SIMILAR PATTERNS OF AMINO ACIDS FOR 6NM4_B_SAMB402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 ILE A 282
ALA A 340
GLY A 339
LEU A 342
GLY A 205
 None
 1.08A 6nm4B-1a87A:
undetectable		 6nm4B-1a87A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 ILE A 457
GLY A 135
LEU A 138
GLY A  26
ARG A 463
 None
 1.34A 6nm4B-1b41A:
0.0		 6nm4B-1b41A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A 311
GLY A 407
LEU A 408
GLY A 236
ASN A 262
 None
None
None
None
AMP  A 527 ( 4.8A)
 1.26A 6nm4B-1gpmA:
0.0		 6nm4B-1gpmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 ILE A  76
ALA A  44
GLY A  43
GLY A  84
TYR A 175
 None
ATP  A1433 (-3.8A)
TYE  A1434 ( 3.5A)
None
TYE  A1434 (-4.3A)
 1.28A 6nm4B-1h3eA:
undetectable		 6nm4B-1h3eA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 332
ALA A 259
GLY A 260
CYH A 328
ARG A 381
 None
 1.35A 6nm4B-1ivhA:
undetectable		 6nm4B-1ivhA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		5 ILE A  71
ALA A  39
GLY A  38
GLY A  79
TYR A 170
 None
545  A 421 (-4.1A)
545  A 421 (-4.2A)
None
545  A 421 (-4.6A)
 1.14A 6nm4B-1jikA:
0.0		 6nm4B-1jikA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 ILE A 256
ALA A 215
GLY A 216
LEU A 217
GLY A 411
 None
 1.31A 6nm4B-1kq0A:
undetectable		 6nm4B-1kq0A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 ILE A 104
ALA A  99
GLY A 100
LEU A 101
GLY A  92
 None
 1.19A 6nm4B-1m32A:
0.0		 6nm4B-1m32A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		5 ILE A 223
ALA A 226
GLY A 227
GLY A 264
ASN A 296
 SAH  A   1 ( 4.5A)
SAH  A   1 (-3.8A)
SAH  A   1 ( 4.0A)
SAH  A   1 ( 4.1A)
SAH  A   1 (-3.3A)
 0.48A 6nm4B-1mt6A:
9.2		 6nm4B-1mt6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 ILE A 270
ALA A 272
GLY A  25
LEU A  26
GLY A 447
 None
 1.29A 6nm4B-1o5wA:
undetectable		 6nm4B-1o5wA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		5 ILE A 255
ALA A 223
GLY A 301
LEU A 250
GLY A 335
 None
 0.93A 6nm4B-1pjqA:
undetectable		 6nm4B-1pjqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		5 ILE A 141
ALA A  64
GLY A  65
LEU A 138
ARG A  39
 None
 1.28A 6nm4B-1t5eA:
undetectable		 6nm4B-1t5eA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 ALA A 191
GLY A 190
GLY A 267
ASN A 274
ARG A 193
 None
 1.12A 6nm4B-1uarA:
undetectable		 6nm4B-1uarA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		5 ILE A 295
ALA A 282
GLY A 281
LEU A 303
GLY A 307
 None
None
None
None
FMN  A1500 (-3.3A)
 1.02A 6nm4B-1z48A:
undetectable		 6nm4B-1z48A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 ILE A 256
ALA A 215
GLY A 216
LEU A 217
GLY A 411
 None
 1.30A 6nm4B-2aduA:
undetectable		 6nm4B-2aduA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4g DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF01180
(DHO_dh) 		5 ILE A 282
ALA A 274
GLY A 272
GLY A  61
TYR A  59
 None
None
FMN  A1400 (-3.3A)
None
FMN  A1400 (-4.8A)
 1.27A 6nm4B-2b4gA:
undetectable		 6nm4B-2b4gA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 ILE A 233
ALA A  85
GLY A  86
LEU A  90
GLY A  10
 None
 1.17A 6nm4B-2cu2A:
undetectable		 6nm4B-2cu2A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 ILE A 165
ALA A 112
GLY A 111
LEU A 114
GLY A  84
 None
 1.28A 6nm4B-2h8oA:
undetectable		 6nm4B-2h8oA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		5 ILE A 493
ALA A 495
GLY A 496
GLY A 500
ASN A 477
 None
 0.86A 6nm4B-2putA:
undetectable		 6nm4B-2putA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		5 ILE A 269
GLY A 150
LEU A 151
GLY A  90
ASN A 510
 None
 1.13A 6nm4B-2pyxA:
undetectable		 6nm4B-2pyxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		5 ILE A 396
ALA A 395
GLY A 399
LEU A 402
GLY A 275
 None
 1.11A 6nm4B-2ragA:
undetectable		 6nm4B-2ragA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 ILE A  38
ALA A  27
GLY A  26
LEU A  25
GLY A 121
 None
 1.06A 6nm4B-2rdyA:
undetectable		 6nm4B-2rdyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 ILE A 655
ALA A 674
GLY A 673
GLY A 629
ARG A 664
 None
 1.36A 6nm4B-2rdyA:
undetectable		 6nm4B-2rdyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 ALA A  70
GLY A  69
LEU A 225
CYH A 220
ARG A  72
 ZN  A 501 ( 4.5A)
None
None
None
None
 1.27A 6nm4B-2rjbA:
undetectable		 6nm4B-2rjbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A 340
GLY A 442
LEU A 443
GLY A 245
ASN A 272
 None
 1.08A 6nm4B-2vxoA:
undetectable		 6nm4B-2vxoA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A 340
GLY A 442
LEU A 443
GLY A 246
ASN A 272
 None
None
None
SO4  A1697 (-3.2A)
None
 1.29A 6nm4B-2vxoA:
undetectable		 6nm4B-2vxoA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		5 ALA A 322
GLY A 113
LEU A 110
GLY A 216
TYR A 107
 None
 1.23A 6nm4B-2x1cA:
undetectable		 6nm4B-2x1cA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 208
ALA A 268
GLY A 269
LEU A 265
GLY A  98
 None
None
None
None
CIT  A1307 (-3.3A)
 1.02A 6nm4B-2x7iA:
undetectable		 6nm4B-2x7iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		5 ILE A  41
ALA A  29
GLY A  39
LEU A  38
GLY A 191
 None
None
None
None
FMN  A 401 (-3.2A)
 1.21A 6nm4B-2z6iA:
undetectable		 6nm4B-2z6iA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		5 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.81A 6nm4B-2zj4A:
undetectable		 6nm4B-2zj4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ILE A 167
ALA A 171
GLY A 325
LEU A 326
GLY A 271
 None
 1.20A 6nm4B-3b9yA:
undetectable		 6nm4B-3b9yA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		5 ILE A 223
ALA A 226
GLY A 227
GLY A 264
ASN A 296
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
 0.37A 6nm4B-3cboA:
8.8		 6nm4B-3cboA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  98
ALA A 323
GLY A 322
LEU A 120
GLY A 116
 None
 1.22A 6nm4B-3db2A:
undetectable		 6nm4B-3db2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 206
GLY A 213
ASN A 391
CYH A 388
ARG A 387
 None
 0.98A 6nm4B-3dwbA:
undetectable		 6nm4B-3dwbA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		5 ILE A 361
ALA A 334
GLY A 333
LEU A 326
GLY A 402
 None
 1.08A 6nm4B-3ecdA:
undetectable		 6nm4B-3ecdA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 ILE A  43
ALA A  45
GLY A  46
LEU A  73
GLY A  85
 None
 1.29A 6nm4B-3eegA:
undetectable		 6nm4B-3eegA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewg PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Methanocaldococcus
jannaschii) 		PF03439
(Spt5-NGN) 		5 ILE A  33
ALA A  16
GLY A  17
LEU A  18
GLY A  10
 None
 1.30A 6nm4B-3ewgA:
undetectable		 6nm4B-3ewgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 312
ALA A 215
GLY A 214
TYR A 242
CYH A 208
 FAD  A 612 (-4.4A)
None
None
None
None
 0.99A 6nm4B-3eyaA:
undetectable		 6nm4B-3eyaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		5 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.91A 6nm4B-3ezjA:
undetectable		 6nm4B-3ezjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		5 ILE A 295
ALA A 282
GLY A 281
LEU A 303
GLY A 307
 None
None
None
None
FMN  A 341 (-3.2A)
 1.10A 6nm4B-3gr8A:
undetectable		 6nm4B-3gr8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 5 ILE A 358
GLY A 318
LEU A 317
GLY A 395
ARG A 378
 None
 1.34A 6nm4B-3hlyA:
undetectable		 6nm4B-3hlyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 ALA A 198
GLY A 197
GLY A 272
ASN A 279
ARG A 200
 None
 1.02A 6nm4B-3hzuA:
undetectable		 6nm4B-3hzuA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 ILE A  43
ALA A 265
GLY A 262
LEU A 263
ARG A  47
 None
 1.09A 6nm4B-3i4jA:
undetectable		 6nm4B-3i4jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A 283
ALA A 219
GLY A 218
LEU A 221
GLY A 259
 EDO  A  23 ( 4.7A)
None
None
None
None
 1.33A 6nm4B-3ihvA:
undetectable		 6nm4B-3ihvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		5 ILE A 516
ALA A 553
GLY A 552
GLY A 544
CYH A 498
 None
 1.09A 6nm4B-3k13A:
undetectable		 6nm4B-3k13A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0a PUTATIVE EXONUCLEASE

([Eubacterium]
rectale) 		PF12684
(DUF3799) 		5 ILE A 203
ALA A 195
GLY A 194
GLY A  58
ARG A  99
 None
 1.16A 6nm4B-3l0aA:
undetectable		 6nm4B-3l0aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1

(Homo sapiens) 		PF00790
(VHS) 		5 ILE A  29
ALA A  71
GLY A  70
LEU A  69
GLY A  77
 None
 1.04A 6nm4B-3ldzA:
undetectable		 6nm4B-3ldzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ALA B 158
GLY B 162
LEU B 161
GLY B  52
ARG B  72
 None
 1.16A 6nm4B-3m2rB:
undetectable		 6nm4B-3m2rB:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 ILE A  88
GLY A 267
LEU A 266
GLY A 117
ARG A  90
 None
 1.32A 6nm4B-3m5hA:
undetectable		 6nm4B-3m5hA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 ILE A 732
ALA A 724
GLY A 723
GLY A 585
TYR A 584
 None
 1.34A 6nm4B-3m6aA:
undetectable		 6nm4B-3m6aA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 301
ALA A 462
LEU A 460
GLY A 466
ASN A 463
 None
 1.33A 6nm4B-3mosA:
undetectable		 6nm4B-3mosA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		5 ILE A 141
GLY A 143
LEU A 145
GLY A 125
ASN A 139
 None
 1.18A 6nm4B-3o0yA:
undetectable		 6nm4B-3o0yA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ILE D 168
ALA D 167
GLY D 172
GLY D  85
ARG D 164
 None
 1.14A 6nm4B-3oaaD:
undetectable		 6nm4B-3oaaD:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3a THIOSULFATE
SULFURTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00581
(Rhodanese) 		5 ALA A 199
GLY A 198
GLY A 273
ASN A 280
ARG A 201
 None
 1.10A 6nm4B-3p3aA:
undetectable		 6nm4B-3p3aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 ALA A  85
GLY A 264
LEU A 263
GLY A  95
ARG A  25
 None
 1.31A 6nm4B-3x0yA:
undetectable		 6nm4B-3x0yA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ILE A 266
ALA A 357
GLY A 356
LEU A 354
GLY A 388
 None
 1.32A 6nm4B-4ay1A:
undetectable		 6nm4B-4ay1A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 ILE A 344
ALA A 341
GLY A 338
LEU A 339
ARG A  69
 None
 1.34A 6nm4B-4b98A:
undetectable		 6nm4B-4b98A:
18.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus musculus) 		PF00856
(SET) 		8 ILE A 253
ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
ARG A 323
 SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-4.7A)
None
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
 0.47A 6nm4B-4c1qA:
25.8		 6nm4B-4c1qA:
88.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus musculus) 		PF00856
(SET) 		7 ILE A 253
ALA A 256
GLY A 257
TYR A 291
ASN A 320
CYH A 321
ARG A 323
 SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
None
 0.68A 6nm4B-4c1qA:
25.8		 6nm4B-4c1qA:
88.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ILE A  80
ALA A 168
GLY A 169
LEU A 173
GLY A 184
 None
 1.05A 6nm4B-4c51A:
undetectable		 6nm4B-4c51A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ALA A 260
GLY A 259
LEU A  32
GLY A  60
TYR A  80
 None
 1.25A 6nm4B-4egvA:
undetectable		 6nm4B-4egvA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 296
ALA A 312
GLY A 291
LEU A 266
GLY A 307
 None
 1.00A 6nm4B-4eudA:
undetectable		 6nm4B-4eudA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 ILE A 145
GLY A 330
LEU A 139
GLY A 304
ARG A 149
 None
 1.19A 6nm4B-4hxxA:
undetectable		 6nm4B-4hxxA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ijd HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Homo sapiens) 		PF00856
(SET) 		9 ILE A 253
ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
CYH A 321
ARG A 323
 None
 0.56A 6nm4B-4ijdA:
32.6		 6nm4B-4ijdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		5 ILE A  40
ALA A  28
GLY A  38
LEU A  37
GLY A 192
 None
None
None
None
FMN  A 401 (-3.4A)
 1.25A 6nm4B-4iqlA:
undetectable		 6nm4B-4iqlA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 ILE A 145
GLY A 330
LEU A 139
GLY A 304
ARG A 149
 None
 1.16A 6nm4B-4iu6A:
undetectable		 6nm4B-4iu6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		5 ILE D 137
ALA D 139
GLY D 140
GLY D 655
ARG D 742
 None
 1.27A 6nm4B-4j3oD:
undetectable		 6nm4B-4j3oD:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 ILE A 397
ALA A 471
GLY A 474
LEU A 477
GLY A  27
 None
 0.96A 6nm4B-4k0eA:
undetectable		 6nm4B-4k0eA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 ILE A 423
ALA A 406
GLY A 407
LEU A 251
GLY A 247
 None
 1.30A 6nm4B-4knaA:
undetectable		 6nm4B-4knaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ILE A 393
ALA A 365
GLY A 300
ASN A 361
ARG A 362
 None
 1.30A 6nm4B-4kpgA:
undetectable		 6nm4B-4kpgA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 ILE A 773
ALA A 596
GLY A 597
LEU A 598
GLY A 700
 None
 1.35A 6nm4B-4lglA:
undetectable		 6nm4B-4lglA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		5 ALA A 265
GLY A 285
LEU A 287
GLY A 228
ASN A 253
 None
 1.13A 6nm4B-4m1rA:
undetectable		 6nm4B-4m1rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A  94
ALA A 133
GLY A 132
LEU A 131
GLY A 146
 None
 1.14A 6nm4B-4nbqA:
undetectable		 6nm4B-4nbqA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Brachybacterium
faecium) 		PF00156
(Pribosyltran) 		5 ILE A 171
ALA A 154
LEU A  79
TYR A 183
ARG A 157
 None
 1.36A 6nm4B-4pfqA:
undetectable		 6nm4B-4pfqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		5 ILE A  41
ALA A  29
GLY A  39
LEU A  38
GLY A 239
 None
None
None
None
FMN  A 401 (-3.3A)
 1.27A 6nm4B-4qiuA:
undetectable		 6nm4B-4qiuA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ILE A 137
ALA A 146
GLY A 108
LEU A 101
GLY A 150
 None
 1.06A 6nm4B-4r7uA:
undetectable		 6nm4B-4r7uA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 GLY B 378
LEU B 454
GLY B 276
TYR B 275
ARG B 284
 GOL  B 504 (-3.1A)
GOL  B 504 (-4.8A)
None
LLP  B 304 ( 4.8A)
None
 1.31A 6nm4B-4ritB:
undetectable		 6nm4B-4ritB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		5 ALA A  82
GLY A  81
LEU A 352
GLY A 356
CYH A 395
 None
 1.07A 6nm4B-4rp8A:
undetectable		 6nm4B-4rp8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		5 ILE A 245
ALA A 248
GLY A 249
LEU A 251
ARG A 259
 None
 1.18A 6nm4B-4uhhA:
undetectable		 6nm4B-4uhhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ILE A 347
ALA A 307
GLY A 377
TYR A  31
ASN A 309
 None
 1.21A 6nm4B-4xg1A:
undetectable		 6nm4B-4xg1A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		5 ILE A 286
ALA A 456
GLY A 457
GLY A 161
CYH A 402
 None
 1.03A 6nm4B-4yjiA:
undetectable		 6nm4B-4yjiA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 ILE A5406
GLY A5408
LEU A5409
TYR A5451
ASN A5474
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
 0.63A 6nm4B-4z4pA:
9.1		 6nm4B-4z4pA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Methanocaldococcus
jannaschii) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		5 ILE A  33
ALA A  16
GLY A  17
LEU A  18
GLY A  10
 None
 1.23A 6nm4B-4zn1A:
undetectable		 6nm4B-4zn1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		5 ILE A 479
ALA A  15
GLY A  14
LEU A  13
GLY A   9
 None
 1.32A 6nm4B-5dgqA:
undetectable		 6nm4B-5dgqA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 335
GLY A 334
LEU A 597
GLY A  87
ARG A 174
 None
 1.28A 6nm4B-5dmyA:
undetectable		 6nm4B-5dmyA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 ALA B 299
GLY B 300
LEU B 301
GLY B 376
ARG B 138
 None
PLP  B 501 (-4.2A)
PLP  B 501 ( 4.9A)
None
None
 1.28A 6nm4B-5ey5B:
undetectable		 6nm4B-5ey5B:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ILE A 424
GLY A 315
GLY A 362
TYR A 340
ASN A 381
 None
 1.31A 6nm4B-5ficA:
undetectable		 6nm4B-5ficA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		5 ILE A  43
ALA A  31
GLY A  41
LEU A  40
GLY A 193
 None
None
None
None
FMN  A 402 (-3.4A)
 1.30A 6nm4B-5gvhA:
undetectable		 6nm4B-5gvhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 ILE B 737
ALA B 739
GLY B 740
GLY B 696
TYR B 695
 None
 1.31A 6nm4B-5gztB:
undetectable		 6nm4B-5gztB:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ILE A 424
GLY A 315
GLY A 362
TYR A 340
ASN A 381
 None
 1.34A 6nm4B-5hqnA:
undetectable		 6nm4B-5hqnA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 ILE A 426
GLY A 317
GLY A 364
TYR A 342
ASN A 383
 SO4  A 716 ( 4.8A)
None
None
None
None
 1.28A 6nm4B-5i85A:
undetectable		 6nm4B-5i85A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		5 ALA A 292
GLY A 312
LEU A 314
GLY A 255
ASN A 280
 None
 1.19A 6nm4B-5ihsA:
undetectable		 6nm4B-5ihsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 ILE A 302
ALA A 222
GLY A 306
GLY A 237
ARG A 219
 None
 1.19A 6nm4B-5jboA:
undetectable		 6nm4B-5jboA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ILE B 911
ALA B 875
GLY B 874
LEU B 914
GLY B 918
 None
 1.33A 6nm4B-5nd1B:
undetectable		 6nm4B-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA B 316
GLY B 317
LEU B 318
GLY B 393
ARG B 155
 MLI  B 501 (-3.6A)
LLP  B 101 ( 4.2A)
None
None
None
 1.07A 6nm4B-5tchB:
undetectable		 6nm4B-5tchB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wva SHORT-CHAIN
DEHYDROGENASE

(Serratia
marcescens) 		no annotation 5 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.16A 6nm4B-5wvaA:
undetectable		 6nm4B-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 5 ILE A 399
ALA A  82
GLY A  81
LEU A 352
GLY A 356
 None
 1.03A 6nm4B-5zovA:
undetectable		 6nm4B-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 ILE F  17
ALA F  48
GLY F  49
LEU F  53
GLY B  71
 None
 1.17A 6nm4B-6cfwF:
undetectable		 6nm4B-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA

(Chromobacterium
violaceum) 		no annotation 5 ILE B 238
ALA B 240
GLY B  16
LEU B  17
GLY B 400
 None
 1.28A 6nm4B-6esdB:
undetectable		 6nm4B-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 ILE B1071
ALA A1091
GLY A1090
GLY A1098
CYH B1069
 None
 1.26A 6nm4B-6f42B:
undetectable		 6nm4B-6f42B:
undetectable