SIMILAR PATTERNS OF AMINO ACIDS FOR 6NMP_C_CHDC307

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		4 GLN A 265
PHE A 274
LEU A 287
PHE A 204
 None
 1.25A 6nmpC-1bpoA:
undetectable
6nmpJ-1bpoA:
0.0		 6nmpC-1bpoA:
18.51
6nmpJ-1bpoA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		4 GLN A 265
PHE A 274
LEU A 287
PHE A 204
 None
 1.21A 6nmpC-1c9lA:
undetectable
6nmpJ-1c9lA:
0.0		 6nmpC-1c9lA:
19.46
6nmpJ-1c9lA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 0.92A 6nmpC-1ecoA:
undetectable
6nmpJ-1ecoA:
0.0		 6nmpC-1ecoA:
20.00
6nmpJ-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrv GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A 485
PHE A 484
LEU A 512
PHE A 506
 None
 1.01A 6nmpC-1nrvA:
undetectable
6nmpJ-1nrvA:
undetectable		 6nmpC-1nrvA:
16.86
6nmpJ-1nrvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 LYS A 330
GLN A 331
LEU A 283
PHE A 272
 None
 1.15A 6nmpC-1ovwA:
undetectable
6nmpJ-1ovwA:
undetectable		 6nmpC-1ovwA:
19.35
6nmpJ-1ovwA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR

(Homo sapiens) 		no annotation 4 LYS C  13
GLN C  27
PHE C  64
LEU C  96
 None
 1.31A 6nmpC-1ow0C:
undetectable
6nmpJ-1ow0C:
undetectable		 6nmpC-1ow0C:
21.58
6nmpJ-1ow0C:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 GLN A   8
PHE A   7
LEU A 153
PHE A  90
 ACY  A4004 (-3.0A)
None
None
None
 1.30A 6nmpC-1pp0A:
undetectable
6nmpJ-1pp0A:
0.0		 6nmpC-1pp0A:
18.63
6nmpJ-1pp0A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLN B 244
PHE B 243
LEU B 210
PHE B 203
 None
 1.31A 6nmpC-1qhhB:
undetectable
6nmpJ-1qhhB:
0.0		 6nmpC-1qhhB:
18.33
6nmpJ-1qhhB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A  25
PHE A  21
LEU A   9
PHE A   7
 None
 1.35A 6nmpC-1qp8A:
0.7
6nmpJ-1qp8A:
0.0		 6nmpC-1qp8A:
22.73
6nmpJ-1qp8A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq AGGRECAN CORE
PROTEIN

(Rattus
norvegicus) 		PF00059
(Lectin_C) 		4 GLN B  80
PHE B  81
LEU B  62
PHE B  71
 None
 1.19A 6nmpC-1tdqB:
undetectable
6nmpJ-1tdqB:
undetectable		 6nmpC-1tdqB:
14.23
6nmpJ-1tdqB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLN A 217
PHE A 213
LEU A 431
PHE A 317
 FE2  A 600 (-3.8A)
None
None
None
 1.34A 6nmpC-1uliA:
undetectable
6nmpJ-1uliA:
undetectable		 6nmpC-1uliA:
19.61
6nmpJ-1uliA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LYS A 172
GLN A 170
LEU A 226
PHE A 192
 None
 1.13A 6nmpC-1vrpA:
0.0
6nmpJ-1vrpA:
undetectable		 6nmpC-1vrpA:
22.11
6nmpJ-1vrpA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LYS C  62
GLN C 104
LEU C  40
PHE C  36
 None
 1.22A 6nmpC-1wa5C:
3.5
6nmpJ-1wa5C:
undetectable		 6nmpC-1wa5C:
12.06
6nmpJ-1wa5C:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		4 ARG X  61
GLN X 171
LEU X  17
PHE X  52
 None
None
2HS  X 600 (-4.1A)
None
 1.16A 6nmpC-1ys2X:
0.0
6nmpJ-1ys2X:
undetectable		 6nmpC-1ys2X:
22.32
6nmpJ-1ys2X:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LYS A 285
GLN A 213
LEU A 266
PHE A 259
 None
 1.26A 6nmpC-1zr6A:
undetectable
6nmpJ-1zr6A:
undetectable		 6nmpC-1zr6A:
18.22
6nmpJ-1zr6A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aug GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A 489
PHE A 488
LEU A 516
PHE A 510
 None
 1.29A 6nmpC-2augA:
undetectable
6nmpJ-2augA:
undetectable		 6nmpC-2augA:
18.68
6nmpJ-2augA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLN A 288
PHE A 143
LEU A 152
PHE A 179
 None
 1.28A 6nmpC-2be7A:
undetectable
6nmpJ-2be7A:
undetectable		 6nmpC-2be7A:
21.89
6nmpJ-2be7A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm0 TYROSINE-PROTEIN
KINASE TXK

(Homo sapiens) 		PF00017
(SH2) 		4 LYS A  74
GLN A  72
LEU A  95
PHE A  89
 None
 1.35A 6nmpC-2dm0A:
undetectable
6nmpJ-2dm0A:
undetectable		 6nmpC-2dm0A:
15.65
6nmpJ-2dm0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 LYS A 271
GLN A 218
LEU A 278
PHE A 247
 None
 1.33A 6nmpC-2el7A:
undetectable
6nmpJ-2el7A:
undetectable		 6nmpC-2el7A:
21.31
6nmpJ-2el7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmq HYPOTHETICAL PROTEIN
EF0006

(Enterococcus
faecalis) 		PF09627
(PrgU) 		4 LYS A 100
PHE A  97
LEU A  34
PHE A 108
 None
 1.29A 6nmpC-2gmqA:
undetectable
6nmpJ-2gmqA:
undetectable		 6nmpC-2gmqA:
18.57
6nmpJ-2gmqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		4 GLN A  49
PHE A  50
LEU A  98
PHE A 103
 None
FMN  A 149 ( 3.1A)
None
None
 1.29A 6nmpC-2kb2A:
undetectable
6nmpJ-2kb2A:
undetectable		 6nmpC-2kb2A:
20.31
6nmpJ-2kb2A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kj9 INTEGRASE

(Pectobacterium
atrosepticum) 		no annotation 4 LYS A  80
GLN A  81
LEU A  39
PHE A  44
 None
 1.22A 6nmpC-2kj9A:
undetectable
6nmpJ-2kj9A:
undetectable		 6nmpC-2kj9A:
18.39
6nmpJ-2kj9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLN A  83
PHE A 117
LEU A  92
PHE A  55
 None
 1.01A 6nmpC-2nx9A:
undetectable
6nmpJ-2nx9A:
undetectable		 6nmpC-2nx9A:
18.63
6nmpJ-2nx9A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.14A 6nmpC-2nyfA:
3.5
6nmpJ-2nyfA:
undetectable		 6nmpC-2nyfA:
17.96
6nmpJ-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		4 GLN A 155
PHE A 229
LEU A 190
PHE A 187
 None
 1.33A 6nmpC-2oaaA:
undetectable
6nmpJ-2oaaA:
undetectable		 6nmpC-2oaaA:
20.00
6nmpJ-2oaaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5s RAS AND EF-HAND
DOMAIN CONTAINING

(Homo sapiens) 		PF00071
(Ras) 		4 LYS A 578
GLN A 593
LEU A 561
PHE A 557
 None
 1.17A 6nmpC-2p5sA:
undetectable
6nmpJ-2p5sA:
undetectable		 6nmpC-2p5sA:
20.74
6nmpJ-2p5sA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qar TELSAM DOMAIN

(Escherichia
coli) 		PF02198
(SAM_PNT) 		4 LYS B  39
GLN B  36
LEU B  84
PHE B  45
 None
 1.27A 6nmpC-2qarB:
undetectable
6nmpJ-2qarB:
1.6		 6nmpC-2qarB:
15.87
6nmpJ-2qarB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkl SPAC19A8.12 PROTEIN

(Schizosaccharomyces
pombe) 		PF05026
(DCP2) 		4 LYS B   2
GLN B  52
PHE B  48
LEU B  15
 None
 1.26A 6nmpC-2qklB:
undetectable
6nmpJ-2qklB:
undetectable		 6nmpC-2qklB:
14.62
6nmpJ-2qklB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rv8 DNA-BINDING RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		4 LYS A 167
PHE A 153
LEU A 158
PHE A 179
 None
 1.24A 6nmpC-2rv8A:
undetectable
6nmpJ-2rv8A:
undetectable		 6nmpC-2rv8A:
17.31
6nmpJ-2rv8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLN A 347
PHE A 348
LEU A 340
PHE A 309
 None
None
None
MTY  A 300 ( 3.9A)
 1.23A 6nmpC-2tohA:
undetectable
6nmpJ-2tohA:
undetectable		 6nmpC-2tohA:
21.19
6nmpJ-2tohA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ARG A 379
GLN A 313
LEU A 413
PHE A 420
 None
 1.33A 6nmpC-2xdfA:
1.9
6nmpJ-2xdfA:
undetectable		 6nmpC-2xdfA:
16.41
6nmpJ-2xdfA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE

(Thermus
thermophilus) 		no annotation 4 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 1.24A 6nmpC-2yvsA:
undetectable
6nmpJ-2yvsA:
undetectable		 6nmpC-2yvsA:
20.59
6nmpJ-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5

(Homo sapiens) 		PF13869
(NUDIX_2) 		4 LYS A 192
GLN A  98
LEU A 129
PHE A 185
 None
 1.17A 6nmpC-3bhoA:
undetectable
6nmpJ-3bhoA:
undetectable		 6nmpC-3bhoA:
19.00
6nmpJ-3bhoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLN A 218
PHE A 217
LEU A 194
PHE A 193
 None
 1.33A 6nmpC-3ciyA:
undetectable
6nmpJ-3ciyA:
undetectable		 6nmpC-3ciyA:
15.20
6nmpJ-3ciyA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ARG A  77
LYS A  76
GLN A 107
PHE A  73
 None
 1.06A 6nmpC-3e1tA:
undetectable
6nmpJ-3e1tA:
undetectable		 6nmpC-3e1tA:
18.96
6nmpJ-3e1tA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 GLN A1325
PHE A1324
LEU A1244
PHE A1221
 None
 1.09A 6nmpC-3f5fA:
undetectable
6nmpJ-3f5fA:
undetectable		 6nmpC-3f5fA:
15.17
6nmpJ-3f5fA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.30A 6nmpC-3gs3A:
undetectable
6nmpJ-3gs3A:
undetectable		 6nmpC-3gs3A:
19.29
6nmpJ-3gs3A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLN A 288
PHE A 289
LEU A 281
PHE A 250
 None
 1.28A 6nmpC-3hf8A:
undetectable
6nmpJ-3hf8A:
undetectable		 6nmpC-3hf8A:
21.23
6nmpJ-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLN A 296
PHE A 295
LEU A 513
PHE A 515
 None
 1.21A 6nmpC-3k4xA:
undetectable
6nmpJ-3k4xA:
undetectable		 6nmpC-3k4xA:
14.85
6nmpJ-3k4xA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 LYS A 190
GLN A 188
PHE A 187
LEU A 218
 None
 1.28A 6nmpC-3l7gA:
undetectable
6nmpJ-3l7gA:
undetectable		 6nmpC-3l7gA:
17.41
6nmpJ-3l7gA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 CALCINEURIN SUBUNIT
B TYPE 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LYS B  28
PHE B  71
LEU B  37
PHE B  42
 None
 1.26A 6nmpC-3ll8B:
undetectable
6nmpJ-3ll8B:
undetectable		 6nmpC-3ll8B:
18.65
6nmpJ-3ll8B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 264
GLN A 272
PHE A 274
LEU A 294
 None
 1.17A 6nmpC-3nv3A:
undetectable
6nmpJ-3nv3A:
undetectable		 6nmpC-3nv3A:
20.76
6nmpJ-3nv3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ARG A 331
PHE A 216
LEU A 315
PHE A 312
 None
 1.34A 6nmpC-3o57A:
undetectable
6nmpJ-3o57A:
undetectable		 6nmpC-3o57A:
20.05
6nmpJ-3o57A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		4 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 1.00A 6nmpC-3on4A:
2.6
6nmpJ-3on4A:
undetectable		 6nmpC-3on4A:
19.85
6nmpJ-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 LYS A  60
GLN A  58
LEU A  55
PHE A  63
 None
 1.31A 6nmpC-3q33A:
undetectable
6nmpJ-3q33A:
undetectable		 6nmpC-3q33A:
19.95
6nmpJ-3q33A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A  47
PHE A 131
LEU A 462
PHE A 463
 None
 1.33A 6nmpC-3q5iA:
2.5
6nmpJ-3q5iA:
undetectable		 6nmpC-3q5iA:
17.23
6nmpJ-3q5iA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 GLN A 292
PHE A 293
LEU A 299
PHE A 230
 None
 1.17A 6nmpC-3u4vA:
undetectable
6nmpJ-3u4vA:
undetectable		 6nmpC-3u4vA:
16.35
6nmpJ-3u4vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u58 TETRAHYMENA TEB1 AB

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 GLN A 292
PHE A 293
LEU A 299
PHE A 230
 None
 1.34A 6nmpC-3u58A:
undetectable
6nmpJ-3u58A:
undetectable		 6nmpC-3u58A:
21.88
6nmpJ-3u58A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.79A 6nmpC-3wi3A:
2.6
6nmpJ-3wi3A:
undetectable		 6nmpC-3wi3A:
18.93
6nmpJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 GLN B1146
PHE B1144
LEU B1023
PHE B1451
 None
 1.29A 6nmpC-3zefB:
undetectable
6nmpJ-3zefB:
undetectable		 6nmpC-3zefB:
10.07
6nmpJ-3zefB:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 GLN A 132
PHE A 158
LEU A 129
PHE A 176
 None
 1.09A 6nmpC-4aefA:
undetectable
6nmpJ-4aefA:
undetectable		 6nmpC-4aefA:
19.49
6nmpJ-4aefA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 ARG A 297
LYS A 298
GLN A 302
PHE A 304
 None
 1.31A 6nmpC-4b3gA:
1.5
6nmpJ-4b3gA:
undetectable		 6nmpC-4b3gA:
17.24
6nmpJ-4b3gA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 ARG A 288
GLN A 295
LEU A 206
PHE A 229
 None
 1.31A 6nmpC-4cnkA:
undetectable
6nmpJ-4cnkA:
undetectable		 6nmpC-4cnkA:
20.76
6nmpJ-4cnkA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLN A 728
PHE A 727
LEU A 723
PHE A 709
 None
 0.97A 6nmpC-4crsA:
undetectable
6nmpJ-4crsA:
undetectable		 6nmpC-4crsA:
20.63
6nmpJ-4crsA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ARG A  48
PHE A 202
LEU A  45
PHE A  42
 None
 1.29A 6nmpC-4ewgA:
undetectable
6nmpJ-4ewgA:
undetectable		 6nmpC-4ewgA:
19.76
6nmpJ-4ewgA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gao DCN1-LIKE PROTEIN 2

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 LYS A 155
GLN A 159
LEU A 186
PHE A 190
 None
 1.35A 6nmpC-4gaoA:
undetectable
6nmpJ-4gaoA:
undetectable		 6nmpC-4gaoA:
20.08
6nmpJ-4gaoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		4 GLN A 215
PHE A 155
LEU A 272
PHE A 247
 None
 1.23A 6nmpC-4gewA:
undetectable
6nmpJ-4gewA:
undetectable		 6nmpC-4gewA:
19.83
6nmpJ-4gewA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hde SCO1/SENC FAMILY
LIPOPROTEIN

(Bacillus
anthracis) 		PF02630
(SCO1-SenC) 		4 LYS A  58
GLN A  95
PHE A  96
LEU A 164
 None
 1.31A 6nmpC-4hdeA:
undetectable
6nmpJ-4hdeA:
undetectable		 6nmpC-4hdeA:
17.79
6nmpJ-4hdeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.33A 6nmpC-4imiA:
undetectable
6nmpJ-4imiA:
undetectable		 6nmpC-4imiA:
19.53
6nmpJ-4imiA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 ARG A 645
GLN A 325
PHE A 433
LEU A 411
 None
 1.25A 6nmpC-4ka8A:
4.2
6nmpJ-4ka8A:
undetectable		 6nmpC-4ka8A:
16.02
6nmpJ-4ka8A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		4 ARG A  58
LYS A  57
PHE A  80
LEU A 324
 None
 1.22A 6nmpC-4limA:
undetectable
6nmpJ-4limA:
undetectable		 6nmpC-4limA:
20.96
6nmpJ-4limA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 GLN A 284
PHE A 287
LEU A 295
PHE A 298
 None
 1.35A 6nmpC-4nhyA:
undetectable
6nmpJ-4nhyA:
undetectable		 6nmpC-4nhyA:
17.63
6nmpJ-4nhyA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 GLN A 375
PHE A 372
LEU A 299
PHE A 301
 None
 1.03A 6nmpC-4oyaA:
undetectable
6nmpJ-4oyaA:
undetectable		 6nmpC-4oyaA:
19.62
6nmpJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.21A 6nmpC-4ppmA:
undetectable
6nmpJ-4ppmA:
undetectable		 6nmpC-4ppmA:
14.00
6nmpJ-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 LYS A 328
GLN A 327
LEU A 371
PHE A 344
 None
 1.08A 6nmpC-4pzvA:
undetectable
6nmpJ-4pzvA:
undetectable		 6nmpC-4pzvA:
18.22
6nmpJ-4pzvA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS K 482
GLN K 478
PHE K 477
LEU K 407
 None
 1.24A 6nmpC-4q66K:
1.1
6nmpJ-4q66K:
undetectable		 6nmpC-4q66K:
17.17
6nmpJ-4q66K:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 ARG A 400
LYS A 397
GLN A 394
LEU A 436
 CL  A 909 (-3.4A)
None
None
None
 1.29A 6nmpC-4qnlA:
undetectable
6nmpJ-4qnlA:
undetectable		 6nmpC-4qnlA:
15.36
6nmpJ-4qnlA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdu HOMEOBOX PROTEIN
DLX-5

(Homo sapiens) 		PF00046
(Homeobox) 		4 ARG A 189
LYS A 188
GLN A 153
LEU A 162
 None
 1.31A 6nmpC-4rduA:
undetectable
6nmpJ-4rduA:
undetectable		 6nmpC-4rduA:
13.51
6nmpJ-4rduA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8d SORCIN

(Homo sapiens) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		4 ARG A  76
GLN A  55
PHE A  70
LEU A  77
 None
 1.33A 6nmpC-4u8dA:
undetectable
6nmpJ-4u8dA:
undetectable		 6nmpC-4u8dA:
21.98
6nmpJ-4u8dA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LYS A 144
GLN A 158
LEU A 125
PHE A 121
 None
 1.04A 6nmpC-4ud4A:
undetectable
6nmpJ-4ud4A:
undetectable		 6nmpC-4ud4A:
19.95
6nmpJ-4ud4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		4 ARG A 119
GLN A 142
PHE A 141
LEU A 185
 None
 1.31A 6nmpC-4uegA:
undetectable
6nmpJ-4uegA:
undetectable		 6nmpC-4uegA:
21.54
6nmpJ-4uegA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE

(Homo sapiens;
Homo sapiens) 		PF00992
(Troponin)
PF00992
(Troponin)
PF11636
(Troponin-I_N) 		4 ARG C 111
LYS B 247
GLN B 251
PHE B 254
 None
 1.11A 6nmpC-4y99C:
undetectable
6nmpJ-4y99C:
3.0		 6nmpC-4y99C:
15.15
6nmpJ-4y99C:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LYS A 188
GLN A 269
LEU A 169
PHE A 247
 None
 1.33A 6nmpC-4zn6A:
undetectable
6nmpJ-4zn6A:
undetectable		 6nmpC-4zn6A:
21.07
6nmpJ-4zn6A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 LYS A 228
PHE A 222
LEU A 239
PHE A 237
 None
 1.24A 6nmpC-5a2aA:
undetectable
6nmpJ-5a2aA:
undetectable		 6nmpC-5a2aA:
19.09
6nmpJ-5a2aA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9h TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.03A 6nmpC-5c9hA:
undetectable
6nmpJ-5c9hA:
undetectable		 6nmpC-5c9hA:
18.61
6nmpJ-5c9hA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLN B 389
PHE B 388
LEU B 312
PHE B 384
 None
 1.26A 6nmpC-5fq6B:
undetectable
6nmpJ-5fq6B:
undetectable		 6nmpC-5fq6B:
15.57
6nmpJ-5fq6B:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLN A 518
PHE A 517
LEU A 586
PHE A 588
 None
 1.14A 6nmpC-5fr8A:
undetectable
6nmpJ-5fr8A:
undetectable		 6nmpC-5fr8A:
16.67
6nmpJ-5fr8A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		4 ARG A 176
GLN A 178
LEU A 158
PHE A 288
 None
 1.24A 6nmpC-5gzaA:
undetectable
6nmpJ-5gzaA:
undetectable		 6nmpC-5gzaA:
21.02
6nmpJ-5gzaA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 ARG A 284
GLN A 292
PHE A 293
LEU A 568
 None
 1.23A 6nmpC-5h3kA:
undetectable
6nmpJ-5h3kA:
undetectable		 6nmpC-5h3kA:
18.17
6nmpJ-5h3kA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ARG A1870
PHE A2162
LEU A1901
PHE A1902
 None
 1.06A 6nmpC-5i6gA:
undetectable
6nmpJ-5i6gA:
undetectable		 6nmpC-5i6gA:
11.97
6nmpJ-5i6gA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ARG A1870
PHE A2162
LEU A1901
PHE A1902
 None
 1.07A 6nmpC-5i6hA:
undetectable
6nmpJ-5i6hA:
undetectable		 6nmpC-5i6hA:
9.27
6nmpJ-5i6hA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ARG A1870
PHE A2162
LEU A1901
PHE A1902
 None
 1.07A 6nmpC-5i6iA:
undetectable
6nmpJ-5i6iA:
undetectable		 6nmpC-5i6iA:
7.86
6nmpJ-5i6iA:
2.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
LYS C 157
GLN C 161
PHE C 164
LEU C 223
 CHD  C 307 (-4.0A)
None
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
 0.59A 6nmpC-5iy5C:
35.8
6nmpJ-5iy5C:
undetectable		 6nmpC-5iy5C:
100.00
6nmpJ-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 GLN A 261
PHE A 265
LEU A 333
PHE A  99
 None
 1.26A 6nmpC-5jxmA:
undetectable
6nmpJ-5jxmA:
undetectable		 6nmpC-5jxmA:
21.17
6nmpJ-5jxmA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLN C  79
PHE C 113
LEU C  88
PHE C  51
 None
 1.02A 6nmpC-5ks8C:
undetectable
6nmpJ-5ks8C:
undetectable		 6nmpC-5ks8C:
16.72
6nmpJ-5ks8C:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLN A 288
PHE A 289
LEU A 281
PHE A 250
 None
 1.27A 6nmpC-5l01A:
undetectable
6nmpJ-5l01A:
undetectable		 6nmpC-5l01A:
19.02
6nmpJ-5l01A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA

(Klebsiella
pneumoniae;
Homo sapiens) 		PF01475
(FUR)
PF02198
(SAM_PNT) 		4 LYS A 121
GLN A 118
LEU A 166
PHE A 127
 None
 1.26A 6nmpC-5l0pA:
undetectable
6nmpJ-5l0pA:
undetectable		 6nmpC-5l0pA:
20.11
6nmpJ-5l0pA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 ARG B 490
GLN B 485
PHE B 482
LEU B 257
 None
 1.12A 6nmpC-5ltmB:
undetectable
6nmpJ-5ltmB:
undetectable		 6nmpC-5ltmB:
18.82
6nmpJ-5ltmB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 4 GLN A 265
PHE A 274
LEU A 287
PHE A 204
 None
 1.31A 6nmpC-5odsA:
undetectable
6nmpJ-5odsA:
undetectable		 6nmpC-5odsA:
undetectable
6nmpJ-5odsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 GLN T1726
PHE T1725
LEU T1703
PHE T1752
 None
 1.23A 6nmpC-5ojsT:
undetectable
6nmpJ-5ojsT:
undetectable		 6nmpC-5ojsT:
5.12
6nmpJ-5ojsT:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 GLN A1589
PHE A1592
LEU A1614
PHE A1670
 None
 1.34A 6nmpC-5t8vA:
2.6
6nmpJ-5t8vA:
undetectable		 6nmpC-5t8vA:
9.66
6nmpJ-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LYS A 487
GLN A 484
PHE A 434
LEU A 224
 None
 1.33A 6nmpC-5u47A:
undetectable
6nmpJ-5u47A:
undetectable		 6nmpC-5u47A:
13.82
6nmpJ-5u47A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 4 LYS G 204
GLN G 202
PHE G 201
LEU G 215
 None
 1.35A 6nmpC-5uz5G:
undetectable
6nmpJ-5uz5G:
undetectable		 6nmpC-5uz5G:
18.31
6nmpJ-5uz5G:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		4 LYS A1155
GLN A1159
LEU A1186
PHE A1190
 None
 1.25A 6nmpC-5v88A:
undetectable
6nmpJ-5v88A:
undetectable		 6nmpC-5v88A:
20.73
6nmpJ-5v88A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 LYS A 170
GLN A 173
LEU A 158
PHE A 159
 None
 1.21A 6nmpC-5vanA:
undetectable
6nmpJ-5vanA:
undetectable		 6nmpC-5vanA:
undetectable
6nmpJ-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3r LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		no annotation 4 GLN A 141
PHE A 144
LEU A  79
PHE A  78
 None
 1.19A 6nmpC-5x3rA:
undetectable
6nmpJ-5x3rA:
undetectable		 6nmpC-5x3rA:
undetectable
6nmpJ-5x3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 GLN A 233
PHE A 212
LEU A 183
PHE A  81
 None
 1.27A 6nmpC-5xwbA:
undetectable
6nmpJ-5xwbA:
undetectable		 6nmpC-5xwbA:
20.54
6nmpJ-5xwbA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 1.05A 6nmpC-6c0tA:
2.1
6nmpJ-6c0tA:
undetectable		 6nmpC-6c0tA:
undetectable
6nmpJ-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 4 ARG A 425
GLN A 431
PHE A 437
LEU A 486
 None
 0.99A 6nmpC-6d0sA:
undetectable
6nmpJ-6d0sA:
undetectable		 6nmpC-6d0sA:
undetectable
6nmpJ-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A2370
PHE A2360
LEU A2275
PHE A2297
 None
 1.34A 6nmpC-6emkA:
undetectable
6nmpJ-6emkA:
undetectable		 6nmpC-6emkA:
undetectable
6nmpJ-6emkA:
undetectable