DRUG BINDING INTERFACES MAPPED TO 'DNA TOPOISOMERASE I'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
1K4T_D_TTCD990
1k4t
TTC
DB01030(Topotecan)
;Homo sapiens
DNA TOPOISOMERASE I
PF01028(Topoisom_I)PF02919(Topoisom_I_N)PF14370(Topo_C_assoc)no annotation
5
GLU A 356ARG A 364LYS A 532ASP A 533THR A 718
TTC D 990
1QZR_B_CDXB901
1qzr
CDX
DB00380(Dexrazoxane)
Saccharomycescerevisiae
DNA TOPOISOMERASE II
PF00204(DNA_gyraseB)PF02518(HATPase_c)no annotation
14
HIS A 20HIS B 20THR B 27THR A 27TYR A 28TYR B 28ASN B 142ASN A 142TYR B 144TYR A 144LEU A 148LEU B 148GLN B 365GLN A 365
CDX B 901
1RR8_A_TTCA100
1rr8
TTC
DB01030(Topotecan)
;Homo sapiens
DNA TOPOISOMERASE I
PF01028(Topoisom_I)PF02919(Topoisom_I_N)PF14370(Topo_C_assoc)no annotation
5
GLU C 356ARG C 364LYS C 532ASP C 533THR C 718
TTC A 100
1RRJ_B_TTCB990
1rrj
TTC
DB01030(Topotecan)
;Homo sapiens
DNA TOPOISOMERASE I
PF01028(Topoisom_I)PF02919(Topoisom_I_N)PF14370(Topo_C_assoc)no annotation
5
GLU A 356ARG A 364LYS A 532ASP A 533THR A 718
TTC B 990
4URN_A_NOVA2000
4urn
NOV
DB01051(Novobiocin)
Staphylococcusaureus
DNA TOPOISOMERASEIV, B SUBUNIT
PF02518(HATPase_c)no annotation
14
ASP B 35LYS B 36ASN A 49SER A 50ASP A 52GLU A 53ASP A 76ARG A 79MET A 81PRO A 82ILE A 96ARG A 138THR A 168ASN B 186
NOV A2000
4URN_B_NOVB2000
4urn
NOV
DB01051(Novobiocin)
Staphylococcusaureus
DNA TOPOISOMERASEIV, B SUBUNIT
no annotation
11
ASN B 49SER B 50ASP B 52GLU B 53ASP B 76ARG B 79MET B 81PRO B 82ILE B 96ARG B 138THR B 168
NOV B2000
4URN_C_NOVC2000
4urn
NOV
DB01051(Novobiocin)
Staphylococcusaureus
DNA TOPOISOMERASEIV, B SUBUNIT
no annotation
11
ASN C 49SER C 50ASP C 52GLU C 53ASP C 76ARG C 79MET C 81PRO C 82ILE C 96ARG C 138THR C 168
NOV C2000
[["1K4T_D_TTCD990","1k4t","TTC","DB01030(Topotecan)",";Homo sapiens","DNA TOPOISOMERASE I","PF01028(Topoisom_I);PF02919(Topoisom_I_N);PF14370(Topo_C_assoc);no annotation",5,"GLU A 356;ARG A 364;LYS A 532;ASP A 533;THR A 718","TTC D 990\r"],["1QZR_B_CDXB901","1qzr","CDX","DB00380(Dexrazoxane)","Saccharomyces cerevisiae","DNA TOPOISOMERASE II","PF00204(DNA_gyraseB);PF02518(HATPase_c);no annotation",14,"HIS A 20;HIS B 20;THR B 27;THR A 27;TYR A 28;TYR B 28;ASN B 142;ASN A 142;TYR B 144;TYR A 144;LEU A 148;LEU B 148;GLN B 365;GLN A 365","CDX B 901\r"],["1RR8_A_TTCA100","1rr8","TTC","DB01030(Topotecan)",";Homo sapiens","DNA TOPOISOMERASE I","PF01028(Topoisom_I);PF02919(Topoisom_I_N);PF14370(Topo_C_assoc);no annotation",5,"GLU C 356;ARG C 364;LYS C 532;ASP C 533;THR C 718","TTC A 100\r"],["1RRJ_B_TTCB990","1rrj","TTC","DB01030(Topotecan)",";Homo sapiens","DNA TOPOISOMERASE I","PF01028(Topoisom_I);PF02919(Topoisom_I_N);PF14370(Topo_C_assoc);no annotation",5,"GLU A 356;ARG A 364;LYS A 532;ASP A 533;THR A 718","TTC B 990\r"],["4URN_A_NOVA2000","4urn","NOV","DB01051(Novobiocin)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","PF02518(HATPase_c);no annotation",14,"ASP B 35;LYS B 36;ASN A 49;SER A 50;ASP A 52;GLU A 53;ASP A 76;ARG A 79;MET A 81;PRO A 82;ILE A 96;ARG A 138;THR A 168;ASN B 186","NOV A2000\r"],["4URN_B_NOVB2000","4urn","NOV","DB01051(Novobiocin)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","no annotation",11,"ASN B 49;SER B 50;ASP B 52;GLU B 53;ASP B 76;ARG B 79;MET B 81;PRO B 82;ILE B 96;ARG B 138;THR B 168","NOV B2000\r"],["4URN_C_NOVC2000","4urn","NOV","DB01051(Novobiocin)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","no annotation",11,"ASN C 49;SER C 50;ASP C 52;GLU C 53;ASP C 76;ARG C 79;MET C 81;PRO C 82;ILE C 96;ARG C 138;THR C 168","NOV C2000\r"]]