SIMILAR PATTERNS OF AMINO ACIDS FOR 6NMF_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 0.86A 6nmfA-1floA:
0.6
6nmfJ-1floA:
0.0		 6nmfA-1floA:
21.78
6nmfJ-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ILE A 128
ARG A  14
THR A  96
LEU A  97
 None
 0.85A 6nmfA-1g0dA:
0.0
6nmfJ-1g0dA:
0.0		 6nmfA-1g0dA:
19.23
6nmfJ-1g0dA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g13 GANGLIOSIDE M2
ACTIVATOR PROTEIN

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 ILE A  66
LEU A  55
THR A 134
LEU A 159
 None
 0.92A 6nmfA-1g13A:
undetectable
6nmfJ-1g13A:
undetectable		 6nmfA-1g13A:
15.26
6nmfJ-1g13A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.87A 6nmfA-1harA:
undetectable
6nmfJ-1harA:
0.1		 6nmfA-1harA:
18.00
6nmfJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hom ANTENNAPEDIA PROTEIN

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		4 LEU A  38
ARG A  29
THR A  27
LEU A  26
 None
 0.99A 6nmfA-1homA:
undetectable
6nmfJ-1homA:
0.1		 6nmfA-1homA:
8.24
6nmfJ-1homA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 6nmfA-1lrwA:
undetectable
6nmfJ-1lrwA:
0.0		 6nmfA-1lrwA:
21.34
6nmfJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT

(Bacillus
subtilis) 		PF11563
(Protoglobin) 		4 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.00A 6nmfA-1or4A:
0.0
6nmfJ-1or4A:
0.0		 6nmfA-1or4A:
14.76
6nmfJ-1or4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv7 GENERAL SECRETION
PATHWAY PROTEIN M

(Vibrio cholerae) 		PF04612
(T2SSM) 		4 ILE A 143
LEU A 159
ARG A 147
LEU A 120
 None
 0.78A 6nmfA-1uv7A:
undetectable
6nmfJ-1uv7A:
undetectable		 6nmfA-1uv7A:
11.07
6nmfJ-1uv7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 227
TYR A  72
THR A  77
LEU A  80
 None
 0.69A 6nmfA-2b9bA:
0.8
6nmfJ-2b9bA:
2.8		 6nmfA-2b9bA:
21.63
6nmfJ-2b9bA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.90A 6nmfA-2bwgA:
0.0
6nmfJ-2bwgA:
undetectable		 6nmfA-2bwgA:
21.02
6nmfJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzq GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		4 ILE A  53
LEU A  49
ARG A  67
LEU A  15
 None
 0.96A 6nmfA-2dzqA:
undetectable
6nmfJ-2dzqA:
undetectable		 6nmfA-2dzqA:
10.62
6nmfJ-2dzqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 6nmfA-2eg5A:
0.0
6nmfJ-2eg5A:
undetectable		 6nmfA-2eg5A:
22.14
6nmfJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.90A 6nmfA-2idcA:
undetectable
6nmfJ-2idcA:
undetectable		 6nmfA-2idcA:
13.97
6nmfJ-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnu REGULATOR OF
G-PROTEIN SIGNALING
14

(Homo sapiens) 		PF00615
(RGS) 		4 ILE A 109
LEU A 112
THR A  29
LEU A  32
 None
 0.87A 6nmfA-2jnuA:
undetectable
6nmfJ-2jnuA:
undetectable		 6nmfA-2jnuA:
16.82
6nmfJ-2jnuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.86A 6nmfA-2kbqA:
undetectable
6nmfJ-2kbqA:
undetectable		 6nmfA-2kbqA:
8.84
6nmfJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE A 142
LEU A 117
THR A  38
LEU A  39
 None
 0.84A 6nmfA-2m6kA:
0.0
6nmfJ-2m6kA:
undetectable		 6nmfA-2m6kA:
18.83
6nmfJ-2m6kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.84A 6nmfA-2p0dA:
undetectable
6nmfJ-2p0dA:
undetectable		 6nmfA-2p0dA:
12.67
6nmfJ-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.67A 6nmfA-2p3gX:
1.2
6nmfJ-2p3gX:
undetectable		 6nmfA-2p3gX:
19.81
6nmfJ-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 0.97A 6nmfA-2p4oA:
undetectable
6nmfJ-2p4oA:
undetectable		 6nmfA-2p4oA:
20.92
6nmfJ-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 ILE A 503
LEU A 466
ARG A 473
LEU A 518
 None
 0.93A 6nmfA-2v9pA:
0.0
6nmfJ-2v9pA:
undetectable		 6nmfA-2v9pA:
19.27
6nmfJ-2v9pA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		4 ILE A 183
LEU A 195
ARG A 241
LEU A 229
 None
 0.96A 6nmfA-2vbkA:
undetectable
6nmfJ-2vbkA:
undetectable		 6nmfA-2vbkA:
22.01
6nmfJ-2vbkA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.97A 6nmfA-2wy0C:
undetectable
6nmfJ-2wy0C:
undetectable		 6nmfA-2wy0C:
21.21
6nmfJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ILE A 311
LEU A 305
ARG A 282
LEU A 275
 None
 0.81A 6nmfA-2x7jA:
0.0
6nmfJ-2x7jA:
undetectable		 6nmfA-2x7jA:
23.17
6nmfJ-2x7jA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.66A 6nmfA-2y24A:
undetectable
6nmfJ-2y24A:
undetectable		 6nmfA-2y24A:
22.63
6nmfJ-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.41A 6nmfA-2y69J:
undetectable
6nmfJ-2y69J:
7.7		 6nmfA-2y69J:
10.31
6nmfJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.58A 6nmfA-2ziuA:
undetectable
6nmfJ-2ziuA:
undetectable		 6nmfA-2ziuA:
18.55
6nmfJ-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.96A 6nmfA-3ak5A:
undetectable
6nmfJ-3ak5A:
undetectable		 6nmfA-3ak5A:
20.80
6nmfJ-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.91A 6nmfA-3bn1A:
undetectable
6nmfJ-3bn1A:
undetectable		 6nmfA-3bn1A:
21.12
6nmfJ-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321

(Pyrococcus
horikoshii) 		no annotation 4 ILE A  24
LEU A 208
ARG A  32
LEU A 249
 None
 0.93A 6nmfA-3bs4A:
undetectable
6nmfJ-3bs4A:
undetectable		 6nmfA-3bs4A:
18.10
6nmfJ-3bs4A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.96A 6nmfA-3c9bA:
undetectable
6nmfJ-3c9bA:
undetectable		 6nmfA-3c9bA:
16.41
6nmfJ-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN

(Vibrio
parahaemolyticus) 		PF01544
(CorA) 		4 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.94A 6nmfA-3ck6A:
1.6
6nmfJ-3ck6A:
undetectable		 6nmfA-3ck6A:
17.82
6nmfJ-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		4 ILE X  25
LEU X  27
ARG X  43
LEU X  37
 None
 0.86A 6nmfA-3du1X:
undetectable
6nmfJ-3du1X:
undetectable		 6nmfA-3du1X:
17.83
6nmfJ-3du1X:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.84A 6nmfA-3e7fA:
undetectable
6nmfJ-3e7fA:
undetectable		 6nmfA-3e7fA:
19.65
6nmfJ-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.91A 6nmfA-3fg4A:
undetectable
6nmfJ-3fg4A:
undetectable		 6nmfA-3fg4A:
20.56
6nmfJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 LEU A 216
TYR A  68
MET A 105
THR A 104
LEU A 103
 None
 1.50A 6nmfA-3gf6A:
undetectable
6nmfJ-3gf6A:
undetectable		 6nmfA-3gf6A:
19.49
6nmfJ-3gf6A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.85A 6nmfA-3h5tA:
undetectable
6nmfJ-3h5tA:
undetectable		 6nmfA-3h5tA:
21.02
6nmfJ-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.92A 6nmfA-3hi8A:
undetectable
6nmfJ-3hi8A:
undetectable		 6nmfA-3hi8A:
20.53
6nmfJ-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.91A 6nmfA-3k13A:
undetectable
6nmfJ-3k13A:
undetectable		 6nmfA-3k13A:
20.20
6nmfJ-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.94A 6nmfA-3k1rA:
undetectable
6nmfJ-3k1rA:
undetectable		 6nmfA-3k1rA:
14.45
6nmfJ-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ILE A  56
LEU A  63
ARG A  98
LEU A  44
 None
 0.96A 6nmfA-3kydA:
undetectable
6nmfJ-3kydA:
undetectable		 6nmfA-3kydA:
18.34
6nmfJ-3kydA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		4 LEU A  34
ARG A  20
MET A  18
LEU A  14
 None
 0.97A 6nmfA-3mt1A:
undetectable
6nmfJ-3mt1A:
undetectable		 6nmfA-3mt1A:
21.20
6nmfJ-3mt1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.91A 6nmfA-3ng9A:
undetectable
6nmfJ-3ng9A:
undetectable		 6nmfA-3ng9A:
21.77
6nmfJ-3ng9A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		4 ILE A  75
LEU A  78
THR A  39
LEU A  40
 None
 0.99A 6nmfA-3o6cA:
undetectable
6nmfJ-3o6cA:
undetectable		 6nmfA-3o6cA:
18.76
6nmfJ-3o6cA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 0.95A 6nmfA-3ozxA:
undetectable
6nmfJ-3ozxA:
undetectable		 6nmfA-3ozxA:
18.83
6nmfJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.81A 6nmfA-3pf2A:
undetectable
6nmfJ-3pf2A:
undetectable		 6nmfA-3pf2A:
18.65
6nmfJ-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 375
LEU A 250
ARG A 246
LEU A 318
 None
 0.90A 6nmfA-3ra2A:
undetectable
6nmfJ-3ra2A:
undetectable		 6nmfA-3ra2A:
23.22
6nmfJ-3ra2A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.75A 6nmfA-3rr1A:
undetectable
6nmfJ-3rr1A:
undetectable		 6nmfA-3rr1A:
22.10
6nmfJ-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.97A 6nmfA-3shmA:
undetectable
6nmfJ-3shmA:
undetectable		 6nmfA-3shmA:
22.63
6nmfJ-3shmA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.93A 6nmfA-3stoA:
undetectable
6nmfJ-3stoA:
undetectable		 6nmfA-3stoA:
20.56
6nmfJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		4 ILE A  36
ARG A  87
MET A 101
LEU A 102
 None
 0.84A 6nmfA-3u15A:
undetectable
6nmfJ-3u15A:
undetectable		 6nmfA-3u15A:
11.22
6nmfJ-3u15A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaf TTR-52

(Caenorhabditis
elegans) 		PF01060
(TTR-52) 		4 ILE A 110
LEU A  91
ARG A 130
LEU A  31
 None
 0.98A 6nmfA-3uafA:
undetectable
6nmfJ-3uafA:
undetectable		 6nmfA-3uafA:
12.58
6nmfJ-3uafA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.97A 6nmfA-3ux1A:
undetectable
6nmfJ-3ux1A:
undetectable		 6nmfA-3ux1A:
22.87
6nmfJ-3ux1A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgs NUCLEOSIDE
DIPHOSPHATE KINASE

(Halomonas sp.
#593) 		PF00334
(NDK) 		4 ILE A 103
ARG A  87
THR A   6
LEU A  77
 None
 0.95A 6nmfA-3vgsA:
undetectable
6nmfJ-3vgsA:
undetectable		 6nmfA-3vgsA:
13.81
6nmfJ-3vgsA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		4 LEU A  68
ARG A 164
THR A 105
LEU A 106
 None
 0.82A 6nmfA-3wa8A:
undetectable
6nmfJ-3wa8A:
undetectable		 6nmfA-3wa8A:
13.36
6nmfJ-3wa8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ILE A 261
LEU A 264
THR A 250
LEU A 249
 None
 0.78A 6nmfA-3wibA:
undetectable
6nmfJ-3wibA:
undetectable		 6nmfA-3wibA:
20.31
6nmfJ-3wibA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.83A 6nmfA-3zqjA:
1.9
6nmfJ-3zqjA:
undetectable		 6nmfA-3zqjA:
18.59
6nmfJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.76A 6nmfA-4b8cD:
undetectable
6nmfJ-4b8cD:
undetectable		 6nmfA-4b8cD:
21.05
6nmfJ-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		4 LEU A 119
MET A  59
THR A  60
LEU A  54
 None
 0.96A 6nmfA-4blpA:
undetectable
6nmfJ-4blpA:
undetectable		 6nmfA-4blpA:
20.49
6nmfJ-4blpA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 ILE A 578
ARG A 461
THR A 562
LEU A 561
 None
 0.96A 6nmfA-4bugA:
undetectable
6nmfJ-4bugA:
undetectable		 6nmfA-4bugA:
22.22
6nmfJ-4bugA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.91A 6nmfA-4htfB:
undetectable
6nmfJ-4htfB:
undetectable		 6nmfA-4htfB:
18.97
6nmfJ-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A  93
LEU A  99
ARG A 109
LEU A  81
 None
 0.95A 6nmfA-4i9fA:
undetectable
6nmfJ-4i9fA:
undetectable		 6nmfA-4i9fA:
20.93
6nmfJ-4i9fA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.98A 6nmfA-4ia5A:
undetectable
6nmfJ-4ia5A:
undetectable		 6nmfA-4ia5A:
21.70
6nmfJ-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00659
(POLO_box) 		4 ILE B 523
LEU B 532
MET B 368
LEU B 372
 None
 0.99A 6nmfA-4j7bB:
undetectable
6nmfJ-4j7bB:
undetectable		 6nmfA-4j7bB:
17.32
6nmfJ-4j7bB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 LEU A 275
ARG A 303
MET A 307
LEU A 308
 None
 0.95A 6nmfA-4kemA:
undetectable
6nmfJ-4kemA:
undetectable		 6nmfA-4kemA:
21.75
6nmfJ-4kemA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 ILE A 186
MET A  97
THR A  98
LEU A 101
 None
 0.98A 6nmfA-4lw6A:
undetectable
6nmfJ-4lw6A:
undetectable		 6nmfA-4lw6A:
18.40
6nmfJ-4lw6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjd KETOSTEROID
ISOMERASE FOLD
PROTEIN HMUK_0747

(Halomicrobium
mukohataei) 		PF12680
(SnoaL_2) 		4 ILE A 100
LEU A  26
ARG A   8
LEU A  14
 None
 0.82A 6nmfA-4mjdA:
undetectable
6nmfJ-4mjdA:
undetectable		 6nmfA-4mjdA:
12.00
6nmfJ-4mjdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 280
ARG A 294
THR A 342
LEU A 343
 None
None
ZN  A 907 ( 4.8A)
None
 1.00A 6nmfA-4mnaA:
undetectable
6nmfJ-4mnaA:
undetectable		 6nmfA-4mnaA:
22.41
6nmfJ-4mnaA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odb OUTER CAPSID PROTEIN
SIGMA-1

(Mammalian
orthoreovirus) 		PF01664
(Reo_sigma1) 		4 ILE A 463
LEU A 367
ARG A 429
LEU A 341
 None
 0.95A 6nmfA-4odbA:
undetectable
6nmfJ-4odbA:
undetectable		 6nmfA-4odbA:
13.36
6nmfJ-4odbA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.63A 6nmfA-4oqfA:
undetectable
6nmfJ-4oqfA:
undetectable		 6nmfA-4oqfA:
20.15
6nmfJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		4 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.89A 6nmfA-4rk9A:
undetectable
6nmfJ-4rk9A:
undetectable		 6nmfA-4rk9A:
21.64
6nmfJ-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE M   9
ARG M 108
THR M  43
LEU M  42
 None
 0.87A 6nmfA-4rrpM:
undetectable
6nmfJ-4rrpM:
undetectable		 6nmfA-4rrpM:
13.87
6nmfJ-4rrpM:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 ILE A 215
LEU A 218
ARG A 251
THR A 263
 None
 0.89A 6nmfA-4uzjA:
undetectable
6nmfJ-4uzjA:
undetectable		 6nmfA-4uzjA:
19.47
6nmfJ-4uzjA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 ILE A 259
MET A 368
THR A 367
LEU A 319
 None
 0.95A 6nmfA-4xkqA:
0.6
6nmfJ-4xkqA:
undetectable		 6nmfA-4xkqA:
20.93
6nmfJ-4xkqA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo0 PROTEIN REP68

(Adeno-associated
dependoparvovirus
A) 		PF08724
(Rep_N) 		4 ILE A   9
ARG A 119
THR A  65
LEU A  64
 None
 0.92A 6nmfA-4zo0A:
undetectable
6nmfJ-4zo0A:
undetectable		 6nmfA-4zo0A:
16.50
6nmfJ-4zo0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 653
MET A 344
THR A 341
LEU A 340
 None
 0.95A 6nmfA-5a0zA:
2.7
6nmfJ-5a0zA:
undetectable		 6nmfA-5a0zA:
21.19
6nmfJ-5a0zA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeo R. EQUI VAPG PROTEIN

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 ILE A 132
LEU A 112
THR A  61
LEU A  60
 None
 0.82A 6nmfA-5aeoA:
undetectable
6nmfJ-5aeoA:
undetectable		 6nmfA-5aeoA:
15.81
6nmfJ-5aeoA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 LEU A 356
ARG A 505
THR A 468
LEU A 469
 None
 1.00A 6nmfA-5cxwA:
undetectable
6nmfJ-5cxwA:
undetectable		 6nmfA-5cxwA:
23.22
6nmfJ-5cxwA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ARG A 276
MET A 279
THR A 280
LEU A 283
 None
 0.84A 6nmfA-5ezrA:
undetectable
6nmfJ-5ezrA:
undetectable		 6nmfA-5ezrA:
20.35
6nmfJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		4 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.98A 6nmfA-5gk2A:
undetectable
6nmfJ-5gk2A:
undetectable		 6nmfA-5gk2A:
19.85
6nmfJ-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.88A 6nmfA-5hdhA:
undetectable
6nmfJ-5hdhA:
undetectable		 6nmfA-5hdhA:
19.75
6nmfJ-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.74A 6nmfA-5idiA:
undetectable
6nmfJ-5idiA:
undetectable		 6nmfA-5idiA:
21.38
6nmfJ-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.66A 6nmfA-5jw7B:
undetectable
6nmfJ-5jw7B:
undetectable		 6nmfA-5jw7B:
10.76
6nmfJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 LEU A 286
ARG A 277
THR A 275
LEU A 274
 None
 0.96A 6nmfA-5k9tA:
undetectable
6nmfJ-5k9tA:
undetectable		 6nmfA-5k9tA:
21.11
6nmfJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.79A 6nmfA-5mqmA:
0.7
6nmfJ-5mqmA:
undetectable		 6nmfA-5mqmA:
19.15
6nmfJ-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 163
ARG A 149
MET A 604
LEU A 600
 None
 0.88A 6nmfA-5nqdA:
undetectable
6nmfJ-5nqdA:
undetectable		 6nmfA-5nqdA:
undetectable
6nmfJ-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ILE A 427
MET A 477
THR A 476
LEU A 475
 None
 0.69A 6nmfA-5ny0A:
undetectable
6nmfJ-5ny0A:
undetectable		 6nmfA-5ny0A:
undetectable
6nmfJ-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 4 LEU A  92
ARG A  82
MET A 113
THR A 112
 None
 0.95A 6nmfA-5tiwA:
undetectable
6nmfJ-5tiwA:
undetectable		 6nmfA-5tiwA:
16.34
6nmfJ-5tiwA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob ENVELOPE
GLYCOPROTEIN UL128

(Human
betaherpesvirus
5) 		no annotation 4 ILE C 109
LEU C 103
THR C  85
LEU C  84
 None
 0.91A 6nmfA-5vobC:
undetectable
6nmfJ-5vobC:
undetectable		 6nmfA-5vobC:
14.92
6nmfJ-5vobC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 LEU A 289
ARG A 345
THR A 263
LEU A 264
 None
 0.98A 6nmfA-5wypA:
undetectable
6nmfJ-5wypA:
undetectable		 6nmfA-5wypA:
undetectable
6nmfJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 4 ILE A 205
LEU A  75
MET A 249
LEU A 251
 None
 0.91A 6nmfA-5x3hA:
undetectable
6nmfJ-5x3hA:
undetectable		 6nmfA-5x3hA:
19.53
6nmfJ-5x3hA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.79A 6nmfA-5xagF:
undetectable
6nmfJ-5xagF:
undetectable		 6nmfA-5xagF:
undetectable
6nmfJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 LEU A 538
ARG A 511
THR A 505
LEU A 550
 None
 0.95A 6nmfA-5xfaA:
undetectable
6nmfJ-5xfaA:
undetectable		 6nmfA-5xfaA:
22.80
6nmfJ-5xfaA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk8 UNDECAPRENYL
DIPHOSPHATE SYNTHASE

(Streptomyces
sp. CNH189) 		no annotation 4 TYR A  26
MET A  29
THR A  30
LEU A  33
 None
 0.90A 6nmfA-5xk8A:
undetectable
6nmfJ-5xk8A:
undetectable		 6nmfA-5xk8A:
undetectable
6nmfJ-5xk8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20

(Homo sapiens) 		no annotation 4 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.92A 6nmfA-5z4iA:
undetectable
6nmfJ-5z4iA:
undetectable		 6nmfA-5z4iA:
undetectable
6nmfJ-5z4iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 4 ILE A 186
LEU A 142
THR A 220
LEU A 221
 None
 0.88A 6nmfA-6ap4A:
undetectable
6nmfJ-6ap4A:
undetectable		 6nmfA-6ap4A:
undetectable
6nmfJ-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 ILE A 155
LEU A 171
THR A 243
LEU A 227
 None
 0.99A 6nmfA-6c29A:
undetectable
6nmfJ-6c29A:
undetectable		 6nmfA-6c29A:
undetectable
6nmfJ-6c29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c96 TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Mus musculus) 		no annotation 4 LEU A 721
TYR A 361
THR A 383
LEU A 382
 None
 0.85A 6nmfA-6c96A:
2.2
6nmfJ-6c96A:
undetectable		 6nmfA-6c96A:
undetectable
6nmfJ-6c96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 4 LEU A 172
ARG A 227
THR A 211
LEU A 214
 None
 0.91A 6nmfA-6co9A:
undetectable
6nmfJ-6co9A:
undetectable		 6nmfA-6co9A:
undetectable
6nmfJ-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 169
ARG A 224
THR A 208
LEU A 211
 None
 0.97A 6nmfA-6conA:
undetectable
6nmfJ-6conA:
undetectable		 6nmfA-6conA:
undetectable
6nmfJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 4 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.84A 6nmfA-6gsaD:
undetectable
6nmfJ-6gsaD:
undetectable		 6nmfA-6gsaD:
undetectable
6nmfJ-6gsaD:
undetectable