DRUG BINDING INTERFACES MAPPED TO 'CHOLINESTERASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)| DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
|---|---|---|---|---|---|---|---|---|
| 1ACJ_A_THAA999 | 1acj | THA DB00382(Tacrine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 9 | TRP A 84GLY A 118GLU A 199PHE A 330TYR A 334TRP A 432ILE A 439HIS A 440GLY A 441 | THA A 999 |
| 1ACL_A_DMEA999 | 1acl | DME DB01245(Decamethonium) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 10 | TYR A 70TRP A 84TYR A 121GLU A 199SER A 200TRP A 279PHE A 330TYR A 334HIS A 440GLY A 441 | DME A 999 |
| 1AX9_A_EDRA999 | 1ax9 | EDR DB01010(Edrophonium) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 8 | TRP A 84GLY A 118TYR A 121GLU A 199SER A 200PHE A 330PHE A 331HIS A 440 | EDR A 999 |
| 1DX6_A_GNTA602 | 1dx6 | GNT DB00674(Galantamine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 13 | ASP A 72TRP A 84GLY A 117GLY A 118GLY A 119TYR A 121GLU A 199SER A 200TRP A 233PHE A 290PHE A 330PHE A 331HIS A 440 | GNT A 602 |
| 1EVE_A_E20A2001 | 1eve | E20 DB00843(Donepezil) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 10 | TRP A 84GLY A 118TYR A 121GLU A 199TRP A 279LEU A 282PHE A 330PHE A 331TYR A 334HIS A 440 | E20 A2001 |
| 1MAA_A_DMEA998 | 1maa | DME DB01245(Decamethonium) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 12 | TYR A 72ASP A 74TRP A 86GLY A 121TYR A 124GLU A 202SER A 203TRP A 286PHE A 297TYR A 337TYR A 341HIS A 447 | DME A 998 |
| 1MAA_B_DMEB996 | 1maa | DME DB01245(Decamethonium) | Mus musculus | ACETYLCHOLINESTERASE | no annotation | 6 | TRP B 86TYR B 124GLU B 202GLY D 261ILE B 294TYR B 341 | DME B 996 |
| 1MAA_C_DMEC997 | 1maa | DME DB01245(Decamethonium) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase)no annotation | 14 | TYR C 72TRP C 86GLY C 121TYR C 124TYR C 133GLU C 202SER C 203GLY A 261TRP C 286PHE C 297TYR C 337PHE C 338TYR C 341HIS C 447 | DME C 997 |
| 1MAA_D_DMED999 | 1maa | DME DB01245(Decamethonium) | Mus musculus | ACETYLCHOLINESTERASE | no annotation | 8 | TRP D 86GLY D 121TYR D 124GLU D 202SER D 203TRP D 286TYR D 341HIS D 447 | DME D 999 |
| 1QTI_A_GNTA600 | 1qti | GNT DB00674(Galantamine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 12 | ASP A 72TRP A 84GLY A 117GLY A 118GLY A 119TYR A 121GLU A 199SER A 200PHE A 288PHE A 290PHE A 331HIS A 440 | GNT A 600 |
| 1U65_A_CP0A1000 | 1u65 | CP0 DB00762(Irinotecan) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 11 | TYR A 70GLN A 74TRP A 84TYR A 121GLU A 199TRP A 279LEU A 282ASP A 285PHE A 330TYR A 334HIS A 440 | CP0 A1000 |
| 1W6R_A_GNTA1536 | 1w6r | GNT DB00674(Galantamine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 13 | ASP A 72TRP A 84GLY A 117GLY A 118GLY A 119TYR A 121GLU A 199SER A 200PHE A 288PHE A 290PHE A 330PHE A 331HIS A 440 | GNT A1536 |
| 1W76_A_GNTA1538 | 1w76 | GNT DB00674(Galantamine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 11 | ASP A 72TRP A 84GLY A 118GLY A 119TYR A 121GLU A 199SER A 200PHE A 290PHE A 330PHE A 331HIS A 440 | GNT A1538 |
| 1W76_B_GNTB1538 | 1w76 | GNT DB00674(Galantamine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | no annotation | 10 | ASP B 72TRP B 84GLY B 117GLY B 118TYR B 121GLU B 199SER B 200PHE B 290PHE B 331HIS B 440 | GNT B1538 |
| 2ACE_A_ACHA998 | 2ace | ACH DB03128(Acetylcholine) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 9 | GLY A 118GLY A 119SER A 200ALA A 201TRP A 233PHE A 288PHE A 290PHE A 330HIS A 440 | ACH A 998 |
| 2ACK_A_EDRA999 | 2ack | EDR DB01010(Edrophonium) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 7 | TRP A 84GLY A 118TYR A 121GLU A 199SER A 200PHE A 331HIS A 440 | EDR A 999 |
| 2HA2_A_SCKA901 | 2ha2 | SCK DB00202(Succinylcholine) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 8 | TYR A 72ASP A 74TRP A 86TYR A 124TRP A 286TYR A 337TYR A 341HIS A 447 | SCK A 901 |
| 2HA2_B_SCKB951 | 2ha2 | SCK DB00202(Succinylcholine) | Mus musculus | ACETYLCHOLINESTERASE | no annotation | 8 | TYR B 72ASP B 74TRP B 86TYR B 124TRP B 286TYR B 337TYR B 341HIS B 447 | SCK B 951 |
| 2HA4_A_ACHA545 | 2ha4 | ACH DB03128(Acetylcholine) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 4 | TYR A 72TYR A 124TRP A 286TYR A 341 | ACH A 545 |
| 2HA4_A_ACHA546 | 2ha4 | ACH DB03128(Acetylcholine) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 8 | TRP A 86TYR A 124TYR A 133GLU A 202TYR A 337PHE A 338HIS A 447GLY A 448 | ACH A 546 |
| 2HA4_A_ACTA544 | 2ha4 | ACT DB03166(Aceticacid) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 8 | GLY A 121GLY A 122ALA A 203ALA A 204TRP A 236PHE A 295PHE A 297HIS A 447 | ACT A 544 |
| 2HA4_B_ACHB602 | 2ha4 | ACH DB03128(Acetylcholine) | Mus musculus | ACETYLCHOLINESTERASE | None | 4 | TYR B 72TYR B 124TRP B 286TYR B 341 | ACH B 602 |
| 2HA4_B_ACHB603 | 2ha4 | ACH DB03128(Acetylcholine) | Mus musculus | ACETYLCHOLINESTERASE | None | 7 | TRP B 86TYR B 124TYR B 133GLU B 202TYR B 337HIS B 447GLY B 448 | ACH B 603 |
| 2HA4_B_ACTB601 | 2ha4 | ACT DB03166(Aceticacid) | Mus musculus | ACETYLCHOLINESTERASE | None | 7 | GLY B 121GLY B 122ALA B 203ALA B 204TRP B 236PHE B 297HIS B 447 | ACT B 601 |
| 2HA6_A_SCKA901 | 2ha6 | SCK DB00202(Succinylcholine) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 9 | TYR A 72ASP A 74TRP A 86TYR A 124GLU A 202ALA A 203TRP A 286TYR A 337TYR A 341 | SCK A 901 |
| 2HA6_A_SCKA902 | 2ha6 | SCK DB00202(Succinylcholine) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 10 | GLU A 81GLU A 84MET A 85ASN A 87ASP A 131THR A 436GLU A 452LEU A 457LEU A 463TYR A 465 | SCK A 902 |
| 2HA6_B_SCKB951 | 2ha6 | SCK DB00202(Succinylcholine) | Mus musculus | ACETYLCHOLINESTERASE | no annotation | 9 | TYR B 72TRP B 86TYR B 124TRP B 286TYR B 337PHE B 338TYR B 341HIS B 447GLY B 448 | SCK B 951 |
| 2HA6_B_SCKB952 | 2ha6 | SCK DB00202(Succinylcholine) | Mus musculus | ACETYLCHOLINESTERASE | no annotation | 10 | GLU B 81GLU B 84MET B 85ASN B 87ASP B 131THR B 436GLU B 452LEU B 457LEU B 463TYR B 465 | SCK B 952 |
| 2XUD_A_DMEA1544 | 2xud | DME DB01245(Decamethonium) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 6 | TYR A 72TRP A 86TYR A 124TRP A 286TYR A 341HIS A 447 | DME A1544 |
| 3O9M_A_BEZA999 | 3o9m | BEZ DB03793(BenzoicAcid) | Homo sapiens | CHOLINESTERASE | PF00135(COesterase) | 7 | GLY A 116GLY A 117SER A 198TRP A 231LEU A 286PHE A 398HIS A 438 | BEZ A 999 |
| 3O9M_B_BEZB999 | 3o9m | BEZ DB03793(BenzoicAcid) | Homo sapiens | CHOLINESTERASE | None | 6 | GLY B 116GLY B 117SER B 198TRP B 231LEU B 286HIS B 438 | BEZ B 999 |
| 4BDS_A_THAA701 | 4bds | THA DB00382(Tacrine) | Homo sapiens | CHOLINESTERASE | PF00135(COesterase) | 9 | TRP A 82GLU A 197SER A 198ALA A 328TYR A 332TRP A 430MET A 437HIS A 438GLY A 439 | THA A 701 |
| 4EY6_A_GNTA604 | 4ey6 | GNT DB00674(Galantamine) | Homo sapiens | ACETYLCHOLINESTERASE | PF00135(COesterase) | 14 | ASP A 74TRP A 86GLY A 120GLY A 121GLY A 122TYR A 124SER A 125GLU A 202SER A 203PHE A 295PHE A 297TYR A 337PHE A 338HIS A 447 | GNT A 604 |
| 4EY6_B_GNTB605 | 4ey6 | GNT DB00674(Galantamine) | Homo sapiens | ACETYLCHOLINESTERASE | no annotation | 12 | TRP B 86GLY B 120GLY B 121GLY B 122TYR B 124GLU B 202SER B 203PHE B 295PHE B 297TYR B 337PHE B 338HIS B 447 | GNT B 605 |
| 4EY7_A_E20A604 | 4ey7 | E20 DB00843(Donepezil) | Homo sapiens | ACETYLCHOLINESTERASE | PF00135(COesterase) | 11 | TYR A 72TRP A 86GLY A 121TYR A 124GLU A 202SER A 203TRP A 286TYR A 337TYR A 341HIS A 447GLY A 448 | E20 A 604 |
| 4EY7_B_E20B605 | 4ey7 | E20 DB00843(Donepezil) | Homo sapiens | ACETYLCHOLINESTERASE | no annotation | 11 | TYR B 72TRP B 86GLY B 121TYR B 124GLU B 202SER B 203TRP B 286TYR B 337TYR B 341HIS B 447GLY B 448 | E20 B 605 |
| 5E2I_A_DMEA605 | 5e2i | DME DB01245(Decamethonium) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 6 | TYR A 70ASP A 72TYR A 121TRP A 279PHE A 330TYR A 334 | DME A 605 |
| 5E4J_A_DMEA608 | 5e4j | DME DB01245(Decamethonium) | Tetronarcecalifornica | ACETYLCHOLINESTERASE | PF00135(COesterase) | 9 | TYR A 70TRP A 84TYR A 121GLU A 199TRP A 279PHE A 330TYR A 334HIS A 440GLY A 441 | DME A 608 |
| 5OV9_A_CVIA608 | 5ov9 | CVI DB00406(GentianViolet) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 7 | TYR A 72ASP A 74THR A 75LEU A 76THR A 83VAL A 340TYR A 341 | CVI A 608 |
| 5OV9_A_CVIA609 | 5ov9 | CVI DB00406(GentianViolet) | Mus musculus | ACETYLCHOLINESTERASE | PF00135(COesterase) | 6 | TYR A 72TYR A 124ASP A 283TRP A 286HIS A 287TYR A 341 | CVI A 609 |
| 5OV9_B_CVIB602 | 5ov9 | CVI DB00406(GentianViolet) | Mus musculus | ACETYLCHOLINESTERASE | None | 8 | TYR B 72ASP B 74THR B 75LEU B 76TYR B 77THR B 83VAL B 340TYR B 341 | CVI B 602 |
| 5OV9_B_CVIB603 | 5ov9 | CVI DB00406(GentianViolet) | Mus musculus | ACETYLCHOLINESTERASE | None | 7 | TYR B 72TYR B 124GLN B 279ASP B 283TRP B 286HIS B 287TYR B 341 | CVI B 603 |
| 6EP4_A_DMEA601 | 6ep4 | DME DB01245(Decamethonium) | Homo sapiens | CHOLINESTERASE | no annotation | 5 | TRP A 82TYR A 128GLU A 197TYR A 332HIS A 438 | DME A 601 |
| 6EQP_A_BUWA601 | 6eqp | BUW DB00392(Ethopropazine) | Homo sapiens | CHOLINESTERASE | no annotation | 8 | TRP A 82GLY A 117GLN A 119THR A 120SER A 198TRP A 231PHE A 329TYR A 332 | BUW A 601 |