SIMILAR PATTERNS OF AMINO ACIDS FOR 7DFR_A_FOLA161_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7) 		PF01068
(DNA_ligase_A_M) 		3 ASP A  86
LEU A 154
ARG A 230
 None
 0.87A 7dfrA-1a0iA:
0.0		 7dfrA-1a0iA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 FRAGMENT OF COAT
PROTEIN VP2

(Mus musculus
polyomavirus 1) 		PF00761
(Polyoma_coat2) 		3 ASP F  18
LEU F  21
ARG F  14
 None
 0.85A 7dfrA-1cn3F:
undetectable		 7dfrA-1cn3F:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		3 ASP A 342
LEU A 343
ARG A 299
 None
 0.68A 7dfrA-1g5gA:
undetectable		 7dfrA-1g5gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ASP A 161
LEU A 165
ARG A 205
 None
 0.81A 7dfrA-1gtuA:
undetectable		 7dfrA-1gtuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 ASP A 974
LEU A 979
ARG A  43
 None
 0.77A 7dfrA-1h7wA:
undetectable		 7dfrA-1h7wA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		3 ASP A  63
LEU A  66
ARG A 327
 FE  A 702 ( 3.1A)
None
None
 0.70A 7dfrA-1jnfA:
undetectable		 7dfrA-1jnfA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		3 ASP A  36
LEU A  37
ARG A  66
 None
 0.61A 7dfrA-1juvA:
17.9		 7dfrA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 ASP A 614
LEU A 607
ARG A 665
 None
 0.74A 7dfrA-1md7A:
undetectable		 7dfrA-1md7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASP A 314
LEU A 310
ARG A 183
 None
 0.88A 7dfrA-1qf7A:
undetectable		 7dfrA-1qf7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ASP A  63
LEU A  66
ARG A 327
 FE  A 329 ( 3.2A)
None
None
 0.59A 7dfrA-1ryoA:
undetectable		 7dfrA-1ryoA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 ASP A 278
LEU A 274
ARG A 147
 None
 0.82A 7dfrA-1sy7A:
undetectable		 7dfrA-1sy7A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		3 ASP A 152
LEU A 151
ARG A 328
 None
2OS  A 602 (-4.9A)
2OS  A 602 (-4.1A)
 0.89A 7dfrA-1t3iA:
undetectable		 7dfrA-1t3iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 ASP A 217
LEU A 216
ARG A 254
 None
 0.88A 7dfrA-1t8hA:
undetectable		 7dfrA-1t8hA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		3 ASP A 183
LEU A 186
ARG A 198
 None
 0.74A 7dfrA-1ujnA:
2.2		 7dfrA-1ujnA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 131
LEU A 134
ARG A 200
 None
 0.65A 7dfrA-1v10A:
undetectable		 7dfrA-1v10A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		3 ASP A 229
LEU A 227
ARG A 223
 CA  A1004 (-2.6A)
None
None
 0.89A 7dfrA-1vclA:
undetectable		 7dfrA-1vclA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		3 ASP A 105
LEU A 103
ARG A   4
 None
 0.85A 7dfrA-1wa4A:
undetectable		 7dfrA-1wa4A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		3 ASP C 368
LEU C 369
ARG C 486
 None
 0.73A 7dfrA-1wa5C:
undetectable		 7dfrA-1wa5C:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		3 ASP A 618
LEU A 622
ARG A 146
 None
 0.69A 7dfrA-1wacA:
undetectable		 7dfrA-1wacA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		3 ASP A 215
LEU A 459
ARG A 454
 None
 0.86A 7dfrA-1xr5A:
undetectable		 7dfrA-1xr5A:
16.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  28
ARG A  57
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
 0.67A 7dfrA-1zdrA:
25.1		 7dfrA-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA

(Lactococcus
lactis) 		no annotation 3 ASP A 111
LEU A 115
ARG A  44
 None
 0.90A 7dfrA-1zs3A:
undetectable		 7dfrA-1zs3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE

(Thermoplasma
acidophilum) 		PF03099
(BPL_LplA_LipB) 		3 ASP A 128
LEU A 126
ARG A 195
 None
 0.88A 7dfrA-2c7iA:
undetectable		 7dfrA-2c7iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A  37
LEU A  34
ARG A  43
 None
 0.74A 7dfrA-2gp6A:
undetectable		 7dfrA-2gp6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		3 ASP A 367
LEU A 363
ARG A 401
 None
 0.90A 7dfrA-2gq0A:
undetectable		 7dfrA-2gq0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASP A 236
LEU A 232
ARG A 109
 None
 0.86A 7dfrA-2isaA:
undetectable		 7dfrA-2isaA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A 242
LEU A 241
ARG A 168
 None
 0.74A 7dfrA-2ldxA:
undetectable		 7dfrA-2ldxA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		3 ASP A  48
LEU A  49
ARG A  56
 None
 0.86A 7dfrA-2lklA:
undetectable		 7dfrA-2lklA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		3 ASP A 326
LEU A  26
ARG A  21
 None
 0.82A 7dfrA-2nrjA:
undetectable		 7dfrA-2nrjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASP A  32
LEU A  33
ARG A  70
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.1A)
 0.38A 7dfrA-2oipA:
21.5		 7dfrA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		3 ASP A 133
LEU A  95
ARG A  99
 None
 0.82A 7dfrA-2osyA:
undetectable		 7dfrA-2osyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASP A  73
LEU A  77
ARG A 243
 None
 0.75A 7dfrA-2qo3A:
undetectable		 7dfrA-2qo3A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpz NAPHTHALENE
1,2-DIOXYGENASE
SYSTEM FERREDOXIN
SUBUNIT

(Pseudomonas
putida) 		PF00355
(Rieske) 		3 ASP A  17
LEU A  19
ARG A  50
 None
 0.83A 7dfrA-2qpzA:
undetectable		 7dfrA-2qpzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 ASP A 289
LEU A 223
ARG A 285
 None
 0.89A 7dfrA-2vcaA:
undetectable		 7dfrA-2vcaA:
13.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		3 ASP A  31
LEU A  32
ARG A  64
 VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
 0.50A 7dfrA-2w3wA:
24.5		 7dfrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  28
ARG A  57
 TOP  A1160 (-2.8A)
TOP  A1160 ( 4.6A)
None
 0.35A 7dfrA-2w9sA:
25.7		 7dfrA-2w9sA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN

(Escherichia
coli) 		PF09084
(NMT1) 		3 ASP A 204
LEU A 205
ARG A 149
 None
 0.86A 7dfrA-2x26A:
undetectable		 7dfrA-2x26A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASP A 247
LEU A 243
ARG A 120
 None
 0.83A 7dfrA-2xq1A:
undetectable		 7dfrA-2xq1A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 ASP A 509
LEU A 508
ARG A 488
 None
 0.69A 7dfrA-2xtlA:
undetectable		 7dfrA-2xtlA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 ASP A 359
LEU A 362
ARG A 484
 None
 0.79A 7dfrA-2xymA:
undetectable		 7dfrA-2xymA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASP A 225
LEU A 224
ARG A  26
 None
 0.87A 7dfrA-2yxxA:
undetectable		 7dfrA-2yxxA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		3 ASP A 395
LEU A 394
ARG A 316
 None
 0.76A 7dfrA-3ab4A:
undetectable		 7dfrA-3ab4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		3 ASP A 196
LEU A 195
ARG A 155
 None
ADP  A 210 (-4.2A)
ADP  A 210 (-4.2A)
 0.82A 7dfrA-3akcA:
undetectable		 7dfrA-3akcA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 ASP A  95
LEU A  98
ARG A 272
 None
CHD  A   1 (-4.3A)
FES  A 501 (-4.1A)
 0.83A 7dfrA-3aqiA:
undetectable		 7dfrA-3aqiA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION

(Methanothermobacter
thermautotrophicus) 		PF11576
(DUF3236) 		3 ASP A   4
LEU A   5
ARG A  18
 None
 0.73A 7dfrA-3brcA:
undetectable		 7dfrA-3brcA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		3 ASP A  26
LEU A  27
ARG A  57
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
 0.35A 7dfrA-3dfrA:
24.3		 7dfrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ASP A 273
LEU A 320
ARG A 597
 None
 0.91A 7dfrA-3dlaA:
undetectable		 7dfrA-3dlaA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		3 ASP A 531
LEU A 535
ARG A  40
 None
 0.78A 7dfrA-3epmA:
undetectable		 7dfrA-3epmA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffc CF34 ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASP D 173
LEU D  92
ARG D  71
 None
 0.70A 7dfrA-3ffcD:
undetectable		 7dfrA-3ffcD:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 ASP A 127
LEU A 183
ARG A 188
 None
 0.75A 7dfrA-3g05A:
undetectable		 7dfrA-3g05A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 ASP A 389
LEU A 385
ARG A 380
 None
 0.90A 7dfrA-3gsiA:
undetectable		 7dfrA-3gsiA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		3 ASP A 116
LEU A 115
ARG A  39
 None
None
FAD  A 600 (-3.8A)
 0.79A 7dfrA-3i3lA:
undetectable		 7dfrA-3i3lA:
16.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		3 ASP X  27
LEU X  28
ARG X  57
 N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
 0.51A 7dfrA-3i8aX:
25.8		 7dfrA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 365
LEU A 366
ARG A 395
 None
 0.76A 7dfrA-3iplA:
undetectable		 7dfrA-3iplA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kev GALIERIA SULFURARIA
DCUN1
DOMAIN-CONTAINING
PROTEIN

(Galdieria
sulphuraria) 		PF03556
(Cullin_binding) 		3 ASP A 153
LEU A 157
ARG A  98
 None
 0.87A 7dfrA-3kevA:
undetectable		 7dfrA-3kevA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		3 ASP A 149
LEU A 152
ARG A 157
 None
 0.85A 7dfrA-3ksrA:
undetectable		 7dfrA-3ksrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 ASP A 124
LEU A  99
ARG A  71
 None
 0.84A 7dfrA-3lkdA:
undetectable		 7dfrA-3lkdA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqv SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		PF08920
(SF3b1) 		3 ASP P 401
LEU P 404
ARG P 397
 None
 0.79A 7dfrA-3lqvP:
undetectable		 7dfrA-3lqvP:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbe TCR 21.3 ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASP C 179
LEU C  96
ARG C  78
 None
 0.79A 7dfrA-3mbeC:
undetectable		 7dfrA-3mbeC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oga NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		3 ASP A  97
LEU A  10
ARG A  73
 None
None
BME  A 142 ( 3.9A)
 0.74A 7dfrA-3ogaA:
undetectable		 7dfrA-3ogaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		3 ASP A 192
LEU A 197
ARG A 255
 None
None
SO4  A 265 (-3.9A)
 0.84A 7dfrA-3onqA:
undetectable		 7dfrA-3onqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		3 ASP A 132
LEU A 154
ARG A 186
 None
PEG  A 230 (-4.9A)
None
 0.67A 7dfrA-3q58A:
undetectable		 7dfrA-3q58A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiu TCR 226 ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASP C 159
LEU C  78
ARG C  57
 None
 0.71A 7dfrA-3qiuC:
undetectable		 7dfrA-3qiuC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		3 ASP A 112
LEU A 111
ARG A 103
 None
None
FAD  A 385 (-4.7A)
 0.84A 7dfrA-3rp7A:
undetectable		 7dfrA-3rp7A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1t ASPARTOKINASE

(Mycobacterium
tuberculosis) 		PF01842
(ACT)
PF13840
(ACT_7) 		3 ASP A 146
LEU A 145
ARG A  67
 None
 0.76A 7dfrA-3s1tA:
undetectable		 7dfrA-3s1tA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		3 ASP A 259
LEU A 260
ARG A  39
 None
 0.86A 7dfrA-3s6hA:
undetectable		 7dfrA-3s6hA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3

(Homo sapiens) 		PF00617
(RasGEF) 		3 ASP A 643
LEU A 557
ARG A 562
 None
 0.90A 7dfrA-3t6aA:
undetectable		 7dfrA-3t6aA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		3 ASP A 208
LEU A 206
ARG A  37
 None
 0.77A 7dfrA-3tg9A:
undetectable		 7dfrA-3tg9A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		3 ASP A  28
LEU A  29
ARG A  58
 MTX  A2001 (-2.7A)
MTX  A2001 (-3.9A)
MTX  A2001 (-2.8A)
 0.28A 7dfrA-3tq9A:
25.5		 7dfrA-3tq9A:
43.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE

(Sphaerobacter
thermophilus) 		PF00583
(Acetyltransf_1) 		3 ASP A 216
LEU A 219
ARG A 274
 MES  A 343 ( 3.8A)
None
None
 0.78A 7dfrA-3tt2A:
undetectable		 7dfrA-3tt2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 174
LEU A 175
ARG A  39
 None
 0.69A 7dfrA-3v4bA:
undetectable		 7dfrA-3v4bA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		3 ASP A 189
LEU A 217
ARG A 223
 None
None
GOL  A 402 (-3.9A)
 0.89A 7dfrA-3vovA:
undetectable		 7dfrA-3vovA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		3 ASP A 247
LEU A 250
ARG A 267
 None
 0.86A 7dfrA-3wvoA:
undetectable		 7dfrA-3wvoA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ASP A 302
LEU A 301
ARG A 313
 None
 0.83A 7dfrA-3zhyA:
undetectable		 7dfrA-3zhyA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c98 CAS6B

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		3 ASP A 160
LEU A 163
ARG A 189
 None
 0.88A 7dfrA-4c98A:
undetectable		 7dfrA-4c98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		3 ASP A  55
LEU A  58
ARG A  76
 ASP  A  55 (-0.6A)
LEU  A  58 (-0.6A)
ARG  A  76 ( 0.6A)
 0.84A 7dfrA-4c9gA:
undetectable		 7dfrA-4c9gA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		3 ASP A 278
LEU A 455
ARG A  10
 None
 0.90A 7dfrA-4dyoA:
undetectable		 7dfrA-4dyoA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		3 ASP A  24
LEU A  25
ARG A 328
 None
 0.81A 7dfrA-4eipA:
undetectable		 7dfrA-4eipA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ASP A 449
LEU A 432
ARG A 497
 None
 0.79A 7dfrA-4fnqA:
undetectable		 7dfrA-4fnqA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		3 ASP E1207
LEU E1208
ARG E1215
 None
 0.82A 7dfrA-4gk5E:
undetectable		 7dfrA-4gk5E:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12

(Oryctolagus
cuniculus;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00229
(TNF) 		3 ASP T  85
LEU T  87
ARG L  96
 None
 0.89A 7dfrA-4ht1T:
undetectable		 7dfrA-4ht1T:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 ASP B 246
LEU B 537
ARG B 566
 None
 0.79A 7dfrA-4iglB:
undetectable		 7dfrA-4iglB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 3 ASP A 565
LEU A 569
ARG A 366
 None
 0.80A 7dfrA-4jzaA:
undetectable		 7dfrA-4jzaA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		3 ASP A  52
LEU A  55
ARG A 336
 None
 0.85A 7dfrA-4k6nA:
undetectable		 7dfrA-4k6nA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 3 ASP A1589
LEU A1634
ARG A1639
 None
 0.73A 7dfrA-4kf8A:
undetectable		 7dfrA-4kf8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		3 ASP A 359
LEU A 358
ARG A 232
 None
 0.89A 7dfrA-4kqbA:
undetectable		 7dfrA-4kqbA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 3 ASP H  61
LEU H  62
ARG H 291
 None
 0.53A 7dfrA-4l0oH:
undetectable		 7dfrA-4l0oH:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 462
LEU A 470
ARG A 340
 None
 0.90A 7dfrA-4lixA:
undetectable		 7dfrA-4lixA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 3 ASP A 110
LEU A 342
ARG A 220
 None
None
HEC  A 803 (-2.8A)
 0.88A 7dfrA-4lmhA:
undetectable		 7dfrA-4lmhA:
11.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  28
ARG A  58
 RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
 0.43A 7dfrA-4m7vA:
24.4		 7dfrA-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 ASP A 187
LEU A 190
ARG A 136
 None
 0.80A 7dfrA-4nmeA:
undetectable		 7dfrA-4nmeA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 ASP A 187
LEU A 193
ARG A 153
 None
 0.80A 7dfrA-4oh0A:
undetectable		 7dfrA-4oh0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ASP A 303
LEU A 302
ARG A 405
 None
 0.89A 7dfrA-4qs9A:
undetectable		 7dfrA-4qs9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASP A 642
LEU A 643
ARG A 717
 None
 0.89A 7dfrA-4rcnA:
undetectable		 7dfrA-4rcnA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		3 ASP A 529
LEU A 528
ARG A 468
 None
 0.84A 7dfrA-4rt6A:
undetectable		 7dfrA-4rt6A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		3 ASP A 540
LEU A 544
ARG A 116
 None
 0.77A 7dfrA-4s28A:
undetectable		 7dfrA-4s28A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		3 ASP B 396
LEU B 424
ARG B 232
 None
 0.81A 7dfrA-4tx2B:
undetectable		 7dfrA-4tx2B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utt PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Clostridium
perfringens) 		PF04131
(NanE) 		3 ASP A 126
LEU A 148
ARG A 182
 None
 0.59A 7dfrA-4uttA:
undetectable		 7dfrA-4uttA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 315
LEU A 317
ARG A 104
 None
 0.86A 7dfrA-4yzwA:
undetectable		 7dfrA-4yzwA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		3 ASP A 198
LEU A 197
ARG A  20
 None
 0.84A 7dfrA-4zemA:
undetectable		 7dfrA-4zemA:
16.96