SIMILAR PATTERNS OF AMINO ACIDS FOR 6NMP_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		4 ILE A 239
LEU A 243
THR A 215
LEU A 214
 None
None
SO4  A 109 (-4.1A)
None
 0.93A 6nmpA-1aihA:
0.0
6nmpJ-1aihA:
0.0		 6nmpA-1aihA:
15.90
6nmpJ-1aihA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 0.86A 6nmpA-1floA:
0.1
6nmpJ-1floA:
0.0		 6nmpA-1floA:
21.78
6nmpJ-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ILE A 128
ARG A  14
THR A  96
LEU A  97
 None
 0.83A 6nmpA-1g0dA:
0.0
6nmpJ-1g0dA:
0.0		 6nmpA-1g0dA:
19.23
6nmpJ-1g0dA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g13 GANGLIOSIDE M2
ACTIVATOR PROTEIN

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 ILE A  66
LEU A  55
THR A 134
LEU A 159
 None
 0.95A 6nmpA-1g13A:
undetectable
6nmpJ-1g13A:
undetectable		 6nmpA-1g13A:
15.26
6nmpJ-1g13A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.96A 6nmpA-1harA:
undetectable
6nmpJ-1harA:
0.1		 6nmpA-1harA:
18.00
6nmpJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.83A 6nmpA-1jedA:
0.0
6nmpJ-1jedA:
0.0		 6nmpA-1jedA:
21.17
6nmpJ-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfi TRANSCRIPTION
REGULATOR NC2 ALPHA
CHAIN
TRANSCRIPTION
REGULATOR NC2 BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 ILE B 122
LEU B 126
THR A  67
LEU A  70
 None
 0.93A 6nmpA-1jfiB:
undetectable
6nmpJ-1jfiB:
1.7		 6nmpA-1jfiB:
14.49
6nmpJ-1jfiB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.91A 6nmpA-1lrwA:
undetectable
6nmpJ-1lrwA:
0.0		 6nmpA-1lrwA:
21.34
6nmpJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.85A 6nmpA-1r6xA:
0.0
6nmpJ-1r6xA:
undetectable		 6nmpA-1r6xA:
21.48
6nmpJ-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.85A 6nmpA-1rt8A:
0.0
6nmpJ-1rt8A:
undetectable		 6nmpA-1rt8A:
22.05
6nmpJ-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv7 GENERAL SECRETION
PATHWAY PROTEIN M

(Vibrio cholerae) 		PF04612
(T2SSM) 		4 ILE A 143
LEU A 159
ARG A 147
LEU A 120
 None
 0.83A 6nmpA-1uv7A:
undetectable
6nmpJ-1uv7A:
undetectable		 6nmpA-1uv7A:
11.07
6nmpJ-1uv7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		4 ILE A 216
LEU A  10
ARG A 180
LEU A 130
 None
 0.93A 6nmpA-1vlpA:
0.0
6nmpJ-1vlpA:
undetectable		 6nmpA-1vlpA:
20.47
6nmpJ-1vlpA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx5 NATRIN 1

(Naja atra) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 0.97A 6nmpA-1xx5A:
undetectable
6nmpJ-1xx5A:
undetectable		 6nmpA-1xx5A:
16.47
6nmpJ-1xx5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 367
LEU A 340
ARG A 305
LEU A 277
 None
 0.94A 6nmpA-1ycgA:
0.0
6nmpJ-1ycgA:
undetectable		 6nmpA-1ycgA:
22.05
6nmpJ-1ycgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB

(Mycobacterium
tuberculosis) 		PF02518
(HATPase_c) 		4 ILE A 378
LEU A 365
THR A 361
LEU A 324
 None
 0.88A 6nmpA-1ysrA:
undetectable
6nmpJ-1ysrA:
undetectable		 6nmpA-1ysrA:
14.09
6nmpJ-1ysrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 ILE A  48
LEU A 144
THR A 148
LEU A 211
 None
 0.92A 6nmpA-1yw6A:
0.0
6nmpJ-1yw6A:
undetectable		 6nmpA-1yw6A:
20.62
6nmpJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		4 ILE A 111
LEU A 108
ARG A 125
LEU A  37
 None
GM3  A1212 ( 4.9A)
None
None
 0.91A 6nmpA-2bv7A:
2.2
6nmpJ-2bv7A:
undetectable		 6nmpA-2bv7A:
18.09
6nmpJ-2bv7A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 ILE A 232
LEU A 235
ARG A 285
LEU A 308
 None
 0.95A 6nmpA-2f31A:
undetectable
6nmpJ-2f31A:
undetectable		 6nmpA-2f31A:
17.22
6nmpJ-2f31A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3

(Homo sapiens) 		no annotation 4 ILE A 492
LEU A 434
ARG A 393
LEU A 396
 None
 0.95A 6nmpA-2gkwA:
undetectable
6nmpJ-2gkwA:
undetectable		 6nmpA-2gkwA:
16.87
6nmpJ-2gkwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.93A 6nmpA-2idcA:
undetectable
6nmpJ-2idcA:
undetectable		 6nmpA-2idcA:
13.97
6nmpJ-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnu REGULATOR OF
G-PROTEIN SIGNALING
14

(Homo sapiens) 		PF00615
(RGS) 		4 ILE A 109
LEU A 112
THR A  29
LEU A  32
 None
 0.91A 6nmpA-2jnuA:
1.3
6nmpJ-2jnuA:
undetectable		 6nmpA-2jnuA:
16.82
6nmpJ-2jnuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.84A 6nmpA-2kbqA:
undetectable
6nmpJ-2kbqA:
undetectable		 6nmpA-2kbqA:
8.84
6nmpJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE A 142
LEU A 117
THR A  38
LEU A  39
 None
 0.77A 6nmpA-2m6kA:
undetectable
6nmpJ-2m6kA:
undetectable		 6nmpA-2m6kA:
18.83
6nmpJ-2m6kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		4 ARG A 157
MET A 335
THR A 336
LEU A 337
 None
 0.95A 6nmpA-2ocdA:
undetectable
6nmpJ-2ocdA:
undetectable		 6nmpA-2ocdA:
20.19
6nmpJ-2ocdA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.83A 6nmpA-2p0dA:
undetectable
6nmpJ-2p0dA:
undetectable		 6nmpA-2p0dA:
12.67
6nmpJ-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.69A 6nmpA-2p3gX:
undetectable
6nmpJ-2p3gX:
undetectable		 6nmpA-2p3gX:
19.81
6nmpJ-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 0.94A 6nmpA-2p4oA:
undetectable
6nmpJ-2p4oA:
undetectable		 6nmpA-2p4oA:
20.92
6nmpJ-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 0.94A 6nmpA-2pziA:
0.7
6nmpJ-2pziA:
undetectable		 6nmpA-2pziA:
21.85
6nmpJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 ILE A 503
LEU A 466
ARG A 473
LEU A 518
 None
 0.94A 6nmpA-2v9pA:
undetectable
6nmpJ-2v9pA:
undetectable		 6nmpA-2v9pA:
19.27
6nmpJ-2v9pA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.67A 6nmpA-2y24A:
undetectable
6nmpJ-2y24A:
undetectable		 6nmpA-2y24A:
22.63
6nmpJ-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.48A 6nmpA-2y69J:
undetectable
6nmpJ-2y69J:
7.5		 6nmpA-2y69J:
10.31
6nmpJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE B 447
LEU B 450
THR B 492
LEU B 491
 None
 0.92A 6nmpA-2z7xB:
undetectable
6nmpJ-2z7xB:
undetectable		 6nmpA-2z7xB:
23.01
6nmpJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 0.80A 6nmpA-2z81A:
undetectable
6nmpJ-2z81A:
undetectable		 6nmpA-2z81A:
19.70
6nmpJ-2z81A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.49A 6nmpA-2ziuA:
undetectable
6nmpJ-2ziuA:
undetectable		 6nmpA-2ziuA:
18.55
6nmpJ-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.94A 6nmpA-3ak5A:
undetectable
6nmpJ-3ak5A:
undetectable		 6nmpA-3ak5A:
20.80
6nmpJ-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.95A 6nmpA-3bn1A:
undetectable
6nmpJ-3bn1A:
undetectable		 6nmpA-3bn1A:
21.12
6nmpJ-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 ILE A 129
LEU A 125
THR A 139
LEU A 138
 None
 0.95A 6nmpA-3cf4A:
undetectable
6nmpJ-3cf4A:
undetectable		 6nmpA-3cf4A:
21.47
6nmpJ-3cf4A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN

(Vibrio
parahaemolyticus) 		PF01544
(CorA) 		4 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.96A 6nmpA-3ck6A:
undetectable
6nmpJ-3ck6A:
undetectable		 6nmpA-3ck6A:
17.82
6nmpJ-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ILE A  64
TYR A 128
MET A 132
LEU A 136
 None
 0.55A 6nmpA-3ctzA:
undetectable
6nmpJ-3ctzA:
undetectable		 6nmpA-3ctzA:
21.45
6nmpJ-3ctzA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 ILE A 105
LEU A 120
THR A  97
LEU A  96
 None
 0.88A 6nmpA-3dkaA:
2.6
6nmpJ-3dkaA:
undetectable		 6nmpA-3dkaA:
13.42
6nmpJ-3dkaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.95A 6nmpA-3k1rA:
1.7
6nmpJ-3k1rA:
undetectable		 6nmpA-3k1rA:
14.45
6nmpJ-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		4 LEU A  34
ARG A  20
MET A  18
LEU A  14
 None
 0.83A 6nmpA-3mt1A:
undetectable
6nmpJ-3mt1A:
undetectable		 6nmpA-3mt1A:
21.20
6nmpJ-3mt1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.84A 6nmpA-3muuA:
undetectable
6nmpJ-3muuA:
undetectable		 6nmpA-3muuA:
21.45
6nmpJ-3muuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373

(Bacillus cereus) 		PF07537
(CamS) 		4 ILE A 105
LEU A 109
THR A 123
LEU A 122
 None
 0.83A 6nmpA-3n2qA:
undetectable
6nmpJ-3n2qA:
undetectable		 6nmpA-3n2qA:
19.96
6nmpJ-3n2qA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.96A 6nmpA-3ng9A:
undetectable
6nmpJ-3ng9A:
undetectable		 6nmpA-3ng9A:
21.77
6nmpJ-3ng9A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 229
LEU A 232
TYR A 212
ARG A 215
 None
 0.87A 6nmpA-3nzgA:
undetectable
6nmpJ-3nzgA:
undetectable		 6nmpA-3nzgA:
20.90
6nmpJ-3nzgA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		4 ILE A  75
LEU A  78
THR A  39
LEU A  40
 None
 0.93A 6nmpA-3o6cA:
undetectable
6nmpJ-3o6cA:
undetectable		 6nmpA-3o6cA:
18.76
6nmpJ-3o6cA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 0.93A 6nmpA-3ozxA:
undetectable
6nmpJ-3ozxA:
undetectable		 6nmpA-3ozxA:
18.83
6nmpJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pju CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL) 		4 ILE A 569
LEU A 572
ARG A 605
LEU A 614
 None
 0.79A 6nmpA-3pjuA:
undetectable
6nmpJ-3pjuA:
undetectable		 6nmpA-3pjuA:
17.23
6nmpJ-3pjuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 375
LEU A 250
ARG A 246
LEU A 318
 None
 0.95A 6nmpA-3ra2A:
undetectable
6nmpJ-3ra2A:
undetectable		 6nmpA-3ra2A:
23.22
6nmpJ-3ra2A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.79A 6nmpA-3rr1A:
undetectable
6nmpJ-3rr1A:
undetectable		 6nmpA-3rr1A:
22.10
6nmpJ-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 231
MET A 335
THR A 336
LEU A 339
 None
 0.79A 6nmpA-3sheA:
undetectable
6nmpJ-3sheA:
undetectable		 6nmpA-3sheA:
19.73
6nmpJ-3sheA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.81A 6nmpA-3t6qA:
undetectable
6nmpJ-3t6qA:
undetectable		 6nmpA-3t6qA:
19.07
6nmpJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 167
LEU A 168
THR A 126
LEU A 129
 None
 0.89A 6nmpA-3tpfA:
undetectable
6nmpJ-3tpfA:
undetectable		 6nmpA-3tpfA:
21.35
6nmpJ-3tpfA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		4 ILE A  36
ARG A  87
MET A 101
LEU A 102
 None
 0.91A 6nmpA-3u15A:
undetectable
6nmpJ-3u15A:
undetectable		 6nmpA-3u15A:
11.22
6nmpJ-3u15A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		4 LEU A  68
ARG A 164
THR A 105
LEU A 106
 None
 0.87A 6nmpA-3wa8A:
undetectable
6nmpJ-3wa8A:
undetectable		 6nmpA-3wa8A:
13.36
6nmpJ-3wa8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.90A 6nmpA-3zqjA:
undetectable
6nmpJ-3zqjA:
undetectable		 6nmpA-3zqjA:
18.59
6nmpJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ILE A 438
MET A 390
THR A 391
LEU A 394
 None
 0.75A 6nmpA-4a2qA:
0.9
6nmpJ-4a2qA:
undetectable		 6nmpA-4a2qA:
18.94
6nmpJ-4a2qA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0e F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13954
(PapC_N) 		4 ILE A  48
LEU A 111
THR A  71
LEU A  70
 None
 0.87A 6nmpA-4b0eA:
undetectable
6nmpJ-4b0eA:
undetectable		 6nmpA-4b0eA:
13.28
6nmpJ-4b0eA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.80A 6nmpA-4b8cD:
undetectable
6nmpJ-4b8cD:
undetectable		 6nmpA-4b8cD:
21.05
6nmpJ-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj6 RAP1-INTERACTING
FACTOR 2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 366
TYR A 309
THR A 314
LEU A 317
 None
None
SO4  A1390 ( 3.5A)
None
 0.91A 6nmpA-4bj6A:
undetectable
6nmpJ-4bj6A:
undetectable		 6nmpA-4bj6A:
19.28
6nmpJ-4bj6A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		4 LEU A 119
MET A  59
THR A  60
LEU A  54
 None
 0.95A 6nmpA-4blpA:
undetectable
6nmpJ-4blpA:
undetectable		 6nmpA-4blpA:
20.49
6nmpJ-4blpA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 ILE A 578
ARG A 461
THR A 562
LEU A 561
 None
 0.93A 6nmpA-4bugA:
undetectable
6nmpJ-4bugA:
undetectable		 6nmpA-4bugA:
22.22
6nmpJ-4bugA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.92A 6nmpA-4fhoA:
undetectable
6nmpJ-4fhoA:
undetectable		 6nmpA-4fhoA:
18.22
6nmpJ-4fhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A  71
LEU A  95
THR A  67
LEU A  90
 None
 0.95A 6nmpA-4hq1A:
undetectable
6nmpJ-4hq1A:
undetectable		 6nmpA-4hq1A:
22.32
6nmpJ-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.92A 6nmpA-4ia5A:
undetectable
6nmpJ-4ia5A:
undetectable		 6nmpA-4ia5A:
21.70
6nmpJ-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 ILE A 176
LEU A 175
ARG A 185
LEU A 198
 None
 0.91A 6nmpA-4ihqA:
undetectable
6nmpJ-4ihqA:
undetectable		 6nmpA-4ihqA:
20.33
6nmpJ-4ihqA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 ILE A 186
MET A  97
THR A  98
LEU A 101
 None
 0.92A 6nmpA-4lw6A:
undetectable
6nmpJ-4lw6A:
undetectable		 6nmpA-4lw6A:
18.40
6nmpJ-4lw6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.73A 6nmpA-4oqfA:
undetectable
6nmpJ-4oqfA:
undetectable		 6nmpA-4oqfA:
20.15
6nmpJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		4 ILE A  31
LEU A  58
THR A 245
LEU A 244
 None
 0.91A 6nmpA-4oteA:
undetectable
6nmpJ-4oteA:
undetectable		 6nmpA-4oteA:
17.12
6nmpJ-4oteA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  81
ARG 3 196
THR 3 126
LEU 3 157
 None
 0.92A 6nmpA-4q4y3:
undetectable
6nmpJ-4q4y3:
undetectable		 6nmpA-4q4y3:
19.75
6nmpJ-4q4y3:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 0.96A 6nmpA-4r8lA:
undetectable
6nmpJ-4r8lA:
undetectable		 6nmpA-4r8lA:
23.21
6nmpJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		4 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.96A 6nmpA-4rk9A:
undetectable
6nmpJ-4rk9A:
undetectable		 6nmpA-4rk9A:
21.64
6nmpJ-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE M   9
ARG M 108
THR M  43
LEU M  42
 None
 0.93A 6nmpA-4rrpM:
undetectable
6nmpJ-4rrpM:
undetectable		 6nmpA-4rrpM:
13.87
6nmpJ-4rrpM:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 ILE A 215
LEU A 218
ARG A 251
THR A 263
 None
 0.93A 6nmpA-4uzjA:
undetectable
6nmpJ-4uzjA:
undetectable		 6nmpA-4uzjA:
19.47
6nmpJ-4uzjA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo0 PROTEIN REP68

(Adeno-associated
dependoparvovirus
A) 		PF08724
(Rep_N) 		4 ILE A   9
ARG A 119
THR A  65
LEU A  64
 None
 0.90A 6nmpA-4zo0A:
undetectable
6nmpJ-4zo0A:
undetectable		 6nmpA-4zo0A:
16.50
6nmpJ-4zo0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeo R. EQUI VAPG PROTEIN

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 ILE A 132
LEU A 112
THR A  61
LEU A  60
 None
 0.83A 6nmpA-5aeoA:
undetectable
6nmpJ-5aeoA:
undetectable		 6nmpA-5aeoA:
15.81
6nmpJ-5aeoA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 LEU A 356
ARG A 505
THR A 468
LEU A 469
 None
 0.95A 6nmpA-5cxwA:
undetectable
6nmpJ-5cxwA:
undetectable		 6nmpA-5cxwA:
23.22
6nmpJ-5cxwA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ARG A 276
MET A 279
THR A 280
LEU A 283
 None
 0.76A 6nmpA-5ezrA:
undetectable
6nmpJ-5ezrA:
undetectable		 6nmpA-5ezrA:
20.35
6nmpJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		4 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.96A 6nmpA-5f59A:
undetectable
6nmpJ-5f59A:
undetectable		 6nmpA-5f59A:
13.20
6nmpJ-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.79A 6nmpA-5hdhA:
undetectable
6nmpJ-5hdhA:
undetectable		 6nmpA-5hdhA:
19.75
6nmpJ-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.74A 6nmpA-5idiA:
undetectable
6nmpJ-5idiA:
undetectable		 6nmpA-5idiA:
21.38
6nmpJ-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.76A 6nmpA-5jw7B:
undetectable
6nmpJ-5jw7B:
undetectable		 6nmpA-5jw7B:
10.76
6nmpJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.88A 6nmpA-5kdxA:
undetectable
6nmpJ-5kdxA:
undetectable		 6nmpA-5kdxA:
20.04
6nmpJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 TYR B 224
MET B 228
THR B 229
LEU B 232
 None
 0.56A 6nmpA-5l9wB:
undetectable
6nmpJ-5l9wB:
undetectable		 6nmpA-5l9wB:
22.24
6nmpJ-5l9wB:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 ILE A  40
LEU A 102
THR A  36
LEU A 107
 None
 0.96A 6nmpA-5lfrA:
undetectable
6nmpJ-5lfrA:
undetectable		 6nmpA-5lfrA:
21.04
6nmpJ-5lfrA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.72A 6nmpA-5mqmA:
0.8
6nmpJ-5mqmA:
undetectable		 6nmpA-5mqmA:
19.15
6nmpJ-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 163
ARG A 149
MET A 604
LEU A 600
 None
 0.96A 6nmpA-5nqdA:
undetectable
6nmpJ-5nqdA:
undetectable		 6nmpA-5nqdA:
undetectable
6nmpJ-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ILE A 427
MET A 477
THR A 476
LEU A 475
 None
 0.69A 6nmpA-5ny0A:
undetectable
6nmpJ-5ny0A:
undetectable		 6nmpA-5ny0A:
undetectable
6nmpJ-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 4 LEU A  92
ARG A  82
MET A 113
THR A 112
 None
 0.96A 6nmpA-5tiwA:
undetectable
6nmpJ-5tiwA:
undetectable		 6nmpA-5tiwA:
16.34
6nmpJ-5tiwA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvd NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Paracoccidioides
brasiliensis) 		no annotation 4 ILE A 143
ARG A 125
THR A 127
LEU A 128
 None
 0.96A 6nmpA-5uvdA:
undetectable
6nmpJ-5uvdA:
undetectable		 6nmpA-5uvdA:
undetectable
6nmpJ-5uvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob ENVELOPE
GLYCOPROTEIN UL128

(Human
betaherpesvirus
5) 		no annotation 4 ILE C 109
LEU C 103
THR C  85
LEU C  84
 None
 0.91A 6nmpA-5vobC:
undetectable
6nmpJ-5vobC:
undetectable		 6nmpA-5vobC:
14.92
6nmpJ-5vobC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 LEU A 289
ARG A 345
THR A 263
LEU A 264
 None
 0.94A 6nmpA-5wypA:
undetectable
6nmpJ-5wypA:
undetectable		 6nmpA-5wypA:
undetectable
6nmpJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.75A 6nmpA-5xagF:
undetectable
6nmpJ-5xagF:
undetectable		 6nmpA-5xagF:
undetectable
6nmpJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A  46
LEU A  56
THR A  71
LEU A  72
 None
None
ADP  A 401 (-3.7A)
None
 0.93A 6nmpA-6blbA:
undetectable
6nmpJ-6blbA:
undetectable		 6nmpA-6blbA:
21.43
6nmpJ-6blbA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOME PRODUCTION
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE I 117
LEU I 114
THR I 264
LEU I 265
 None
 0.93A 6nmpA-6c0fI:
undetectable
6nmpJ-6c0fI:
undetectable		 6nmpA-6c0fI:
undetectable
6nmpJ-6c0fI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 ILE A 155
LEU A 171
THR A 243
LEU A 227
 None
 0.95A 6nmpA-6c29A:
undetectable
6nmpJ-6c29A:
undetectable		 6nmpA-6c29A:
undetectable
6nmpJ-6c29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 4 LEU A 172
ARG A 227
THR A 211
LEU A 214
 None
 0.94A 6nmpA-6co9A:
undetectable
6nmpJ-6co9A:
undetectable		 6nmpA-6co9A:
undetectable
6nmpJ-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 ILE A  16
LEU A  18
THR A  71
LEU A  72
 None
None
NAG  A 603 (-3.8A)
None
 0.92A 6nmpA-6g21A:
undetectable
6nmpJ-6g21A:
undetectable		 6nmpA-6g21A:
undetectable
6nmpJ-6g21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 4 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.83A 6nmpA-6gsaD:
undetectable
6nmpJ-6gsaD:
undetectable		 6nmpA-6gsaD:
undetectable
6nmpJ-6gsaD:
undetectable