DRUG BINDING INTERFACES MAPPED TO 'CATECHOL O-METHYLTRANSFERASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1VID_A_SAMA301 | 1vid | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 17 | MET A 40ASN A 41VAL A 42GLU A 64GLY A 66TYR A 68TYR A 71SER A 72GLU A 90MET A 91ASN A 92TYR A 95SER A 119GLN A 120ASP A 141HIS A 142TRP A 143 | SAM A 301 |
2CL5_A_SAMA1217 | 2cl5 | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 16 | MET A 40ASN A 41VAL A 42GLY A 66TYR A 68TYR A 71SER A 72GLU A 90MET A 91ASN A 92TYR A 95SER A 119GLN A 120ASP A 141HIS A 142TRP A 143 | SAM A1217 |
2CL5_B_SAMB1217 | 2cl5 | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | None | 18 | MET B 40ASN B 41VAL B 42GLU B 64GLY B 66TYR B 68TYR B 71SER B 72GLU B 90MET B 91ASN B 92TYR B 95SER B 119GLN B 120ASP B 141HIS B 142TRP B 143ARG B 146 | SAM B1217 |
2ZTH_A_SAMA305 | 2zth | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 15 | VAL A 42GLY A 66TYR A 68TYR A 71SER A 72GLU A 90MET A 91ASN A 92TYR A 95SER A 119GLN A 120ASP A 141HIS A 142TRP A 143ARG A 146 | SAM A 305 |
2ZVJ_A_SAMA301 | 2zvj | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 18 | MET A 40ASN A 41VAL A 42GLU A 64GLY A 66TYR A 68TYR A 71SER A 72GLU A 90MET A 91ASN A 92TYR A 95SER A 119GLN A 120ASP A 141HIS A 142TRP A 143ARG A 146 | SAM A 301 |
3A7E_A_SAMA216 | 3a7e | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 18 | MET A 40VAL A 42GLU A 64GLY A 66TYR A 68TYR A 71SER A 72ILE A 89GLU A 90ILE A 91ASN A 92CYS A 95SER A 119GLN A 120ASP A 141HIS A 142TRP A 143ARG A 146 | SAM A 216 |
3BWM_A_SAMA301 | 3bwm | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 15 | MET A 40ASN A 41VAL A 42GLY A 66TYR A 68TYR A 71SER A 72GLU A 90ILE A 91ASN A 92SER A 119GLN A 120ASP A 141HIS A 142TRP A 143 | SAM A 301 |
3S68_A_SAMA228 | 3s68 | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 22 | MET A 40ASN A 41VAL A 42GLU A 64GLY A 66TYR A 68TYR A 71SER A 72MET A 89GLU A 90MET A 91ASN A 92TYR A 95ALA A 118SER A 119GLN A 120PHE A 139ASP A 141HIS A 142TRP A 143LYS A 144ARG A 146 | SAM A 228 |
3S68_A_TCWA227 | 3s68 | TCW DB00323(Tolcapone) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 10 | TRP A 38MET A 40ASP A 141TRP A 143LYS A 144ASP A 169ASN A 170PRO A 174LEU A 198GLU A 199 | TCW A 227 |
4PYL_A_TCWA303 | 4pyl | TCW DB00323(Tolcapone) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 10 | TRP A 81MET A 83ASP A 184TRP A 186LYS A 187ASP A 212ASN A 213PRO A 217LEU A 241GLU A 242 | TCW A 303 |
4XUC_A_SAMA303 | 4xuc | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 16 | MET A 90ASN A 91VAL A 92GLU A 114GLY A 116TYR A 118TYR A 121SER A 122ILE A 139GLU A 140ILE A 141SER A 169GLN A 170ASP A 191HIS A 192TRP A 193 | SAM A 303 |
4XUD_A_SAMA303 | 4xud | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 15 | MET A 90VAL A 92GLU A 114GLY A 116TYR A 118TYR A 121SER A 122ILE A 139GLU A 140ILE A 141SER A 169GLN A 170ASP A 191HIS A 192TRP A 193 | SAM A 303 |
4XUE_A_SAMA303 | 4xue | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 17 | MET A 90ASN A 91VAL A 92GLY A 116TYR A 118TYR A 121SER A 122ILE A 139GLU A 140ILE A 141ASN A 142CYS A 145SER A 169GLN A 170ASP A 191HIS A 192TRP A 193 | SAM A 303 |
4XUE_B_SAMB303 | 4xue | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | None | 14 | MET B 90VAL B 92GLY B 116TYR B 118TYR B 121SER B 122GLU B 140ILE B 141ASN B 142SER B 169GLN B 170ASP B 191HIS B 192TRP B 193 | SAM B 303 |
5FHQ_A_SAMA301 | 5fhq | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 21 | MET A 40VAL A 42GLU A 64GLY A 66TYR A 68TYR A 71SER A 72MET A 89GLU A 90MET A 91ASN A 92TYR A 95ALA A 118SER A 119GLN A 120ASP A 141HIS A 142TRP A 143LYS A 144ARG A 146ASP A 150 | SAM A 301 |
5FHR_A_SAMA303 | 5fhr | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 17 | MET A 83ASN A 84VAL A 85GLU A 107GLY A 109TYR A 111TYR A 114SER A 115GLU A 133MET A 134ASN A 135TYR A 138SER A 162GLN A 163ASP A 184HIS A 185TRP A 186 | SAM A 303 |
5FHR_B_SAMB303 | 5fhr | SAM DB00118(S-Adenosylmethionine) | Rattus norvegicus | CATECHOLO-METHYLTRANSFERASE | None | 17 | MET B 83ASN B 84VAL B 85GLU B 107GLY B 109TYR B 111TYR B 114SER B 115GLU B 133MET B 134ASN B 135TYR B 138SER B 162GLN B 163ASP B 184HIS B 185TRP B 186 | SAM B 303 |
5LSA_A_SAMA303 | 5lsa | SAM DB00118(S-Adenosylmethionine) | Homo sapiens | CATECHOLO-METHYLTRANSFERASE | PF01596(Methyltransf_3) | 16 | MET A 90ASN A 91VAL A 92GLU A 114GLY A 116TYR A 118TYR A 121SER A 122GLU A 140ILE A 141SER A 169GLN A 170ASP A 191HIS A 192TRP A 193ARG A 196 | SAM A 303 |