DRUG BINDING INTERFACES MAPPED TO 'CARD'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1DTL_A_BEPA204 1dtl BEP

DB01244
(Bepridil) 		Gallus gallus CARDIAC TROPONIN C PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		11 PHE A  27
ILE A  36
LEU A  41
MET A  45
LEU A  48
MET A  60
VAL A  64
MET A  80
GLU A  96
LEU A  97
LEU A 100
 BEP A 204
1DTL_A_BEPA205 1dtl BEP

DB01244
(Bepridil) 		Gallus gallus CARDIAC TROPONIN C PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		12 ALA A  23
ILE A  26
PHE A  27
PHE A  77
MET A  81
LEU A 100
PHE A 104
LEU A 117
MET A 120
LEU A 136
PHE A 156
MET A 157
 BEP A 205
1DTL_A_BEPA206 1dtl BEP

DB01244
(Bepridil) 		Gallus gallus CARDIAC TROPONIN C PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		8 MET A  45
GLN A  50
PRO A  52
GLU A  56
GLU A  96
ASP A  99
ARG A 102
MET A 103
 BEP A 206
1LXF_C_BEPC92 1lxf BEP

DB01244
(Bepridil) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES;
TROPONIN I, CARDIAC
MUSCLE 		PF13833
(EF-hand_8)
no annotation 		17 PHE C  27
ILE C  36
LEU C  41
MET C  45
LEU C  48
MET C  60
ILE C  61
GLU C  63
VAL C  72
PHE C  77
MET C  80
MET C  81
CYS C  84
ARG I 147
ILE I 148
ALA I 152
MET I 153
 BEP C  92
1WRK_A_TFPA202 1wrk TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8)
no annotation 		10 GLU B  15
GLU B  19
ALA B  23
MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
MET A  81
 TFP A 202
1WRK_A_TFPA204 1wrk TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8)
no annotation 		9 PHE B  20
PHE A  20
PHE A  27
VAL A  44
LEU A  48
LEU B  48
PHE A  77
MET A  81
SER A  84
 TFP A 204
1WRK_B_TFPB201 1wrk TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8)
no annotation 		10 GLU A  15
GLU A  19
ALA A  23
MET B  45
LEU B  48
GLN B  50
MET B  60
MET B  80
MET B  81
SER B  84
 TFP B 201
1WRK_B_TFPB203 1wrk TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 5 PHE B  27
LEU B  48
PHE B  77
MET B  81
SER B  84
 TFP B 203
1WRL_A_TFPA202 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8)
no annotation 		9 GLU B  19
ALA B  23
MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
SER A  84
 TFP A 202
1WRL_A_TFPA204 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8)
no annotation 		7 PHE A  27
LEU A  48
PHE A  77
MET A  81
VAL A  82
SER A  84
MET B  85
 TFP A 204
1WRL_B_TFPB201 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8)
no annotation 		9 GLU A  15
GLU A  19
MET B  45
LEU B  48
GLN B  50
GLU B  56
MET B  60
MET B  80
MET B  81
 TFP B 201
1WRL_B_TFPB203 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 6 PHE B  27
VAL B  44
LEU B  48
PHE B  77
MET B  81
SER B  84
 TFP B 203
1WRL_C_TFPC206 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 9 GLU D  15
GLU D  19
MET C  45
LEU C  48
GLN C  50
GLU C  56
MET C  60
MET C  80
MET C  81
 TFP C 206
1WRL_C_TFPC208 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 5 PHE C  27
LEU C  48
PHE C  77
MET C  81
SER C  84
 TFP C 208
1WRL_D_TFPD205 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 10 GLU C  19
ALA C  23
MET D  45
LEU D  48
GLN D  50
GLU D  56
MET D  60
MET D  80
MET D  81
SER D  84
 TFP D 205
1WRL_D_TFPD207 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 8 LEU D  12
PHE D  20
PHE D  27
LEU D  48
PHE D  77
MET D  81
SER D  84
SER C  84
 TFP D 207
1WRL_E_TFPE210 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 9 GLU F  19
ALA F  23
MET E  45
LEU E  48
GLN E  50
GLU E  56
MET E  60
MET E  80
SER E  84
 TFP E 210
1WRL_E_TFPE212 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 7 PHE E  20
PHE E  27
LEU E  48
PHE E  77
MET E  81
SER E  84
MET E  85
 TFP E 212
1WRL_F_TFPF209 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 10 GLU E  15
GLU E  19
MET F  45
LEU F  48
GLN F  50
GLU F  56
MET F  60
MET F  80
MET F  81
SER F  84
 TFP F 209
1WRL_F_TFPF211 1wrl TFP

DB00831
(Trifluoperazine) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		no annotation 7 PHE F  20
PHE F  27
LEU F  48
LEU E  48
PHE F  77
MET F  81
SER F  84
 TFP F 211
3RV5_A_DXCA91 3rv5 DXC

DB03619
(Deoxycholic
Acid) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		PF13833
(EF-hand_8) 		3 PHE A  27
GLN A  50
PHE A  77
 DXC A  91
3RV5_A_DXCA92 3rv5 DXC

DB03619
(Deoxycholic
Acid) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		None
PF13833
(EF-hand_8) 		4 LYS A  17
PHE A  20
PHE A  24
VAL B  82
 DXC A  92
3RV5_B_DXCB92 3rv5 DXC

DB03619
(Deoxycholic
Acid) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		None
PF13833
(EF-hand_8) 		5 LYS B  17
LYS B  21
VAL A  79
VAL A  82
ARG A  83
 DXC B  92
3RV5_C_DXCC92 3rv5 DXC

DB03619
(Deoxycholic
Acid) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		None 4 VAL C   9
PHE C  20
PHE C  24
VAL D  82
 DXC C  92
3RV5_D_DXCD92 3rv5 DXC

DB03619
(Deoxycholic
Acid) 		Homo sapiens TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES 		None 5 GLU D  10
LYS D  17
LYS D  21
PHE D  24
VAL C  82
 DXC D  92