DRUG BINDING INTERFACES MAPPED TO 'AMYLASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1AGM_A_ACRA495 | 1agm | ACR DB00284(Acarbose) | Aspergillusawamori | GLUCOAMYLASE-471 | PF00723(Glyco_hydro_15) | 16 | ALA A 39TYR A 48TRP A 52ARG A 54ASP A 55TRP A 120GLY A 121TRP A 178GLU A 179GLU A 180ARG A 305TYR A 311TRP A 317GLU A 400LEU A 415TRP A 417 | ACR A 495 |
1AGM_A_ACRA496 | 1agm | ACR DB00284(Acarbose) | Aspergillusawamori | GLUCOAMYLASE-471 | PF00723(Glyco_hydro_15) | 17 | ALA A 39TYR A 48TRP A 52ARG A 54ASP A 55SER A 119TRP A 120GLY A 121TRP A 178GLU A 179GLU A 180ARG A 305TYR A 311TRP A 317GLU A 400LEU A 415TRP A 417 | ACR A 496 |
1GAH_A_ACRA497 | 1gah | ACR DB00284(Acarbose) | Aspergillusawamori | GLUCOAMYLASE-471 | PF00723(Glyco_hydro_15) | 18 | ALA A 39TYR A 48TRP A 52ARG A 54ASP A 55SER A 119TRP A 120GLY A 121TYR A 175TRP A 178GLU A 179GLU A 180ARG A 305TYR A 311TRP A 317GLU A 400LEU A 415TRP A 417 | ACR A 497 |
1KXH_A_ACRA598 | 1kxh | ACR DB00284(Acarbose) | Pseudoalteromonashaloplanktis | ALPHA-AMYLASE | PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 15 | TRP A 46TRP A 47TYR A 50GLN A 51HIS A 89ALA A 92VAL A 140GLY A 141LEU A 142ASN A 174ALA A 175GLU A 200ILE A 202ASP A 264HIS A 269 | ACR A 598 |
1LF9_A_ACRA700 | 1lf9 | ACR DB00284(Acarbose) | Thermoanaerobacteriumthermosaccharolyticum | GLUCOAMYLASE | PF00723(Glyco_hydro_15)PF09137(Glucodextran_N)no annotation | 18 | ALA A 319TYR A 337TRP A 341ARG A 343ASP A 344GLN A 380TRP A 390TRP A 437GLU A 438GLU A 439LEU B 508SER B 509ASN A 521ARG A 575TYR A 581TRP A 599LEU A 652TRP A 654 | ACR A 700 |
1LF9_B_ACRB701 | 1lf9 | ACR DB00284(Acarbose) | Thermoanaerobacteriumthermosaccharolyticum | GLUCOAMYLASE | PF00723(Glyco_hydro_15)PF09137(Glucodextran_N)no annotation | 18 | ALA B 319TYR B 337TRP B 341ARG B 343ASP B 344GLN B 380TRP B 390TRP B 437GLU B 438GLU B 439LEU A 508SER A 509ASN B 521ARG B 575TYR B 581TRP B 599LEU B 652TRP B 654 | ACR B 701 |
1MXD_A_ACRA732 | 1mxd | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 9 | GLY A 9LYS A 241PRO A 278GLU A 307GLY A 308GLY A 338GLY A 339ASP A 358ARG A 361 | ACR A 732 |
1MXD_A_ACRA733 | 1mxd | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 6 | SER A 132THR A 140ASN A 142LEU A 144ASP A 145TRP A 171 | ACR A 733 |
1MXD_A_ACRA734 | 1mxd | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 6 | ASN A 328TRP A 331HIS A 390TYR A 392GLY A 394TRP A 399 | ACR A 734 |
1MXD_A_ACRA735 | 1mxd | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 12 | TRP A 18TYR A 62HIS A 111PHE A 159ARG A 196ASP A 198TYR A 199LYS A 201GLU A 222TRP A 224HIS A 288ASP A 289 | ACR A 735 |
1MXG_A_ACRA442 | 1mxg | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 11 | GLY A 9LYS A 241PRO A 278PHE A 279GLU A 307GLY A 308GLN A 309GLY A 338GLY A 339ASP A 358ARG A 361 | ACR A 442 |
1MXG_A_ACRA443 | 1mxg | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 8 | SER A 132THR A 140ASN A 142LEU A 144ASP A 145GLU A 150LYS A 169TRP A 171 | ACR A 443 |
1MXG_A_ACRA444 | 1mxg | ACR DB00284(Acarbose) | Pyrococcus woesei | ALPHA AMYLASE | PF00128(Alpha-amylase)PF09154(DUF1939) | 7 | TYR A 3ASN A 328TRP A 331HIS A 390TYR A 392GLY A 394TRP A 399 | ACR A 444 |
2F6D_A_ACRA995 | 2f6d | ACR DB00284(Acarbose) | Saccharomycopsisfibuligera | GLUCOAMYLASE GLU1 | PF00723(Glyco_hydro_15) | 16 | ALA A 54TYR A 63TRP A 67ARG A 69ASP A 70TRP A 139GLY A 140TRP A 209GLU A 210GLU A 211ARG A 345TYR A 351TRP A 362GLU A 456LEU A 471TRP A 473 | ACR A 995 |
2F6D_A_ACRA996 | 2f6d | ACR DB00284(Acarbose) | Saccharomycopsisfibuligera | GLUCOAMYLASE GLU1 | PF00723(Glyco_hydro_15) | 7 | ARG A 15HIS A 447ASN A 449ASP A 450THR A 462GLY A 463TYR A 464 | ACR A 996 |
2QMJ_A_ACRA1001 | 2qmj | ACR DB00284(Acarbose) | Homo sapiens | MALTASE-GLUCOAMYLASE, INTESTINAL | PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 18 | ASP A 203THR A 205ASN A 207TYR A 299ASP A 327ILE A 328ILE A 364TRP A 406TRP A 441ASP A 443MET A 444ARG A 526TRP A 539ASP A 542THR A 544PHE A 575ALA A 576HIS A 600 | ACR A1001 |
2QPU_B_QPSB3000 | 2qpu | QPS DB00284(Acarbose) | Hordeum vulgare | ALPHA-AMYLASE TYPE AISOZYME | no annotation | 9 | LYS B 375TYR B 380ASP B 381VAL B 382THR B 392HIS B 395ASP B 398ALA B 400TRP B 402 | QPS B3000 |
2XFF_A_QPSA600 | 2xff | QPS DB00284(Acarbose) | Hordeum vulgare | BETA-AMYLASE | PF01373(Glyco_hydro_14) | 16 | ALA A 182GLU A 184ARG A 186TYR A 190GLN A 192TRP A 196PHE A 198LYS A 293SER A 295GLY A 296HIS A 298TRP A 299THR A 340MET A 344LEU A 381PRO A 382 | QPS A 600 |
3BC9_A_ACRA901 | 3bc9 | ACR DB00284(Acarbose) | Halothermothrixorenii | ALPHA AMYLASE,CATALYTIC REGION | PF00128(Alpha-amylase)PF09154(DUF1939) | 7 | ASP A 449SER A 458SER A 461LYS A 463TRP A 488GLU A 588ASP A 589 | ACR A 901 |
3K8M_A_ACRA720 | 3k8m | ACR DB00284(Acarbose) | Bacteroidesthetaiotaomicron | ALPHA-AMYLASE, SUSG | PF00128(Alpha-amylase) | 7 | TYR A 260GLU A 263TRP A 287LEU A 290TRP A 299LYS A 304ASN A 330 | ACR A 720 |
3K8M_A_ACRA730 | 3k8m | ACR DB00284(Acarbose) | Bacteroidesthetaiotaomicron | ALPHA-AMYLASE, SUSG | PF00128(Alpha-amylase) | 5 | ARG A 457TRP A 460TYR A 469LYS A 472ASP A 473 | ACR A 730 |
3K8M_B_ACRB820 | 3k8m | ACR DB00284(Acarbose) | Bacteroidesthetaiotaomicron | ALPHA-AMYLASE, SUSG | no annotation | 7 | TYR B 260GLU B 263TRP B 287LEU B 290TRP B 299LYS B 304ASN B 330 | ACR B 820 |
3K8M_B_ACRB830 | 3k8m | ACR DB00284(Acarbose) | Bacteroidesthetaiotaomicron | ALPHA-AMYLASE, SUSG | no annotation | 5 | ARG B 457TRP B 460TYR B 469LYS B 472ASP B 473 | ACR B 830 |
3L4W_A_MIGA1001 | 3l4w | MIG DB00491(Miglitol) | Homo sapiens | MALTASE-GLUCOAMYLASE, INTESTINAL | PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 13 | TYR A 299ASP A 327ILE A 328ILE A 364TRP A 406TRP A 441ASP A 443MET A 444ARG A 526TRP A 539ASP A 542PHE A 575HIS A 600 | MIG A1001 |
3TOP_A_ACRA1 | 3top | ACR DB00284(Acarbose) | Homo sapiens | MALTASE-GLUCOAMYLASE, INTESTINAL | PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 17 | ASP A1157PRO A1159ASP A1279ILE A1280ILE A1315TRP A1355TRP A1418ASP A1420MET A1421LYS A1460ARG A1510TRP A1523ASP A1526THR A1528PHE A1559PHE A1560HIS A1584 | ACR A 1 |
3TOP_B_ACRB1 | 3top | ACR DB00284(Acarbose) | Homo sapiens | MALTASE-GLUCOAMYLASE, INTESTINAL | no annotation | 17 | ASP B1157PRO B1159LYS B1164ASP B1279ILE B1280ILE B1315TRP B1355TRP B1418ASP B1420MET B1421LYS B1460ARG B1510TRP B1523ASP B1526PHE B1559PHE B1560HIS B1584 | ACR B 1 |
3ZOA_A_ACRA1587 | 3zoa | ACR DB00284(Acarbose) | Mycolicibacteriumsmegmatis | TREHALOSESYNTHASE/AMYLASETRES | PF00128(Alpha-amylase)PF16657(Malt_amylase_C)no annotation | 13 | TRP A 476ASN A 479MET A 480ARG B 534PHE B 535PRO B 536GLU A 553MET A 554THR A 555TYR A 557PHE A 577TYR A 578TRP A 579 | ACR A1587 |
6AG0_A_ACRA605 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | PF00128(DUF1939)PF09154(Alpha-amylase) | 8 | TYR A 159GLY A 180ILE A 181LYS A 183ASP A 205ASP A 207HIS A 208PRO A 209 | ACR A 605 |
6AG0_A_ACRA606 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | PF00128(DUF1939)PF09154(Alpha-amylase) | 7 | GLY A 302GLY A 303TRP A 345GLY A 431PRO A 432GLY A 474GLY A 475 | ACR A 606 |
6AG0_A_ACRA607 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | PF00128(DUF1939)PF09154(Alpha-amylase) | 4 | ARG A 456SER A 457ASP A 458ASN A 473 | ACR A 607 |
6AG0_A_ACRA608 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | PF00128(DUF1939)PF09154(Alpha-amylase) | 6 | PHE A 4GLY A 6THR A 39GLN A 97TYR A 99TYR A 361 | ACR A 608 |
6AG0_A_ACRA609 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | PF00128(DUF1939)PF09154(Alpha-amylase) | 7 | LYS A 71GLY A 109TRP A 139ASP A 165TRP A 166MET A 200TYR A 201 | ACR A 609 |
6AG0_A_ACRA610 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | PF00128(DUF1939)PF09154(Alpha-amylase) | 14 | TRP A 14TYR A 57HIS A 106GLU A 192TYR A 196LEU A 199MET A 200ASP A 234LYS A 237HIS A 238TYR A 268HIS A 330ASP A 331LEU A 338 | ACR A 610 |
6AG0_C_ACRC605 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | None | 8 | TYR C 159GLY C 180ILE C 181LYS C 183ASP C 205ASP C 207HIS C 208PRO C 209 | ACR C 605 |
6AG0_C_ACRC606 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | None | 6 | PHE C 4GLY C 6THR C 39GLN C 97TYR C 99TYR C 361 | ACR C 606 |
6AG0_C_ACRC607 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | None | 6 | GLY C 302ASP C 343TRP C 345GLY C 431PRO C 432GLY C 475 | ACR C 607 |
6AG0_C_ACRC608 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | None | 15 | TRP C 14TYR C 57GLU C 192TYR C 196LEU C 199MET C 200ASP C 234LYS C 237HIS C 238TYR C 268HIS C 330ASP C 331GLN C 336ALA C 337LEU C 338 | ACR C 608 |
6AG0_C_ACRC609 | 6ag0 | ACR DB00284(Acarbose) | Geobacillusstearothermophilus | ALPHA-AMYLASE | None | 7 | LYS C 71GLY C 109TRP C 139ASP C 165TRP C 166MET C 200TYR C 201 | ACR C 609 |
6FHW_A_ACRA801 | 6fhw | ACR DB00284(Acarbose) | Amorphothecaresinae | GLUCOAMYLASE P | no annotation | 15 | ALA A 67TYR A 76TRP A 80ARG A 82ASP A 83TRP A 149GLY A 150TRP A 207GLU A 208GLU A 209ARG A 335TYR A 341TRP A 347GLU A 432TRP A 449 | ACR A 801 |
6FHW_B_ACRB801 | 6fhw | ACR DB00284(Acarbose) | Amorphothecaresinae | GLUCOAMYLASE P | no annotation | 16 | ALA B 67TYR B 76TRP B 80ARG B 82ASP B 83TRP B 149GLY B 150TRP B 207GLU B 208GLU B 209ARG B 335TYR B 341TRP B 347GLU B 432LEU B 447TRP B 449 | ACR B 801 |