DRUG BINDING INTERFACES MAPPED TO 'ALPHA-1'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
2X2I_A_QPSA1050 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | PF01055(Glyco_hydro_31) | 18 | ASP A 239LEU A 241GLN A 245PHE A 373ASP A 412VAL A 413ASN A 459TYR A 513TRP A 551ASP A 553MET A 554ARG A 649TRP A 662ASP A 665PHE A 698THR A 699HIS A 731HIS A 741 | QPS A1050 |
2X2I_A_QPSA1060 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | PF01055(Glyco_hydro_31) | 12 | THR A 24VAL A 28PHE A 33SER A 34SER A 37THR A 39ASN A 40TRP A 41VAL A 185GLY A 190ALA A 192GLN A 318 | QPS A1060 |
2X2I_B_QPSB1050 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | no annotation | 18 | ASP B 239LEU B 241GLN B 245PHE B 373ASP B 412VAL B 413ASN B 459TYR B 513TRP B 551ASP B 553MET B 554ARG B 649TRP B 662ASP B 665PHE B 698THR B 699HIS B 731HIS B 741 | QPS B1050 |
2X2I_B_QPSB1060 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | no annotation | 10 | THR B 24VAL B 28PHE B 33SER B 34SER B 37ASN B 40TRP B 41GLY B 190ALA B 192GLN B 318 | QPS B1060 |
2X2I_C_QPSC1050 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | no annotation | 17 | ASP C 239LEU C 241GLN C 245PHE C 373ASP C 412VAL C 413ASN C 459TYR C 513TRP C 551ASP C 553MET C 554ARG C 649TRP C 662ASP C 665PHE C 698HIS C 731HIS C 741 | QPS C1050 |
2X2I_C_QPSC1060 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | no annotation | 12 | THR C 24VAL C 28PHE C 33SER C 34SER C 37THR C 39ASN C 40TRP C 41VAL C 185GLY C 190ALA C 192GLN C 318 | QPS C1060 |
2X2I_D_QPSD1050 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | no annotation | 17 | ASP D 239LEU D 241GLN D 245PHE D 373ASP D 412VAL D 413ASN D 459TYR D 513TRP D 551ASP D 553MET D 554ARG D 649TRP D 662ASP D 665PHE D 698HIS D 731HIS D 741 | QPS D1050 |
2X2I_D_QPSD1060 | 2x2i | QPS DB00284(Acarbose) | Gracilariopsislemaneiformis | ALPHA-1,4-GLUCANLYASE ISOZYME 1 | no annotation | 10 | THR D 24VAL D 28PHE D 33SER D 34SER D 37ASN D 40TRP D 41VAL D 185GLY D 190GLN D 318 | QPS D1060 |
3APV_A_TP0A190 | 3apv | TP0 DB00321(Amitriptyline) | Homo sapiens | ALPHA-1-ACIDGLYCOPROTEIN 2 | PF00061(Lipocalin) | 12 | TYR A 37VAL A 41PHE A 49PHE A 51LEU A 62GLU A 64ARG A 90HIS A 97ALA A 99SER A 114SER A 125TYR A 127 | TP0 A 190 |
3APV_B_TP0B190 | 3apv | TP0 DB00321(Amitriptyline) | Homo sapiens | ALPHA-1-ACIDGLYCOPROTEIN 2 | no annotation | 12 | PHE B 32TYR B 37VAL B 41PHE B 49PHE B 51LEU B 62GLU B 64ARG B 90HIS B 97ALA B 99SER B 125TYR B 127 | TP0 B 190 |
3APW_A_DP0A190 | 3apw | DP0 DB00280(Disopyramide) | Homo sapiens | ALPHA-1-ACIDGLYCOPROTEIN 2 | PF00061(Lipocalin) | 16 | TYR A 27PHE A 32TYR A 37VAL A 41ILE A 44PHE A 49PHE A 51GLU A 64VAL A 88ARG A 90HIS A 97ALA A 99PHE A 112SER A 114SER A 125TYR A 127 | DP0 A 190 |
3APW_B_DP0B190 | 3apw | DP0 DB00280(Disopyramide) | Homo sapiens | ALPHA-1-ACIDGLYCOPROTEIN 2 | no annotation | 14 | VAL B 41ILE B 44PHE B 49PHE B 51LEU B 62GLU B 64GLN B 66VAL B 88ARG B 90HIS B 97ALA B 99PHE B 112SER B 125TYR B 127 | DP0 B 190 |
3APX_A_Z80A190 | 3apx | Z80 DB00477(Chlorpromazine) | Homo sapiens | ALPHA-1-ACIDGLYCOPROTEIN 2 | PF00061(Lipocalin) | 14 | PHE A 32VAL A 41THR A 47PHE A 49PHE A 51GLU A 64LEU A 79VAL A 88ARG A 90GLU A 92HIS A 97ALA A 99PHE A 112TYR A 127 | Z80 A 190 |
3E22_B_LOCB700 | 3e22 | LOC DB01394(Colchicine) | Bos taurus | TUBULIN ALPHA-1CCHAIN;TUBULIN BETA-2BCHAIN | PF00091(Tubulin)PF03953(Tubulin_C) | 14 | SER A 178ALA A 180VAL A 181CYS B 241LEU B 242LEU B 248ALA B 250LYS B 254LEU B 255ASN B 258MET B 259ALA B 316VAL B 318LYS B 352 | LOC B 700 |
3E22_D_LOCD700 | 3e22 | LOC DB01394(Colchicine) | Bos taurus | TUBULIN ALPHA-1CCHAIN;TUBULIN BETA-2BCHAIN | no annotation | 14 | SER C 178ALA C 180VAL C 181CYS D 241LEU D 242LEU D 248ALA D 250LYS D 254LEU D 255ASN D 258MET D 259ALA D 316VAL D 318LYS D 352 | LOC D 700 |
3N23_A_OBNA1 | 3n23 | OBN DB01092(Ouabain) | Sus scrofa | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 11 | GLN A 111PRO A 118ASP A 121ASN A 122VAL A 322ALA A 323PHE A 783PHE A 786THR A 797ILE A 800ARG A 880 | OBN A 1 |
3N23_C_OBNC1 | 3n23 | OBN DB01092(Ouabain) | Sus scrofa | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | no annotation | 11 | GLN C 111PRO C 118ASP C 121ASN C 122LEU C 125VAL C 322ALA C 323PHE C 783PHE C 786THR C 797ARG C 880 | OBN C 1 |
4HYT_A_OBNA1104 | 4hyt | OBN DB01092(Ouabain) | Sus scrofa | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 17 | GLN A 111GLU A 117PRO A 118ASP A 121ASN A 122LEU A 125GLU A 312ILE A 315GLY A 319VAL A 322ALA A 323PHE A 783PHE A 786LEU A 793THR A 797ILE A 800ARG A 880 | OBN A1104 |
4HYT_C_OBNC2004 | 4hyt | OBN DB01092(Ouabain) | Sus scrofa | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | no annotation | 16 | GLN C 111GLU C 117PRO C 118ASP C 121ASN C 122LEU C 125GLU C 312ILE C 315GLY C 319ALA C 323PHE C 783PHE C 786LEU C 793THR C 797ILE C 800ARG C 880 | OBN C2004 |
4O2B_B_LOCB503 | 4o2b | LOC DB01394(Colchicine) | Bos taurus | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA-2BCHAIN | PF00091(Tubulin)PF03953(Tubulin_C) | 16 | SER A 178ALA A 180VAL A 181CYS B 241LEU B 242LEU B 248ALA B 250LYS B 254LEU B 255ASN B 258MET B 259THR B 314ALA B 316ILE B 318LYS B 352ILE B 378 | LOC B 503 |
4O2B_D_LOCD503 | 4o2b | LOC DB01394(Colchicine) | Bos taurus | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA-2BCHAIN | no annotation | 17 | SER C 178ALA C 180VAL C 181CYS D 241LEU D 242LEU D 248ALA D 250LYS D 254LEU D 255ASN D 258MET D 259THR D 314ALA D 316ILE D 318LYS D 352ALA D 354ILE D 378 | LOC D 503 |
4RET_A_DGXA1107 | 4ret | DGX DB00390(Digoxin) | Sus scrofa | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 16 | GLN A 111ASP A 121ASN A 122LEU A 125LEU A 311GLU A 312PHE A 316GLY A 319VAL A 322ALA A 323GLU A 327PHE A 783LEU A 793THR A 797ILE A 800ARG A 880 | DGX A1107 |
4RET_C_DGXC2005 | 4ret | DGX DB00390(Digoxin) | Sus scrofa | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | no annotation | 16 | GLN C 111GLU C 117ASP C 121ASN C 122LEU C 125LEU C 311GLU C 312GLY C 319VAL C 322ALA C 323GLU C 327PHE C 783LEU C 793THR C 797ILE C 800ARG C 880 | DGX C2005 |
4XE5_A_OBNA1104 | 4xe5 | OBN DB01092(Ouabain) | Bos taurus | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 | PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF00702(Hydrolase)PF13246(Cation_ATPase) | 18 | GLN A 116GLU A 121GLU A 122PRO A 123ASP A 126LEU A 130GLU A 317ILE A 320GLY A 324VAL A 327ALA A 328GLU A 332PHE A 788PHE A 791THR A 802ILE A 805ARG A 885ASP A 889 | OBN A1104 |
5BMV_C_VLBC507 | 5bmv | VLB DB00570(Vinblastine) | Bos taurus;Sus scrofa | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA CHAIN | PF00091(Tubulin)PF03953(Tubulin_C)no annotation | 13 | LYS B 176ASP B 179TYR B 210PRO B 222TYR B 224LEU B 227PRO C 325VAL C 328ASN C 329ILE C 332PHE C 351VAL C 353ILE C 355 | VLB C 507 |
5ITZ_B_LOCB502 | 5itz | LOC DB01394(Colchicine) | Bos taurus | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA-2BCHAIN | PF00091(Tubulin)PF03953(Tubulin_C) | 15 | ALA A 180VAL A 181CYS B 241LEU B 242LEU B 248ALA B 250LYS B 254LEU B 255ASN B 258MET B 259THR B 314ALA B 316ILE B 318LYS B 352ILE B 378 | LOC B 502 |
5J2T_C_VLBC503 | 5j2t | VLB DB00570(Vinblastine) | Bos taurus | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA-2BCHAIN | PF00091(Tubulin)PF03953(Tubulin_C)no annotation | 21 | LYS B 176VAL B 177ASP B 179TYR B 210PHE B 214THR B 221PRO B 222TYR B 224LEU B 227LEU C 248PRO C 325LYS C 326VAL C 328ASN C 329ILE C 332ALA C 333LYS C 336PHE C 351VAL C 353GLY C 354ILE C 355 | VLB C 503 |
5JH7_B_6K9B503 | 5jh7 | 6K9 DB08871(Eribulin) | Bos taurus | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA-2BCHAIN | NonePF00091(Tubulin)PF03953(Tubulin_C) | 18 | GLN B 11ASN B 101VAL B 177SER B 178ASP B 179THR B 180GLU B 183TYR B 210PRO B 222TYR B 224LEU B 227LEU C 248VAL C 250GLU C 254ASN C 329ILE C 332LYS C 352VAL C 353 | 6K9 B 503 |
5LRB_A_ACRA1003 | 5lrb | ACR DB00284(Acarbose) | Hordeum vulgare | ALPHA-1,4 GLUCANPHOSPHORYLASE | PF00343(Phosphorylase) | 6 | GLU A 702PHE A 744THR A 746TYR A 747TYR A 900PHE A 906 | ACR A1003 |
5LRB_B_ACRB1003 | 5lrb | ACR DB00284(Acarbose) | Hordeum vulgare | ALPHA-1,4 GLUCANPHOSPHORYLASE | no annotation | 9 | GLU B 333GLU B 702PHE B 744THR B 746TYR B 747TYR B 900GLY B 901TYR B 905PHE B 906 | ACR B1003 |
5MIO_B_LOCB502 | 5mio | LOC DB01394(Colchicine) | Bos taurus;Ovis aries | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA CHAIN | PF00091(Tubulin)PF03953(Tubulin_C) | 15 | ALA A 180VAL A 181CYS B 241LEU B 242LEU B 248ALA B 250LYS B 254LEU B 255ASN B 258MET B 259THR B 314ALA B 316ILE B 318LYS B 352ILE B 378 | LOC B 502 |
5NM5_B_LOCB502 | 5nm5 | LOC DB01394(Colchicine) | Bos taurus | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA-2BCHAIN | PF00091(Tubulin)PF03953(Tubulin_C) | 18 | ASN A 101SER A 178ALA A 180VAL A 181CYS B 241LEU B 242LEU B 248ALA B 250LYS B 254LEU B 255ASN B 258MET B 259THR B 314ALA B 316ILE B 318LYS B 352ALA B 354ILE B 378 | LOC B 502 |
5OM2_B_DXTB501 | 5om2 | DXT DB00254(Doxycycline) | Homo sapiens | ALPHA-1-ANTICHYMOTRYPSIN | no annotation | 9 | VAL A 31LEU A 273ALA A 274PHE A 277ASP A 278VAL B 381HIS B 383TRP B 386ILE B 388 | DXT B 501 |
5OM3_B_DXTB501 | 5om3 | DXT DB00254(Doxycycline) | Homo sapiens | ALPHA-1-ANTICHYMOTRYPSIN | no annotation | 6 | LEU A 273SER A 274PHE A 277ASP A 278HIS B 383TRP B 386 | DXT B 501 |
5OM7_A_DM2A501 | 5om7 | DM2 DB00445(Epirubicin)DB00997(Doxorubicin) | Homo sapiens | ALPHA-1-ANTICHYMOTRYPSIN | no annotation | 11 | VAL A 31GLN A 242ASN A 244GLN A 270LEU A 273SER A 274PHE A 277GLU A 278VAL B 381ASN B 383TRP B 386 | DM2 A 501 |
5XIW_B_LOCB504 | 5xiw | LOC DB01394(Colchicine) | Sus scrofa | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA CHAIN | no annotation | 17 | SER A 178ALA A 180VAL A 181CYS B 239LEU B 240LEU B 246ALA B 248LYS B 252LEU B 253ASN B 256MET B 257THR B 312ALA B 314ILE B 316LYS B 350ALA B 352ILE B 368 | LOC B 504 |
5XIW_D_LOCD503 | 5xiw | LOC DB01394(Colchicine) | Sus scrofa | TUBULIN ALPHA-1BCHAIN;TUBULIN BETA CHAIN | no annotation | 17 | SER C 178ALA C 180VAL C 181CYS D 239LEU D 240LEU D 246ALA D 248LYS D 252LEU D 253ASN D 256MET D 257THR D 312ALA D 314ILE D 316LYS D 350ALA D 352ILE D 368 | LOC D 503 |
6D6T_D_FYPD406 | 6d6t | FYP DB01205(Flumazenil) | Homo sapiens | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1;HUMAN GABA-ARECEPTOR SUBUNITGAMMA-2 | None | 11 | ASP E 56TYR E 58PHE E 77ALA E 79HIS D 102THR E 142TYR D 160SER D 205SER D 206THR D 207TYR D 210 | FYP D 406 |
6D6U_D_FYPD410 | 6d6u | FYP DB01205(Flumazenil) | Homo sapiens | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1;GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITGAMMA-2,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT GAMMA-2 | NonePF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 9 | ASP E 56TYR E 58ALA E 79HIS D 102THR E 142TYR D 160SER D 205SER D 206TYR D 210 | FYP D 410 |
6FTP_B_DM2B501 | 6ftp | DM2 DB00445(Epirubicin)DB00997(Doxorubicin) | Homo sapiens | ALPHA-1-ANTICHYMOTRYPSIN | no annotation | 9 | GLN A 242LEU A 273SER A 274PHE A 277GLU A 278LEU A 280VAL B 381ASN B 383TRP B 386 | DM2 B 501 |
6HUO_D_08HD501 | 6huo | 08H DB00404(Alprazolam) | Homo sapiens;Homo sapiens;Bos taurus | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1;GAMMA-AMINOBUTYRICACID RECEPTORSUBUNIT GAMMA-2 | NonePF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 8 | TYR C 58ASN C 60PHE C 77PHE D 100HIS D 102VAL D 203SER D 205TYR D 210 | 08H D 501 |
6HUP_B_DZPB502 | 6hup | DZP DB00829(Diazepam) | Homo sapiens;Homo sapiens;Bos taurus | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1;GAMMA-AMINOBUTYRICACID RECEPTORSUBUNIT BETA-3 | PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 11 | ILE A 228LEU A 232PRO A 233MET A 236THR A 237MET B 261THR B 262ASN B 265LEU B 285MET B 286PHE B 289 | DZP B 502 |
6HUP_D_DZPD2001 | 6hup | DZP DB00829(Diazepam) | Homo sapiens;Homo sapiens;Bos taurus | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1;GAMMA-AMINOBUTYRICACID RECEPTORSUBUNIT GAMMA-2 | NonePF02931(Neur_chan_memb)PF02932(Neur_chan_LBD) | 9 | TYR C 58ASN C 60PHE C 77PHE D 100HIS D 102TYR D 160VAL D 203SER D 205TYR D 210 | DZP D2001 |
6HUP_E_DZPE502 | 6hup | DZP DB00829(Diazepam) | Homo sapiens;Homo sapiens;Bos taurus | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1;GAMMA-AMINOBUTYRICACID RECEPTORSUBUNIT BETA-3 | None | 10 | LEU D 232PRO D 233MET D 236MET E 261THR E 262ASN E 265LEU D 269LEU E 285MET E 286PHE E 289 | DZP E 502 |