SIMILAR PATTERNS OF AMINO ACIDS FOR 6NKN_W_CHDW101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		3 ARG A 102
LEU A 106
PHE A 110
 None
 0.49A 6nknP-1jkwA:
0.7		 6nknP-1jkwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 ARG A 315
LEU A 311
PHE A 307
 None
 0.81A 6nknP-1nxuA:
undetectable		 6nknP-1nxuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		3 ARG A 228
LEU A 232
PHE A 236
 None
 0.72A 6nknP-1pztA:
undetectable		 6nknP-1pztA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		3 ARG A  39
LEU A 389
PHE A 391
 None
 0.76A 6nknP-1qfxA:
0.0		 6nknP-1qfxA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1quu HUMAN SKELETAL
MUSCLE ALPHA-ACTININ
2

(Homo sapiens) 		PF00435
(Spectrin) 		3 ARG A  11
LEU A  15
PHE A  19
 None
 0.54A 6nknP-1quuA:
3.9		 6nknP-1quuA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9a CHLOROCATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 ARG A   5
LEU A   9
PHE A  13
 None
HGP  A 304 ( 4.5A)
HGP  A 304 (-3.9A)
 0.79A 6nknP-1s9aA:
undetectable		 6nknP-1s9aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		3 ARG A 392
LEU A 396
PHE A 400
 None
 0.67A 6nknP-1sjjA:
2.6		 6nknP-1sjjA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdj HYPOTHETICAL PROTEIN
TT1808

(Thermus
thermophilus) 		PF05685
(Uma2) 		3 ARG A 156
LEU A 141
PHE A  89
 None
 0.81A 6nknP-1wdjA:
undetectable		 6nknP-1wdjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ARG A  36
LEU A 131
PHE A 132
 ARG  A  36 ( 0.6A)
LEU  A 131 ( 0.6A)
PHE  A 132 ( 1.3A)
 0.80A 6nknP-1wqaA:
0.0		 6nknP-1wqaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		3 ARG A 127
LEU A 123
PHE A 119
 None
 0.51A 6nknP-1zjyA:
undetectable		 6nknP-1zjyA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE

(Helicobacter
pylori) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 ARG A 111
LEU A 116
PHE A 117
 None
 0.74A 6nknP-1zofA:
undetectable		 6nknP-1zofA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		3 ARG A  76
LEU A  80
PHE A  84
 None
 0.50A 6nknP-2aniA:
5.7		 6nknP-2aniA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 ARG A 112
LEU A 116
PHE A 120
 None
 0.65A 6nknP-2becA:
undetectable		 6nknP-2becA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h01 2-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 ARG A 106
LEU A 111
PHE A 112
 None
 0.74A 6nknP-2h01A:
undetectable		 6nknP-2h01A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 ARG A  79
LEU A  83
PHE A  87
 None
 0.66A 6nknP-2h4tA:
undetectable		 6nknP-2h4tA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi3 HOMEODOMAIN-ONLY
PROTEIN

(Mus musculus) 		PF00046
(Homeobox) 		3 ARG A  59
LEU A  55
PHE A  51
 None
 0.70A 6nknP-2hi3A:
undetectable		 6nknP-2hi3A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifd M-PHASE INDUCER
PHOSPHATASE 2

(Homo sapiens) 		PF00581
(Rhodanese) 		3 ARG A 544
LEU A 540
PHE A 536
 None
 0.65A 6nknP-2ifdA:
undetectable		 6nknP-2ifdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		3 ARG A  70
LEU A 136
PHE A 140
 None
 0.52A 6nknP-2jakA:
undetectable		 6nknP-2jakA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ARG A1276
LEU A1278
PHE A1249
 None
 0.73A 6nknP-2nz9A:
3.0		 6nknP-2nz9A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 ARG A  75
LEU A  79
PHE A  83
 None
 0.49A 6nknP-2optA:
3.0		 6nknP-2optA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		3 ARG A1220
LEU A1231
PHE A1229
 None
 0.80A 6nknP-2po3A:
undetectable		 6nknP-2po3A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT

(Paraburkholderia
xenovorans) 		PF02627
(CMD) 		3 ARG A 137
LEU A 141
PHE A 145
 None
 0.57A 6nknP-2q0tA:
undetectable		 6nknP-2q0tA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		3 ARG A 166
LEU A 104
PHE A  91
 KDG  A1313 (-3.3A)
None
None
 0.70A 6nknP-2varA:
undetectable		 6nknP-2varA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		3 ARG A 300
LEU A 310
PHE A 430
 None
 0.76A 6nknP-2wxzA:
undetectable		 6nknP-2wxzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 ARG A 128
LEU A  68
PHE A  94
 AKG  A1223 (-2.7A)
None
None
 0.79A 6nknP-2xkoA:
undetectable		 6nknP-2xkoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 ARG A 604
LEU A 600
PHE A 596
 None
 0.74A 6nknP-2xy9A:
2.1		 6nknP-2xy9A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 ARG A 270
LEU A 174
PHE A 192
 None
 0.61A 6nknP-2y38A:
undetectable		 6nknP-2y38A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 ARG A  50
LEU A  37
PHE A  71
 None
 0.78A 6nknP-2zcwA:
undetectable		 6nknP-2zcwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b47 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Geobacter
sulfurreducens) 		no annotation 3 ARG A  85
LEU A 154
PHE A 129
 None
 0.65A 6nknP-3b47A:
undetectable		 6nknP-3b47A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1

(Saccharomyces
cerevisiae) 		PF03556
(Cullin_binding)
PF14555
(UBA_4) 		3 ARG A 127
LEU A 131
PHE A 135
 None
 0.44A 6nknP-3bq3A:
undetectable		 6nknP-3bq3A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		3 ARG A 449
LEU A 126
PHE A  56
 None
 0.50A 6nknP-3bwsA:
undetectable		 6nknP-3bwsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 ARG A 144
LEU A 151
PHE A 152
 None
 0.80A 6nknP-3cttA:
undetectable		 6nknP-3cttA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		3 ARG A 367
LEU A 408
PHE A 409
 None
 0.80A 6nknP-3fsnA:
undetectable		 6nknP-3fsnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		3 ARG A 188
LEU A 192
PHE A 196
 None
 0.61A 6nknP-3g1zA:
undetectable		 6nknP-3g1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 ARG A 306
LEU A 284
PHE A 279
 None
 0.76A 6nknP-3gcfA:
undetectable		 6nknP-3gcfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		3 ARG A 124
LEU A 128
PHE A 132
 None
 0.66A 6nknP-3gg0A:
undetectable		 6nknP-3gg0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7m SENSOR PROTEIN

(Geobacter
sulfurreducens) 		PF00497
(SBP_bac_3) 		3 ARG A 261
LEU A 257
PHE A 253
 None
 0.79A 6nknP-3h7mA:
undetectable		 6nknP-3h7mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR

(Streptococcus
gordonii) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		3 ARG A  74
LEU A  78
PHE A  82
 None
 0.29A 6nknP-3hrtA:
undetectable		 6nknP-3hrtA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 ARG T  70
LEU T 114
PHE T 116
 None
 0.77A 6nknP-3icqT:
2.2		 6nknP-3icqT:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BL19

(Homo sapiens) 		PF01245
(Ribosomal_L19) 		3 ARG Q 103
LEU Q 166
PHE Q 164
 None
 0.78A 6nknP-3j7yQ:
undetectable		 6nknP-3j7yQ:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		3 ARG A1059
LEU A1055
PHE A1051
 None
 0.69A 6nknP-3jd8A:
3.6		 6nknP-3jd8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)

(Acinetobacter
sp. ADP1) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		3 ARG A  13
LEU A  17
PHE A  21
 None
 0.39A 6nknP-3knwA:
undetectable		 6nknP-3knwA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 ARG A 129
LEU A  69
PHE A  95
 AKG  A 224 (-2.5A)
None
None
 0.77A 6nknP-3la2A:
undetectable		 6nknP-3la2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 ARG A 227
LEU A 231
PHE A 235
 None
 0.57A 6nknP-3lg5A:
undetectable		 6nknP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ARG A 482
LEU A 442
PHE A 443
 None
 0.79A 6nknP-3m07A:
undetectable		 6nknP-3m07A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		3 ARG A 384
LEU A 388
PHE A 392
 None
 0.61A 6nknP-3ncyA:
2.3		 6nknP-3ncyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q19 GLUTATHIONE
S-TRANSFERASE
OMEGA-2

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ARG A 112
LEU A 116
PHE A 120
 None
 0.61A 6nknP-3q19A:
undetectable		 6nknP-3q19A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 ARG A 576
LEU A 543
PHE A 544
 None
 0.66A 6nknP-4a2lA:
undetectable		 6nknP-4a2lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		3 ARG A 150
LEU A 152
PHE A 310
 SO4  A1327 (-4.1A)
None
None
 0.66A 6nknP-4aa9A:
undetectable		 6nknP-4aa9A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7)
PF16453
(IQ_SEC7_PH) 		3 ARG A 629
LEU A 662
PHE A 684
 None
 0.79A 6nknP-4c0aA:
undetectable		 6nknP-4c0aA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF01399
(PCI) 		3 ARG A 242
LEU A 246
PHE A 250
 None
 0.73A 6nknP-4d0pA:
1.8		 6nknP-4d0pA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 3 ARG B 583
LEU B 535
PHE B 539
 None
 0.70A 6nknP-4fdgB:
undetectable		 6nknP-4fdgB:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ARG A 370
LEU A 366
PHE A 362
 None
 0.46A 6nknP-4gqaA:
undetectable		 6nknP-4gqaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		3 ARG A 333
LEU A  87
PHE A  85
 None
 0.75A 6nknP-4gvfA:
undetectable		 6nknP-4gvfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ARG A 368
LEU A 364
PHE A 360
 None
 0.67A 6nknP-4h3vA:
undetectable		 6nknP-4h3vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		3 ARG A 210
LEU A 262
PHE A 263
 ARG  A 210 ( 0.6A)
LEU  A 262 (-0.5A)
PHE  A 263 (-1.3A)
 0.61A 6nknP-4hneA:
undetectable		 6nknP-4hneA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		3 ARG A 357
LEU A 334
PHE A 198
 IOD  A 608 ( 4.9A)
None
None
 0.69A 6nknP-4j8fA:
undetectable		 6nknP-4j8fA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 ARG A 387
LEU A 413
PHE A 300
 None
 0.70A 6nknP-4ksfA:
undetectable		 6nknP-4ksfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4low ACRAF

(Thiomonas
intermedia) 		PF01329
(Pterin_4a) 		3 ARG A  76
LEU A  19
PHE A  20
 FMT  A 104 (-3.8A)
None
FMT  A 105 (-4.5A)
 0.75A 6nknP-4lowA:
undetectable		 6nknP-4lowA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me3 DNA REPLICATION
LICENSING FACTOR MCM
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF17207
(MCM_OB) 		3 ARG A  10
LEU A  14
PHE A  18
 None
 0.75A 6nknP-4me3A:
undetectable		 6nknP-4me3A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		3 ARG A 301
LEU A 305
PHE A 309
 None
 0.38A 6nknP-4o6mA:
2.1		 6nknP-4o6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 ARG A 296
LEU A 506
PHE A 508
 None
 0.59A 6nknP-4pfwA:
undetectable		 6nknP-4pfwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 ARG A 258
LEU A 289
PHE A 383
 None
 0.61A 6nknP-4r4zA:
undetectable		 6nknP-4r4zA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		3 ARG A 128
LEU A 124
PHE A 120
 None
 0.76A 6nknP-4rf3A:
undetectable		 6nknP-4rf3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		3 ARG A 184
LEU A 271
PHE A 275
 None
 0.73A 6nknP-4ud4A:
undetectable		 6nknP-4ud4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhp BACTERIOCIN IMMUNITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF01320
(Colicin_Pyocin) 		3 ARG B  37
LEU B  41
PHE B  45
 None
 0.48A 6nknP-4uhpB:
undetectable		 6nknP-4uhpB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		3 ARG A 147
LEU A 447
PHE A 443
 None
 0.73A 6nknP-4wj3A:
undetectable		 6nknP-4wj3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrn ALGINATE
BIOSYNTHESIS PROTEIN
ALG44

(Pseudomonas
aeruginosa) 		PF07238
(PilZ) 		3 ARG A  18
LEU A  59
PHE A  60
 None
 0.72A 6nknP-4xrnA:
undetectable		 6nknP-4xrnA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG

(Bacillus
subtilis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 ARG A 283
LEU A 247
PHE A 324
 None
 0.74A 6nknP-4yxtA:
undetectable		 6nknP-4yxtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbg ACETYLTRANSFERASE

(Brucella
abortus) 		PF13527
(Acetyltransf_9) 		3 ARG A  40
LEU A  45
PHE A  63
 None
 0.81A 6nknP-4zbgA:
undetectable		 6nknP-4zbgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		3 ARG A 342
LEU A 346
PHE A 350
 None
 0.59A 6nknP-4zlvA:
undetectable		 6nknP-4zlvA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		3 ARG A 183
LEU A 187
PHE A 191
 7E8  A 404 ( 2.6A)
7E8  A 404 ( 4.2A)
None
 0.64A 6nknP-5bz3A:
undetectable		 6nknP-5bz3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ARG A 341
LEU A 361
PHE A 384
 None
 0.58A 6nknP-5co8A:
undetectable		 6nknP-5co8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvi SLOR

(Streptococcus
mutans) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		3 ARG A  74
LEU A  78
PHE A  82
 ZN  A 304 ( 4.3A)
None
None
 0.43A 6nknP-5cviA:
undetectable		 6nknP-5cviA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 ARG A 474
LEU A 394
PHE A 411
 None
 0.76A 6nknP-5e6sA:
undetectable		 6nknP-5e6sA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		3 ARG A 253
LEU A 249
PHE A 245
 None
 0.74A 6nknP-5fshA:
4.6		 6nknP-5fshA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		3 ARG A 139
LEU A 143
PHE A 147
 None
 0.77A 6nknP-5g5uA:
undetectable		 6nknP-5g5uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		3 ARG A 238
LEU A 261
PHE A 265
 None
 0.63A 6nknP-5idiA:
undetectable		 6nknP-5idiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		3 ARG A 441
LEU A 484
PHE A 429
 None
 0.69A 6nknP-5il0A:
undetectable		 6nknP-5il0A:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		3 ARG C 156
LEU C 160
PHE C 164
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
 0.15A 6nknP-5iy5C:
35.8		 6nknP-5iy5C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPRBP

(Homo sapiens) 		no annotation 3 ARG C1079
LEU C1075
PHE C1071
 None
 0.80A 6nknP-5jk7C:
undetectable		 6nknP-5jk7C:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 ARG A 322
LEU A 313
PHE A 309
 None
 0.74A 6nknP-5jmdA:
undetectable		 6nknP-5jmdA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2

(Caenorhabditis
elegans) 		PF03828
(PAP_assoc) 		3 ARG A 692
LEU A 784
PHE A 788
 None
 0.72A 6nknP-5jnbA:
undetectable		 6nknP-5jnbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		3 ARG A 254
LEU A  58
PHE A 576
 None
 0.76A 6nknP-5jxkA:
3.1		 6nknP-5jxkA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		3 ARG A 138
LEU A 142
PHE A 146
 None
 0.79A 6nknP-5k04A:
1.4		 6nknP-5k04A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		3 ARG B 245
LEU B 289
PHE B 232
 None
 0.74A 6nknP-5k7mB:
undetectable		 6nknP-5k7mB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 ARG A 283
LEU A 247
PHE A 324
 None
 0.76A 6nknP-5kp7A:
undetectable		 6nknP-5kp7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6e N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		3 ARG B 245
LEU B 289
PHE B 232
 None
 0.71A 6nknP-5l6eB:
undetectable		 6nknP-5l6eB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		3 ARG A 441
LEU A 484
PHE A 429
 None
 0.68A 6nknP-5teyA:
undetectable		 6nknP-5teyA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		3 ARG B 245
LEU B 289
PHE B 232
 None
 0.71A 6nknP-5teyB:
undetectable		 6nknP-5teyB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 ARG A 480
LEU A 484
PHE A 488
 None
 0.33A 6nknP-5wblA:
undetectable		 6nknP-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		3 ARG A 405
LEU A 494
PHE A 498
 None
 0.77A 6nknP-5wu3A:
undetectable		 6nknP-5wu3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		3 ARG A 405
LEU A 494
PHE A 498
 None
 0.81A 6nknP-5wu6A:
undetectable		 6nknP-5wu6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi PLECTIN/S10 DOMAIN
CONTAINING PROTEIN

(Trichomonas
vaginalis) 		PF03501
(S10_plectin) 		3 ARG K   8
LEU K  12
PHE K  16
 U  21065 ( 4.1A)
None
None
 0.59A 6nknP-5xyiK:
undetectable		 6nknP-5xyiK:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivorans) 		no annotation 3 ARG A 355
LEU A 351
PHE A 347
 None
 0.53A 6nknP-5yapA:
undetectable		 6nknP-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 3 ARG A 756
LEU A 698
PHE A 702
 None
 0.80A 6nknP-5yudA:
undetectable		 6nknP-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 3 ARG A 416
LEU A 420
PHE A 424
 None
 0.59A 6nknP-6b4hA:
2.9		 6nknP-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 3 ARG D  80
LEU D  79
PHE D  77
 None
 0.76A 6nknP-6cetD:
undetectable		 6nknP-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 3 ARG A 119
LEU A 120
PHE A  88
 None
 0.78A 6nknP-6fn0A:
undetectable		 6nknP-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 3 ARG A 289
LEU A 293
PHE A 297
 None
 0.58A 6nknP-6fn0A:
undetectable		 6nknP-6fn0A:
undetectable