SIMILAR PATTERNS OF AMINO ACIDS FOR 6NKN_J_CHDJ101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		3 ARG A 115
PHE A  56
PHE A 144
 None
 1.06A 6nknC-1de6A:
0.0
6nknJ-1de6A:
0.0		 6nknC-1de6A:
20.79
6nknJ-1de6A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ARG B 401
PHE B 356
PHE B 387
 None
 0.70A 6nknC-1e9yB:
0.0
6nknJ-1e9yB:
0.0		 6nknC-1e9yB:
17.77
6nknJ-1e9yB:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		3 ARG A 233
PHE A 490
PHE A 300
 None
 1.03A 6nknC-1f0xA:
0.1
6nknJ-1f0xA:
0.0		 6nknC-1f0xA:
17.79
6nknJ-1f0xA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 177
PHE A 184
PHE A 256
 None
 1.06A 6nknC-1hcyA:
0.5
6nknJ-1hcyA:
0.0		 6nknC-1hcyA:
16.21
6nknJ-1hcyA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 ARG A 430
PHE A 650
PHE A 276
 None
 0.81A 6nknC-1iv8A:
0.0
6nknJ-1iv8A:
0.0		 6nknC-1iv8A:
16.13
6nknJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 ARG A 146
PHE A 126
PHE A 142
 SAH  A 900 (-4.6A)
None
SAH  A 900 ( 4.7A)
 1.06A 6nknC-1l1eA:
0.0
6nknJ-1l1eA:
0.0		 6nknC-1l1eA:
23.29
6nknJ-1l1eA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 ARG H 119
PHE H 143
PHE H  66
 None
 0.82A 6nknC-1mdaH:
undetectable
6nknJ-1mdaH:
0.0		 6nknC-1mdaH:
19.30
6nknJ-1mdaH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		3 ARG A  37
PHE A 507
PHE A  45
 None
 1.07A 6nknC-1rqgA:
3.7
6nknJ-1rqgA:
0.0		 6nknC-1rqgA:
15.21
6nknJ-1rqgA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbq 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
HOMOLOG

(Mycoplasma
pneumoniae) 		PF01812
(5-FTHF_cyc-lig) 		3 ARG A   7
PHE A 109
PHE A 118
 None
 1.08A 6nknC-1sbqA:
undetectable
6nknJ-1sbqA:
undetectable		 6nknC-1sbqA:
20.45
6nknJ-1sbqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		3 ARG C 686
PHE C 507
PHE C 675
 None
 1.04A 6nknC-1u0oC:
0.0
6nknJ-1u0oC:
undetectable		 6nknC-1u0oC:
19.19
6nknJ-1u0oC:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		3 ARG A 175
PHE A 168
PHE A 181
 None
 0.97A 6nknC-1u9cA:
0.0
6nknJ-1u9cA:
undetectable		 6nknC-1u9cA:
20.44
6nknJ-1u9cA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 ARG A  68
PHE A 797
PHE A  76
 None
 0.97A 6nknC-1wkbA:
undetectable
6nknJ-1wkbA:
undetectable		 6nknC-1wkbA:
15.67
6nknJ-1wkbA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		3 ARG A 293
PHE A 254
PHE A 196
 None
 0.98A 6nknC-1xszA:
undetectable
6nknJ-1xszA:
undetectable		 6nknC-1xszA:
19.30
6nknJ-1xszA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 ARG H 119
PHE H 143
PHE H  66
 None
 0.91A 6nknC-2bbkH:
undetectable
6nknJ-2bbkH:
undetectable		 6nknC-2bbkH:
20.44
6nknJ-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		3 ARG A 632
PHE A 605
PHE A 420
 None
 0.93A 6nknC-2ckhA:
undetectable
6nknJ-2ckhA:
undetectable		 6nknC-2ckhA:
19.12
6nknJ-2ckhA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		3 ARG A 418
PHE A 549
PHE A 466
 None
 0.70A 6nknC-2d5wA:
undetectable
6nknJ-2d5wA:
undetectable		 6nknC-2d5wA:
17.89
6nknJ-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		3 ARG A 262
PHE A 168
PHE A 430
 None
 1.00A 6nknC-2dpgA:
undetectable
6nknJ-2dpgA:
undetectable		 6nknC-2dpgA:
19.83
6nknJ-2dpgA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		3 ARG A 362
PHE A 458
PHE A 365
 None
None
TFC  A 600 ( 4.9A)
 1.06A 6nknC-2fj0A:
undetectable
6nknJ-2fj0A:
undetectable		 6nknC-2fj0A:
18.71
6nknJ-2fj0A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		3 ARG A 147
PHE A 192
PHE A  35
 SAH  A 300 (-3.9A)
None
SAH  A 300 (-3.4A)
 1.05A 6nknC-2gb4A:
undetectable
6nknJ-2gb4A:
undetectable		 6nknC-2gb4A:
18.38
6nknJ-2gb4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		3 ARG A 207
PHE A 179
PHE A 204
 None
 0.87A 6nknC-2h8xA:
undetectable
6nknJ-2h8xA:
undetectable		 6nknC-2h8xA:
21.04
6nknJ-2h8xA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9d CHLORAMPHENICOL
ACETYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00302
(CAT) 		3 ARG A  70
PHE A  19
PHE A  67
 None
 1.08A 6nknC-2i9dA:
undetectable
6nknJ-2i9dA:
undetectable		 6nknC-2i9dA:
19.19
6nknJ-2i9dA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		3 ARG 1 120
PHE 1 126
PHE 1 117
 None
 1.09A 6nknC-2oap1:
undetectable
6nknJ-2oap1:
undetectable		 6nknC-2oap1:
18.00
6nknJ-2oap1:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 ARG A 103
PHE A 321
PHE A 159
 None
 1.02A 6nknC-2pidA:
undetectable
6nknJ-2pidA:
undetectable		 6nknC-2pidA:
22.22
6nknJ-2pidA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		3 ARG A 334
PHE A 287
PHE A 332
 None
 0.89A 6nknC-2x1iA:
undetectable
6nknJ-2x1iA:
undetectable		 6nknC-2x1iA:
20.12
6nknJ-2x1iA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		3 ARG A 459
PHE A 444
PHE A  69
 None
 1.07A 6nknC-2xhyA:
undetectable
6nknJ-2xhyA:
undetectable		 6nknC-2xhyA:
18.75
6nknJ-2xhyA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		3 ARG A 372
PHE A 360
PHE A 345
 None
 1.03A 6nknC-2xsgA:
2.1
6nknJ-2xsgA:
undetectable		 6nknC-2xsgA:
14.16
6nknJ-2xsgA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 ARG A 557
PHE A 523
PHE A 480
 None
 1.05A 6nknC-2xswA:
undetectable
6nknJ-2xswA:
undetectable		 6nknC-2xswA:
21.62
6nknJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		3 ARG A  10
PHE A  17
PHE A 198
 SO4  A1300 (-2.7A)
None
None
 1.00A 6nknC-2xt0A:
undetectable
6nknJ-2xt0A:
undetectable		 6nknC-2xt0A:
21.23
6nknJ-2xt0A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ARG A 261
PHE A 120
PHE A 174
 None
 0.85A 6nknC-2yp2A:
undetectable
6nknJ-2yp2A:
undetectable		 6nknC-2yp2A:
17.74
6nknJ-2yp2A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		3 ARG A  53
PHE A 187
PHE A   4
 None
 0.85A 6nknC-2z6vA:
undetectable
6nknJ-2z6vA:
undetectable		 6nknC-2z6vA:
17.17
6nknJ-2z6vA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zdo HEME-DEGRADING
MONOOXYGENASE ISDG

(Staphylococcus
aureus) 		PF03992
(ABM) 		3 ARG A  26
PHE A  64
PHE A  23
 HEM  A 200 (-3.3A)
None
HEM  A 200 (-4.1A)
 1.07A 6nknC-2zdoA:
undetectable
6nknJ-2zdoA:
undetectable		 6nknC-2zdoA:
15.21
6nknJ-2zdoA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		3 ARG A  66
PHE A  61
PHE A  68
 CRQ  A  64 ( 3.8A)
None
None
 1.08A 6nknC-3adfA:
undetectable
6nknJ-3adfA:
undetectable		 6nknC-3adfA:
17.47
6nknJ-3adfA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		3 ARG A  97
PHE A 303
PHE A  94
 None
3B9  A 501 (-3.8A)
None
 0.98A 6nknC-3bacA:
undetectable
6nknJ-3bacA:
undetectable		 6nknC-3bacA:
22.03
6nknJ-3bacA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		3 ARG H 172
PHE H 196
PHE H 119
 None
 0.82A 6nknC-3c75H:
undetectable
6nknJ-3c75H:
undetectable		 6nknC-3c75H:
19.95
6nknJ-3c75H:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 ARG A 451
PHE A 284
PHE A 520
 None
 0.76A 6nknC-3cuxA:
undetectable
6nknJ-3cuxA:
undetectable		 6nknC-3cuxA:
16.70
6nknJ-3cuxA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 ARG A 428
PHE A 638
PHE A 271
 None
 1.09A 6nknC-3hjeA:
undetectable
6nknJ-3hjeA:
undetectable		 6nknC-3hjeA:
15.23
6nknJ-3hjeA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ARG A 383
PHE A 360
PHE A 461
 None
 1.00A 6nknC-3holA:
undetectable
6nknJ-3holA:
undetectable		 6nknC-3holA:
18.40
6nknJ-3holA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrg UNCHARACTERIZED
PROTEIN BT_3980 WITH
ACTIN-LIKE ATPASE
FOLD

(Bacteroides
thetaiotaomicron) 		PF12864
(DUF3822) 		3 ARG A  15
PHE A 139
PHE A  21
 None
 1.02A 6nknC-3hrgA:
undetectable
6nknJ-3hrgA:
undetectable		 6nknC-3hrgA:
21.75
6nknJ-3hrgA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		3 ARG A 134
PHE A  83
PHE A 127
 None
 0.91A 6nknC-3ioyA:
1.8
6nknJ-3ioyA:
undetectable		 6nknC-3ioyA:
19.94
6nknJ-3ioyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k50 PUTATIVE S41
PROTEASE

(Bacteroides
fragilis) 		PF03572
(Peptidase_S41) 		3 ARG A 324
PHE A 386
PHE A  82
 None
 1.09A 6nknC-3k50A:
undetectable
6nknJ-3k50A:
undetectable		 6nknC-3k50A:
19.27
6nknJ-3k50A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 ARG A 196
PHE A 187
PHE A 226
 None
 1.09A 6nknC-3llxA:
undetectable
6nknJ-3llxA:
undetectable		 6nknC-3llxA:
20.66
6nknJ-3llxA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ARG A 176
PHE A 207
PHE A 196
 None
 1.02A 6nknC-3mn3A:
undetectable
6nknJ-3mn3A:
undetectable		 6nknC-3mn3A:
21.58
6nknJ-3mn3A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqo MARR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridioides
difficile) 		PF12802
(MarR_2) 		3 ARG A 181
PHE A 120
PHE A 128
 None
 1.02A 6nknC-3nqoA:
undetectable
6nknJ-3nqoA:
undetectable		 6nknC-3nqoA:
22.01
6nknJ-3nqoA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A  94
PHE A 211
PHE A 261
 None
 1.09A 6nknC-3ov3A:
undetectable
6nknJ-3ov3A:
undetectable		 6nknC-3ov3A:
20.24
6nknJ-3ov3A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p14 L-RHAMNOSE ISOMERASE

(Bacillus
halodurans) 		PF06134
(RhaA) 		3 ARG A 106
PHE A  46
PHE A 135
 None
 1.00A 6nknC-3p14A:
undetectable
6nknJ-3p14A:
undetectable		 6nknC-3p14A:
20.62
6nknJ-3p14A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 ARG A 233
PHE A 158
PHE A 237
 None
 0.97A 6nknC-3pg5A:
undetectable
6nknJ-3pg5A:
undetectable		 6nknC-3pg5A:
18.41
6nknJ-3pg5A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ARG A 305
PHE A 275
PHE A 123
 None
 1.00A 6nknC-3ppcA:
undetectable
6nknJ-3ppcA:
undetectable		 6nknC-3ppcA:
15.63
6nknJ-3ppcA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ARG A 383
PHE A 361
PHE A 461
 GOL  A 529 (-4.2A)
None
None
 1.05A 6nknC-3pqsA:
undetectable
6nknJ-3pqsA:
undetectable		 6nknC-3pqsA:
19.01
6nknJ-3pqsA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ARG A 432
PHE A 409
PHE A 510
 None
 1.01A 6nknC-3pquA:
undetectable
6nknJ-3pquA:
undetectable		 6nknC-3pquA:
18.91
6nknJ-3pquA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 ARG A 325
PHE A 390
PHE A 954
 None
 0.89A 6nknC-3psfA:
undetectable
6nknJ-3psfA:
undetectable		 6nknC-3psfA:
11.54
6nknJ-3psfA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 ARG A 325
PHE A 390
PHE A 954
 None
 0.92A 6nknC-3psiA:
undetectable
6nknJ-3psiA:
undetectable		 6nknC-3psiA:
11.99
6nknJ-3psiA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 ARG A 457
PHE A 442
PHE A  69
 None
 1.08A 6nknC-3qomA:
undetectable
6nknJ-3qomA:
undetectable		 6nknC-3qomA:
19.66
6nknJ-3qomA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 ARG A 118
PHE A  83
PHE A 174
 None
 1.09A 6nknC-3r6hA:
undetectable
6nknJ-3r6hA:
undetectable		 6nknC-3r6hA:
21.40
6nknJ-3r6hA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		3 ARG A 239
PHE A 281
PHE A 228
 HEC  A1002 (-2.8A)
None
HEC  A1002 (-3.8A)
 1.03A 6nknC-3s7wA:
4.1
6nknJ-3s7wA:
undetectable		 6nknC-3s7wA:
17.79
6nknJ-3s7wA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts0 PROTEIN LIN-28
HOMOLOG A

(Mus musculus) 		PF00098
(zf-CCHC)
PF00313
(CSD) 		3 ARG A  85
PHE A  53
PHE A  84
 G  U   7 ( 3.3A)
A  U  10 ( 4.1A)
A  U   6 ( 3.3A)
 0.93A 6nknC-3ts0A:
undetectable
6nknJ-3ts0A:
undetectable		 6nknC-3ts0A:
17.10
6nknJ-3ts0A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ARG A2532
PHE A2537
PHE A2528
 None
 1.04A 6nknC-3vkgA:
undetectable
6nknJ-3vkgA:
undetectable		 6nknC-3vkgA:
6.07
6nknJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ARG A2532
PHE A2538
PHE A2528
 None
 1.06A 6nknC-3vkgA:
undetectable
6nknJ-3vkgA:
undetectable		 6nknC-3vkgA:
6.07
6nknJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ARG A3667
PHE A3263
PHE A3637
 None
 1.08A 6nknC-3vkgA:
undetectable
6nknJ-3vkgA:
undetectable		 6nknC-3vkgA:
6.07
6nknJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ARG A 261
PHE A 120
PHE A 174
 None
 0.84A 6nknC-3wheA:
undetectable
6nknJ-3wheA:
undetectable		 6nknC-3wheA:
18.60
6nknJ-3wheA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		3 ARG A 432
PHE A 322
PHE A 256
 None
 1.04A 6nknC-3wmyA:
undetectable
6nknJ-3wmyA:
undetectable		 6nknC-3wmyA:
21.51
6nknJ-3wmyA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Thermus
thermophilus) 		PF08282
(Hydrolase_3) 		3 ARG A 185
PHE A 210
PHE A 196
 None
 0.81A 6nknC-3ztyA:
undetectable
6nknJ-3ztyA:
undetectable		 6nknC-3ztyA:
19.19
6nknJ-3ztyA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 ARG A 431
PHE A 242
PHE A 430
 None
GSH  A1449 (-3.5A)
None
 1.04A 6nknC-4agsA:
undetectable
6nknJ-4agsA:
undetectable		 6nknC-4agsA:
20.27
6nknJ-4agsA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		3 ARG A 187
PHE A 102
PHE A 185
 None
 0.87A 6nknC-4c51A:
undetectable
6nknJ-4c51A:
undetectable		 6nknC-4c51A:
17.05
6nknJ-4c51A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		3 ARG A 320
PHE A 159
PHE A 341
 None
 1.02A 6nknC-4czbA:
1.4
6nknJ-4czbA:
undetectable		 6nknC-4czbA:
22.04
6nknJ-4czbA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		3 ARG A 250
PHE A 184
PHE A 173
 None
 1.05A 6nknC-4efzA:
undetectable
6nknJ-4efzA:
undetectable		 6nknC-4efzA:
19.75
6nknJ-4efzA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 ARG A 842
PHE A 870
PHE A 835
 None
 0.95A 6nknC-4fgvA:
2.1
6nknJ-4fgvA:
undetectable		 6nknC-4fgvA:
13.10
6nknJ-4fgvA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 ARG A 217
PHE A 191
PHE A 208
 None
 1.08A 6nknC-4hlnA:
undetectable
6nknJ-4hlnA:
undetectable		 6nknC-4hlnA:
17.43
6nknJ-4hlnA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Veillonella
parvula) 		PF13460
(NAD_binding_10) 		3 ARG A  99
PHE A 187
PHE A 198
 None
FMT  A 307 ( 3.9A)
None
 0.92A 6nknC-4hnhA:
undetectable
6nknJ-4hnhA:
undetectable		 6nknC-4hnhA:
20.69
6nknJ-4hnhA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuk NREA PROTEIN

(Staphylococcus
carnosus) 		PF13185
(GAF_2) 		3 ARG A  77
PHE A 147
PHE A 138
 None
 0.83A 6nknC-4iukA:
undetectable
6nknJ-4iukA:
undetectable		 6nknC-4iukA:
19.48
6nknJ-4iukA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		3 ARG A 104
PHE A 303
PHE A 101
 None
 1.08A 6nknC-4lh7A:
undetectable
6nknJ-4lh7A:
undetectable		 6nknC-4lh7A:
19.47
6nknJ-4lh7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8r HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF16023
(DUF4784) 		3 ARG A 117
PHE A 114
PHE A  59
 None
 0.99A 6nknC-4m8rA:
undetectable
6nknJ-4m8rA:
undetectable		 6nknC-4m8rA:
18.18
6nknJ-4m8rA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mda MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		3 ARG A 151
PHE A 246
PHE A 148
 None
 1.07A 6nknC-4mdaA:
undetectable
6nknJ-4mdaA:
undetectable		 6nknC-4mdaA:
18.12
6nknJ-4mdaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		3 ARG A 266
PHE A 156
PHE A  90
 None
 1.07A 6nknC-4n2rA:
undetectable
6nknJ-4n2rA:
undetectable		 6nknC-4n2rA:
20.23
6nknJ-4n2rA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ARG A 389
PHE A 365
PHE A 468
 None
 1.03A 6nknC-4o4xA:
undetectable
6nknJ-4o4xA:
undetectable		 6nknC-4o4xA:
18.55
6nknJ-4o4xA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		3 ARG A 320
PHE A 209
PHE A 143
 None
 0.92A 6nknC-4o8oA:
undetectable
6nknJ-4o8oA:
undetectable		 6nknC-4o8oA:
23.06
6nknJ-4o8oA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 ARG B 527
PHE B 490
PHE B 226
 None
 1.08A 6nknC-4ouaB:
undetectable
6nknJ-4ouaB:
undetectable		 6nknC-4ouaB:
17.41
6nknJ-4ouaB:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgh PROTEIN DDI1 HOMOLOG
2

(Homo sapiens) 		PF09668
(Asp_protease) 		3 ARG A 297
PHE A 273
PHE A 278
 None
 1.03A 6nknC-4rghA:
undetectable
6nknJ-4rghA:
undetectable		 6nknC-4rghA:
19.01
6nknJ-4rghA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unw H3 HAEMAGGLUTININ
HA1 CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ARG A 261
PHE A 120
PHE A 174
 None
 1.00A 6nknC-4unwA:
undetectable
6nknJ-4unwA:
undetectable		 6nknC-4unwA:
18.62
6nknJ-4unwA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05861
(PhnI)
PF06007
(PhnJ) 		3 ARG D 137
PHE D 133
PHE C 312
 None
 0.96A 6nknC-4xb6D:
undetectable
6nknJ-4xb6D:
undetectable		 6nknC-4xb6D:
19.61
6nknJ-4xb6D:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		3 ARG A 250
PHE A 184
PHE A 173
 GSH  A 302 (-3.3A)
None
GSH  A 302 ( 4.9A)
 1.01A 6nknC-4yslA:
undetectable
6nknJ-4yslA:
undetectable		 6nknC-4yslA:
20.31
6nknJ-4yslA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN

(Pleurobrachia
bachei) 		PF10613
(Lig_chan-Glu_bd) 		3 ARG A 101
PHE A 219
PHE A  66
 GLY  A 301 (-2.9A)
None
GLY  A 301 (-3.1A)
 1.04A 6nknC-4zdmA:
undetectable
6nknJ-4zdmA:
undetectable		 6nknC-4zdmA:
24.36
6nknJ-4zdmA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		3 ARG A 295
PHE A  19
PHE A 300
 None
 0.92A 6nknC-4zxwA:
undetectable
6nknJ-4zxwA:
undetectable		 6nknC-4zxwA:
19.76
6nknJ-4zxwA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 ARG A1874
PHE A1865
PHE A1826
 None
 0.76A 6nknC-5a22A:
2.8
6nknJ-5a22A:
undetectable		 6nknC-5a22A:
8.72
6nknJ-5a22A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		3 ARG A 565
PHE A 114
PHE A 556
 None
 0.97A 6nknC-5e3cA:
1.5
6nknJ-5e3cA:
undetectable		 6nknC-5e3cA:
15.73
6nknJ-5e3cA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		3 ARG A  57
PHE A 118
PHE A  50
 None
 1.00A 6nknC-5foeA:
undetectable
6nknJ-5foeA:
undetectable		 6nknC-5foeA:
17.07
6nknJ-5foeA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h98 GEOBACTER
METALLIREDUCENS
SMUG1

(Geobacter
metallireducens) 		no annotation 3 ARG A 131
PHE A 133
PHE A 237
 None
 0.93A 6nknC-5h98A:
undetectable
6nknJ-5h98A:
undetectable		 6nknC-5h98A:
21.07
6nknJ-5h98A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 ARG A 283
PHE A 655
PHE A 287
 None
 1.00A 6nknC-5ipwA:
undetectable
6nknJ-5ipwA:
undetectable		 6nknC-5ipwA:
17.47
6nknJ-5ipwA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		3 ARG A 144
PHE A 303
PHE A 109
 None
 1.05A 6nknC-5jipA:
undetectable
6nknJ-5jipA:
undetectable		 6nknC-5jipA:
19.77
6nknJ-5jipA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ARG A 323
PHE A 297
PHE A 254
 None
 1.00A 6nknC-5jw6A:
undetectable
6nknJ-5jw6A:
undetectable		 6nknC-5jw6A:
19.73
6nknJ-5jw6A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		3 ARG A 138
PHE A 146
PHE A 177
 None
 1.04A 6nknC-5k04A:
1.5
6nknJ-5k04A:
undetectable		 6nknC-5k04A:
16.13
6nknJ-5k04A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 3 ARG A 191
PHE A 212
PHE A 106
 None
 0.61A 6nknC-5mh5A:
undetectable
6nknJ-5mh5A:
undetectable		 6nknC-5mh5A:
undetectable
6nknJ-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 ARG A 860
PHE A 635
PHE A 373
 None
 1.06A 6nknC-5n4lA:
undetectable
6nknJ-5n4lA:
undetectable		 6nknC-5n4lA:
undetectable
6nknJ-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		3 ARG A 168
PHE A 179
PHE A 222
 None
 1.02A 6nknC-5n9jA:
2.9
6nknJ-5n9jA:
undetectable		 6nknC-5n9jA:
18.62
6nknJ-5n9jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		3 ARG A 521
PHE A 541
PHE A 634
 None
 1.02A 6nknC-5te1A:
undetectable
6nknJ-5te1A:
undetectable		 6nknC-5te1A:
15.31
6nknJ-5te1A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 ARG B 521
PHE B 541
PHE B 634
 None
 0.99A 6nknC-5tetB:
undetectable
6nknJ-5tetB:
undetectable		 6nknC-5tetB:
21.30
6nknJ-5tetB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		3 ARG A 186
PHE A 223
PHE A 247
 None
None
BDF  A 301 ( 3.7A)
 1.03A 6nknC-5u9cA:
undetectable
6nknJ-5u9cA:
undetectable		 6nknC-5u9cA:
19.59
6nknJ-5u9cA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2

(Aspergillus
nidulans) 		PF03664
(Glyco_hydro_62) 		3 ARG A 283
PHE A 171
PHE A 105
 None
 1.08A 6nknC-5ubjA:
undetectable
6nknJ-5ubjA:
undetectable		 6nknC-5ubjA:
22.35
6nknJ-5ubjA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umn HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ARG A 261
PHE A 120
PHE A 174
 None
 0.99A 6nknC-5umnA:
undetectable
6nknJ-5umnA:
undetectable		 6nknC-5umnA:
19.60
6nknJ-5umnA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23

(Homo sapiens) 		no annotation 3 ARG B  92
PHE B 108
PHE B 103
 None
 0.96A 6nknC-5w21B:
undetectable
6nknJ-5w21B:
undetectable		 6nknC-5w21B:
undetectable
6nknJ-5w21B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 3 ARG A 514
PHE A 531
PHE A 517
 None
 0.98A 6nknC-5wdxA:
undetectable
6nknJ-5wdxA:
undetectable		 6nknC-5wdxA:
17.82
6nknJ-5wdxA:
9.95