DRUG BINDING INTERFACES MAPPED TO 'DNA GYRASE SUBUNIT B'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1KIJ_A_NOVA400 1kij NOV

DB01051
(Novobiocin) 		Thermus
thermophilus 		DNA GYRASE SUBUNIT B PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation 		16 ILE B  10
ASN A  45
ASP A  48
GLU A  49
ASP A  72
ARG A  75
ILE A  77
PRO A  78
ASP A  80
ILE A  93
LYS A 102
PHE A 103
LYS A 109
VAL A 117
ARG A 135
THR A 166
 NOV A 400
1KIJ_B_NOVB444 1kij NOV

DB01051
(Novobiocin) 		Thermus
thermophilus 		DNA GYRASE SUBUNIT B PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation 		16 ILE A  10
ASN B  45
ASP B  48
GLU B  49
ASP B  72
ARG B  75
ILE B  77
PRO B  78
ASP B  80
ILE B  93
TYR B  94
PHE B 103
VAL B 117
ALA B 119
ARG B 135
THR B 166
 NOV B 444
2XCT_G_CPFG1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 ARG B 458
GLY B 459
SER B1084
 CPF G1020
2XCT_H_CPFH1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		no annotation 3 ARG D 458
GLU D 477
SER D1084
 CPF H1020
2XCT_X_CPFX1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		no annotation 4 ARG S 458
GLY S 459
GLU S 477
SER U1084
 CPF X1020
4URO_A_NOVA2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B PF02518
(HATPase_c)
no annotation 		15 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
GLN A  91
ILE A 102
SER A 128
ARG A 144
THR A 173
ARG D 200
 NOV A2000
4URO_B_NOVB2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B no annotation 13 ASN B  54
SER B  55
ASP B  57
GLU B  58
ASP B  81
ARG B  84
ILE B  86
PRO B  87
ASP B  89
GLN B  91
ILE B 102
SER B 128
ARG B 144
 NOV B2000
4URO_C_NOVC2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B no annotation 14 ASN C  54
ASP C  57
GLU C  58
ASP C  81
ARG C  84
ILE C  86
PRO C  87
ASP C  89
GLN C  91
ALA C  98
ILE C 102
SER C 128
ARG C 144
THR C 173
 NOV C2000
4URO_D_NOVD2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B no annotation 12 ASN D  54
SER D  55
GLU D  58
ASP D  81
ARG D  84
ILE D  86
PRO D  87
ASP D  89
ILE D 102
SER D 128
ARG D 144
THR D 173
 NOV D2000
4Z2C_F_MFXF101 4z2c MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 MFX F 101
4Z2C_H_MFXH101 4z2c MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 MFX H 101
4Z2D_F_LFXF102 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 LFX F 102
4Z2D_H_LFXH101 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 LFX H 101
4Z2E_F_TR6F101 4z2e TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER B  81
GLY C 434
ARG C 456
GLY C 457
GLU C 475
 TR6 F 101
4Z2E_H_TR6H101 4z2e TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		5 SER A  81
GLY D 434
ARG D 456
GLY D 457
GLU D 475
 TR6 H 101
5BS8_G_MFXG101 5bs8 MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 MFX G 101
5BS8_H_MFXH101 5bs8 MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 ALA A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
 MFX H 101
5BTA_G_MFXG101 5bta MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 MFX G 101
5BTA_H_MFXH101 5bta MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 MFX H 101
5BTC_G_CPFG101 5btc CPF

DB00537
(Ciprofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER C  90
ARG A 128
ARG D 482
GLY D 483
THR D 500
GLU D 501
 CPF G 101
5BTC_G_CPFG102 5btc CPF

DB00537
(Ciprofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 CPF G 102
5BTD_E_GFNE101 5btd GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 ALA A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
 GFN E 101
5BTD_G_GFNG101 5btd GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 GFN G 101
5BTF_F_GFNF101 5btf GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 SER A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
 GFN F 101
5BTF_G_GFNG101 5btf GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 GFN G 101
5BTG_E_LFXE101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 ALA A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 LFX E 101
5BTG_F_LFXF101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 LFX F 101
5BTI_E_LFXE101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  90
ARG B 482
GLY B 483
THR B 500
GLU B 501
 LFX E 101
5BTI_F_LFXF101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		no annotation 5 SER C  90
ARG D 482
GLY D 483
THR D 500
GLU D 501
 LFX F 101
5CDN_G_EVPG2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
 EVP G2101
5CDN_N_EVPN2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 6 SER R  84
GLU R  88
GLY S 436
ASP S 437
ARG S 458
GLY S 459
 EVP N2101
5CDN_O_EVPO2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 6 SER C  84
GLU C  88
GLY D 436
ASP D 437
ARG D 458
GLY D 459
 EVP O2101
5CDN_P_EVPP2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 6 SER T  84
GLU T  88
GLY U 436
ASP U 437
ARG U 458
GLY U 459
 EVP P2101
5CDP_H_EVPH2101 5cdp EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
 EVP H2101
5CDQ_E_MFXE2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  84
ARG C 122
ARG B 458
GLY B 459
GLU B 477
 MFX E2101
5CDQ_F_MFXF2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER C  84
ARG A 122
ASP D 437
ARG D 458
GLY D 459
GLU D 477
 MFX F2101
5CDQ_V_MFXV2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 5 SER R  84
ARG T 122
ARG S 458
GLY S 459
GLU S 477
 MFX V2101
5CDQ_W_MFXW2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 5 SER T  84
ARG R 122
ASP U 437
ARG U 458
GLU U 477
 MFX W2101