DRUG BINDING INTERFACES MAPPED TO 'ALPHA-GLUCOSIDASE'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
2ZQ0_A_ACRA801 | 2zq0 | ACR DB00284(Acarbose) | Bacteroidesthetaiotaomicron | ALPHA-GLUCOSIDASE(ALPHA-GLUCOSIDASESUSB) | PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 21 | GLU A 194ASN A 216SER A 217TRP A 331ILE A 335TRP A 341GLU A 391TRP A 397TRP A 400PHE A 401HIS A 437GLU A 439LYS A 467VAL A 471HIS A 507GLU A 508GLU A 526GLU A 532TYR A 533PHE A 536GLY A 537 | ACR A 801 |
2ZQ0_B_ACRB811 | 2zq0 | ACR DB00284(Acarbose) | Bacteroidesthetaiotaomicron | ALPHA-GLUCOSIDASE(ALPHA-GLUCOSIDASESUSB) | no annotation | 21 | GLU B 194ASN B 216SER B 217TRP B 331ILE B 335TRP B 341GLU B 391TRP B 397TRP B 400PHE B 401HIS B 437GLU B 439LYS B 467VAL B 471HIS B 507GLU B 508GLU B 526GLU B 532TYR B 533PHE B 536GLY B 537 | ACR B 811 |
3PHA_A_ACRA701 | 3pha | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)no annotation | 18 | ASP A 73PRO A 75ILE A 76TYR A 169ASP A 197ILE A 198ILE A 234TRP A 271TRP A 305ASP A 307MET A 308LYS B 348ARG A 404TRP A 417ASP A 420LYS A 422PHE A 453HIS A 478 | ACR A 701 |
3PHA_B_ACRB701 | 3pha | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)no annotation | 18 | ASP B 73PRO B 75ILE B 76TYR B 169ASP B 197ILE B 198ILE B 234TRP B 271TRP B 305ASP B 307MET B 308TRP A 341ARG B 404TRP B 417ASP B 420LYS B 422PHE B 453HIS B 478 | ACR B 701 |
3PHA_C_ACRC701 | 3pha | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | no annotation | 18 | ASP C 73PRO C 75ILE C 76TYR C 169ASP C 197ILE C 198TRP C 271TRP C 305ASP C 307MET C 308TRP D 341LYS D 348ARG C 404TRP C 417ASP C 420LYS C 422PHE C 453HIS C 478 | ACR C 701 |
3PHA_D_ACRD701 | 3pha | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | no annotation | 18 | ASP D 73PRO D 75ILE D 76TYR D 169ASP D 197ILE D 198TRP D 271TRP D 305ASP D 307MET D 308TRP C 341LYS C 348ARG D 404TRP D 417ASP D 420LYS D 422PHE D 453HIS D 478 | ACR D 701 |
3POC_A_ACRA664 | 3poc | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)no annotation | 13 | TRP A 169ASP A 197ILE A 198ILE A 234TRP A 271TRP A 305MET A 308TRP B 341ARG A 404TRP A 417ASP A 420PHE A 453HIS A 478 | ACR A 664 |
3POC_B_ACRB664 | 3poc | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | no annotation | 12 | TRP B 169ASP B 197ILE B 198ILE B 234TRP B 271TRP B 305MET B 308ARG B 404TRP B 417ASP B 420PHE B 453HIS B 478 | ACR B 664 |
3POC_B_ACRB665 | 3poc | ACR DB00284(Acarbose) | Blautia obeum | ALPHA-GLUCOSIDASE | no annotation | 6 | GLU B 396LYS B 650ASP B 651TYR B 652ASP B 653LYS B 654 | ACR B 665 |
3W37_A_ACRA1001 | 3w37 | ACR DB00284(Acarbose) | Beta vulgaris | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 17 | ASP A 232ALA A 234PHE A 236ASN A 237TRP A 329ASP A 357ILE A 358ILE A 396TRP A 432TRP A 467ASP A 469MET A 470ARG A 552TRP A 565ASP A 568PHE A 601HIS A 626 | ACR A1001 |
3WEL_A_ACRA1001 | 3wel | ACR DB00284(Acarbose) | Beta vulgaris | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 18 | ASP A 232ILE A 233ALA A 234PHE A 236ASN A 237TRP A 329ASP A 357ILE A 358ILE A 396TRP A 432TRP A 467ASP A 469MET A 470ARG A 552TRP A 565ASP A 568PHE A 601HIS A 626 | ACR A1001 |
3WEM_A_ACRA1001 | 3wem | ACR DB00284(Acarbose) | Beta vulgaris | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 17 | ASP A 232ILE A 233ALA A 234PHE A 236ASN A 237TRP A 329ASP A 357ILE A 358TRP A 432TRP A 467ASP A 469MET A 470ARG A 552TRP A 565ASP A 568PHE A 601HIS A 626 | ACR A1001 |
3WEN_A_ACRA1001 | 3wen | ACR DB00284(Acarbose) | Beta vulgaris | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 16 | ASP A 232ILE A 233ALA A 234ASN A 237TRP A 329ASP A 357ILE A 358TRP A 432TRP A 467ASP A 469MET A 470ARG A 552TRP A 565ASP A 568PHE A 601HIS A 626 | ACR A1001 |
3WEO_A_ACRA1001 | 3weo | ACR DB00284(Acarbose) | Beta vulgaris | ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 18 | ASP A 232ILE A 233ALA A 234PHE A 236ASN A 237TRP A 329ASP A 357ILE A 358ILE A 396TRP A 432TRP A 467ASP A 469MET A 470ARG A 552TRP A 565ASP A 568PHE A 601HIS A 626 | ACR A1001 |
3WFA_A_EDTA802 | 3wfa | EDT DB00974(EdeticAcid) | Bacteroidesthetaiotaomicron | ALPHA-GLUCOSIDASE | NonePF10566(GH97_N)PF14508(GH97_C)PF14509(Glyco_hydro_97) | 5 | TYR B 407ARG B 449ASN A 488TYR A 492LYS A 495 | EDT A 802 |
3WFA_B_EDTB802 | 3wfa | EDT DB00974(EdeticAcid) | Bacteroidesthetaiotaomicron | ALPHA-GLUCOSIDASE | NonePF10566(GH97_N)PF14508(GH97_C)PF14509(Glyco_hydro_97) | 6 | ASP B 250TYR A 407ARG A 449ASN B 488TYR B 492LYS B 495 | EDT B 802 |
4B9Z_A_ACRA1818 | 4b9z | ACR DB00284(Acarbose) | Cellvibriojaponicus | ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF17137(DUF5110) | 17 | TYR A 179PHE A 271ASP A 299LEU A 300ILE A 341TYR A 376PHE A 377TRP A 410ASP A 412LEU A 413GLU A 417ARG A 463TRP A 477ASP A 480PHE A 513HIS A 540GLN A 542 | ACR A1818 |
5HQA_A_ACRA705 | 5hqa | ACR DB00284(Acarbose) | Pseudoalteromonassp. K8 | ALPHA-GLUCOSIDASE | PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 20 | ASN A 170ARG A 171GLU A 173TRP A 289HIS A 293TRP A 299GLU A 330TRP A 336TRP A 340PHE A 341HIS A 375GLU A 377LYS A 405VAL A 409HIS A 455GLU A 456GLU A 474GLU A 480TRP A 484THR A 486 | ACR A 705 |
5IEF_A_NBVA1005 | 5ief | NBV DB00419(Miglustat) | Mus musculus | NEUTRALALPHA-GLUCOSIDASE AB | PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 16 | TRP A 423ASP A 451ILE A 452ILE A 488TRP A 525TRP A 562ASP A 564MET A 565PHE A 571ARG A 624TRP A 637ASP A 640ASP A 669PHE A 673ARG A 696HIS A 698 | NBV A1005 |
5NN4_A_SC2A1016 | 5nn4 | SC2 DB06151(Acetylcysteine) | Homo sapiens | LYSOSOMALALPHA-GLUCOSIDASE | no annotation | 4 | HIS A 432GLY A 435ARG A 437THR A 834 | SC2 A1016 |
5NN6_A_MIGA1013 | 5nn6 | MIG DB00491(Miglitol) | Homo sapiens | LYSOSOMALALPHA-GLUCOSIDASE | no annotation | 13 | TRP A 376ASP A 404LEU A 405ILE A 441TRP A 481TRP A 516ASP A 518MET A 519ARG A 600TRP A 613ASP A 616PHE A 649HIS A 674 | MIG A1013 |
5NN8_A_ACRA1015 | 5nn8 | ACR DB00284(Acarbose) | Homo sapiens | LYSOSOMALALPHA-GLUCOSIDASE | no annotation | 16 | ASP A 282TRP A 376ASP A 404LEU A 405ILE A 441TRP A 481TRP A 516ASP A 518MET A 519ARG A 600TRP A 613ASP A 616TRP A 618PHE A 649LEU A 650HIS A 674 | ACR A1015 |
5NN8_A_ACRA1016 | 5nn8 | ACR DB00284(Acarbose) | Homo sapiens | LYSOSOMALALPHA-GLUCOSIDASE | no annotation | 5 | ASP A 91GLY A 123PRO A 125TRP A 126CYS A 127 | ACR A1016 |
5X7P_A_ACRA1401 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110)no annotation | 19 | GLN B 174GLN B 194TRP B 284ASP B 311TYR B 312ILE B 354LYS B 356TRP A 427ASP A 429GLU A 430GLY B 437SER B 438ARG A 474TRP A 488ASP A 491TRP A 504PHE A 533ASN A 534HIS A 565 | ACR A1401 |
5X7P_A_ACRA1421 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | MET A 35TYR A 218TYR A 230GLY A 232GLY A 233 | ACR A1421 |
5X7P_A_ACRA1431 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 7 | ASN A 875HIS A 876ASP A 886ASP A 889TRP A 943GLY A 975ASN A 977 | ACR A1431 |
5X7P_A_ACRA1471 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 13 | ARG A 362ARG A 368TYR A 373ASP A1160LEU A1165GLU A1169ARG A1177TYR A1179HIS A1181LYS A1212ASN A1213THR A1269HIS A1271 | ACR A1471 |
5X7P_A_ACRA1481 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 6 | TRP A1148SER A1189HIS A1191ARG A1220GLU A1222TYR A1261 | ACR A1481 |
5X7P_B_ACRB1401 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110)no annotation | 20 | GLN A 174GLN A 194TRP A 284ASP A 311TYR A 312ILE A 354LYS A 356TYR B 391TRP B 427ASP B 429GLU B 430GLY A 437SER A 438ARG B 474TRP B 488ASP B 491TRP B 504PHE B 533ASN B 534HIS B 565 | ACR B1401 |
5X7P_B_ACRB1421 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | no annotation | 6 | MET B 35TYR B 218GLU B 228TYR B 230GLY B 232GLY B 233 | ACR B1421 |
5X7P_B_ACRB1431 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | no annotation | 5 | HIS B 876ASP B 889TRP B 943GLY B 975ASN B 977 | ACR B1431 |
5X7P_B_ACRB1471 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | no annotation | 13 | ARG B 362ARG B 368ASP B1160GLY B1162LEU B1165GLU B1169ARG B1177TYR B1179HIS B1181LYS B1212ASN B1213THR B1269HIS B1271 | ACR B1471 |
5X7P_B_ACRB1481 | 5x7p | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | no annotation | 6 | TRP B1148SER B1189HIS B1191ARG B1220GLU B1222TYR B1261 | ACR B1481 |
5X7Q_A_ACRA1481 | 5x7q | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 6 | TRP A1148SER A1189HIS A1191ARG A1220GLU A1222TYR A1261 | ACR A1481 |
5X7Q_B_ACRB1481 | 5x7q | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | no annotation | 6 | TRP B1148SER B1189HIS B1191ARG B1220GLU B1222TYR B1261 | ACR B1481 |
5X7R_A_ACRA1481 | 5x7r | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 6 | TRP A1148SER A1189HIS A1191ARG A1220GLU A1222TYR A1261 | ACR A1481 |
5X7R_B_ACRB1481 | 5x7r | ACR DB00284(Acarbose) | Paenibacillus sp.598K | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE | no annotation | 6 | TRP B1148SER B1189HIS B1191ARG B1220GLU B1222TYR B1261 | ACR B1481 |