DRUG BINDING INTERFACES MAPPED TO 'CYTOCHROME P450 2D6'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)| DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
|---|---|---|---|---|---|---|---|---|
| 3TBG_A_RTZA1 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | PF00067(p450) | 12 | LEU A 110PHE A 112PHE A 120LEU A 121GLY A 212LEU A 213GLU A 216GLN A 244PHE A 247ASP A 301SER A 304PHE A 483 | RTZ A 1 |
| 3TBG_A_RTZA2 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | PF00067(p450) | 11 | THR A 54LEU A 73THR A 76VAL A 78SER A 217GLU A 222LEU A 372VAL A 374THR A 375PHE A 481PHE A 483 | RTZ A 2 |
| 3TBG_B_RTZB1 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 12 | LEU B 110PHE B 112PHE B 120LEU B 121GLY B 212LEU B 213GLU B 216GLN B 244PHE B 247ALA B 300ASP B 301SER B 304 | RTZ B 1 |
| 3TBG_B_RTZB2 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 8 | LEU B 73THR B 76VAL B 78GLU B 222LEU B 372THR B 375ILE B 396PHE B 483 | RTZ B 2 |
| 3TBG_C_RTZC1 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 12 | LEU C 110PHE C 112PHE C 120LEU C 121GLY C 212LEU C 213GLU C 216GLN C 244PHE C 247ASP C 301SER C 304PHE C 483 | RTZ C 1 |
| 3TBG_C_RTZC2 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 10 | THR C 54LEU C 73THR C 76VAL C 78GLU C 222LEU C 372VAL C 374THR C 375PHE C 481PHE C 483 | RTZ C 2 |
| 3TBG_D_RTZD1 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 12 | LEU D 110PHE D 112PHE D 120LEU D 121GLY D 212LEU D 213GLU D 216GLN D 244PHE D 247ALA D 300ASP D 301SER D 304 | RTZ D 1 |
| 3TBG_D_RTZD2 | 3tbg | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 9 | PHE D 58LEU D 73THR D 76VAL D 78GLU D 222LEU D 372THR D 375ILE D 396PHE D 483 | RTZ D 2 |
| 4WNU_A_QDNA602 | 4wnu | QDN DB00908(Quinidine) | Homo sapiens | CYTOCHROME P450 2D6 | PF00067(p450) | 11 | LEU A 110PHE A 120GLY A 212LEU A 213GLU A 216GLN A 244PHE A 247LEU A 248ALA A 300SER A 304PHE A 483 | QDN A 602 |
| 4WNU_B_QDNB602 | 4wnu | QDN DB00908(Quinidine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 9 | LEU B 110PHE B 120GLU B 216GLN B 244PHE B 247ALA B 300ASP B 301SER B 304ALA B 305 | QDN B 602 |
| 4WNU_C_QDNC602 | 4wnu | QDN DB00908(Quinidine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 11 | LEU C 110PHE C 120GLY C 212LEU C 213GLU C 216GLN C 244PHE C 247ALA C 300ASP C 301SER C 304PHE C 483 | QDN C 602 |
| 4WNU_D_QDND602 | 4wnu | QDN DB00908(Quinidine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 10 | PHE D 120GLY D 212GLU D 216GLN D 244PHE D 247LEU D 248ALA D 300ASP D 301SER D 304ALA D 305 | QDN D 602 |
| 4WNV_A_QI9A602 | 4wnv | QI9 DB00468(Quinine) | Homo sapiens | CYTOCHROME P450 2D6 | PF00067(p450) | 9 | PHE A 120LEU A 121GLU A 216SER A 304THR A 309VAL A 370VAL A 374PHE A 483LEU A 484 | QI9 A 602 |
| 4WNV_B_QI9B602 | 4wnv | QI9 DB00468(Quinine) | Homo sapiens | CYTOCHROME P450 2D6 | None | 9 | PHE B 120LEU B 121LEU B 213GLU B 216SER B 304THR B 309VAL B 370VAL B 374PHE B 483 | QI9 B 602 |
| 4WNV_C_QI9C602 | 4wnv | QI9 DB00468(Quinine) | Homo sapiens | CYTOCHROME P450 2D6 | None | 9 | PHE C 120LEU C 121GLU C 216ASP C 301SER C 304THR C 309VAL C 370VAL C 374PHE C 483 | QI9 C 602 |
| 4WNV_D_QI9D602 | 4wnv | QI9 DB00468(Quinine) | Homo sapiens | CYTOCHROME P450 2D6 | None | 7 | PHE D 120LEU D 121GLU D 216SER D 304THR D 309VAL D 374PHE D 483 | QI9 D 602 |
| 4WNW_A_RTZA602 | 4wnw | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | PF00067(p450) | 13 | PHE A 112PHE A 120LEU A 121GLY A 212LEU A 213GLU A 216GLN A 244ASP A 301SER A 304VAL A 308THR A 309VAL A 374PHE A 483 | RTZ A 602 |
| 4WNW_B_RTZB602 | 4wnw | RTZ DB00679(Thioridazine) | Homo sapiens | CYTOCHROME P450 2D6 | no annotation | 15 | PHE B 112PHE B 120LEU B 121GLY B 212LEU B 213GLU B 216GLN B 244ILE B 297ALA B 300ASP B 301SER B 304ALA B 305VAL B 308VAL B 374PHE B 483 | RTZ B 602 |