DRUG BINDING INTERFACES MAPPED TO 'DNA TOPOISOMERASE 2'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
3QX3_A_EVPA1
3qx3
EVP
DB00773(Etoposide)
Homo sapiens
DNA TOPOISOMERASE2-BETA
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C)
5
GLY A 478ASP A 479ARG A 503GLN A 778MET A 782
EVP A 1
3QX3_D_EVPD1
3qx3
EVP
DB00773(Etoposide)
;Homo sapiens
DNA TOPOISOMERASE2-BETA
no annotation
5
GLY B 478ASP B 479ARG B 503GLN B 778MET B 782
EVP D 1
4G0U_B_ASWB1301
4g0u
ASW
DB00276(Amsacrine)
Homo sapiens
DNA TOPOISOMERASE2-BETA
no annotation
7
ILE B 454PRO B 455ARG B 503GLY B 504ALA B 521GLU B 522GLN B 778
ASW B1301
4G0U_F_ASWF101
4g0u
ASW
DB00276(Amsacrine)
;Homo sapiens
DNA TOPOISOMERASE2-BETA
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C)no annotation
6
PRO A 455ARG A 503GLY A 504ALA A 521GLU A 522GLN A 778
ASW F 101
4G0V_A_MIXA1301
4g0v
MIX
DB01204(Mitoxantrone)
Homo sapiens
DNA TOPOISOMERASE2-BETA
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C)
7
ARG A 503GLY A 504ILE A 506ASN A 520GLU A 522GLN A 778MET A 782
MIX A1301
4G0V_D_MIXD101
4g0v
MIX
DB01204(Mitoxantrone)
;Homo sapiens
DNA TOPOISOMERASE2-BETA
no annotation
6
ARG B 503GLY B 504ASN B 520GLU B 522GLN B 778MET B 782
MIX D 101
5GWK_D_EVPD102
5gwk
EVP
DB00773(Etoposide)
Homo sapiens;syntheticconstruct
DNA TOPOISOMERASE2-ALPHA
no annotation
4
GLY B 462ASP B 463ARG B 487MET B 766
EVP D 102
5GWK_F_EVPF102
5gwk
EVP
DB00773(Etoposide)
Homo sapiens;syntheticconstruct
DNA TOPOISOMERASE2-ALPHA
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C)no annotation
5
GLY A 462ASP A 463ARG A 487MET A 762MET A 766
EVP F 102
[["3QX3_A_EVPA1","3qx3","EVP","DB00773(Etoposide)","Homo sapiens","DNA TOPOISOMERASE 2-BETA","PF00521(DNA_topoisoIV);PF01751(Toprim);PF16898(TOPRIM_C)",5,"GLY A 478;ASP A 479;ARG A 503;GLN A 778;MET A 782","EVP A 1\r"],["3QX3_D_EVPD1","3qx3","EVP","DB00773(Etoposide)",";Homo sapiens","DNA TOPOISOMERASE 2-BETA","no annotation",5,"GLY B 478;ASP B 479;ARG B 503;GLN B 778;MET B 782","EVP D 1\r"],["4G0U_B_ASWB1301","4g0u","ASW","DB00276(Amsacrine)","Homo sapiens","DNA TOPOISOMERASE 2-BETA","no annotation",7,"ILE B 454;PRO B 455;ARG B 503;GLY B 504;ALA B 521;GLU B 522;GLN B 778","ASW B1301\r"],["4G0U_F_ASWF101","4g0u","ASW","DB00276(Amsacrine)",";Homo sapiens","DNA TOPOISOMERASE 2-BETA","PF00521(DNA_topoisoIV);PF01751(Toprim);PF16898(TOPRIM_C);no annotation",6,"PRO A 455;ARG A 503;GLY A 504;ALA A 521;GLU A 522;GLN A 778","ASW F 101\r"],["4G0V_A_MIXA1301","4g0v","MIX","DB01204(Mitoxantrone)","Homo sapiens","DNA TOPOISOMERASE 2-BETA","PF00521(DNA_topoisoIV);PF01751(Toprim);PF16898(TOPRIM_C)",7,"ARG A 503;GLY A 504;ILE A 506;ASN A 520;GLU A 522;GLN A 778;MET A 782","MIX A1301\r"],["4G0V_D_MIXD101","4g0v","MIX","DB01204(Mitoxantrone)",";Homo sapiens","DNA TOPOISOMERASE 2-BETA","no annotation",6,"ARG B 503;GLY B 504;ASN B 520;GLU B 522;GLN B 778;MET B 782","MIX D 101\r"],["5GWK_D_EVPD102","5gwk","EVP","DB00773(Etoposide)","Homo sapiens;synthetic construct","DNA TOPOISOMERASE 2-ALPHA","no annotation",4,"GLY B 462;ASP B 463;ARG B 487;MET B 766","EVP D 102\r"],["5GWK_F_EVPF102","5gwk","EVP","DB00773(Etoposide)","Homo sapiens;synthetic construct","DNA TOPOISOMERASE 2-ALPHA","PF00521(DNA_topoisoIV);PF01751(Toprim);PF16898(TOPRIM_C);no annotation",5,"GLY A 462;ASP A 463;ARG A 487;MET A 762;MET A 766","EVP F 102\r"]]