SIMILAR PATTERNS OF AMINO ACIDS FOR 6NM4_A_SAMA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		4 ALA A 252
GLY A 253
LEU A 257
CYH A 187
 None
 0.79A 6nm4A-1fp3A:
undetectable		 6nm4A-1fp3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA A  70
GLY A  69
LEU A  68
GLY A 140
 None
 0.82A 6nm4A-1fq3A:
undetectable		 6nm4A-1fq3A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 ALA A  48
GLY A  47
LEU A 157
GLY A 305
 None
 0.86A 6nm4A-1j33A:
undetectable		 6nm4A-1j33A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 197
GLY A 196
GLY A 217
CYH A 189
 None
 0.80A 6nm4A-1lehA:
undetectable		 6nm4A-1lehA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		4 ALA A 226
GLY A 227
GLY A 264
ASN A 296
 SAH  A   1 (-3.8A)
SAH  A   1 ( 4.0A)
SAH  A   1 ( 4.1A)
SAH  A   1 (-3.3A)
 0.50A 6nm4A-1mt6A:
9.3		 6nm4A-1mt6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ALA A  16
GLY A  17
LEU A  54
GLY A  62
 None
 0.72A 6nm4A-1muuA:
0.0		 6nm4A-1muuA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		4 ALA A 223
GLY A 301
LEU A 250
GLY A 335
 None
 0.76A 6nm4A-1pjqA:
0.0		 6nm4A-1pjqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 112
GLY A 113
LEU A  42
GLY A  32
 None
None
HEM  A 350 ( 3.9A)
None
 0.59A 6nm4A-1qpaA:
undetectable		 6nm4A-1qpaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA B 292
GLY B 291
LEU B 290
GLY B 324
 None
 0.69A 6nm4A-1t3qB:
undetectable		 6nm4A-1t3qB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 204
LEU A 205
GLY A  47
CYH A 174
 None
None
NAD  A1377 (-3.7A)
ZN  A 376 (-2.2A)
 0.78A 6nm4A-1u3tA:
undetectable		 6nm4A-1u3tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 ALA A 251
LEU A 399
GLY A 231
ASN A 258
 None
 0.75A 6nm4A-1x1qA:
undetectable		 6nm4A-1x1qA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		4 ALA A 106
GLY A 105
GLY A 199
CYH A 109
 SO4  A1001 (-2.7A)
None
None
None
 0.86A 6nm4A-1yisA:
undetectable		 6nm4A-1yisA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 ALA A 282
GLY A 281
LEU A 303
GLY A 307
 None
None
None
FMN  A1500 (-3.3A)
 0.76A 6nm4A-1z48A:
undetectable		 6nm4A-1z48A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A 234
LEU A 344
GLY A 241
TYR A 242
 FAD  A1385 (-3.5A)
FAD  A1385 ( 4.7A)
None
None
 0.68A 6nm4A-2bi7A:
undetectable		 6nm4A-2bi7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		4 ALA A 221
GLY A 222
LEU A 223
GLY A 290
 None
 0.81A 6nm4A-2bufA:
undetectable		 6nm4A-2bufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		4 ALA A  44
GLY A  43
GLY A  51
CYH A  10
 ADN  A1301 ( 4.1A)
ADN  A1301 (-3.3A)
None
None
 0.86A 6nm4A-2c49A:
undetectable		 6nm4A-2c49A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		4 ALA A 117
GLY A 116
LEU A 114
GLY A 139
 None
 0.73A 6nm4A-2c49A:
undetectable		 6nm4A-2c49A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 ALA A  22
GLY A  21
LEU A  20
GLY A  73
 None
 0.82A 6nm4A-2el7A:
undetectable		 6nm4A-2el7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ALA A 284
GLY A 285
LEU A 286
GLY A 295
 None
 0.79A 6nm4A-2gfpA:
undetectable		 6nm4A-2gfpA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvz SPLICING FACTOR,
ARGININE/SERINE-RICH
7

(Homo sapiens) 		PF00076
(RRM_1) 		4 ALA A  12
GLY A  13
LEU A  17
CYH A  63
 None
 0.73A 6nm4A-2hvzA:
undetectable		 6nm4A-2hvzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ALA A 264
GLY A 265
LEU A 276
GLY A 100
 None
 0.66A 6nm4A-2ip4A:
undetectable		 6nm4A-2ip4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 ALA A 206
GLY A 205
GLY A 213
TYR A 157
 None
 0.76A 6nm4A-2jc4A:
undetectable		 6nm4A-2jc4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3m RV1761C

(Mycobacterium
tuberculosis) 		PF16817
(DUF5073) 		4 ALA A  31
GLY A  32
LEU A  33
CYH A  48
 None
None
None
MTN  A 129 (-2.0A)
 0.84A 6nm4A-2k3mA:
undetectable		 6nm4A-2k3mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ALA A 236
GLY A 227
GLY A 231
CYH A 386
 None
None
BG6  A1002 (-3.5A)
None
 0.76A 6nm4A-2nztA:
undetectable		 6nm4A-2nztA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p61 HYPOTHETICAL PROTEIN
TM_1646

(Thermotoga
maritima) 		PF03885
(DUF327) 		4 GLY A 145
LEU A 146
GLY A  62
TYR A  77
 None
 0.83A 6nm4A-2p61A:
undetectable		 6nm4A-2p61A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		4 ALA A  18
GLY A  19
LEU A 110
GLY A 303
 None
 0.85A 6nm4A-2qa1A:
undetectable		 6nm4A-2qa1A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Novosphingobium
aromaticivorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 164
GLY A 121
TYR A 138
ASN A 124
 None
 0.80A 6nm4A-2qjjA:
undetectable		 6nm4A-2qjjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN

(Escherichia
coli) 		PF09084
(NMT1) 		4 ALA A  65
GLY A  66
LEU A  70
GLY A 137
 None
 0.81A 6nm4A-2x26A:
undetectable		 6nm4A-2x26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 ALA A 401
GLY A 400
ASN A 429
CYH A 426
 None
 0.84A 6nm4A-2xfgA:
undetectable		 6nm4A-2xfgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		4 ALA A  25
GLY A 103
LEU A  52
GLY A 137
 None
SAH  A1267 (-4.8A)
UP2  A1268 ( 4.0A)
None
 0.81A 6nm4A-2ybqA:
undetectable		 6nm4A-2ybqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ALA A 149
GLY A 150
GLY A 377
TYR A 336
 None
ATP  A 646 (-3.1A)
None
None
 0.56A 6nm4A-2yw2A:
undetectable		 6nm4A-2yw2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		4 ALA A 257
GLY A  21
LEU A  24
GLY A 217
 None
 0.81A 6nm4A-2yzwA:
undetectable		 6nm4A-2yzwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ALA A 311
GLY A 310
LEU A 309
GLY A 315
 None
 0.86A 6nm4A-2z1uA:
undetectable		 6nm4A-2z1uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 166
GLY A 103
LEU A 104
GLY A 145
 None
 0.84A 6nm4A-3b96A:
undetectable		 6nm4A-3b96A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		4 ALA A 171
GLY A 325
LEU A 326
GLY A 271
 None
 0.84A 6nm4A-3b9yA:
undetectable		 6nm4A-3b9yA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		4 ALA A 226
GLY A 227
GLY A 264
ASN A 296
 SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
 0.40A 6nm4A-3cboA:
8.9		 6nm4A-3cboA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 GLY A 160
GLY A 287
TYR A 284
ASN A 183
 None
 0.82A 6nm4A-3clqA:
undetectable		 6nm4A-3clqA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewk SENSOR PROTEIN

(Methylococcus
capsulatus) 		PF13426
(PAS_9) 		4 ALA A 228
GLY A 229
LEU A 274
GLY A 315
 None
 0.74A 6nm4A-3ewkA:
undetectable		 6nm4A-3ewkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 ALA A 282
GLY A 281
LEU A 303
GLY A 307
 None
None
None
FMN  A 341 (-3.2A)
 0.77A 6nm4A-3gr8A:
undetectable		 6nm4A-3gr8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 GLY A 257
LEU A 258
GLY A 304
ASN A 242
 None
 0.85A 6nm4A-3humA:
undetectable		 6nm4A-3humA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		4 ALA A 198
GLY A 197
GLY A 272
ASN A 279
 None
 0.84A 6nm4A-3hzuA:
undetectable		 6nm4A-3hzuA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		4 ALA A 271
GLY A 272
LEU A 273
GLY A 236
 None
 0.70A 6nm4A-3i4jA:
undetectable		 6nm4A-3i4jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00497
(SBP_bac_3) 		4 ALA A 116
GLY A 117
GLY A  81
ASN A  65
 None
 0.85A 6nm4A-3i6vA:
undetectable		 6nm4A-3i6vA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		4 GLY A 258
LEU A 418
TYR A 421
CYH A 411
 CL  A 497 ( 3.8A)
CL  A 497 (-4.9A)
None
None
 0.82A 6nm4A-3k2wA:
undetectable		 6nm4A-3k2wA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ALA A 219
GLY A 344
GLY A 170
ASN A 327
 None
 0.75A 6nm4A-3kydA:
undetectable		 6nm4A-3kydA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 ALA A 234
GLY A 235
GLY A 173
TYR A 176
 LLP  A  46 ( 3.8A)
LLP  A  46 ( 3.5A)
TRS  A 383 ( 3.9A)
TRS  A 383 ( 4.1A)
 0.85A 6nm4A-3llxA:
undetectable		 6nm4A-3llxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 ALA A 220
GLY A 219
GLY A  46
ASN A  40
 None
 0.80A 6nm4A-3lnbA:
undetectable		 6nm4A-3lnbA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ALA A 369
GLY A 368
LEU A  55
GLY A 151
 None
 0.78A 6nm4A-3mduA:
undetectable		 6nm4A-3mduA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmz PUTATIVE HAD FAMILY
HYDROLASE

(Streptomyces
avermitilis) 		PF08282
(Hydrolase_3) 		4 ALA A   5
GLY A   4
LEU A   3
GLY A 122
 None
 0.77A 6nm4A-3mmzA:
undetectable		 6nm4A-3mmzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 348
GLY A 349
LEU A 118
GLY A 332
 None
 0.83A 6nm4A-3q4dA:
undetectable		 6nm4A-3q4dA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 ALA A  73
GLY A  74
TYR A 223
ASN A 251
 SAM  A 484 (-3.3A)
SAM  A 484 (-3.4A)
SAM  A 484 (-3.6A)
SAM  A 484 (-3.1A)
 0.58A 6nm4A-3rc0A:
4.7		 6nm4A-3rc0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		4 ALA A 156
GLY A 157
GLY A  33
ASN A 147
 None
 0.71A 6nm4A-4akkA:
undetectable		 6nm4A-4akkA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		4 ALA A 186
GLY A 185
GLY A 153
ASN A 248
 None
 0.85A 6nm4A-4b0sA:
undetectable		 6nm4A-4b0sA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 113
GLY A 114
LEU A  43
GLY A  33
 None
None
HEM  A 500 ( 3.3A)
None
 0.49A 6nm4A-4bm1A:
undetectable		 6nm4A-4bm1A:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus musculus) 		PF00856
(SET) 		4 ALA A 256
GLY A 257
ASN A 320
CYH A 321
 SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.4A)
None
 0.65A 6nm4A-4c1qA:
25.7		 6nm4A-4c1qA:
88.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus musculus) 		PF00856
(SET) 		6 ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
 SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-4.7A)
None
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
 0.47A 6nm4A-4c1qA:
25.7		 6nm4A-4c1qA:
88.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		4 ALA A 294
GLY A 293
LEU A  40
GLY A  17
 None
 0.83A 6nm4A-4czbA:
undetectable		 6nm4A-4czbA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq7 MEMBRANE PROTEIN
PHI6 P5

(Pseudomonas
virus phi6) 		PF10464
(Peptidase_U40) 		4 ALA A 182
GLY A 181
GLY A 124
ASN A 156
 None
 0.57A 6nm4A-4dq7A:
undetectable		 6nm4A-4dq7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		4 ALA A   7
GLY A   8
GLY A 221
ASN A  22
 None
DAU  A 301 ( 3.3A)
None
None
 0.69A 6nm4A-4ecmA:
undetectable		 6nm4A-4ecmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iit PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAC

(Klebsiella
pneumoniae) 		PF05138
(PaaA_PaaC) 		4 ALA C  52
GLY C  15
GLY C 129
TYR C 111
 None
 0.86A 6nm4A-4iitC:
undetectable		 6nm4A-4iitC:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ijd HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Homo sapiens) 		PF00856
(SET) 		7 ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
CYH A 321
 None
 0.46A 6nm4A-4ijdA:
32.7		 6nm4A-4ijdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		4 GLY A  84
LEU A  87
GLY A 102
ASN A 138
 None
 0.79A 6nm4A-4ikvA:
undetectable		 6nm4A-4ikvA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 117
GLY A  49
LEU A  50
GLY A 327
 None
 0.85A 6nm4A-4ip4A:
undetectable		 6nm4A-4ip4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 371
GLY A 370
LEU A 452
GLY A 430
 None
None
None
SO4  A 603 (-3.5A)
 0.85A 6nm4A-4ksiA:
undetectable		 6nm4A-4ksiA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 GLY A 290
LEU A 291
GLY A 356
TYR A 357
 None
 0.82A 6nm4A-4nz0A:
undetectable		 6nm4A-4nz0A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE

(Burkholderia
thailandensis) 		PF03309
(Pan_kinase) 		4 ALA A 105
GLY A 106
LEU A 247
GLY A  23
 None
 0.76A 6nm4A-4o5fA:
undetectable		 6nm4A-4o5fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ALA A 147
GLY A 148
TYR A 439
ASN A 158
 None
FAD  A 601 (-3.3A)
FAD  A 601 ( 4.5A)
FAD  A 601 (-3.9A)
 0.73A 6nm4A-4pveA:
undetectable		 6nm4A-4pveA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ALA A 917
GLY A 918
LEU A 961
GLY A 896
 None
 0.67A 6nm4A-4rcnA:
undetectable		 6nm4A-4rcnA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 ALA A  82
GLY A  81
LEU A 352
GLY A 356
 None
 0.85A 6nm4A-4rp8A:
undetectable		 6nm4A-4rp8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzm EPOXIDE HYDROLASE
LASB

(Streptomyces
lasaliensis) 		PF12680
(SnoaL_2) 		4 ALA A 199
GLY A 200
LEU A 201
TYR A  71
 None
 0.55A 6nm4A-4rzmA:
undetectable		 6nm4A-4rzmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		4 ALA A 265
GLY A 264
LEU A 263
GLY A 211
 None
 0.74A 6nm4A-4xmrA:
undetectable		 6nm4A-4xmrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		4 ALA A 342
GLY A 341
LEU A 304
GLY A 313
 HEM  A 504 ( 3.7A)
None
None
HEM  A 504 (-3.3A)
 0.68A 6nm4A-4xydA:
undetectable		 6nm4A-4xydA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		4 GLY A5408
LEU A5409
TYR A5451
ASN A5474
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
 0.61A 6nm4A-4z4pA:
9.0		 6nm4A-4z4pA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ALA A 459
GLY A 503
GLY A 416
TYR A 481
 None
 0.83A 6nm4A-5a7mA:
undetectable		 6nm4A-5a7mA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 ALA A 243
GLY A 244
LEU A 245
GLY A 171
 None
 0.76A 6nm4A-5dl6A:
undetectable		 6nm4A-5dl6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 ALA A 182
GLY A 181
LEU A 187
GLY A 251
 None
 0.70A 6nm4A-5dxxA:
undetectable		 6nm4A-5dxxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebg T-CELL SURFACE
GLYCOPROTEIN CD8
ALPHA CHAIN

(Bos taurus) 		PF07686
(V-set) 		4 ALA A  72
GLY A  71
LEU A  81
GLY A  33
 None
 0.67A 6nm4A-5ebgA:
undetectable		 6nm4A-5ebgA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1
GLUTATHIONE
S-TRANSFERASE U20

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF03321
(GH3)
PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ALA A 396
GLY A 397
LEU A  89
GLY B 140
 None
 0.75A 6nm4A-5ecoA:
undetectable		 6nm4A-5ecoA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		4 GLY A4782
LEU A4783
TYR A4825
ASN A4848
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.3A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
 0.69A 6nm4A-5f59A:
9.6		 6nm4A-5f59A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 ALA A 413
GLY A 412
ASN A 441
CYH A 438
 None
 0.84A 6nm4A-5gy0A:
undetectable		 6nm4A-5gy0A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 4 ALA E  33
GLY E  34
LEU E  38
GLY E  73
 None
 0.75A 6nm4A-5h36E:
undetectable		 6nm4A-5h36E:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 ALA A 739
GLY A 738
LEU A 733
GLY A 683
 None
 0.85A 6nm4A-5hlbA:
undetectable		 6nm4A-5hlbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ALA A 337
GLY A 338
LEU A 342
GLY A 331
 None
 0.84A 6nm4A-5ipwA:
undetectable		 6nm4A-5ipwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 ALA A 464
GLY A 463
GLY A 680
TYR A  89
 None
 0.68A 6nm4A-5j44A:
undetectable		 6nm4A-5j44A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ALA A 294
GLY A 293
GLY A 302
ASN A  25
 None
 0.67A 6nm4A-5jd5A:
undetectable		 6nm4A-5jd5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzd N-ACETYLNEURAMINATE
LYASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		4 ALA A 266
GLY A 267
LEU A 268
GLY A  50
 None
 0.70A 6nm4A-5kzdA:
undetectable		 6nm4A-5kzdA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 811
GLY A 812
GLY A 847
ASN A 603
 None
 0.86A 6nm4A-5lewA:
undetectable		 6nm4A-5lewA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 GLY A 129
LEU A 130
GLY A 257
TYR A 252
 None
 0.82A 6nm4A-5mq6A:
undetectable		 6nm4A-5mq6A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		4 ALA A 220
GLY A 219
LEU A 218
GLY A 207
 None
 0.76A 6nm4A-5mz8A:
undetectable		 6nm4A-5mz8A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 ALA A 160
GLY A 161
LEU A 212
GLY A 431
 None
 0.66A 6nm4A-5n6mA:
undetectable		 6nm4A-5n6mA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj5 V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00137
(ATP-synt_C)
PF00137
(ATP-synt_C) 		4 ALA D 108
GLY D 148
LEU D 149
GLY E  61
 None
 0.82A 6nm4A-5tj5D:
undetectable		 6nm4A-5tj5D:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 4 GLY A 257
LEU A 258
GLY A 304
ASN A 242
 None
 0.84A 6nm4A-5ty7A:
undetectable		 6nm4A-5ty7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux1 TRNA-(MS(2)IO(6)A)-H
YDROXYLASE-LIKE

(Synechococcus
sp. CC9605) 		no annotation 4 ALA A 133
GLY A 134
GLY A 111
TYR A 110
 None
 0.85A 6nm4A-5ux1A:
undetectable		 6nm4A-5ux1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqm PA41 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  57
GLY H  56
GLY H  49
ASN H  52
 None
 0.76A 6nm4A-5vqmH:
undetectable		 6nm4A-5vqmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 4 ALA A 298
GLY A 602
LEU A 601
GLY A 551
 None
 0.84A 6nm4A-5ws4A:
undetectable		 6nm4A-5ws4A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 ALA A 209
GLY A 210
LEU A 211
TYR A 386
 None
SAM  A 505 ( 3.9A)
None
SAM  A 505 (-4.5A)
 0.80A 6nm4A-5yf0A:
undetectable		 6nm4A-5yf0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE

(Cyberlindnera
mrakii) 		no annotation 4 ALA A 291
GLY A 295
GLY A 199
ASN A 204
 None
 0.68A 6nm4A-6bkaA:
undetectable		 6nm4A-6bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 ALA A 448
GLY A 446
GLY A 412
ASN A 381
 None
 0.82A 6nm4A-6cmzA:
undetectable		 6nm4A-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 4 ALA A  95
GLY A  96
LEU A 128
GLY A  16
 None
 0.86A 6nm4A-6e85A:
undetectable		 6nm4A-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 4 ALA D 176
GLY D 175
LEU D 174
GLY D  89
 None
 0.85A 6nm4A-6f45D:
undetectable		 6nm4A-6f45D:
undetectable