DRUG BINDING INTERFACES MAPPED TO 'DNA'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1I6V_C_RFPC1640 1i6v RFP

DB01045
(Rifampicin) 		Thermus aquaticus DNA-DIRECTED RNA
POLYMERASE 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 ARG C 134
GLN C 390
LEU C 391
GLN C 393
PHE C 394
ASP C 396
ARG C 405
HIS C 406
ARG C 409
SER C 411
GLU C 445
ILE C 452
 RFP C1640
1J7K_A_ACTA701 1j7k ACT

DB03166
(Acetic
acid) 		Thermotoga
maritima 		HOLLIDAY JUNCTION
DNA HELICASE RUVB 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 GLY A 278
LEU A 279
GLY A 313
ARG A 314
 ACT A 701
1K4T_D_TTCD990 1k4t TTC

DB01030
(Topotecan) 		;
Homo sapiens 		DNA TOPOISOMERASE I PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc)
no annotation 		5 GLU A 356
ARG A 364
LYS A 532
ASP A 533
THR A 718
 TTC D 990
1KIJ_A_NOVA400 1kij NOV

DB01051
(Novobiocin) 		Thermus
thermophilus 		DNA GYRASE SUBUNIT B PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation 		16 ILE B  10
ASN A  45
ASP A  48
GLU A  49
ASP A  72
ARG A  75
ILE A  77
PRO A  78
ASP A  80
ILE A  93
LYS A 102
PHE A 103
LYS A 109
VAL A 117
ARG A 135
THR A 166
 NOV A 400
1KIJ_B_NOVB444 1kij NOV

DB01051
(Novobiocin) 		Thermus
thermophilus 		DNA GYRASE SUBUNIT B PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation 		16 ILE A  10
ASN B  45
ASP B  48
GLU B  49
ASP B  72
ARG B  75
ILE B  77
PRO B  78
ASP B  80
ILE B  93
TYR B  94
PHE B 103
VAL B 117
ALA B 119
ARG B 135
THR B 166
 NOV B 444
1QZR_B_CDXB901 1qzr CDX

DB00380
(Dexrazoxane) 		Saccharomyces
cerevisiae 		DNA TOPOISOMERASE II PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
no annotation 		14 HIS A  20
HIS B  20
THR B  27
THR A  27
TYR A  28
TYR B  28
ASN B 142
ASN A 142
TYR B 144
TYR A 144
LEU A 148
LEU B 148
GLN B 365
GLN A 365
 CDX B 901
1RFF_A_SPMA700 1rff SPM

DB00127
(Spermine) 		;
Homo sapiens 		TOPOISOMERASE
I-DERIVED PEPTIDE;
TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho)
no annotation 		4 ASN A 591
TRP A 605
VAL A 606
TYR C 724
 SPM A 700
1RFF_B_SPMB700 1rff SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		no annotation 4 ASN B 591
ASN B 603
TRP B 605
PRO B 607
 SPM B 700
1RFI_A_SPMA999 1rfi SPM

DB00127
(Spermine) 		;
Homo sapiens 		TOPOISOMERASE
I-DERIVED PEPTIDE;
TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho)
no annotation 		5 TRP A 590
TRP A 605
VAL A 606
PRO A 607
LYS C 724
 SPM A 999
1RG1_A_SPMA999 1rg1 SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		3 TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RG2_A_SPMA999 1rg2 SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RGU_A_SPMA999 1rgu SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RH0_A_SPMA999 1rh0 SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		3 TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RR8_A_TTCA100 1rr8 TTC

DB01030
(Topotecan) 		;
Homo sapiens 		DNA TOPOISOMERASE I PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc)
no annotation 		5 GLU C 356
ARG C 364
LYS C 532
ASP C 533
THR C 718
 TTC A 100
1RRJ_B_TTCB990 1rrj TTC

DB01030
(Topotecan) 		;
Homo sapiens 		DNA TOPOISOMERASE I PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc)
no annotation 		5 GLU A 356
ARG A 364
LYS A 532
ASP A 533
THR A 718
 TTC B 990
1YNN_C_RFPC1120 1ynn RFP

DB01045
(Rifampicin) 		Thermus aquaticus DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 ARG C 134
GLN C 390
GLN C 393
PHE C 394
ASP C 396
ARG C 405
HIS C 406
ARG C 409
SER C 411
LEU C 413
PRO C 444
ILE C 452
 RFP C1120
2A68_C_RBTC8001 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RBT C8001
2A68_M_RBTM8002 2a68 RBT

DB00615
(Rifabutin) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 13 ARG M 134
ASP P 323
LYS P 325
GLN M 390
GLN M 393
PHE M 394
ASP M 396
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
 RBT M8002
2A69_C_RPTC8001 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN;
RNA POLYMERASE SIGMA
FACTOR RPOD 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 134
ASP F 323
GLN C 390
GLN C 393
PHE C 394
ASP C 396
HIS C 406
ARG C 409
SER C 411
PRO C 444
ILE C 452
 RPT C8001
2A69_M_RPTM8002 2a69 RPT

DB01201
(Rifapentine) 		Thermus
thermophilus 		DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN 		no annotation 14 ARG M 134
GLN M 390
GLN M 393
PHE M 394
ASP M 396
ARG M 405
HIS M 406
ARG M 409
SER M 411
PRO M 444
ILE M 452
ASN M 563
MET M1000
GLU M1002
 RPT M8002
2ADM_A_SAMA500 2adm SAM

DB00118
(S-
Adenosylmethionine) 		Thermus aquaticus ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		11 THR A  23
GLU A  45
ALA A  47
PRO A  52
GLU A  71
ILE A  72
ASP A  73
ALA A  76
ASP A  89
PRO A 107
PHE A 146
 SAM A 500
2ADM_B_SAMB500 2adm SAM

DB00118
(S-
Adenosylmethionine) 		Thermus aquaticus ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI 		None 11 VAL B  21
THR B  23
GLU B  45
ALA B  47
PRO B  52
GLU B  71
ILE B  72
ALA B  76
ASP B  89
PRO B 107
PHE B 146
 SAM B 500
2XCT_G_CPFG1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 ARG B 458
GLY B 459
SER B1084
 CPF G1020
2XCT_H_CPFH1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		no annotation 3 ARG D 458
GLU D 477
SER D1084
 CPF H1020
2XCT_X_CPFX1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		no annotation 4 ARG S 458
GLY S 459
GLU S 477
SER U1084
 CPF X1020
2XKK_E_MFXE1100 2xkk MFX

DB00218
(Moxifloxacin) 		Acinetobacter
baumannii;
synthetic
construct 		DNA;
TOPOISOMERASE IV 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 GLU C 437
SER C1084
ARG A1123
 MFX E1100
3AV6_A_SAMA1 3av6 SAM

DB00118
(S-
Adenosylmethionine) 		Mus musculus DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1 		PF00145
(BAH)
PF01426
(zf-CXXC)
PF02008
(BAH)
PF12047
(DNMT1-RFD) 		14 PHE A1148
GLY A1150
GLY A1153
LEU A1154
GLU A1171
MET A1172
TRP A1173
ASP A1193
CYS A1194
PRO A1228
LEU A1250
ASN A1580
ALA A1581
VAL A1582
 SAM A   1
3FOF_F_MFXF0 3fof MFX

DB00218
(Moxifloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A 		no annotation 3 GLY B  77
SER B  79
SER B  80
 MFX F   0
3FOF_H_MFXH0 3fof MFX

DB00218
(Moxifloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 GLY A  77
SER A  79
SER A  80
ARG C 456
 MFX H   0
3K9F_F_LFXF0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  79
ARG B 117
ARG C 456
GLY C 457
GLU C 475
 LFX F   0
3K9F_H_LFXH0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER B  79
ARG A 117
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H   0
3KD5_E_PPFE914 3kd5 PPF

DB00529
(Foscarnet) 		Escherichia virus
RB69 		DNA POLYMERASE PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASP E 411
LEU E 415
ARG E 482
LYS E 560
ASP E 623
 PPF E 914
3Q87_B_SAMB300 3q87 SAM

DB00118
(S-
Adenosylmethionine) 		Encephalitozoon
cuniculi 		N6 ADENINE SPECIFIC
DNA METHYLASE 		PF05175
(MTS) 		12 TYR B   4
THR B  10
GLY B  31
SER B  33
ILE B  37
ASP B  51
LEU B  52
ASN B  53
ASP B  69
LEU B  70
ASN B  85
PRO B  87
 SAM B 300
3QWU_A_ADNA501 3qwu ADN

DB00640
(Adenosine) 		Aquifex aeolicus DNA LIGASE PF09414
(RNA_ligase) 		12 TYR A  51
ILE A  54
GLU A  75
LYS A  77
ASN A  82
ARG A  97
GLU A 129
PHE A 154
VAL A 182
VAL A 214
LYS A 216
LYS A 226
 ADN A 501
3QWU_B_ADNB501 3qwu ADN

DB00640
(Adenosine) 		Aquifex aeolicus DNA LIGASE no annotation 11 TYR B  51
ILE B  54
GLU B  75
LYS B  77
ASN B  82
ARG B  97
GLU B 129
PHE B 154
VAL B 182
VAL B 214
LYS B 216
 ADN B 501
3QX3_A_EVPA1 3qx3 EVP

DB00773
(Etoposide) 		Homo sapiens DNA TOPOISOMERASE
2-BETA 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 GLY A 478
ASP A 479
ARG A 503
GLN A 778
MET A 782
 EVP A   1
3QX3_D_EVPD1 3qx3 EVP

DB00773
(Etoposide) 		;
Homo sapiens 		DNA TOPOISOMERASE
2-BETA 		no annotation 5 GLY B 478
ASP B 479
ARG B 503
GLN B 778
MET B 782
 EVP D   1
3RAE_F_LFXF101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
3RAE_H_LFXH101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		no annotation 5 SER B  79
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H 101
4G0U_B_ASWB1301 4g0u ASW

DB00276
(Amsacrine) 		Homo sapiens DNA TOPOISOMERASE
2-BETA 		no annotation 7 ILE B 454
PRO B 455
ARG B 503
GLY B 504
ALA B 521
GLU B 522
GLN B 778
 ASW B1301
4G0U_F_ASWF101 4g0u ASW

DB00276
(Amsacrine) 		;
Homo sapiens 		DNA TOPOISOMERASE
2-BETA 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C)
no annotation 		6 PRO A 455
ARG A 503
GLY A 504
ALA A 521
GLU A 522
GLN A 778
 ASW F 101
4G0V_A_MIXA1301 4g0v MIX

DB01204
(Mitoxantrone) 		Homo sapiens DNA TOPOISOMERASE
2-BETA 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		7 ARG A 503
GLY A 504
ILE A 506
ASN A 520
GLU A 522
GLN A 778
MET A 782
 MIX A1301
4G0V_D_MIXD101 4g0v MIX

DB01204
(Mitoxantrone) 		;
Homo sapiens 		DNA TOPOISOMERASE
2-BETA 		no annotation 6 ARG B 503
GLY B 504
ASN B 520
GLU B 522
GLN B 778
MET B 782
 MIX D 101
4JUO_F_LFXF101 4juo LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
4KMU_C_RFPC1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		14 GLN C 510
LEU C 511
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ASN C 568
ILE C 572
ARG C 687
 RFP C1401
4KMU_H_RFPH1401 4kmu RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR RPOD 		no annotation 14 GLN H 510
GLN H 513
ASP Y 514
PHE H 514
ASP H 516
HIS H 526
ARG H 529
SER H 531
LEU H 533
ARG H 540
PRO H 564
ASN H 568
ILE H 572
ARG H 687
 RFP H1401
4KOE_F_TR6F101 4koe TR6

DB00685
(Trovafloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA2 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  79
ARG B 117
GLY C 434
ASP C 435
ARG C 456
GLY C 457
 TR6 F 101
4KOE_H_TR6H101 4koe TR6

DB00685
(Trovafloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA4 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER B  79
ARG A 117
GLY D 434
ASP D 435
ARG D 456
GLY D 457
GLU D 475
 TR6 H 101
4MJQ_A_27RA401 4mjq 27R

DB00963
(Bromfenac) 		Escherichia coli DNA POLYMERASE III
SUBUNIT BETA 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ARG A 152
TYR A 154
THR A 172
PRO A 242
VAL A 247
 27R A 401
4MJR_A_0LAA404 4mjr 0LA

DB00821
(Carprofen) 		Escherichia coli DNA POLYMERASE III
SUBUNIT BETA 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		9 ARG A 152
TYR A 154
THR A 172
GLY A 174
LEU A 177
PRO A 242
VAL A 247
VAL A 360
MET A 362
 0LA A 404
4RTM_A_SAMA301 4rtm SAM

DB00118
(S-
Adenosylmethionine) 		Escherichia coli DNA ADENINE
METHYLASE 		PF02086
(MethyltransfD12) 		16 TRP A  10
GLY A  12
GLY A  13
PHE A  35
GLY A  37
ALA A  38
SER A  40
ASP A  54
ILE A  55
ASN A  56
SER A 164
TYR A 165
ASP A 181
PRO A 183
TYR A 184
GLN A 205
 SAM A 301
4RTP_A_SAMA301 4rtp SAM

DB00118
(S-
Adenosylmethionine) 		Escherichia coli DNA ADENINE
METHYLASE 		PF02086
(MethyltransfD12) 		13 TRP A  10
PHE A  35
GLY A  37
ALA A  38
SER A  40
ASP A  54
ILE A  55
ASN A  56
SER A 164
TYR A 165
ASP A 181
PRO A 183
GLN A 205
 SAM A 301
4RTR_A_SAMA301 4rtr SAM

DB00118
(S-
Adenosylmethionine) 		Escherichia coli DNA ADENINE
METHYLASE 		PF02086
(MethyltransfD12) 		11 TRP A  10
GLY A  12
PHE A  35
ASP A  54
ILE A  55
ASN A  56
SER A 164
TYR A 165
ASP A 181
PRO A 183
TYR A 184
 SAM A 301
4RTS_A_SAMA301 4rts SAM

DB00118
(S-
Adenosylmethionine) 		Escherichia coli DNA ADENINE
METHYLASE 		PF02086
(MethyltransfD12) 		12 TRP A  10
GLY A  12
PHE A  35
GLY A  37
ASP A  54
ILE A  55
ASN A  56
SER A 164
TYR A 165
ASP A 181
PRO A 183
TYR A 184
 SAM A 301
4URN_A_NOVA2000 4urn NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA TOPOISOMERASE
IV, B SUBUNIT 		PF02518
(HATPase_c)
no annotation 		14 ASP B  35
LYS B  36
ASN A  49
SER A  50
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
ARG A 138
THR A 168
ASN B 186
 NOV A2000
4URN_B_NOVB2000 4urn NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA TOPOISOMERASE
IV, B SUBUNIT 		no annotation 11 ASN B  49
SER B  50
ASP B  52
GLU B  53
ASP B  76
ARG B  79
MET B  81
PRO B  82
ILE B  96
ARG B 138
THR B 168
 NOV B2000
4URN_C_NOVC2000 4urn NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA TOPOISOMERASE
IV, B SUBUNIT 		no annotation 11 ASN C  49
SER C  50
ASP C  52
GLU C  53
ASP C  76
ARG C  79
MET C  81
PRO C  82
ILE C  96
ARG C 138
THR C 168
 NOV C2000
4URO_A_NOVA2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B PF02518
(HATPase_c)
no annotation 		15 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
GLN A  91
ILE A 102
SER A 128
ARG A 144
THR A 173
ARG D 200
 NOV A2000
4URO_B_NOVB2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B no annotation 13 ASN B  54
SER B  55
ASP B  57
GLU B  58
ASP B  81
ARG B  84
ILE B  86
PRO B  87
ASP B  89
GLN B  91
ILE B 102
SER B 128
ARG B 144
 NOV B2000
4URO_C_NOVC2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B no annotation 14 ASN C  54
ASP C  57
GLU C  58
ASP C  81
ARG C  84
ILE C  86
PRO C  87
ASP C  89
GLN C  91
ALA C  98
ILE C 102
SER C 128
ARG C 144
THR C 173
 NOV C2000
4URO_D_NOVD2000 4uro NOV

DB01051
(Novobiocin) 		Staphylococcus
aureus 		DNA GYRASE SUBUNIT B no annotation 12 ASN D  54
SER D  55
GLU D  58
ASP D  81
ARG D  84
ILE D  86
PRO D  87
ASP D  89
ILE D 102
SER D 128
ARG D 144
THR D 173
 NOV D2000
4WRY_A_URFA302 4wry URF

DB00544
(Fluorouracil) 		Mycobacterium
tuberculosis 		URACIL-DNA
GLYCOSYLASE 		PF03167
(UDG) 		8 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
SER A  93
ASN A 127
HIS A 191
 URF A 302
4WRZ_A_URFA302 4wrz URF

DB00544
(Fluorouracil) 		Mycobacterium
tuberculosis 		URACIL-DNA
GLYCOSYLASE 		PF03167
(UDG) 		8 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
SER A  93
ASN A 127
HIS A 191
 URF A 302
4WS0_A_URFA301 4ws0 URF

DB00544
(Fluorouracil) 		Mycobacterium
tuberculosis 		URACIL-DNA
GLYCOSYLASE 		PF03167
(UDG) 		7 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
ASN A 127
HIS A 191
 URF A 301
4WS1_A_URFA301 4ws1 URF

DB00544
(Fluorouracil) 		Mycobacterium
tuberculosis 		URACIL-DNA
GLYCOSYLASE 		PF03167
(UDG) 		8 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
SER A  93
ASN A 127
HIS A 191
 URF A 301
4Z2C_F_MFXF101 4z2c MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 MFX F 101
4Z2C_H_MFXH101 4z2c MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 MFX H 101
4Z2D_F_LFXF102 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 LFX F 102
4Z2D_H_LFXH101 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 LFX H 101
4Z2E_F_TR6F101 4z2e TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER B  81
GLY C 434
ARG C 456
GLY C 457
GLU C 475
 TR6 F 101
4Z2E_H_TR6H101 4z2e TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		5 SER A  81
GLY D 434
ARG D 456
GLY D 457
GLU D 475
 TR6 H 101
4Z3O_F_MFXF101 4z3o MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 ARG B 456
GLY B 457
GLU B 475
SER B1079
ARG A1117
 MFX F 101
4Z3O_H_MFXH101 4z3o MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 ARG A 456
GLU A 475
SER A1079
 MFX H 101
4Z53_F_TR6F101 4z53 TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 GLY A 434
ASP A 435
ARG A 456
GLY A 457
SER A1079
ARG B1117
 TR6 F 101
4Z53_H_TR6H101 4z53 TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 GLY B 434
ASP B 435
ARG B 456
GLY B 457
GLU B 475
SER B1079
ARG A1117
 TR6 H 101
5BS8_G_MFXG101 5bs8 MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 MFX G 101
5BS8_H_MFXH101 5bs8 MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 ALA A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
 MFX H 101
5BTA_G_MFXG101 5bta MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 MFX G 101
5BTA_H_MFXH101 5bta MFX

DB00218
(Moxifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 MFX H 101
5BTC_G_CPFG101 5btc CPF

DB00537
(Ciprofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER C  90
ARG A 128
ARG D 482
GLY D 483
THR D 500
GLU D 501
 CPF G 101
5BTC_G_CPFG102 5btc CPF

DB00537
(Ciprofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 CPF G 102
5BTD_E_GFNE101 5btd GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 ALA A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
 GFN E 101
5BTD_G_GFNG101 5btd GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 GFN G 101
5BTF_F_GFNF101 5btf GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 SER A  90
ARG C 128
ASP B 461
ARG B 482
GLY B 483
THR B 500
GLU B 501
 GFN F 101
5BTF_G_GFNG101 5btf GFN

DB01044
(Gatifloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 GFN G 101
5BTG_E_LFXE101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 ALA A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 LFX E 101
5BTG_F_LFXF101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 LFX F 101
5BTI_E_LFXE101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  90
ARG B 482
GLY B 483
THR B 500
GLU B 501
 LFX E 101
5BTI_F_LFXF101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		no annotation 5 SER C  90
ARG D 482
GLY D 483
THR D 500
GLU D 501
 LFX F 101
5CDN_G_EVPG2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
 EVP G2101
5CDN_N_EVPN2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 6 SER R  84
GLU R  88
GLY S 436
ASP S 437
ARG S 458
GLY S 459
 EVP N2101
5CDN_O_EVPO2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 6 SER C  84
GLU C  88
GLY D 436
ASP D 437
ARG D 458
GLY D 459
 EVP O2101
5CDN_P_EVPP2101 5cdn EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 6 SER T  84
GLU T  88
GLY U 436
ASP U 437
ARG U 458
GLY U 459
 EVP P2101
5CDP_H_EVPH2101 5cdp EVP

DB00773
(Etoposide) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
 EVP H2101
5CDQ_E_MFXE2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  84
ARG C 122
ARG B 458
GLY B 459
GLU B 477
 MFX E2101
5CDQ_F_MFXF2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER C  84
ARG A 122
ASP D 437
ARG D 458
GLY D 459
GLU D 477
 MFX F2101
5CDQ_V_MFXV2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 5 SER R  84
ARG T 122
ARG S 458
GLY S 459
GLU S 477
 MFX V2101
5CDQ_W_MFXW2101 5cdq MFX

DB00218
(Moxifloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B 		no annotation 5 SER T  84
ARG R 122
ASP U 437
ARG U 458
GLU U 477
 MFX W2101
5FXT_A_0LAA1376 5fxt 0LA

DB00821
(Carprofen) 		Helicobacter
pylori 		DNA POLYMERASE III
SUBUNIT BETA 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		7 LYS A 152
LEU A 155
THR A 174
PRO A 244
ILE A 249
LEU A 369
MET A 371
 0LA A1376
5G48_A_1FLA1375 5g48 1FL

DB00861
(Diflunisal) 		Helicobacter
pylori 		DNA POLYMERASE III
SUBUNIT BETA 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		8 THR A 173
THR A 175
LEU A 178
PRO A 243
ILE A 248
PRO A 347
LEU A 368
MET A 370
 1FL A1375
5G48_B_1FLB1375 5g48 1FL

DB00861
(Diflunisal) 		Helicobacter
pylori 		DNA POLYMERASE III
SUBUNIT BETA 		no annotation 9 LEU B 154
THR B 173
THR B 175
LEU B 178
PRO B 243
ILE B 248
PRO B 347
LEU B 368
MET B 370
 1FL B1375
5GWK_D_EVPD102 5gwk EVP

DB00773
(Etoposide) 		Homo sapiens;
synthetic
construct 		DNA TOPOISOMERASE
2-ALPHA 		no annotation 4 GLY B 462
ASP B 463
ARG B 487
MET B 766
 EVP D 102
5GWK_F_EVPF102 5gwk EVP

DB00773
(Etoposide) 		Homo sapiens;
synthetic
construct 		DNA TOPOISOMERASE
2-ALPHA 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C)
no annotation 		5 GLY A 462
ASP A 463
ARG A 487
MET A 762
MET A 766
 EVP F 102
5HFJ_A_SAMA301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		PF01555
(N6_N4_Mtase) 		14 ASP A   8
ALA A   9
ASP A  29
PRO A  31
LYS A 165
LYS A 167
PHE A 195
GLY A 197
SER A 198
THR A 200
GLU A 216
SER A 217
GLU A 218
TYR A 221
 SAM A 301
5HFJ_B_SAMB301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 14 ASP B   8
ALA B   9
ASP B  29
PRO B  31
HIS B 168
THR B 170
GLN B 171
PHE B 195
GLY B 197
SER B 198
THR B 200
GLU B 216
SER B 217
TYR B 221
 SAM B 301
5HFJ_C_SAMC301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 16 ASP C   8
ALA C   9
ASP C  29
PRO C  31
HIS C 168
THR C 170
GLN C 171
LYS C 172
PHE C 195
GLY C 197
SER C 198
THR C 200
GLU C 216
SER C 217
GLU C 218
TYR C 221
 SAM C 301
5HFJ_D_SAMD301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 12 ASP D   8
ALA D   9
ASP D  29
PRO D  31
PHE D 195
GLY D 197
SER D 198
THR D 200
GLU D 216
SER D 217
GLU D 218
TYR D 221
 SAM D 301
5HFJ_E_SAME301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 12 ASP E   8
ALA E   9
ASP E  29
PRO E 169
LYS E 172
PHE E 195
GLY E 197
SER E 198
THR E 200
GLU E 216
SER E 217
TYR E 221
 SAM E 301
5HFJ_F_SAMF301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 12 ASP F   8
ALA F   9
ASP F  29
PRO F  31
THR F 170
GLN F 171
PHE F 195
GLY F 197
SER F 198
GLU F 216
SER F 217
TYR F 221
 SAM F 301
5HFJ_G_SAMG301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 16 ASP G   8
ALA G   9
ASP G  29
PRO G  31
HIS G 168
THR G 170
GLN G 171
LYS G 172
PHE G 195
GLY G 197
SER G 198
THR G 200
GLU G 216
SER G 217
GLU G 218
TYR G 221
 SAM G 301
5HFJ_H_SAMH301 5hfj SAM

DB00118
(S-
Adenosylmethionine) 		Helicobacter
pylori 		ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA) 		None 14 ASP H   8
ALA H   9
ASP H  29
PRO H  31
THR H 170
GLN H 171
LYS H 172
PHE H 195
GLY H 197
SER H 198
THR H 200
GLU H 216
SER H 217
TYR H 221
 SAM H 301
5NR3_A_95EA401 5nr3 95E

DB00330
(Ethambutol) 		Homo sapiens DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B 		PF00855
(PWWP) 		7 ILE A 233
PHE A 236
TRP A 239
TRP A 263
ASP A 266
LYS A 268
SER A 297
 95E A 401
5NR3_B_95EB401 5nr3 95E

DB00330
(Ethambutol) 		Homo sapiens DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B 		None 4 TRP B 239
TRP B 263
ASP B 266
SER B 297
 95E B 401
5NZW_A_9F2A1102 5nzw 9F2

DB01212
(Ceftriaxone) 		Homo sapiens DNA CROSS-LINK
REPAIR 1A PROTEIN 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		10 HIS A 732
HIS A 734
ASP A 736
HIS A 737
HIS A 793
ASP A 815
TYR A 841
TYR A 879
THR A 962
HIS A 994
 9F2 A1102
5NZX_A_9F2A1102 5nzx 9F2

DB01212
(Ceftriaxone) 		Homo sapiens DNA CROSS-LINK
REPAIR 1A PROTEIN 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		8 ASN A 938
PHE A 939
ARG A 960
THR A 962
GLN A 979
LYS A 981
ILE A 986
GLY A 988
 9F2 A1102
5NZY_A_CE3A1102 5nzy CE3

DB00493
(Cefotaxime) 		Homo sapiens DNA CROSS-LINK
REPAIR 1A PROTEIN 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		7 ASN A 938
PHE A 939
ARG A 960
THR A 962
GLN A 979
ILE A 986
GLY A 988
 CE3 A1102
5NZY_A_CE3A1103 5nzy CE3

DB00493
(Cefotaxime) 		Homo sapiens DNA CROSS-LINK
REPAIR 1A PROTEIN 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		8 THR A 700
PRO A 702
TYR A 704
GLN A 718
ASP A 736
VAL A1018
GLY A1019
ARG A1024
 CE3 A1103
5Q1S_A_AWYA1103 5q1s AWY

DB06594
(Agomelatine) 		Homo sapiens DNA CROSS-LINK
REPAIR 1A PROTEIN 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		6 LYS A 831
VAL A1004
LYS A1008
ILE A1012
LYS A1035
TYR A1040
 AWY A1103
5UAC_C_RFPC3001 5uac RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		12 GLN C 510
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ILE C 572
ARG C 687
 RFP C3001
5UAH_C_RFPC3001 5uah RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		13 ARG C 143
GLN C 510
LEU C 511
GLN C 513
PHE C 514
VAL C 516
ARG C 529
SER C 531
LEU C 533
ARG C 540
PRO C 564
ILE C 572
ARG C 687
 RFP C3001
5UAL_C_RFPC3001 5ual RFP

DB01045
(Rifampicin) 		Escherichia coli DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 GLN C 510
GLN C 513
PHE C 514
ASP C 516
HIS C 526
ARG C 529
LEU C 531
PRO C 564
ILE C 572
ARG C 687
GLN C 761
 RFP C3001
5UH6_C_RFPC1201 5uh6 RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ARG C 173
ASP F 429
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHB_C_RFPC1201 5uhb RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		15 GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHC_C_RFPC1201 5uhc RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_6)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		17 ASP F 429
GLU F 430
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHD_C_RFPC1201 5uhd RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		16 ARG C 173
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
5UHG_C_RFPC1201 5uhg RFP

DB01045
(Rifampicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		16 ARG C 173
GLN C 435
LEU C 436
GLN C 438
PHE C 439
ASP C 441
HIS C 451
ARG C 454
SER C 456
LEU C 458
ARG C 465
PRO C 489
ASN C 493
ILE C 497
ARG C 613
HIS C 680
 RFP C1201
6BZO_C_FI8C1201 6bzo FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_5)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_2)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		28 ARG J  10
VAL J  14
ARG D  84
LYS D  86
ARG D  89
GLU D 323
LEU D 324
PRO D 326
SER D 338
ARG D 412
GLN D 415
LEU F 423
ASP F 424
GLN F 434
VAL F 445
MET C1051
ILE C1052
THR C1053
GLN C1054
ASP C1094
THR C1096
VAL C1097
VAL C1100
LYS C1101
GLU C1119
SER C1120
VAL C1123
GLU C1127
 FI8 C1201
6C06_D_FI8D1404 6c06 FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA;
RNA
POLYMERASE-BINDING
PROTEIN RBPA 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF00562
(RNA_pol_Rpb2_7)
PF04560
(RNA_pol_Rpb2_3)
PF04561
(RNA_pol_Rpb2_45)
PF04565
(RNA_pol_Rpb2_6)
PF10385
(RNA_pol_Rpb2_2)
PF00623
(RNA_pol_Rpb1_3)
PF04983
(RNA_pol_Rpb1_2)
PF04997
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_1)
PF13397
(RbpA) 		13 ARG J  10
ARG D  84
LYS D  86
ARG D 412
GLN F 434
ILE C1052
THR C1053
GLN C1054
THR C1096
ARG C1099
LYS C1101
GLU C1119
SER C1120
 FI8 D1404
6FBV_D_FI8D1904 6fbv FI8

DB08874
(Fidaxomicin) 		Mycobacterium
tuberculosis 		DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA;
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA';
RNA POLYMERASE SIGMA
FACTOR SIGA 		PF00140
(Sigma70_r1_2)
PF00562
(RNA_pol_Rpb2_45)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_5)
PF04998
(RNA_pol_Rpb1_4)
PF05000
(RNA_pol_Rpb1_1) 		18 ASP D  57
ARG D  84
LYS D  86
ARG D  89
GLU D 323
VAL D 328
ARG D 412
GLN D 415
LEU F 423
ASP F 424
MET C1051
ILE C1052
GLN C1054
THR C1096
VAL C1097
LYS C1101
GLU C1119
SER C1120
 FI8 D1904