SIMILAR PATTERNS OF AMINO ACIDS FOR 6QGB_A_BEZA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		5 GLY A 239
LEU A 262
ALA A 230
TRP A 199
ALA A 214
 GLY  A 239 ( 0.0A)
LEU  A 262 ( 0.6A)
ALA  A 230 ( 0.0A)
TRP  A 199 ( 0.5A)
ALA  A 214 ( 0.0A)
 1.48A 6qgbA-1c8xA:
undetectable		 6qgbA-1c8xA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.97A 6qgbA-1cleA:
10.2		 6qgbA-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.94A 6qgbA-1crlA:
9.7		 6qgbA-1crlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 LEU A 454
ALA A 405
PHE A 435
PHE A 395
HIS A 397
 None
 1.48A 6qgbA-1gq1A:
undetectable		 6qgbA-1gq1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.87A 6qgbA-1gz7A:
10.3		 6qgbA-1gz7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.21A 6qgbA-1qonA:
11.4		 6qgbA-1qonA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		5 GLY B  57
LEU B  64
ALA B 108
PHE B  94
ALA B 104
 ATP  B   5 (-3.8A)
None
None
None
None
 1.24A 6qgbA-1r4nB:
undetectable		 6qgbA-1r4nB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		5 GLY A 130
LEU A  17
SER A 115
PHE A 123
HIS A  64
 None
 1.28A 6qgbA-1tzsA:
0.0		 6qgbA-1tzsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 160
LEU A 171
ALA A 140
PHE A 115
ALA A 128
 None
 1.23A 6qgbA-1w5fA:
0.3		 6qgbA-1w5fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		5 GLY A 296
SER A 316
ALA A 324
ARG A 283
ALA A 261
 PLP  B 801 ( 4.3A)
None
None
None
None
 1.49A 6qgbA-1xrsA:
0.8		 6qgbA-1xrsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvh IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLY A 111
SER A 109
ALA A  50
ALA A  97
PHE A  37
 None
 1.49A 6qgbA-1zvhA:
undetectable		 6qgbA-1zvhA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 GLY B 661
SER B 623
LEU B 644
ALA B 647
PHE B 619
 None
 1.13A 6qgbA-2bkuB:
undetectable		 6qgbA-2bkuB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		5 GLY C 134
LEU C  24
ALA C  95
PHE C 114
ALA C  99
 None
 1.26A 6qgbA-2d6fC:
undetectable		 6qgbA-2d6fC:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 GLY A  56
LEU A 188
ALA A 139
ALA A 135
PHE A 192
 None
 1.18A 6qgbA-2i3oA:
undetectable		 6qgbA-2i3oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mux UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Homo sapiens) 		PF02809
(UIM) 		5 GLY A  45
LEU A  49
PHE A  20
ALA A  39
PHE A  53
 None
 1.44A 6qgbA-2muxA:
undetectable		 6qgbA-2muxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrk HYPOTHETICAL PROTEIN
GRPB

(Enterococcus
faecalis) 		PF04229
(GrpB) 		5 GLY A  38
SER A  41
LEU A  45
ALA A 128
PHE A 117
 None
 1.50A 6qgbA-2nrkA:
undetectable		 6qgbA-2nrkA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 GLY B2057
LEU B2064
ALA B2108
PHE B2094
ALA B2104
 ATP  B 103 (-4.9A)
None
None
None
None
 1.18A 6qgbA-2nvuB:
0.0		 6qgbA-2nvuB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 GLY A 275
LEU A 278
ALA A 381
ALA A 385
PHE A 317
 None
 1.29A 6qgbA-2w5fA:
undetectable		 6qgbA-2w5fA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8r GLYCOSYL HYDROLASE

(Aspergillus
fumigatus) 		PF01183
(Glyco_hydro_25) 		5 GLY A  33
LEU A  64
ALA A  62
ALA A  28
HIS A 198
 None
 1.38A 6qgbA-2x8rA:
undetectable		 6qgbA-2x8rA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		5 GLY A 239
LEU A 132
ALA A 225
ALA A 229
PHE A 165
 None
 1.42A 6qgbA-2xhyA:
undetectable		 6qgbA-2xhyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 SER A 115
LEU A 134
ALA A  93
ALA A  89
PHE A 130
 None
 1.45A 6qgbA-2yxlA:
undetectable		 6qgbA-2yxlA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		5 GLY A 127
LEU A 109
ALA A 111
ARG A 123
PHE A  82
 None
 1.01A 6qgbA-3a9gA:
undetectable		 6qgbA-3a9gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 LEU A 422
ARG A 348
PHE A 382
SER A 384
PHE A 453
 None
 1.24A 6qgbA-3cskA:
undetectable		 6qgbA-3cskA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 GLY A 787
LEU A 749
ALA A 752
SER A 794
ALA A 697
 None
 1.27A 6qgbA-3egiA:
undetectable		 6qgbA-3egiA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 SER A 367
LEU A 382
ALA A 375
ARG A 321
PHE A 274
 None
 1.09A 6qgbA-3ejnA:
undetectable		 6qgbA-3ejnA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A  15
LEU A  31
ALA A  49
PHE A  11
SER A  42
 None
 1.42A 6qgbA-3fhlA:
0.5		 6qgbA-3fhlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN

(Ruegeria
pomeroyi) 		PF13462
(Thioredoxin_4) 		5 GLY A  99
LEU A  88
ALA A  87
ALA A 104
PHE A  84
 None
 1.37A 6qgbA-3gykA:
undetectable		 6qgbA-3gykA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.23A 6qgbA-3hbjA:
2.7		 6qgbA-3hbjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwg HP0420 HOMOLOGUE

(Helicobacter
felis) 		no annotation 5 GLY A  54
LEU A  38
ALA A  24
ALA A  60
PHE A  94
 None
 1.36A 6qgbA-3lwgA:
undetectable		 6qgbA-3lwgA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		5 GLY A 405
LEU A 408
ALA A 469
PHE A 453
ALA A 467
 None
 1.16A 6qgbA-3no8A:
undetectable		 6qgbA-3no8A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		5 GLY A 406
LEU A  19
ALA A  15
PHE A 408
ALA A 399
 None
 1.42A 6qgbA-3nrnA:
undetectable		 6qgbA-3nrnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		5 GLY A 274
LEU A 603
ALA A 599
ALA A 280
PHE A 342
 None
 1.20A 6qgbA-3odnA:
undetectable		 6qgbA-3odnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 GLY A 154
LEU A 236
ALA A 235
ALA A 223
PHE A 232
 None
 1.24A 6qgbA-3tp9A:
0.0		 6qgbA-3tp9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A 414
ALA A 417
PHE A 381
ALA A 421
HIS A 276
 None
 1.46A 6qgbA-3wfpA:
undetectable		 6qgbA-3wfpA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		5 GLY A  60
SER A 194
ALA A 219
ALA A  67
HIS A 166
 PLG  A 401 (-3.2A)
None
None
None
None
 1.10A 6qgbA-3wgcA:
undetectable		 6qgbA-3wgcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 SER A 228
ALA A 138
TRP A 153
SER A 136
HIS A 183
 None
 1.44A 6qgbA-3wheA:
undetectable		 6qgbA-3wheA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.98A 6qgbA-4be9A:
1.8		 6qgbA-4be9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC

(Aquifex
aeolicus) 		PF00902
(TatC) 		5 GLY A 199
LEU A 216
ALA A 163
ALA A 159
PHE A 160
 None
 1.31A 6qgbA-4htsA:
undetectable		 6qgbA-4htsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 GLY A 530
SER A 632
LEU A 617
ALA A 615
HIS A 598
 None
 1.46A 6qgbA-4n3nA:
undetectable		 6qgbA-4n3nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 GLY A 412
SER A 514
LEU A 499
ALA A 497
HIS A 480
 None
 1.49A 6qgbA-4n3sA:
undetectable		 6qgbA-4n3sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		5 GLY A 496
ALA A 543
ALA A 534
PHE A 540
HIS A  22
 None
 1.39A 6qgbA-4onyA:
undetectable		 6qgbA-4onyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 SER A 195
LEU A 391
ALA A 203
PHE A 519
PHE A 199
HIS A 352
 None
None
HEM  A 602 ( 3.9A)
None
None
None
 1.40A 6qgbA-4ph9A:
undetectable		 6qgbA-4ph9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 GLY A 281
LEU A 173
ALA A 128
ALA A 237
PHE A 243
 None
 1.29A 6qgbA-4pprA:
0.5		 6qgbA-4pprA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3m MGS-M4

(unidentified) 		PF00248
(Aldo_ket_red) 		5 GLY A 134
LEU A 146
ALA A 114
PHE A 121
PHE A 138
 None
 1.40A 6qgbA-4q3mA:
undetectable		 6qgbA-4q3mA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpc 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE

(Danio rerio) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A 262
ALA A 271
TRP A 213
PHE A 244
ALA A 267
 None
 1.38A 6qgbA-4qpcA:
undetectable		 6qgbA-4qpcA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 GLY A 229
LEU A 121
ALA A  76
ALA A 187
PHE A 193
 None
 1.12A 6qgbA-4ryeA:
undetectable		 6qgbA-4ryeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.19A 6qgbA-4tkmA:
3.2		 6qgbA-4tkmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 533
LEU A 597
ALA A 436
ALA A 432
PHE A 601
 None
 1.09A 6qgbA-4tptA:
undetectable		 6qgbA-4tptA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.20A 6qgbA-4w7hA:
undetectable		 6qgbA-4w7hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		5 GLY A 177
SER A 201
LEU A 192
ALA A 182
PHE A 205
 None
 1.28A 6qgbA-4xa9A:
undetectable		 6qgbA-4xa9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 GLY A  82
LEU A  17
ALA A  16
PHE A  13
HIS A  87
 None
None
4M4  A 607 (-3.3A)
None
None
 1.26A 6qgbA-4zaaA:
undetectable		 6qgbA-4zaaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 LEU A  13
ALA A  26
PHE A 158
ALA A  22
PHE A  15
 None
 1.28A 6qgbA-5bshA:
undetectable		 6qgbA-5bshA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 GLY A 187
LEU A 182
ALA A 222
PHE A  25
PHE A 218
 None
 1.39A 6qgbA-5cm5A:
2.5		 6qgbA-5cm5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dur HEAVY CHAIN OF
ANTIBODY 100F4

(Homo sapiens) 		no annotation 5 GLY H  51
LEU H  39
ALA H  98
ALA H 100
PHE H 108
 None
 1.20A 6qgbA-5durH:
undetectable		 6qgbA-5durH:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 125
LEU A 238
ALA A 236
PHE A 286
HIS A 449
 None
 1.00A 6qgbA-5fv4A:
10.5		 6qgbA-5fv4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 125
SER A 204
LEU A 238
PHE A 286
HIS A 449
 None
 0.79A 6qgbA-5fv4A:
10.5		 6qgbA-5fv4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 126
SER A 204
PHE A 286
PHE A 407
HIS A 449
 None
 1.01A 6qgbA-5fv4A:
10.5		 6qgbA-5fv4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 126
SER A 204
PHE A 300
PHE A 407
HIS A 449
 None
 1.38A 6qgbA-5fv4A:
10.5		 6qgbA-5fv4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		6 GLY A 575
LEU A 165
ALA A 164
ALA A 198
PHE A 161
HIS A 146
 None
 1.44A 6qgbA-5gamA:
undetectable		 6qgbA-5gamA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpo SENSOR PROTEIN CZCS

(Pseudomonas
aeruginosa) 		no annotation 5 SER A  87
ALA A 110
SER A 140
ALA A 106
HIS A  85
 None
 1.43A 6qgbA-5gpoA:
0.8		 6qgbA-5gpoA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		5 GLY A 273
LEU A 317
ALA A 101
ALA A 105
PHE A 321
 None
 1.26A 6qgbA-5hh9A:
undetectable		 6qgbA-5hh9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 SER A 194
ALA A 202
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 (-2.8A)
None
None
None
 1.34A 6qgbA-5ikrA:
undetectable		 6qgbA-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.37A 6qgbA-5ikrA:
undetectable		 6qgbA-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtf PUTATIVE
PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Pseudomonas
putida) 		PF13420
(Acetyltransf_4) 		5 GLY A 138
LEU A 108
ALA A 119
ALA A 121
HIS A 134
 None
 1.32A 6qgbA-5jtfA:
2.5		 6qgbA-5jtfA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		5 GLY A 285
LEU A 287
ALA A 292
ALA A 247
PHE A 266
 None
 1.47A 6qgbA-5jxmA:
undetectable		 6qgbA-5jxmA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 GLY A 283
ALA A 345
ARG A 379
SER A 343
ALA A 280
 PO4  A 902 (-3.5A)
7A2  A 901 (-3.6A)
7A2  A 901 (-2.9A)
7A2  A 901 (-3.6A)
7A2  A 901 ( 4.1A)
 1.49A 6qgbA-5te1A:
4.2		 6qgbA-5te1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txw PEPTIDASE

(Thermococcus
thioreducens) 		PF01965
(DJ-1_PfpI) 		5 LEU A 165
ALA A  64
PHE A   5
ALA A  97
PHE A 161
 None
 1.33A 6qgbA-5txwA:
undetectable		 6qgbA-5txwA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 GLY A 156
ALA A 540
ALA A 104
PHE A 544
HIS A  95
 None
 1.41A 6qgbA-5vylA:
undetectable		 6qgbA-5vylA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 GLY G 451
LEU G 454
TRP G 338
PHE G 288
PHE G 391
 None
 1.24A 6qgbA-5wduG:
undetectable		 6qgbA-5wduG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 5 GLY A 184
LEU A 189
ALA A 198
ARG A 200
ALA A 460
 None
 1.24A 6qgbA-5xwwA:
undetectable		 6qgbA-5xwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 5 SER A 337
LEU A 357
SER A  77
ALA A 335
PHE A 324
 None
 1.36A 6qgbA-5y6tA:
undetectable		 6qgbA-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghd -

(-) 		no annotation 5 GLY D  47
LEU D  81
ALA D  77
TRP D  62
PHE D  59
 None
 1.42A 6qgbA-6ghdD:
undetectable		 6qgbA-6ghdD:
undetectable