143
GLN C 510
LEU C 511
GLN C 513
PHE C 514
VAL C 516
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ILE C 572
ARG C 687
 RFP C3001
5UAL_C_RFPC3001 5ual RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 GLN C 510
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
LEU C 531
PRO C 564
ILE C 572
ARG C 687
GLN C 761
 RFP C3001
5UH6_C_RFPC1201 5uh6 RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ARG C 173
ASP F 429
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHB_C_RFPC1201 5uhb RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		15 GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHC_C_RFPC1201 5uhc RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ASP F 429
GLU F 430
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHD_C_RFPC1201 5uhd RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		16 ARG C 173
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHG_C_RFPC1201 5uhg RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		16 ARG C 173
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
6BZO_C_FI8C1201 6bzo FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_5)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_2)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		28 ARG J  10
VAL J  14
ARG D  84
LYS D  86
ARG D  89
GLU D 323
LEU D 324
PRO D 326
SER D 338
ARG D 412
GLN D 415
LEU F 423
ASP F 424
GLN F 434
VAL F 445
MET C1051
ILE C1052
THR C1053
GLN C1054
ASP C1094
THR C1096
VAL C1097
VAL C1100
LYS C1101
GLU C1119
SER C1120
VAL C1123
GLU C1127
 FI8 C1201
6C06_D_FI8D1404 6c06 FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_2)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		13 ARG J  10
ARG D  84
LYS D  86
ARG D 412
GLN F 434
ILE C1052
THR C1053
GLN C1054
THR C1096
ARG C1099
LYS C1101
GLU C1119
SER C1120
 FI8 D1404
6FBV_D_FI8D1904 6fbv FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_45)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_5)
PF04998
(RNA_pol_Rpb1_4)
PF05000
(RNA_pol_Rpb1_1) 		18 ASP D  57
ARG D  84
LYS D  86
ARG D  89
GLU D 323
VAL D 328
ARG D 412
GLN D 415
LEU F 423
ASP F 424
MET C1051
ILE C1052
GLN C1054
THR C1096
VAL C1097
LYS C1101
GLU C1119
SER C1120
 FI8 D1904