SIMILAR PATTERNS OF AMINO ACIDS FOR 6NMP_W_CHDW101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541

(Methanocaldococcus
jannaschii) 		PF01467
(CTP_transf_like) 		4 ILE A   5
ARG A   2
THR A  66
LEU A  65
 ATP  A 700 (-4.5A)
None
None
None
 0.88A 6nmpN-1f9aA:
0.0
6nmpW-1f9aA:
undetectable		 6nmpN-1f9aA:
15.18
6nmpW-1f9aA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ILE A 128
ARG A  14
THR A  96
LEU A  97
 None
 0.92A 6nmpN-1g0dA:
0.0
6nmpW-1g0dA:
0.0		 6nmpN-1g0dA:
19.23
6nmpW-1g0dA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A  12
LEU A  13
THR A  23
LEU A  24
 None
 0.88A 6nmpN-1gg4A:
0.0
6nmpW-1gg4A:
0.0		 6nmpN-1gg4A:
24.55
6nmpW-1gg4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.94A 6nmpN-1jedA:
0.0
6nmpW-1jedA:
0.0		 6nmpN-1jedA:
21.17
6nmpW-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 335
LEU A 339
ARG A 328
THR A 312
 None
None
HG  A 614 ( 4.9A)
None
 0.90A 6nmpN-1pm2A:
0.7
6nmpW-1pm2A:
0.0		 6nmpN-1pm2A:
19.19
6nmpW-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.96A 6nmpN-1r6xA:
0.0
6nmpW-1r6xA:
0.0		 6nmpN-1r6xA:
21.48
6nmpW-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.88A 6nmpN-1rt8A:
0.0
6nmpW-1rt8A:
0.0		 6nmpN-1rt8A:
22.05
6nmpW-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv7 GENERAL SECRETION
PATHWAY PROTEIN M

(Vibrio cholerae) 		PF04612
(T2SSM) 		4 ILE A 143
LEU A 159
ARG A 147
LEU A 120
 None
 0.78A 6nmpN-1uv7A:
undetectable
6nmpW-1uv7A:
undetectable		 6nmpN-1uv7A:
11.07
6nmpW-1uv7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbc POLIOVIRUS TYPE 3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  82
ARG 3 197
THR 3 127
LEU 3 158
 None
 0.93A 6nmpN-1vbc3:
undetectable
6nmpW-1vbc3:
0.0		 6nmpN-1vbc3:
18.30
6nmpW-1vbc3:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 250
LEU A 253
ARG A 211
LEU A 204
 None
 0.92A 6nmpN-1w1kA:
0.0
6nmpW-1w1kA:
undetectable		 6nmpN-1w1kA:
22.15
6nmpW-1w1kA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj4 KIAA0794 PROTEIN

(Homo sapiens) 		PF00789
(UBX) 		4 ILE A  58
LEU A  60
ARG A  49
LEU A  85
 None
 0.82A 6nmpN-1wj4A:
undetectable
6nmpW-1wj4A:
undetectable		 6nmpN-1wj4A:
12.06
6nmpW-1wj4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.90A 6nmpN-1wqlB:
undetectable
6nmpW-1wqlB:
undetectable		 6nmpN-1wqlB:
16.39
6nmpW-1wqlB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB

(Mycobacterium
tuberculosis) 		PF02518
(HATPase_c) 		4 ILE A 378
LEU A 365
THR A 361
LEU A 324
 None
 0.88A 6nmpN-1ysrA:
0.0
6nmpW-1ysrA:
undetectable		 6nmpN-1ysrA:
14.09
6nmpW-1ysrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.90A 6nmpN-1zv4X:
1.7
6nmpW-1zv4X:
undetectable		 6nmpN-1zv4X:
13.67
6nmpW-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 ILE A  67
LEU A  23
THR A  18
LEU A  17
 None
 0.89A 6nmpN-1zypA:
undetectable
6nmpW-1zypA:
undetectable		 6nmpN-1zypA:
16.98
6nmpW-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		4 ILE A 111
LEU A 108
ARG A 125
LEU A  37
 None
GM3  A1212 ( 4.9A)
None
None
 0.92A 6nmpN-2bv7A:
1.9
6nmpW-2bv7A:
undetectable		 6nmpN-2bv7A:
18.09
6nmpW-2bv7A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 6nmpN-2eg5A:
undetectable
6nmpW-2eg5A:
undetectable		 6nmpN-2eg5A:
22.14
6nmpW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		4 ILE A 158
LEU A 151
THR A 181
LEU A 182
 None
 0.89A 6nmpN-2fmlA:
undetectable
6nmpW-2fmlA:
undetectable		 6nmpN-2fmlA:
16.86
6nmpW-2fmlA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.90A 6nmpN-2idcA:
undetectable
6nmpW-2idcA:
undetectable		 6nmpN-2idcA:
13.97
6nmpW-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnu REGULATOR OF
G-PROTEIN SIGNALING
14

(Homo sapiens) 		PF00615
(RGS) 		4 ILE A 109
LEU A 112
THR A  29
LEU A  32
 None
 0.85A 6nmpN-2jnuA:
1.4
6nmpW-2jnuA:
undetectable		 6nmpN-2jnuA:
16.82
6nmpW-2jnuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE A 142
LEU A 117
THR A  38
LEU A  39
 None
 0.74A 6nmpN-2m6kA:
undetectable
6nmpW-2m6kA:
undetectable		 6nmpN-2m6kA:
18.83
6nmpW-2m6kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m80 GLUTAREDOXIN-8

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 ILE A 113
LEU A 115
THR A 105
LEU A 106
 None
 0.90A 6nmpN-2m80A:
undetectable
6nmpW-2m80A:
undetectable		 6nmpN-2m80A:
10.89
6nmpW-2m80A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.84A 6nmpN-2p0dA:
undetectable
6nmpW-2p0dA:
undetectable		 6nmpN-2p0dA:
12.67
6nmpW-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppw CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.86A 6nmpN-2ppwA:
undetectable
6nmpW-2ppwA:
undetectable		 6nmpN-2ppwA:
16.47
6nmpW-2ppwA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.90A 6nmpN-2r6fA:
undetectable
6nmpW-2r6fA:
undetectable		 6nmpN-2r6fA:
19.77
6nmpW-2r6fA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 ILE A 503
LEU A 466
ARG A 473
LEU A 518
 None
 0.91A 6nmpN-2v9pA:
undetectable
6nmpW-2v9pA:
undetectable		 6nmpN-2v9pA:
19.27
6nmpW-2v9pA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr3 CLUMPING FACTOR A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 ILE A 297
LEU A 304
THR A 233
LEU A 236
 None
 0.87A 6nmpN-2vr3A:
undetectable
6nmpW-2vr3A:
undetectable		 6nmpN-2vr3A:
20.08
6nmpW-2vr3A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 ILE A 572
LEU A 591
ARG A 440
LEU A 546
 None
 0.88A 6nmpN-2whxA:
undetectable
6nmpW-2whxA:
undetectable		 6nmpN-2whxA:
21.69
6nmpW-2whxA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.67A 6nmpN-2y24A:
undetectable
6nmpW-2y24A:
undetectable		 6nmpN-2y24A:
22.63
6nmpW-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE B 447
LEU B 450
THR B 492
LEU B 491
 None
 0.92A 6nmpN-2z7xB:
undetectable
6nmpW-2z7xB:
undetectable		 6nmpN-2z7xB:
23.01
6nmpW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		5 ILE A 554
LEU A 556
ARG A 608
THR A 637
LEU A 638
 None
 1.44A 6nmpN-2zwaA:
undetectable
6nmpW-2zwaA:
undetectable		 6nmpN-2zwaA:
20.73
6nmpW-2zwaA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.73A 6nmpN-3b2dA:
undetectable
6nmpW-3b2dA:
undetectable		 6nmpN-3b2dA:
20.65
6nmpW-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.82A 6nmpN-3c5yA:
undetectable
6nmpW-3c5yA:
undetectable		 6nmpN-3c5yA:
17.70
6nmpW-3c5yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.73A 6nmpN-3c9bA:
undetectable
6nmpW-3c9bA:
undetectable		 6nmpN-3c9bA:
16.41
6nmpW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 ILE A 105
LEU A 120
THR A  97
LEU A  96
 None
 0.87A 6nmpN-3dkaA:
undetectable
6nmpW-3dkaA:
undetectable		 6nmpN-3dkaA:
13.42
6nmpW-3dkaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.93A 6nmpN-3e7fA:
undetectable
6nmpW-3e7fA:
undetectable		 6nmpN-3e7fA:
19.65
6nmpW-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.84A 6nmpN-3fg4A:
undetectable
6nmpW-3fg4A:
undetectable		 6nmpN-3fg4A:
20.56
6nmpW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.83A 6nmpN-3gzyB:
undetectable
6nmpW-3gzyB:
undetectable		 6nmpN-3gzyB:
15.34
6nmpW-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.84A 6nmpN-3h5tA:
undetectable
6nmpW-3h5tA:
undetectable		 6nmpN-3h5tA:
21.02
6nmpW-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290

(Bacteroides
fragilis) 		PF12866
(DUF3823) 		4 ILE A 105
ARG A  36
THR A  34
LEU A  33
 None
 0.91A 6nmpN-3hn5A:
undetectable
6nmpW-3hn5A:
undetectable		 6nmpN-3hn5A:
17.12
6nmpW-3hn5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		4 ILE A 131
LEU A  89
THR A 124
LEU A 123
 None
 0.90A 6nmpN-3k4zA:
undetectable
6nmpW-3k4zA:
undetectable		 6nmpN-3k4zA:
17.89
6nmpW-3k4zA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.74A 6nmpN-3muuA:
undetectable
6nmpW-3muuA:
undetectable		 6nmpN-3muuA:
21.45
6nmpW-3muuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373

(Bacillus cereus) 		PF07537
(CamS) 		4 ILE A 105
LEU A 109
THR A 123
LEU A 122
 None
 0.91A 6nmpN-3n2qA:
undetectable
6nmpW-3n2qA:
undetectable		 6nmpN-3n2qA:
19.96
6nmpW-3n2qA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE

(Pelobacter
carbinolicus) 		PF00072
(Response_reg) 		4 ILE A   4
LEU A  47
ARG A  14
LEU A  80
 None
 0.85A 6nmpN-3n53A:
undetectable
6nmpW-3n53A:
undetectable		 6nmpN-3n53A:
13.12
6nmpW-3n53A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.85A 6nmpN-3ng9A:
undetectable
6nmpW-3ng9A:
undetectable		 6nmpN-3ng9A:
21.77
6nmpW-3ng9A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 0.92A 6nmpN-3ozxA:
undetectable
6nmpW-3ozxA:
undetectable		 6nmpN-3ozxA:
18.83
6nmpW-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.78A 6nmpN-3p8cB:
3.5
6nmpW-3p8cB:
undetectable		 6nmpN-3p8cB:
18.35
6nmpW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.82A 6nmpN-3pf2A:
undetectable
6nmpW-3pf2A:
undetectable		 6nmpN-3pf2A:
18.65
6nmpW-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		4 ILE A 125
LEU A 122
THR A   6
LEU A   7
 None
 0.91A 6nmpN-3q1yA:
undetectable
6nmpW-3q1yA:
undetectable		 6nmpN-3q1yA:
20.86
6nmpW-3q1yA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 375
LEU A 250
ARG A 246
LEU A 318
 None
 0.85A 6nmpN-3ra2A:
undetectable
6nmpW-3ra2A:
undetectable		 6nmpN-3ra2A:
23.22
6nmpW-3ra2A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.80A 6nmpN-3rr1A:
undetectable
6nmpW-3rr1A:
undetectable		 6nmpN-3rr1A:
22.10
6nmpW-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.90A 6nmpN-3shmA:
undetectable
6nmpW-3shmA:
undetectable		 6nmpN-3shmA:
22.63
6nmpW-3shmA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.80A 6nmpN-3t6qA:
undetectable
6nmpW-3t6qA:
undetectable		 6nmpN-3t6qA:
19.07
6nmpW-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 637
LEU A 590
ARG A 606
LEU A 598
 None
 0.91A 6nmpN-3uk1A:
1.5
6nmpW-3uk1A:
undetectable		 6nmpN-3uk1A:
22.10
6nmpW-3uk1A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ILE A 261
LEU A 264
THR A 250
LEU A 249
 None
 0.75A 6nmpN-3wibA:
undetectable
6nmpW-3wibA:
undetectable		 6nmpN-3wibA:
20.31
6nmpW-3wibA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.73A 6nmpN-4b8cD:
undetectable
6nmpW-4b8cD:
undetectable		 6nmpN-4b8cD:
21.05
6nmpW-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 LEU A 732
ARG A 425
THR A 759
LEU A 758
 None
 0.77A 6nmpN-4ecnA:
undetectable
6nmpW-4ecnA:
undetectable		 6nmpN-4ecnA:
19.75
6nmpW-4ecnA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.93A 6nmpN-4fhoA:
undetectable
6nmpW-4fhoA:
undetectable		 6nmpN-4fhoA:
18.22
6nmpW-4fhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07738
(Sad1_UNC) 		4 ILE A 648
LEU A 662
ARG A 710
LEU A 615
 None
 0.90A 6nmpN-4fi9A:
undetectable
6nmpW-4fi9A:
undetectable		 6nmpN-4fi9A:
17.12
6nmpW-4fi9A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 ILE A 128
LEU A 150
THR A 124
LEU A 145
 None
 0.89A 6nmpN-4fmzA:
undetectable
6nmpW-4fmzA:
undetectable		 6nmpN-4fmzA:
20.75
6nmpW-4fmzA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Kribbella
flavida) 		PF12840
(HTH_20) 		4 LEU A  82
ARG A  78
THR A  36
LEU A  39
 None
 0.91A 6nmpN-4g6qA:
undetectable
6nmpW-4g6qA:
undetectable		 6nmpN-4g6qA:
16.97
6nmpW-4g6qA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A  71
LEU A  95
THR A  67
LEU A  90
 None
 0.87A 6nmpN-4hq1A:
undetectable
6nmpW-4hq1A:
undetectable		 6nmpN-4hq1A:
22.32
6nmpW-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.89A 6nmpN-4htfB:
undetectable
6nmpW-4htfB:
undetectable		 6nmpN-4htfB:
18.97
6nmpW-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 ILE A 176
LEU A 175
ARG A 185
LEU A 198
 None
 0.92A 6nmpN-4ihqA:
undetectable
6nmpW-4ihqA:
undetectable		 6nmpN-4ihqA:
20.33
6nmpW-4ihqA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 5 ILE A 290
LEU A 274
ARG A  31
THR A 303
LEU A   5
 None
 1.49A 6nmpN-4k3zA:
undetectable
6nmpW-4k3zA:
undetectable		 6nmpN-4k3zA:
20.96
6nmpW-4k3zA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kha SPT16M-HISTONE H2B
1.1 CHIMERA

(Xenopus laevis;
Chaetomium
thermophilum) 		PF00125
(Histone)
PF08512
(Rtt106)
PF08644
(SPT16) 		4 ILE A 816
LEU A 819
THR A 851
LEU A 852
 None
 0.78A 6nmpN-4khaA:
undetectable
6nmpW-4khaA:
undetectable		 6nmpN-4khaA:
20.96
6nmpW-4khaA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kho UNCHARACTERIZED
PROTEIN SPT16M

(Chaetomium
thermophilum) 		PF08512
(Rtt106)
PF08644
(SPT16) 		4 ILE A 818
LEU A 821
THR A 853
LEU A 854
 None
 0.86A 6nmpN-4khoA:
undetectable
6nmpW-4khoA:
undetectable		 6nmpN-4khoA:
20.19
6nmpW-4khoA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqo SORTING NEXIN-14

(Homo sapiens) 		PF00787
(PX) 		4 ILE A 591
LEU A 683
ARG A 616
LEU A 623
 None
 0.91A 6nmpN-4pqoA:
undetectable
6nmpW-4pqoA:
undetectable		 6nmpN-4pqoA:
11.11
6nmpW-4pqoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ILE A 189
LEU A  98
ARG A 363
LEU A 386
 None
 0.93A 6nmpN-4qbuA:
2.0
6nmpW-4qbuA:
undetectable		 6nmpN-4qbuA:
20.36
6nmpW-4qbuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Colwellia
psychrerythraea) 		PF02441
(Flavoprotein) 		4 ILE A 194
LEU A 189
THR A  10
LEU A  11
 None
 0.87A 6nmpN-4rheA:
undetectable
6nmpW-4rheA:
undetectable		 6nmpN-4rheA:
17.27
6nmpW-4rheA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE M   9
ARG M 108
THR M  43
LEU M  42
 None
 0.92A 6nmpN-4rrpM:
undetectable
6nmpW-4rrpM:
undetectable		 6nmpN-4rrpM:
13.87
6nmpW-4rrpM:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 ILE A 153
LEU A 176
THR A 147
LEU A 169
 None
 0.89A 6nmpN-4tzhA:
undetectable
6nmpW-4tzhA:
undetectable		 6nmpN-4tzhA:
14.99
6nmpW-4tzhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8f PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1892

(Streptococcus
agalactiae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.77A 6nmpN-4u8fA:
undetectable
6nmpW-4u8fA:
undetectable		 6nmpN-4u8fA:
15.72
6nmpW-4u8fA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 ILE A 121
LEU A 122
THR A 111
LEU A 110
 None
 0.85A 6nmpN-4wcxA:
undetectable
6nmpW-4wcxA:
undetectable		 6nmpN-4wcxA:
20.57
6nmpW-4wcxA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 LEU A 210
ARG A 227
THR A 225
LEU A 224
 None
 0.86A 6nmpN-4wpzA:
undetectable
6nmpW-4wpzA:
undetectable		 6nmpN-4wpzA:
21.80
6nmpW-4wpzA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 ILE C 163
LEU C 207
ARG C 157
LEU C 154
 None
 0.68A 6nmpN-4wsbC:
undetectable
6nmpW-4wsbC:
undetectable		 6nmpN-4wsbC:
22.62
6nmpW-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.67A 6nmpN-4wsbC:
undetectable
6nmpW-4wsbC:
undetectable		 6nmpN-4wsbC:
22.62
6nmpW-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeo R. EQUI VAPG PROTEIN

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 ILE A 132
LEU A 112
THR A  61
LEU A  60
 None
 0.88A 6nmpN-5aeoA:
undetectable
6nmpW-5aeoA:
undetectable		 6nmpN-5aeoA:
15.81
6nmpW-5aeoA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 ILE A 609
LEU A 591
THR A 614
LEU A 615
 None
 0.89A 6nmpN-5bs5A:
undetectable
6nmpW-5bs5A:
undetectable		 6nmpN-5bs5A:
22.28
6nmpW-5bs5A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		4 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 0.87A 6nmpN-5ce0A:
undetectable
6nmpW-5ce0A:
undetectable		 6nmpN-5ce0A:
20.49
6nmpW-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 ILE A 630
LEU A 644
ARG A 692
LEU A 597
 None
 0.93A 6nmpN-5ed8A:
undetectable
6nmpW-5ed8A:
undetectable		 6nmpN-5ed8A:
19.08
6nmpW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.76A 6nmpN-5hdhA:
undetectable
6nmpW-5hdhA:
undetectable		 6nmpN-5hdhA:
19.75
6nmpW-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.83A 6nmpN-5idiA:
undetectable
6nmpW-5idiA:
undetectable		 6nmpN-5idiA:
21.38
6nmpW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.73A 6nmpN-5jw7B:
undetectable
6nmpW-5jw7B:
undetectable		 6nmpN-5jw7B:
10.76
6nmpW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A 700
LEU A 697
THR A  82
LEU A  81
 None
 0.93A 6nmpN-5jxkA:
1.7
6nmpW-5jxkA:
undetectable		 6nmpN-5jxkA:
18.80
6nmpW-5jxkA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 LEU A 286
ARG A 277
THR A 275
LEU A 274
 None
 0.75A 6nmpN-5k9tA:
undetectable
6nmpW-5k9tA:
undetectable		 6nmpN-5k9tA:
21.11
6nmpW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 LEU B 554
ARG B 531
THR B 535
LEU B 538
 None
 0.91A 6nmpN-5l3xB:
undetectable
6nmpW-5l3xB:
undetectable		 6nmpN-5l3xB:
21.91
6nmpW-5l3xB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ILE A1465
LEU A1468
THR A1490
LEU A1491
 None
 0.84A 6nmpN-5m5pA:
undetectable
6nmpW-5m5pA:
undetectable		 6nmpN-5m5pA:
13.20
6nmpW-5m5pA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.74A 6nmpN-5mqmA:
undetectable
6nmpW-5mqmA:
undetectable		 6nmpN-5mqmA:
19.15
6nmpW-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.87A 6nmpN-5o0lA:
undetectable
6nmpW-5o0lA:
undetectable		 6nmpN-5o0lA:
20.26
6nmpW-5o0lA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 ILE A  12
LEU A  20
THR A  91
LEU A  90
 None
 0.85A 6nmpN-5ohsA:
undetectable
6nmpW-5ohsA:
undetectable		 6nmpN-5ohsA:
undetectable
6nmpW-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 4 ILE A 360
LEU A 384
ARG A 400
LEU A 328
 None
 0.88A 6nmpN-5oieA:
undetectable
6nmpW-5oieA:
undetectable		 6nmpN-5oieA:
undetectable
6nmpW-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 ILE A1253
LEU A1294
ARG A1247
LEU A1276
 None
 0.90A 6nmpN-5t8vA:
undetectable
6nmpW-5t8vA:
undetectable		 6nmpN-5t8vA:
15.48
6nmpW-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 4 ILE A  42
LEU A  43
THR A  20
LEU A  21
 None
None
A3P  A 301 (-2.5A)
A3P  A 301 (-4.2A)
 0.90A 6nmpN-5tizA:
undetectable
6nmpW-5tizA:
undetectable		 6nmpN-5tizA:
17.49
6nmpW-5tizA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.80A 6nmpN-5xagF:
undetectable
6nmpW-5xagF:
undetectable		 6nmpN-5xagF:
undetectable
6nmpW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 LEU A 538
ARG A 511
THR A 505
LEU A 550
 None
 0.88A 6nmpN-5xfaA:
2.6
6nmpW-5xfaA:
undetectable		 6nmpN-5xfaA:
22.80
6nmpW-5xfaA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20

(Homo sapiens) 		no annotation 4 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.89A 6nmpN-5z4iA:
undetectable
6nmpW-5z4iA:
undetectable		 6nmpN-5z4iA:
undetectable
6nmpW-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 4 ILE A 451
LEU A 454
THR A 735
LEU A 738
 None
 0.87A 6nmpN-6bbjA:
undetectable
6nmpW-6bbjA:
undetectable		 6nmpN-6bbjA:
undetectable
6nmpW-6bbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 4 ILE A 451
LEU A 454
THR A 735
LEU A 738
 None
 0.86A 6nmpN-6c8gA:
undetectable
6nmpW-6c8gA:
undetectable		 6nmpN-6c8gA:
undetectable
6nmpW-6c8gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elj FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ILE A  48
LEU A  64
ARG A  19
LEU A  86
 None
 0.87A 6nmpN-6eljA:
undetectable
6nmpW-6eljA:
undetectable		 6nmpN-6eljA:
17.57
6nmpW-6eljA:
15.21