DRUG BINDING INTERFACES MAPPED TO 'CYCLIC PHOSPHODIESTERASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)| DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
|---|---|---|---|---|---|---|---|---|
| 1TBF_A_VIAA501 | 1tbf | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 9 | TYR A 612LEU A 725LEU A 765VAL A 782ALA A 783LEU A 804MET A 816GLN A 817PHE A 820 | VIA A 501 |
| 1UDT_A_VIAA1000 | 1udt | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 12 | TYR A 612HIS A 613ASN A 661TYR A 664ALA A 767ILE A 768VAL A 782ALA A 783LEU A 804MET A 816GLN A 817PHE A 820 | VIA A1000 |
| 1UDU_A_CIAA1003 | 1udu | CIA DB00820(Tadalafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 11 | TYR A 612SER A 663ILE A 778VAL A 782ALA A 783PHE A 786LEU A 804ILE A 813MET A 816GLN A 817PHE A 820 | CIA A1003 |
| 1UDU_B_CIAB2003 | 1udu | CIA DB00820(Tadalafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | no annotation | 12 | TYR B 612ALA B 767ILE B 768GLN B 775ILE B 778VAL B 782ALA B 783PHE B 786LEU B 804MET B 816GLN B 817PHE B 820 | CIA B2003 |
| 1UHO_A_VDNA1000 | 1uho | VDN DB00862(Vardenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 10 | TYR A 612HIS A 613TYR A 664ALA A 783PHE A 786LEU A 804MET A 816GLN A 817GLY A 819PHE A 820 | VDN A1000 |
| 1XLX_A_CIOA101 | 1xlx | CIO DB03849(Cilomilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | PF00233(PDEase_I) | 12 | TYR A 233HIS A 234HIS A 278MET A 347LEU A 393ASN A 395THR A 407ILE A 410MET A 411SER A 442GLN A 443PHE A 446 | CIO A 101 |
| 1XLX_B_CIOB102 | 1xlx | CIO DB03849(Cilomilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | no annotation | 13 | TYR B 233HIS B 234HIS B 278MET B 347ASN B 395THR B 407ILE B 410MET B 411PHE B 414MET B 431SER B 442GLN B 443PHE B 446 | CIO B 102 |
| 1XMU_A_ROFA101 | 1xmu | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | PF00233(PDEase_I) | 17 | TYR A 233HIS A 234MET A 347ASP A 392LEU A 393ASN A 395PRO A 396TYR A 403TRP A 406THR A 407ILE A 410MET A 411PHE A 414MET A 431SER A 442GLN A 443PHE A 446 | ROF A 101 |
| 1XMU_B_ROFB102 | 1xmu | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | PF00233(PDEase_I) | 17 | TYR B 233HIS B 234MET B 347ASP B 392LEU B 393ASN B 395PRO B 396TYR B 403TRP B 406THR B 407ILE B 410MET B 411PHE B 414MET B 431SER B 442GLN B 443PHE B 446 | ROF B 102 |
| 1XOM_A_CIOA603 | 1xom | CIO DB03849(Cilomilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | PF00233(PDEase_I) | 14 | TYR A 159HIS A 160MET A 273ASP A 318LEU A 319ASN A 321THR A 333ILE A 336MET A 337PHE A 340MET A 357SER A 368GLN A 369PHE A 372 | CIO A 603 |
| 1XOM_B_CIOB601 | 1xom | CIO DB03849(Cilomilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | no annotation | 13 | TYR B 159HIS B 160MET B 273LEU B 319ASN B 321THR B 333ILE B 336MET B 337PHE B 340MET B 357SER B 368GLN B 369PHE B 372 | CIO B 601 |
| 1XOQ_A_ROFA502 | 1xoq | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | PF00233(PDEase_I) | 15 | TYR A 159HIS A 160MET A 273ASP A 318LEU A 319ASN A 321PRO A 322TYR A 329TRP A 332THR A 333ILE A 336MET A 357SER A 368GLN A 369PHE A 372 | ROF A 502 |
| 1XOQ_B_ROFB501 | 1xoq | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | None | 15 | TYR B 159HIS B 160MET B 273ASP B 318LEU B 319ASN B 321PRO B 322TYR B 329TRP B 332THR B 333ILE B 336MET B 357SER B 368GLN B 369PHE B 372 | ROF B 501 |
| 1XOS_A_VIAA1 | 1xos | VIA DB00203(Sildenafil) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | PF00233(PDEase_I) | 14 | TYR A 233HIS A 234MET A 347ASP A 392LEU A 393ASN A 395ILE A 410MET A 411PHE A 414SER A 429MET A 431GLN A 443PHE A 446ILE A 450 | VIA A 1 |
| 1XOT_A_VDNA101 | 1xot | VDN DB00862(Vardenafil) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | PF00233(PDEase_I) | 14 | TYR A 233HIS A 234MET A 347ASP A 392LEU A 393ASN A 395ILE A 410MET A 411SER A 429MET A 431SER A 442GLN A 443PHE A 446ILE A 450 | VDN A 101 |
| 1XOT_B_VDNB102 | 1xot | VDN DB00862(Vardenafil) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B | no annotation | 12 | TYR B 233HIS B 234MET B 347LEU B 393ASN B 395ILE B 410MET B 411SER B 429MET B 431SER B 442GLN B 443PHE B 446 | VDN B 102 |
| 1XOZ_A_CIAA501 | 1xoz | CIA DB00820(Tadalafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 12 | TYR A 612ALA A 767ILE A 768GLN A 775ILE A 778VAL A 782PHE A 786LEU A 804ILE A 813MET A 816GLN A 817PHE A 820 | CIA A 501 |
| 1XP0_A_VDNA201 | 1xp0 | VDN DB00862(Vardenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 10 | TYR A 612LEU A 765ALA A 767ILE A 768VAL A 782ALA A 783LEU A 804MET A 816GLN A 817PHE A 820 | VDN A 201 |
| 2H42_A_VIAA901 | 2h42 | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 11 | TYR A 612HIS A 613ASN A 661ALA A 767ILE A 768VAL A 782PHE A 786LEU A 804ILE A 813GLN A 817PHE A 820 | VIA A 901 |
| 2H42_B_VIAB902 | 2h42 | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | no annotation | 12 | TYR B 612HIS B 613ASN B 661ALA B 767ILE B 768VAL B 782ALA B 783LEU B 804ILE B 813MET B 816GLN B 817PHE B 820 | VIA B 902 |
| 2H42_C_VIAC903 | 2h42 | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | no annotation | 15 | TYR C 612ASN C 661ILE C 665LEU C 725LEU C 765ALA C 767ILE C 768VAL C 782ALA C 783PHE C 786LEU C 804ILE C 813MET C 816GLN C 817PHE C 820 | VIA C 903 |
| 2WEY_A_EV1A1771 | 2wey | EV1 DB01113(Papaverine) | Homo sapiens | CAMP ANDCAMP-INHIBITED CGMP3', 5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 12 | TYR A 524HIS A 525LEU A 635LEU A 675VAL A 678ILE A 692TYR A 693GLU A 695PHE A 696MET A 713GLN A 726PHE A 729 | EV1 A1771 |
| 2WEY_B_EV1B1771 | 2wey | EV1 DB01113(Papaverine) | Homo sapiens | CAMP ANDCAMP-INHIBITED CGMP3', 5'-CYCLICPHOSPHODIESTERASE | no annotation | 8 | LEU B 635VAL B 678ILE B 692TYR B 693PHE B 696MET B 713GLN B 726PHE B 729 | EV1 B1771 |
| 3B2R_A_VDNA1 | 3b2r | VDN DB00862(Vardenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | PF00233(PDEase_I) | 13 | TYR A 612HIS A 613CYS A 677ILE A 680LEU A 765ALA A 767ILE A 768VAL A 782PHE A 786ILE A 813MET A 816GLN A 817PHE A 820 | VDN A 1 |
| 3B2R_B_VDNB1 | 3b2r | VDN DB00862(Vardenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE | no annotation | 11 | TYR B 612HIS B 613ILE B 680LEU B 765ALA B 767ILE B 768VAL B 782ILE B 813MET B 816GLN B 817PHE B 820 | VDN B 1 |
| 3G4L_A_ROFA901 | 3g4l | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | PF00233(PDEase_I) | 15 | TYR A 325HIS A 326MET A 439ASP A 484LEU A 485ASN A 487PRO A 488TYR A 495TRP A 498THR A 499ILE A 502MET A 523SER A 534GLN A 535PHE A 538 | ROF A 901 |
| 3G4L_B_ROFB902 | 3g4l | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | None | 14 | TYR B 325HIS B 326MET B 439ASP B 484LEU B 485ASN B 487PRO B 488TRP B 498THR B 499ILE B 502MET B 503MET B 523GLN B 535PHE B 538 | ROF B 902 |
| 3G4L_C_ROFC903 | 3g4l | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | None | 15 | TYR C 325HIS C 326MET C 439ASP C 484LEU C 485ASN C 487PRO C 488TYR C 495TRP C 498THR C 499ILE C 502MET C 523SER C 534GLN C 535PHE C 538 | ROF C 903 |
| 3G4L_D_ROFD904 | 3g4l | ROF DB01656(Roflumilast) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | None | 15 | TYR D 325HIS D 326MET D 439ASP D 484LEU D 485ASN D 487PRO D 488TRP D 498THR D 499ILE D 502MET D 503MET D 523SER D 534GLN D 535PHE D 538 | ROF D 904 |
| 3IAK_A_EV1A415 | 3iak | EV1 DB01113(Papaverine) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D | PF00233(PDEase_I) | 9 | TYR A 159MET A 273ASN A 321ILE A 336PHE A 340MET A 357GLN A 369PHE A 372ILE A 376 | EV1 A 415 |
| 3JWQ_A_VIAA901 | 3jwq | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA | PF00233(PDEase_I) | 9 | TYR A 612HIS A 613LEU A 725VAL A 782MET A 804LEU A 813GLN A 817PHE A 820VAL A 824 | VIA A 901 |
| 3JWQ_B_VIAB901 | 3jwq | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA | no annotation | 11 | TYR B 612HIS B 613ASN B 661LEU B 725ALA B 767VAL B 782THR C 795MET B 804LEU B 813GLN B 817PHE B 820 | VIA B 901 |
| 3JWQ_C_VIAC901 | 3jwq | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA | no annotation | 7 | TYR C 612HIS C 613MET C 804LEU C 813GLN C 817PHE C 820VAL C 824 | VIA C 901 |
| 3JWQ_D_VIAD901 | 3jwq | VIA DB00203(Sildenafil) | Homo sapiens | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA | PF00233(PDEase_I)no annotation | 11 | TYR D 612HIS D 613LEU D 725ALA D 767PHE D 786ARG A 794GLN A 798MET D 804LEU D 813GLN D 817PHE D 820 | VIA D 901 |
| 3TVX_A_PNXA902 | 3tvx | PNX DB00806(Pentoxifylline) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4A | PF00233(PDEase_I) | 9 | TYR A 371LEU A 531ASN A 533PRO A 534THR A 545ILE A 548MET A 569GLN A 581PHE A 584 | PNX A 902 |
| 3TVX_B_PNXB902 | 3tvx | PNX DB00806(Pentoxifylline) | Homo sapiens | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4A | no annotation | 7 | TYR B 371ASN B 533ILE B 548PHE B 552MET B 569GLN B 581PHE B 584 | PNX B 902 |