DRUG BINDING INTERFACES MAPPED TO 'DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE'

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1J3J_A_CP6A609	1j3j	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	10	ILE A 14 ALA A 16 ASP A 54 PHE A 58 ASN A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609
1J3J_B_CP6B709	1j3j	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	9	ALA B 16 ASP B 54 PHE B 58 ASN B 108 SER B 111 ILE B 112 ILE B 164 TYR B 170 THR B 185	CP6 B 709
1QZF_A_FOLA605	1qzf	FOL DB00158 (Folic Acid)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (Thymidylat_synt) PF00303 (DHFR_1)	12	VAL A 9 ALA A 11 LEU A 25 ASP A 32 LEU A 33 SER A 37 THR A 58 ILE A 62 LEU A 67 ARG A 70 TYR A 119 THR A 134	FOL A 605
1QZF_B_FOLB609	1qzf	FOL DB00158 (Folic Acid)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL B 9 ALA B 11 LEU B 25 ASP B 32 LEU B 33 SER B 37 THR B 58 ILE B 62 LEU B 67 ARG B 70 TYR B 119 THR B 134	FOL B 609
1QZF_C_FOLC613	1qzf	FOL DB00158 (Folic Acid)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL C 9 ALA C 11 LEU C 25 ASP C 32 LEU C 33 SER C 37 THR C 58 ILE C 62 LEU C 67 ARG C 70 TYR C 119 THR C 134	FOL C 613
1QZF_D_FOLD617	1qzf	FOL DB00158 (Folic Acid)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL D 9 ALA D 11 LEU D 25 ASP D 32 LEU D 33 SER D 37 THR D 58 ILE D 62 LEU D 67 ARG D 70 TYR D 119 THR D 134	FOL D 617
1QZF_E_FOLE621	1qzf	FOL DB00158 (Folic Acid)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL E 9 ALA E 11 LEU E 25 ASP E 32 LEU E 33 SER E 37 THR E 58 ILE E 62 LEU E 67 ARG E 70 TYR E 119 THR E 134	FOL E 621
2BL9_A_CP6A1240	2bl9	CP6 DB00205 (Pyrimethamine)	Plasmodium vivax	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	12	ILE A 13 ALA A 15 LEU A 45 ASP A 53 MET A 54 PHE A 57 SER A 117 SER A 120 ILE A 121 ILE A 173 TYR A 179 THR A 194	CP6 A1240
2BLA_A_CP6A302	2bla	CP6 DB00205 (Pyrimethamine)	Plasmodium vivax	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	11	ILE A 13 ALA A 15 ASP A 53 MET A 54 PHE A 57 ASN A 117 SER A 120 ILE A 121 ILE A 173 TYR A 179 THR A 194	CP6 A 302
3CL9_A_MTXA602	3cl9	MTX DB00563 (Methotrexate)	Trypanosoma cruzi	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	16	VAL A 26 ALA A 28 ILE A 41 ASP A 48 MET A 49 ARG A 53 THR A 80 SER A 83 ILE A 84 PRO A 85 PHE A 88 LEU A 91 PRO A 92 ARG A 94 TYR A 160 THR A 178	MTX A 602
3HBB_A_TMQA611	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	VAL A 26 ALA A 28 ILE A 41 ASP A 48 MET A 49 ILE A 84 PRO A 85 LEU A 91 ILE A 154 TYR A 160	TMQ A 611
3HBB_B_TMQB612	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	9	VAL B 26 ALA B 28 ILE B 41 ASP B 48 THR B 80 SER B 83 PHE B 88 ILE B 154 TYR B 160	TMQ B 612
3HBB_C_TMQC613	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	11	VAL C 26 ALA C 28 ILE C 41 ASP C 48 MET C 49 ILE C 84 PRO C 85 LEU C 91 ILE C 154 TYR C 160 THR C 178	TMQ C 613
3HBB_D_TMQD614	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	10	VAL D 26 ALA D 28 ILE D 41 ASP D 48 MET D 49 ILE D 84 PRO D 85 ILE D 154 TYR D 160 THR D 178	TMQ D 614
3NRR_A_D16A520	3nrr	D16 DB00293 (Raltitrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	12	PHE A 14 ALA A 16 ASP A 37 PHE A 38 LEU A 41 ARG A 42 THR A 69 ILE A 73 PRO A 74 SER A 77 LEU A 123 THR A 144	D16 A 520
3NRR_A_D16A530	3nrr	D16 DB00293 (Raltitrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	12	ALA A 278 SER A 281 GLU A 285 ILE A 306 TRP A 307 ASN A 310 ASP A 416 LEU A 419 GLY A 420 PHE A 423 TYR A 456 MET A 509	D16 A 530
3NRR_B_D16B520	3nrr	D16 DB00293 (Raltitrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	13	PHE B 14 ALA B 16 HIS B 33 ASP B 37 PHE B 38 LEU B 41 ARG B 42 THR B 69 ILE B 73 PRO B 74 SER B 77 LEU B 123 THR B 144	D16 B 520
3NRR_B_D16B530	3nrr	D16 DB00293 (Raltitrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	ALA B 278 SER B 281 GLU B 285 ILE B 306 TRP B 307 ASN B 310 ASP B 416 LEU B 419 GLY B 420 PHE B 423 TYR B 456 MET B 509	D16 B 530
3QFX_A_CP6A602	3qfx	CP6 DB00205 (Pyrimethamine)	Trypanosoma brucei	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	12	VAL A 32 ALA A 34 ILE A 47 ASP A 54 MET A 55 PHE A 58 THR A 86 SER A 89 LEU A 90 ILE A 160 TYR A 166 THR A 184	CP6 A 602
3QFX_B_CP6B702	3qfx	CP6 DB00205 (Pyrimethamine)	Trypanosoma brucei	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	VAL B 32 ALA B 34 ILE B 47 ASP B 54 MET B 55 PHE B 58 THR B 86 SER B 89 LEU B 90 ILE B 160 TYR B 166 THR B 184	CP6 B 702
3QG2_A_CP6A609	3qg2	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	ILE A 14 ALA A 16 ASP A 54 MET A 55 PHE A 58 ASN A 108 SER A 111 ILE A 112 TYR A 170 THR A 185	CP6 A 609
3QG2_B_CP6B709	3qg2	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	11	ILE B 14 ALA B 16 ASP B 54 MET B 55 PHE B 58 ASN B 108 SER B 111 ILE B 112 LEU B 164 TYR B 170 THR B 185	CP6 B 709
3QGT_A_CP6A609	3qgt	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	ILE A 14 ALA A 16 ASP A 54 PHE A 58 SER A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609
3QGT_B_CP6B609	3qgt	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	10	ILE B 14 ALA B 16 ASP B 54 PHE B 58 SER B 108 SER B 111 ILE B 112 ILE B 164 TYR B 170 THR B 185	CP6 B 609
3UM5_A_CP6A609	3um5	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	ILE A 14 VAL A 16 ASP A 54 PHE A 58 THR A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609
3UM5_B_CP6B709	3um5	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	10	ILE B 14 VAL B 16 ASP B 54 PHE B 58 THR B 108 SER B 111 ILE B 112 ILE B 164 TYR B 170 THR B 185	CP6 B 709
4ECK_A_FOLA703	4eck	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	14	VAL A 8 ALA A 10 LEU A 23 ASP A 31 PHE A 32 PHE A 35 SER A 36 MET A 87 PHE A 91 LEU A 94 VAL A 95 ARG A 97 VAL A 151 THR A 172	FOL A 703
4ECK_B_FOLB703	4eck	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL B 8 ALA B 10 LEU B 23 ASP B 31 PHE B 35 SER B 36 MET B 87 PHE B 91 LEU B 94 ARG B 97 VAL B 151 THR B 172	FOL B 703
4EIL_A_FOLA703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (Thymidylat_synt) PF00303 (DHFR_1)	11	VAL A 8 ALA A 10 ASP A 31 PHE A 32 SER A 36 MET A 87 PHE A 91 LEU A 94 ARG A 97 VAL A 151 THR A 172	FOL A 703
4EIL_B_FOLB703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	10	VAL B 8 ALA B 10 ASP B 31 PHE B 32 SER B 36 PHE B 91 LEU B 94 ARG B 97 VAL B 151 THR B 172	FOL B 703
4EIL_C_FOLC703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	11	VAL C 8 ALA C 10 ASP C 31 PHE C 32 SER C 36 MET C 87 PHE C 91 LEU C 94 ARG C 97 VAL C 151 THR C 172	FOL C 703
4EIL_D_FOLD703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	10	VAL D 8 ALA D 10 ASP D 31 PHE D 32 SER D 36 MET D 87 PHE D 91 ARG D 97 VAL D 151 THR D 172	FOL D 703
4EIL_E_FOLE703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	11	VAL E 8 ALA E 10 ASP E 31 PHE E 32 SER E 36 MET E 87 PHE E 91 LEU E 94 ARG E 97 VAL E 151 THR E 172	FOL E 703
4EIL_F_FOLF703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	9	ALA F 10 ASP F 31 PHE F 32 SER F 36 MET F 87 PHE F 91 LEU F 94 ARG F 97 THR F 172	FOL F 703
4EIL_G_FOLG703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	10	VAL G 8 ALA G 10 ASP G 31 PHE G 32 SER G 36 MET G 87 PHE G 91 LEU G 94 ARG G 97 THR G 172	FOL G 703
4EIL_H_FOLH703	4eil	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	9	VAL H 8 ALA H 10 ASP H 31 PHE H 32 LYS H 33 SER H 36 PHE H 91 ARG H 97 THR H 172	FOL H 703
4KYA_A_FOLA703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	11	VAL A 8 ALA A 10 ASP A 31 SER A 36 THR A 83 MET A 87 PHE A 91 LEU A 94 ARG A 97 VAL A 151 THR A 172	FOL A 703
4KYA_B_FOLB703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL B 8 ALA B 10 TRP B 25 ASP B 31 PHE B 32 SER B 36 MET B 87 PHE B 91 LEU B 94 ARG B 97 VAL B 151 THR B 172	FOL B 703
4KYA_C_FOLC703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	10	VAL C 8 ALA C 10 ASP C 31 SER C 36 MET C 87 PHE C 91 LEU C 94 ARG C 97 VAL C 151 THR C 172	FOL C 703
4KYA_D_FOLD703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL D 8 ALA D 10 TRP D 25 ASP D 31 PHE D 32 SER D 36 MET D 87 PHE D 91 LEU D 94 ARG D 97 VAL D 151 THR D 172	FOL D 703
4KYA_E_FOLE703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	11	VAL E 8 ALA E 10 ASP E 31 SER E 36 THR E 83 MET E 87 PHE E 91 LEU E 94 ARG E 97 VAL E 151 THR E 172	FOL E 703
4KYA_F_FOLF703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL F 8 ALA F 10 TRP F 25 ASP F 31 PHE F 32 SER F 36 MET F 87 PHE F 91 LEU F 94 ARG F 97 VAL F 151 THR F 172	FOL F 703
4KYA_G_FOLG703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	11	VAL G 8 ALA G 10 ASP G 31 SER G 36 THR G 83 MET G 87 PHE G 91 LEU G 94 ARG G 97 VAL G 151 THR G 172	FOL G 703
4KYA_H_FOLH703	4kya	FOL DB00158 (Folic Acid)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	12	VAL H 8 ALA H 10 TRP H 25 ASP H 31 PHE H 32 SER H 36 MET H 87 PHE H 91 LEU H 94 ARG H 97 VAL H 151 THR H 172	FOL H 703
4Q0D_A_MTXA604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	12	VAL A 9 ALA A 11 LEU A 25 ASP A 32 LEU A 33 LYS A 34 SER A 37 ILE A 62 LEU A 67 ARG A 70 TYR A 119 THR A 134	MTX A 604
4Q0D_B_MTXB604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	VAL B 9 ALA B 11 LEU B 25 ASP B 32 LEU B 33 LYS B 34 SER B 37 ILE B 62 LEU B 67 ARG B 70 TYR B 119 THR B 134	MTX B 604
4Q0D_C_MTXC604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	14	VAL C 9 ALA C 11 LEU C 25 ASP C 32 LEU C 33 LYS C 34 SER C 37 SER C 61 ILE C 62 LEU C 67 ARG C 70 CYS C 113 TYR C 119 THR C 134	MTX C 604
4Q0D_D_MTXD604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	14	VAL D 9 ALA D 11 LEU D 25 ASP D 32 LEU D 33 LYS D 34 SER D 37 SER D 61 ILE D 62 LEU D 67 ARG D 70 CYS D 113 TYR D 119 THR D 134	MTX D 604
4Q0D_E_MTXE604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	VAL E 9 ALA E 11 LEU E 25 ASP E 32 LEU E 33 LYS E 34 SER E 37 ILE E 62 LEU E 67 ARG E 70 TYR E 119 THR E 134	MTX E 604
6AOG_A_CP6A704	6aog	CP6 DB00205 (Pyrimethamine)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	VAL A 8 ALA A 10 ASP A 31 HIS A 34 PHE A 35 THR A 83 MET A 87 VAL A 151 TYR A 157 THR A 172	CP6 A 704
6AOG_B_CP6B704	6aog	CP6 DB00205 (Pyrimethamine)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	10	VAL B 8 ALA B 10 ASP B 31 HIS B 34 PHE B 35 THR B 83 MET B 87 VAL B 151 TYR B 157 THR B 172	CP6 B 704

[["1J3J_A_CP6A609","1j3j","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",10,"ILE A  14;ALA A  16;ASP A  54;PHE A  58;ASN A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["1J3J_B_CP6B709","1j3j","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",9,"ALA B  16;ASP B  54;PHE B  58;ASN B 108;SER B 111;ILE B 112;ILE B 164;TYR B 170;THR B 185","CP6 B 709\r"],["1QZF_A_FOLA605","1qzf","FOL","DB00158(Folic Acid)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(Thymidylat_synt);PF00303(DHFR_1)",12,"VAL A   9;ALA A  11;LEU A  25;ASP A  32;LEU A  33;SER A  37;THR A  58;ILE A  62;LEU A  67;ARG A  70;TYR A 119;THR A 134","FOL A 605\r"],["1QZF_B_FOLB609","1qzf","FOL","DB00158(Folic Acid)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL B   9;ALA B  11;LEU B  25;ASP B  32;LEU B  33;SER B  37;THR B  58;ILE B  62;LEU B  67;ARG B  70;TYR B 119;THR B 134","FOL B 609\r"],["1QZF_C_FOLC613","1qzf","FOL","DB00158(Folic Acid)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL C   9;ALA C  11;LEU C  25;ASP C  32;LEU C  33;SER C  37;THR C  58;ILE C  62;LEU C  67;ARG C  70;TYR C 119;THR C 134","FOL C 613\r"],["1QZF_D_FOLD617","1qzf","FOL","DB00158(Folic Acid)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL D   9;ALA D  11;LEU D  25;ASP D  32;LEU D  33;SER D  37;THR D  58;ILE D  62;LEU D  67;ARG D  70;TYR D 119;THR D 134","FOL D 617\r"],["1QZF_E_FOLE621","1qzf","FOL","DB00158(Folic Acid)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL E   9;ALA E  11;LEU E  25;ASP E  32;LEU E  33;SER E  37;THR E  58;ILE E  62;LEU E  67;ARG E  70;TYR E 119;THR E 134","FOL E 621\r"],["2BL9_A_CP6A1240","2bl9","CP6","DB00205(Pyrimethamine)","Plasmodium vivax","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",12,"ILE A  13;ALA A  15;LEU A  45;ASP A  53;MET A  54;PHE A  57;SER A 117;SER A 120;ILE A 121;ILE A 173;TYR A 179;THR A 194","CP6 A1240\r"],["2BLA_A_CP6A302","2bla","CP6","DB00205(Pyrimethamine)","Plasmodium vivax","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",11,"ILE A  13;ALA A  15;ASP A  53;MET A  54;PHE A  57;ASN A 117;SER A 120;ILE A 121;ILE A 173;TYR A 179;THR A 194","CP6 A 302\r"],["3CL9_A_MTXA602","3cl9","MTX","DB00563(Methotrexate)","Trypanosoma cruzi","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)","PF00186(DHFR_1);PF00303(Thymidylat_synt)",16,"VAL A  26;ALA A  28;ILE A  41;ASP A  48;MET A  49;ARG A  53;THR A  80;SER A  83;ILE A  84;PRO A  85;PHE A  88;LEU A  91;PRO A  92;ARG A  94;TYR A 160;THR A 178","MTX A 602\r"],["3HBB_A_TMQA611","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"VAL A  26;ALA A  28;ILE A  41;ASP A  48;MET A  49;ILE A  84;PRO A  85;LEU A  91;ILE A 154;TYR A 160","TMQ A 611\r"],["3HBB_B_TMQB612","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",9,"VAL B  26;ALA B  28;ILE B  41;ASP B  48;THR B  80;SER B  83;PHE B  88;ILE B 154;TYR B 160","TMQ B 612\r"],["3HBB_C_TMQC613","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",11,"VAL C  26;ALA C  28;ILE C  41;ASP C  48;MET C  49;ILE C  84;PRO C  85;LEU C  91;ILE C 154;TYR C 160;THR C 178","TMQ C 613\r"],["3HBB_D_TMQD614","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",10,"VAL D  26;ALA D  28;ILE D  41;ASP D  48;MET D  49;ILE D  84;PRO D  85;ILE D 154;TYR D 160;THR D 178","TMQ D 614\r"],["3NRR_A_D16A520","3nrr","D16","DB00293(Raltitrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",12,"PHE A  14;ALA A  16;ASP A  37;PHE A  38;LEU A  41;ARG A  42;THR A  69;ILE A  73;PRO A  74;SER A  77;LEU A 123;THR A 144","D16 A 520\r"],["3NRR_A_D16A530","3nrr","D16","DB00293(Raltitrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",12,"ALA A 278;SER A 281;GLU A 285;ILE A 306;TRP A 307;ASN A 310;ASP A 416;LEU A 419;GLY A 420;PHE A 423;TYR A 456;MET A 509","D16 A 530\r"],["3NRR_B_D16B520","3nrr","D16","DB00293(Raltitrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",13,"PHE B  14;ALA B  16;HIS B  33;ASP B  37;PHE B  38;LEU B  41;ARG B  42;THR B  69;ILE B  73;PRO B  74;SER B  77;LEU B 123;THR B 144","D16 B 520\r"],["3NRR_B_D16B530","3nrr","D16","DB00293(Raltitrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"ALA B 278;SER B 281;GLU B 285;ILE B 306;TRP B 307;ASN B 310;ASP B 416;LEU B 419;GLY B 420;PHE B 423;TYR B 456;MET B 509","D16 B 530\r"],["3QFX_A_CP6A602","3qfx","CP6","DB00205(Pyrimethamine)","Trypanosoma brucei","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",12,"VAL A  32;ALA A  34;ILE A  47;ASP A  54;MET A  55;PHE A  58;THR A  86;SER A  89;LEU A  90;ILE A 160;TYR A 166;THR A 184","CP6 A 602\r"],["3QFX_B_CP6B702","3qfx","CP6","DB00205(Pyrimethamine)","Trypanosoma brucei","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"VAL B  32;ALA B  34;ILE B  47;ASP B  54;MET B  55;PHE B  58;THR B  86;SER B  89;LEU B  90;ILE B 160;TYR B 166;THR B 184","CP6 B 702\r"],["3QG2_A_CP6A609","3qg2","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"ILE A  14;ALA A  16;ASP A  54;MET A  55;PHE A  58;ASN A 108;SER A 111;ILE A 112;TYR A 170;THR A 185","CP6 A 609\r"],["3QG2_B_CP6B709","3qg2","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",11,"ILE B  14;ALA B  16;ASP B  54;MET B  55;PHE B  58;ASN B 108;SER B 111;ILE B 112;LEU B 164;TYR B 170;THR B 185","CP6 B 709\r"],["3QGT_A_CP6A609","3qgt","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"ILE A  14;ALA A  16;ASP A  54;PHE A  58;SER A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["3QGT_B_CP6B609","3qgt","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",10,"ILE B  14;ALA B  16;ASP B  54;PHE B  58;SER B 108;SER B 111;ILE B 112;ILE B 164;TYR B 170;THR B 185","CP6 B 609\r"],["3UM5_A_CP6A609","3um5","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"ILE A  14;VAL A  16;ASP A  54;PHE A  58;THR A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["3UM5_B_CP6B709","3um5","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",10,"ILE B  14;VAL B  16;ASP B  54;PHE B  58;THR B 108;SER B 111;ILE B 112;ILE B 164;TYR B 170;THR B 185","CP6 B 709\r"],["4ECK_A_FOLA703","4eck","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",14,"VAL A   8;ALA A  10;LEU A  23;ASP A  31;PHE A  32;PHE A  35;SER A  36;MET A  87;PHE A  91;LEU A  94;VAL A  95;ARG A  97;VAL A 151;THR A 172","FOL A 703\r"],["4ECK_B_FOLB703","4eck","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL B   8;ALA B  10;LEU B  23;ASP B  31;PHE B  35;SER B  36;MET B  87;PHE B  91;LEU B  94;ARG B  97;VAL B 151;THR B 172","FOL B 703\r"],["4EIL_A_FOLA703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(Thymidylat_synt);PF00303(DHFR_1)",11,"VAL A   8;ALA A  10;ASP A  31;PHE A  32;SER A  36;MET A  87;PHE A  91;LEU A  94;ARG A  97;VAL A 151;THR A 172","FOL A 703\r"],["4EIL_B_FOLB703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",10,"VAL B   8;ALA B  10;ASP B  31;PHE B  32;SER B  36;PHE B  91;LEU B  94;ARG B  97;VAL B 151;THR B 172","FOL B 703\r"],["4EIL_C_FOLC703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",11,"VAL C   8;ALA C  10;ASP C  31;PHE C  32;SER C  36;MET C  87;PHE C  91;LEU C  94;ARG C  97;VAL C 151;THR C 172","FOL C 703\r"],["4EIL_D_FOLD703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",10,"VAL D   8;ALA D  10;ASP D  31;PHE D  32;SER D  36;MET D  87;PHE D  91;ARG D  97;VAL D 151;THR D 172","FOL D 703\r"],["4EIL_E_FOLE703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",11,"VAL E   8;ALA E  10;ASP E  31;PHE E  32;SER E  36;MET E  87;PHE E  91;LEU E  94;ARG E  97;VAL E 151;THR E 172","FOL E 703\r"],["4EIL_F_FOLF703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",9,"ALA F  10;ASP F  31;PHE F  32;SER F  36;MET F  87;PHE F  91;LEU F  94;ARG F  97;THR F 172","FOL F 703\r"],["4EIL_G_FOLG703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",10,"VAL G   8;ALA G  10;ASP G  31;PHE G  32;SER G  36;MET G  87;PHE G  91;LEU G  94;ARG G  97;THR G 172","FOL G 703\r"],["4EIL_H_FOLH703","4eil","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",9,"VAL H   8;ALA H  10;ASP H  31;PHE H  32;LYS H  33;SER H  36;PHE H  91;ARG H  97;THR H 172","FOL H 703\r"],["4KYA_A_FOLA703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",11,"VAL A   8;ALA A  10;ASP A  31;SER A  36;THR A  83;MET A  87;PHE A  91;LEU A  94;ARG A  97;VAL A 151;THR A 172","FOL A 703\r"],["4KYA_B_FOLB703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL B   8;ALA B  10;TRP B  25;ASP B  31;PHE B  32;SER B  36;MET B  87;PHE B  91;LEU B  94;ARG B  97;VAL B 151;THR B 172","FOL B 703\r"],["4KYA_C_FOLC703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",10,"VAL C   8;ALA C  10;ASP C  31;SER C  36;MET C  87;PHE C  91;LEU C  94;ARG C  97;VAL C 151;THR C 172","FOL C 703\r"],["4KYA_D_FOLD703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL D   8;ALA D  10;TRP D  25;ASP D  31;PHE D  32;SER D  36;MET D  87;PHE D  91;LEU D  94;ARG D  97;VAL D 151;THR D 172","FOL D 703\r"],["4KYA_E_FOLE703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",11,"VAL E   8;ALA E  10;ASP E  31;SER E  36;THR E  83;MET E  87;PHE E  91;LEU E  94;ARG E  97;VAL E 151;THR E 172","FOL E 703\r"],["4KYA_F_FOLF703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL F   8;ALA F  10;TRP F  25;ASP F  31;PHE F  32;SER F  36;MET F  87;PHE F  91;LEU F  94;ARG F  97;VAL F 151;THR F 172","FOL F 703\r"],["4KYA_G_FOLG703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",11,"VAL G   8;ALA G  10;ASP G  31;SER G  36;THR G  83;MET G  87;PHE G  91;LEU G  94;ARG G  97;VAL G 151;THR G 172","FOL G 703\r"],["4KYA_H_FOLH703","4kya","FOL","DB00158(Folic Acid)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",12,"VAL H   8;ALA H  10;TRP H  25;ASP H  31;PHE H  32;SER H  36;MET H  87;PHE H  91;LEU H  94;ARG H  97;VAL H 151;THR H 172","FOL H 703\r"],["4Q0D_A_MTXA604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",12,"VAL A   9;ALA A  11;LEU A  25;ASP A  32;LEU A  33;LYS A  34;SER A  37;ILE A  62;LEU A  67;ARG A  70;TYR A 119;THR A 134","MTX A 604\r"],["4Q0D_B_MTXB604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"VAL B   9;ALA B  11;LEU B  25;ASP B  32;LEU B  33;LYS B  34;SER B  37;ILE B  62;LEU B  67;ARG B  70;TYR B 119;THR B 134","MTX B 604\r"],["4Q0D_C_MTXC604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",14,"VAL C   9;ALA C  11;LEU C  25;ASP C  32;LEU C  33;LYS C  34;SER C  37;SER C  61;ILE C  62;LEU C  67;ARG C  70;CYS C 113;TYR C 119;THR C 134","MTX C 604\r"],["4Q0D_D_MTXD604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",14,"VAL D   9;ALA D  11;LEU D  25;ASP D  32;LEU D  33;LYS D  34;SER D  37;SER D  61;ILE D  62;LEU D  67;ARG D  70;CYS D 113;TYR D 119;THR D 134","MTX D 604\r"],["4Q0D_E_MTXE604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"VAL E   9;ALA E  11;LEU E  25;ASP E  32;LEU E  33;LYS E  34;SER E  37;ILE E  62;LEU E  67;ARG E  70;TYR E 119;THR E 134","MTX E 604\r"],["6AOG_A_CP6A704","6aog","CP6","DB00205(Pyrimethamine)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"VAL A   8;ALA A  10;ASP A  31;HIS A  34;PHE A  35;THR A  83;MET A  87;VAL A 151;TYR A 157;THR A 172","CP6 A 704\r"],["6AOG_B_CP6B704","6aog","CP6","DB00205(Pyrimethamine)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",10,"VAL B   8;ALA B  10;ASP B  31;HIS B  34;PHE B  35;THR B  83;MET B  87;VAL B 151;TYR B 157;THR B 172","CP6 B 704\r"]]