DRUG BINDING INTERFACES MAPPED TO 'DNA TOPOISOMERASE 4 SUBUNIT B'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
3FOF_H_MFXH0 3fof MFX

DB00218
(Moxifloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 GLY A  77
SER A  79
SER A  80
ARG C 456
 MFX H   0
3K9F_F_LFXF0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  79
ARG B 117
ARG C 456
GLY C 457
GLU C 475
 LFX F   0
3K9F_H_LFXH0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER B  79
ARG A 117
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H   0
3RAE_F_LFXF101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
3RAE_H_LFXH101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		no annotation 5 SER B  79
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H 101
4JUO_F_LFXF101 4juo LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
4KOE_F_TR6F101 4koe TR6

DB00685
(Trovafloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA2 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  79
ARG B 117
GLY C 434
ASP C 435
ARG C 456
GLY C 457
 TR6 F 101
4KOE_H_TR6H101 4koe TR6

DB00685
(Trovafloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA4 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER B  79
ARG A 117
GLY D 434
ASP D 435
ARG D 456
GLY D 457
GLU D 475
 TR6 H 101
4Z3O_F_MFXF101 4z3o MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 ARG B 456
GLY B 457
GLU B 475
SER B1079
ARG A1117
 MFX F 101
4Z3O_H_MFXH101 4z3o MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 ARG A 456
GLU A 475
SER A1079
 MFX H 101
4Z53_F_TR6F101 4z53 TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 GLY A 434
ASP A 435
ARG A 456
GLY A 457
SER A1079
ARG B1117
 TR6 F 101
4Z53_H_TR6H101 4z53 TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 GLY B 434
ASP B 435
ARG B 456
GLY B 457
GLU B 475
SER B1079
ARG A1117
 TR6 H 101