SIMILAR PATTERNS OF AMINO ACIDS FOR 6NJ9_K_SAMK500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		5 GLY A 163
GLY A 196
VAL A  21
ALA A 204
ASP A 207
 None
 1.03A 6nj9K-1cq3A:
undetectable		 6nj9K-1cq3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 GLY A 164
GLY A 140
VAL A 143
ASP A 241
PHE A 170
 None
 1.04A 6nj9K-1fw8A:
3.1		 6nj9K-1fw8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3l DEMETHYLMENAQUINONE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF03737
(RraA-like) 		6 ASP A  63
GLY A  64
GLY A  66
VAL A 132
ASP A  43
PHE A  61
 None
 1.34A 6nj9K-1j3lA:
undetectable		 6nj9K-1j3lA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PRO A 173
GLY A 523
GLY A 526
GLY A 496
ALA A 531
 None
TPP  A 700 (-4.9A)
None
None
None
 1.03A 6nj9K-1jscA:
3.6		 6nj9K-1jscA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kag SHIKIMATE KINASE I

(Escherichia
coli) 		PF01202
(SKI) 		5 PRO A 121
GLY A  14
GLY A  82
GLY A  11
ALA A  79
 None
 1.03A 6nj9K-1kagA:
2.2		 6nj9K-1kagA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ASP A 206
GLY A 208
GLY A 210
VAL A 214
ASP A 251
 None
 0.59A 6nj9K-1kywA:
9.1		 6nj9K-1kywA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ASP A 206
GLY A 208
VAL A 214
ASP A 251
PHE A 263
 None
 0.98A 6nj9K-1kywA:
9.1		 6nj9K-1kywA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		5 ASP A  39
GLY A  41
GLY A  43
VAL A  47
ASP A  90
 None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.8A)
 0.90A 6nj9K-1l3iA:
11.8		 6nj9K-1l3iA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		5 GLY A  15
ASP A  39
GLY A  41
GLY A  43
ASP A  90
 SAH  A 801 ( 3.8A)
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.2A)
SAH  A 801 (-3.8A)
 1.08A 6nj9K-1l3iA:
11.8		 6nj9K-1l3iA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		5 ASP A 106
GLY A 108
GLY A 110
ASP A 160
PHE A 174
 None
 0.87A 6nj9K-1o54A:
12.9		 6nj9K-1o54A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 497
GLY A 448
GLY A 476
VAL A 473
PHE A 501
 None
HE3  A1406 (-3.4A)
MG  A1405 ( 4.0A)
None
None
 1.09A 6nj9K-1ozhA:
2.2		 6nj9K-1ozhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 GLY A 135
GLY A 117
GLN A 113
VAL A 114
ASP A 181
 None
 0.95A 6nj9K-1pguA:
undetectable		 6nj9K-1pguA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 GLY A 185
ASP A 150
GLY A 153
GLY A 170
ALA A  36
 PCA  A   1 ( 3.3A)
None
None
None
None
 1.08A 6nj9K-1q2eA:
undetectable		 6nj9K-1q2eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		5 ASP A 188
GLY A 190
GLY A 192
ASP A 240
PHE A 241
 ACT  A 421 (-2.8A)
SAM  A 635 (-3.8A)
SAM  A 635 (-3.5A)
SAM  A 635 (-3.7A)
SAM  A 635 (-3.4A)
 0.87A 6nj9K-1qzzA:
8.6		 6nj9K-1qzzA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		5 ASP A  70
GLY A  72
GLY A  74
ALA A  96
ASP A 122
 SAH  A 299 ( 4.9A)
SAH  A 299 (-3.3A)
SAH  A 299 (-3.5A)
SAH  A 299 ( 3.8A)
SAH  A 299 (-3.2A)
 0.66A 6nj9K-1ri3A:
10.3		 6nj9K-1ri3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 GLY A 373
ASP A 397
GLY A 399
GLY A 401
PHE A 460
 SAH  A 801 (-4.2A)
SAH  A 801 (-3.0A)
SAH  A 801 (-3.1A)
SAH  A 801 ( 4.2A)
SAH  A 801 (-3.5A)
 0.57A 6nj9K-1u2zA:
3.1		 6nj9K-1u2zA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 179
GLY A 187
GLY A 182
ALA A 214
ASP A 315
 None
 1.05A 6nj9K-1uufA:
5.3		 6nj9K-1uufA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE

(Escherichia
coli) 		PF04962
(KduI) 		5 GLY A  79
GLY A  49
VAL A  59
PHE A  30
PHE A 115
 None
 1.05A 6nj9K-1xruA:
undetectable		 6nj9K-1xruA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 PRO A 252
GLY A 110
GLY A 130
GLY A  75
ALA A 120
 None
SF4  A 267 ( 3.7A)
None
None
None
 1.02A 6nj9K-1yq9A:
undetectable		 6nj9K-1yq9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ASP A 205
GLY A 207
GLY A 209
VAL A 213
ASP A 250
 SAH  A3994 ( 4.6A)
SAH  A3994 (-3.9A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-4.7A)
SAH  A3994 (-3.4A)
 0.86A 6nj9K-1zgjA:
7.4		 6nj9K-1zgjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		5 GLY A  27
GLY A  24
ALA A  49
ASP A  72
PHE A  97
 None
 0.85A 6nj9K-2bgkA:
4.8		 6nj9K-2bgkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 GLY A  18
VAL A   3
ALA A  44
ASP A  38
PHE A  67
 None
 1.07A 6nj9K-2gr9A:
3.2		 6nj9K-2gr9A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 PRO A  62
GLY A  69
ASP A 123
GLY A 126
ALA A 107
 None
 1.00A 6nj9K-2h8xA:
undetectable		 6nj9K-2h8xA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 PRO A 426
GLY A 278
GLY A 361
GLY A 386
GLN A 288
 None
 1.04A 6nj9K-2jjfA:
undetectable		 6nj9K-2jjfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		5 GLY A 261
GLY A 258
VAL A  72
ALA A 104
PHE A 189
 None
 1.01A 6nj9K-2nq2A:
undetectable		 6nj9K-2nq2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		5 PRO A  34
GLY A  30
ASP A  58
GLY A  25
ALA A  83
 None
 1.00A 6nj9K-2o9rA:
undetectable		 6nj9K-2o9rA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		5 ASP A  79
GLY A  81
GLY A  83
LYS A 105
ASP A 131
 None
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
None
SAH  A 301 (-3.2A)
 0.76A 6nj9K-2oy0A:
7.5		 6nj9K-2oy0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		6 GLY A  57
GLY A   8
GLY A  69
VAL A 135
ALA A 154
PHE A 161
 None
 1.45A 6nj9K-2pbkA:
undetectable		 6nj9K-2pbkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 PRO A  13
GLY A  62
GLY A 122
VAL A  87
ALA A   3
 None
 1.03A 6nj9K-2vwqA:
4.3		 6nj9K-2vwqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		5 GLY A  60
VAL A  35
ALA A  78
ASP A  82
PHE A  33
 None
 1.08A 6nj9K-2wrzA:
2.9		 6nj9K-2wrzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PRO A  71
GLY A  99
GLY A 101
VAL A  96
ALA A 132
 None
COA  A 760 ( 4.0A)
None
COA  A 760 ( 4.6A)
GOL  A 770 (-3.8A)
 1.08A 6nj9K-2x58A:
2.2		 6nj9K-2x58A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 GLY A 148
GLY A 209
GLY A 213
VAL A 237
ALA A  41
 None
NDP  A5502 (-2.9A)
NDP  A5502 (-3.7A)
NDP  A5502 (-4.3A)
None
 1.09A 6nj9K-2xdrA:
2.5		 6nj9K-2xdrA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 ASP A  36
GLY A  38
GLY A  40
LYS A  60
ASP A  86
 SFG  A1198 ( 4.7A)
SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.3A)
SFG  A1198 (-3.9A)
 0.63A 6nj9K-2xvaA:
11.8		 6nj9K-2xvaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		5 ASP A 314
GLY A 316
GLY A 318
ALA A 336
ASP A 346
 SAH  A 900 ( 4.6A)
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
None
SAH  A 900 (-3.6A)
 1.05A 6nj9K-2zfuA:
3.1		 6nj9K-2zfuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 GLY A 424
ASP A  83
GLY A  80
GLY A 427
ALA A  74
 None
 0.89A 6nj9K-3ayfA:
undetectable		 6nj9K-3ayfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		5 GLY A 205
ASP A 171
GLY A 172
GLY A 174
ALA A 106
 None
 0.93A 6nj9K-3c7oA:
undetectable		 6nj9K-3c7oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 ASP A  44
GLY A  46
GLY A  48
ALA A  69
ASP A  89
PHE A 103
 None
 0.96A 6nj9K-3ccfA:
9.7		 6nj9K-3ccfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 ASP A  44
GLY A  46
GLY A  48
GLN A  51
ALA A  69
ASP A  89
 None
 0.79A 6nj9K-3ccfA:
9.7		 6nj9K-3ccfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 5 ASP A 254
GLY A 256
GLY A 258
VAL A 262
PHE A 321
 None
None
CL  A   1 ( 4.7A)
None
None
 0.51A 6nj9K-3e05A:
11.4		 6nj9K-3e05A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 GLY A  75
GLY A 207
VAL A 192
ALA A 232
PHE A  80
 None
 1.04A 6nj9K-3fkdA:
4.2		 6nj9K-3fkdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 ASP A 188
GLY A 190
GLY A 192
ASP A 240
PHE A 241
 SAH  A 350 ( 4.9A)
SAH  A 350 (-4.1A)
SAH  A 350 (-3.6A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
 0.72A 6nj9K-3gxoA:
10.8		 6nj9K-3gxoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		5 ASP A  79
GLY A  81
GLY A  83
LYS A 105
ASP A 131
 SFG  A 301 ( 4.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.1A)
 0.86A 6nj9K-3lkzA:
7.6		 6nj9K-3lkzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 ASP A 187
GLY A 189
GLY A 191
ASP A 237
PHE A 238
 SAH  A 346 ( 4.5A)
SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.4A)
 0.76A 6nj9K-3lstA:
7.4		 6nj9K-3lstA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 GLY X 513
GLY X 395
GLY X 397
VAL X 468
ASP X 387
 None
 1.01A 6nj9K-3lxuX:
2.9		 6nj9K-3lxuX:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 GLY A 616
GLY A 637
ALA A 620
PHE A 416
PHE A 307
 None
 0.95A 6nj9K-3ng9A:
undetectable		 6nj9K-3ng9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 5 ASP A  40
GLY A  42
GLY A  44
VAL A  48
PHE A 106
 SAH  A 300 ( 4.8A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.4A)
None
None
 0.68A 6nj9K-3njrA:
9.6		 6nj9K-3njrA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		5 GLY A 605
GLY A 626
ALA A 609
PHE A 408
PHE A 297
 None
 0.96A 6nj9K-3nttA:
undetectable		 6nj9K-3nttA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		5 GLY A  28
GLY A  23
VAL A 133
ALA A 312
ASP A 330
 None
FAD  A 401 (-3.2A)
None
None
None
 0.92A 6nj9K-3p9uA:
undetectable		 6nj9K-3p9uA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A  14
GLY A 252
VAL A   9
ASP A 280
PHE A 284
 None
 1.03A 6nj9K-3qfkA:
undetectable		 6nj9K-3qfkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 GLY A 618
GLY A 639
ALA A 622
PHE A 418
PHE A 309
 None
 0.98A 6nj9K-3ra2A:
undetectable		 6nj9K-3ra2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		5 GLY A 216
GLY A 165
ALA A 232
ASP A 291
PHE A 238
 None
 1.08A 6nj9K-3s30A:
undetectable		 6nj9K-3s30A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 GLY A 616
GLY A 637
ALA A 620
PHE A 416
PHE A 307
 None
 0.97A 6nj9K-3shmA:
undetectable		 6nj9K-3shmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 PRO A 134
GLY A 151
ASP A 165
GLY A 157
ALA A 170
 None
 1.07A 6nj9K-3ti7A:
undetectable		 6nj9K-3ti7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		5 GLY A 190
ALA A 154
ASP A 159
PHE A 162
PHE A  42
 None
 0.84A 6nj9K-3tsmA:
undetectable		 6nj9K-3tsmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A 250
GLY A 343
VAL A 331
ALA A 189
PHE A 268
 GOL  A 472 (-3.5A)
None
None
None
None
 1.04A 6nj9K-3uw2A:
undetectable		 6nj9K-3uw2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A 250
GLY A 347
GLY A 343
VAL A 331
ALA A 189
 GOL  A 472 (-3.5A)
None
None
None
None
 0.78A 6nj9K-3uw2A:
undetectable		 6nj9K-3uw2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 ASP A 102
GLY A 104
GLY A 106
LYS A 134
ASP A 174
 SAM  A 501 ( 4.9A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.78A 6nj9K-3vywA:
4.7		 6nj9K-3vywA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 PRO A  26
GLY A 296
GLY A 131
GLY A 294
ASP A  10
 None
ACT  A 501 (-3.0A)
None
None
None
 0.98A 6nj9K-4a69A:
3.0		 6nj9K-4a69A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 ASP A 185
GLY A 187
GLY A 189
ASP A 236
PHE A 237
 SAM  A1349 ( 4.6A)
SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-3.5A)
SAM  A1349 (-3.5A)
 0.71A 6nj9K-4a6eA:
9.3		 6nj9K-4a6eA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eaa PEROSAMINE
N-ACETYLTRANSFERASE

(Caulobacter
vibrioides) 		PF00132
(Hexapep) 		5 GLY A  74
GLY A  14
VAL A  22
ALA A  39
PHE A  70
 JB2  A 301 (-3.3A)
JB2  A 301 ( 4.1A)
None
JB2  A 301 (-3.5A)
None
 1.06A 6nj9K-4eaaA:
undetectable		 6nj9K-4eaaA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		7 ASP A 161
GLY A 163
GLY A 165
GLN A 168
ALA A 188
ASP A 222
PHE A 223
 AW2  A 502 (-2.9A)
AW2  A 502 (-3.2A)
AW2  A 502 (-3.5A)
None
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
 0.61A 6nj9K-4er6A:
35.5		 6nj9K-4er6A:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		7 ASP A 161
GLY A 163
GLY A 165
VAL A 169
ALA A 188
ASP A 222
PHE A 223
 AW2  A 502 (-2.9A)
AW2  A 502 (-3.2A)
AW2  A 502 (-3.5A)
AW2  A 502 (-4.4A)
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
 0.48A 6nj9K-4er6A:
35.5		 6nj9K-4er6A:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 PRO A 173
GLY A  89
GLY A  96
GLY A  94
VAL A  48
 None
 1.03A 6nj9K-4f0xA:
undetectable		 6nj9K-4f0xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 432
GLY A 404
GLN A 393
VAL A 390
ALA A 443
 None
 1.09A 6nj9K-4hq6A:
undetectable		 6nj9K-4hq6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 ASP A 230
GLY A 232
GLY A 234
ASP A 281
PHE A 296
 SAH  A 501 ( 4.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.5A)
None
 0.68A 6nj9K-4ineA:
11.0		 6nj9K-4ineA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ASP A  57
GLY A  59
GLY A  61
ASP A 105
PHE A 120
 None
SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.0A)
None
 0.63A 6nj9K-4krgA:
9.8		 6nj9K-4krgA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ASP A 226
GLY A 228
GLY A 230
ASP A 277
PHE A 292
 SAH  A 701 ( 4.6A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
None
 0.69A 6nj9K-4kriA:
8.5		 6nj9K-4kriA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		5 ASP A 164
GLY A 166
GLY A 168
ALA A 191
ASP A 217
 SAH  A 401 ( 4.6A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.5A)
SAH  A 401 ( 3.7A)
 0.56A 6nj9K-4m73A:
8.7		 6nj9K-4m73A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 GLY A 126
VAL A 189
ALA A 270
ASP A 163
PHE A  52
 None
 0.96A 6nj9K-4nfuA:
undetectable		 6nj9K-4nfuA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3h KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		6 GLY A  57
GLY A   8
GLY A  69
VAL A 135
ALA A 154
PHE A 161
 None
 1.41A 6nj9K-4p3hA:
undetectable		 6nj9K-4p3hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		5 GLY A 616
GLY A 637
ALA A 620
PHE A 417
PHE A 308
 None
 1.00A 6nj9K-4rsoA:
undetectable		 6nj9K-4rsoA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		5 PRO A 117
GLY A 211
GLN A 165
VAL A 164
PHE A  79
 None
 0.96A 6nj9K-4wy9A:
undetectable		 6nj9K-4wy9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
purpureum) 		PF00840
(Glyco_hydro_7) 		5 GLY A 184
ASP A 149
GLY A 152
GLY A 169
ALA A  36
 PCA  A   1 ( 3.3A)
None
None
None
None
 1.08A 6nj9K-4zzpA:
undetectable		 6nj9K-4zzpA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 GLY A 214
GLY A 191
VAL A 194
ASP A 295
PHE A 221
 None
 1.03A 6nj9K-5bt8A:
2.9		 6nj9K-5bt8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 GLY A 111
GLY A 113
VAL A 117
ASP A 163
PHE A 179
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-2.7A)
None
 1.05A 6nj9K-5ccxA:
11.9		 6nj9K-5ccxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		6 ASP A 209
GLY A 211
GLY A 213
VAL A 217
ASP A 254
PHE A 266
 SAH  A 401 ( 4.6A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
None
SAH  A 401 (-3.5A)
None
 0.87A 6nj9K-5cvvA:
8.5		 6nj9K-5cvvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		5 ASP A  66
GLY A  68
GLY A  70
VAL A  74
PHE A 129
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
None
None
 0.73A 6nj9K-5dlyA:
6.0		 6nj9K-5dlyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		5 ASP A  65
GLY A  67
GLY A  69
GLN A  72
ASP A 112
 SAH  A 300 ( 4.4A)
SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
None
SAH  A 300 (-2.9A)
 0.80A 6nj9K-5dm4A:
9.3		 6nj9K-5dm4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PRO A 394
GLY A  21
GLY A 235
GLY A 233
VAL A  91
 None
 0.89A 6nj9K-5dmhA:
undetectable		 6nj9K-5dmhA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		8 ASP A 161
GLY A 163
GLY A 165
GLN A 168
LYS A 187
ALA A 188
ASP A 222
PHE A 223
 None
 0.65A 6nj9K-5dtrA:
35.0		 6nj9K-5dtrA:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		9 ASP A 161
GLY A 163
GLY A 165
VAL A 169
LYS A 187
ALA A 188
ASP A 222
PHE A 223
PHE A 239
 None
None
None
None
None
None
None
None
5F7  A 401 (-3.9A)
 0.57A 6nj9K-5dtrA:
35.0		 6nj9K-5dtrA:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 ASP A 203
GLY A 205
GLY A 207
ALA A 229
ASP A 261
 SAH  A 501 ( 4.3A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 ( 4.2A)
SAH  A 501 (-3.5A)
 0.77A 6nj9K-5e9jA:
9.8		 6nj9K-5e9jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 ASP A  79
GLY A  81
GLY A  83
LYS A 105
ASP A 131
 SAM  A 301 ( 4.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
None
SAM  A 301 (-3.4A)
 1.00A 6nj9K-5e9qA:
7.2		 6nj9K-5e9qA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 ASP A 203
GLY A 205
GLY A 207
ALA A 229
ASP A 261
 SAH  A 500 ( 4.8A)
SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 ( 3.9A)
SAH  A 500 (-3.6A)
 0.88A 6nj9K-5e9wA:
9.9		 6nj9K-5e9wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 511
ASP A  93
GLY A 453
GLY A 451
ALA A 449
 None
PEG  A6002 (-3.3A)
None
None
None
 1.09A 6nj9K-5fjjA:
3.6		 6nj9K-5fjjA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron;
Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2)
PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY B 427
GLY B 435
GLY B 433
ASP A 308
PHE B 440
 None
 1.06A 6nj9K-5fq6B:
undetectable		 6nj9K-5fq6B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 GLY A  32
GLY A 405
GLY A  34
ALA A  39
PHE A 408
 None
 1.07A 6nj9K-5h8wA:
3.6		 6nj9K-5h8wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		5 ASP A  79
GLY A  81
GLY A  83
LYS A 105
ASP A 131
 SAM  A 311 ( 4.9A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
MLT  A 313 ( 3.0A)
MLT  A 313 ( 2.6A)
 0.54A 6nj9K-5ikmA:
7.5		 6nj9K-5ikmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 GLY A 168
ASP A  64
GLY A  63
GLY A 148
ALA A  16
 None
 0.87A 6nj9K-5j44A:
undetectable		 6nj9K-5j44A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A  79
GLY A  81
GLY A  83
LYS A 105
ASP A 131
 None
SAH  A1003 (-3.4A)
SAH  A1003 (-3.5A)
SAH  A1003 (-4.8A)
SAH  A1003 (-3.0A)
 0.52A 6nj9K-5jjrA:
6.9		 6nj9K-5jjrA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		5 ASP A 185
GLY A 187
GLY A 189
ASP A 237
PHE A 238
 SAH  A 401 ( 4.7A)
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
 0.76A 6nj9K-5jr3A:
9.4		 6nj9K-5jr3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
vietnamiensis) 		PF00171
(Aldedh) 		5 PRO A 237
GLY A 460
GLY A 259
GLY A 414
ASP A 386
 None
 1.03A 6nj9K-5vbfA:
5.2		 6nj9K-5vbfA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 351
GLY A 356
GLY A 358
ALA A 382
PHE A 231
 None
 1.09A 6nj9K-5wx3A:
undetectable		 6nj9K-5wx3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 PRO A 315
GLY A 290
GLY A 311
VAL A 260
ALA A 442
 None
 1.02A 6nj9K-5x2qA:
4.4		 6nj9K-5x2qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoh BERGAPTOL
O-METHYLTRANSFERASE

(Peucedanum
praeruptorum) 		no annotation 5 ASP A 201
GLY A 203
GLY A 205
ASP A 246
PHE A 258
 SAH  A 401 ( 4.5A)
SAH  A 401 (-3.4A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-3.7A)
None
 0.87A 6nj9K-5xohA:
7.7		 6nj9K-5xohA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 5 PRO A  34
GLY A   8
GLY A  29
VAL A  55
ALA A  41
 None
 1.01A 6nj9K-5y8pA:
3.4		 6nj9K-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 5 ASP A 180
GLY A 182
GLY A 184
ASP A 232
PHE A 233
 FMT  A 502 (-2.6A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.5A)
 0.79A 6nj9K-6c5bA:
8.5		 6nj9K-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f49 -

(-) 		no annotation 5 GLY A  99
GLY A 112
VAL A 164
ASP A 197
PHE A 190
 None
 1.05A 6nj9K-6f49A:
undetectable		 6nj9K-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 5 ASP A  44
GLY A  46
GLY A  48
ASP A  93
PHE A  94
 None
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.92A 6nj9K-6f5zA:
10.0		 6nj9K-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 5 GLY A  50
GLY A  67
VAL A  42
ASP A  93
PHE A  94
 None
None
None
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 1.06A 6nj9K-6f5zA:
10.0		 6nj9K-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		3 THR A 233
GLU A 286
ASN A 280
 None
 0.59A 6nj9K-1bvwA:
undetectable		 6nj9K-1bvwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		3 THR A 209
GLU A 171
ASN A 235
 None
 0.83A 6nj9K-1d2kA:
undetectable		 6nj9K-1d2kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9s CYCLIN-DEPENDENT
KINASE 4 INHIBITOR B

(Mus musculus) 		PF12796
(Ank_2) 		3 THR A  12
GLU A  63
ASN A  36
 None
 0.87A 6nj9K-1d9sA:
undetectable		 6nj9K-1d9sA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		3 THR A 207
GLU A 202
ASN A 176
 None
 0.87A 6nj9K-1dl5A:
9.6		 6nj9K-1dl5A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3a PENICILLIN AMIDASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 THR A 125
GLU A 112
ASN A 108
 None
 0.83A 6nj9K-1e3aA:
undetectable		 6nj9K-1e3aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		3 THR A  23
GLU A  71
ASN A 105
 None
NEA  A 500 (-2.8A)
NEA  A 500 (-4.5A)
 0.82A 6nj9K-1g38A:
10.2		 6nj9K-1g38A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 THR A 214
GLU A 232
ASN A 217
 None
 0.78A 6nj9K-1jscA:
3.6		 6nj9K-1jscA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kec PENICILLIN ACYLASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 THR A 125
GLU A 112
ASN A 108
 None
 0.87A 6nj9K-1kecA:
undetectable		 6nj9K-1kecA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		3 THR A 258
GLU A 116
ASN A 224
 None
 0.79A 6nj9K-1p9mA:
undetectable		 6nj9K-1p9mA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		3 THR B 143
GLU B  54
ASN B 139
 None
 0.72A 6nj9K-1poiB:
undetectable		 6nj9K-1poiB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF04069
(OpuAC) 		3 THR A  66
GLU A  20
ASN A  64
 None
 0.61A 6nj9K-1r9lA:
undetectable		 6nj9K-1r9lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 THR C1091
GLU C1016
ASN C1031
 None
 0.68A 6nj9K-1u6gC:
undetectable		 6nj9K-1u6gC:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 THR A 215
GLU A 133
ASN A 139
 None
 0.75A 6nj9K-1uokA:
undetectable		 6nj9K-1uokA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Mycobacterium
tuberculosis) 		PF00160
(Pro_isomerase) 		3 THR A  14
GLU A 104
ASN A  33
 None
 0.78A 6nj9K-1w74A:
undetectable		 6nj9K-1w74A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		3 THR A  83
GLU A  94
ASN A 144
 None
 0.77A 6nj9K-2a8iA:
undetectable		 6nj9K-2a8iA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 THR A 478
GLU A 433
ASN A 599
 None
 0.85A 6nj9K-2cvtA:
undetectable		 6nj9K-2cvtA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7o FILAMIN-C

(Homo sapiens) 		PF00630
(Filamin) 		3 THR A  67
GLU A  41
ASN A  61
 None
 0.88A 6nj9K-2d7oA:
undetectable		 6nj9K-2d7oA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3c THROMBIN INHIBITOR
INFESTIN

(Triatoma
infestans) 		PF00050
(Kazal_1) 		3 THR I  28
GLU I  45
ASN I  25
 SO4  I 103 (-3.2A)
None
None
 0.89A 6nj9K-2f3cI:
undetectable		 6nj9K-2f3cI:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		3 THR A 378
GLU A  88
ASN A 284
 None
 0.56A 6nj9K-2gj4A:
4.0		 6nj9K-2gj4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		3 THR A 123
GLU A 155
ASN A 119
 None
 0.81A 6nj9K-2h6rA:
undetectable		 6nj9K-2h6rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS)
PF07924
(NuiA) 		3 THR A 200
GLU B  24
ASN A 154
 None
MG  A 303 ( 4.0A)
None
 0.88A 6nj9K-2o3bA:
undetectable		 6nj9K-2o3bA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Escherichia
coli) 		PF09107
(SelB-wing_3) 		3 THR A 537
GLU A 499
ASN A 547
 None
 0.83A 6nj9K-2pjpA:
undetectable		 6nj9K-2pjpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A  30
GLU A 352
ASN A  26
 None
 0.77A 6nj9K-2rjtA:
undetectable		 6nj9K-2rjtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v82 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		3 THR A  66
GLU A  46
ASN A  41
 KDP  A1207 (-3.6A)
None
None
 0.89A 6nj9K-2v82A:
undetectable		 6nj9K-2v82A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		3 THR A 596
GLU A 395
ASN A 345
 None
 0.71A 6nj9K-2wozA:
undetectable		 6nj9K-2wozA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 THR A 363
GLU A 475
ASN A 498
 None
 0.62A 6nj9K-2x40A:
2.6		 6nj9K-2x40A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		3 THR A  14
GLU A 250
ASN A 367
 None
 0.91A 6nj9K-2xkaA:
undetectable		 6nj9K-2xkaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xv7 VASCULAR ENDOTHELIAL
GROWTH FACTOR D

(Homo sapiens) 		PF00341
(PDGF) 		3 THR A 187
GLU A 123
ASN A 185
 NAG  A 500 (-4.8A)
NAG  A 401 ( 4.7A)
NAG  A 500 (-1.7A)
 0.91A 6nj9K-2xv7A:
undetectable		 6nj9K-2xv7A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		3 THR A 197
GLU A 123
ASN A 119
 None
 0.69A 6nj9K-2xwgA:
undetectable		 6nj9K-2xwgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR B 151
GLU B 216
ASN B 266
 None
 0.63A 6nj9K-2y7cB:
8.7		 6nj9K-2y7cB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybr SINGLE CHAIN
ANTIBODY FRAGMENT
9004G
BETA-MAMMAL TOXIN
CN2

(Homo sapiens;
Centruroides
noxius) 		PF07686
(V-set)
PF00537
(Toxin_3) 		3 THR C  10
GLU C  28
ASN A  31
 None
 0.92A 6nj9K-2ybrC:
undetectable		 6nj9K-2ybrC:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 THR A 575
GLU A 596
ASN A 541
 None
 0.91A 6nj9K-2yfnA:
undetectable		 6nj9K-2yfnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		3 THR A 109
GLU A  38
ASN A 111
 None
 0.65A 6nj9K-2z4tA:
2.4		 6nj9K-2z4tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 THR A  51
GLU A  16
ASN A  47
 None
 0.87A 6nj9K-3bgwA:
undetectable		 6nj9K-3bgwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 THR A 445
GLU A 486
ASN A 443
 None
 0.79A 6nj9K-3bmwA:
undetectable		 6nj9K-3bmwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bql ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 THR A1234
GLU A1456
ASN A1271
 None
 0.83A 6nj9K-3bqlA:
undetectable		 6nj9K-3bqlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 THR A 230
GLU A 293
ASN A 376
 None
EDO  A 602 (-3.9A)
None
 0.74A 6nj9K-3byvA:
undetectable		 6nj9K-3byvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		3 THR A  81
GLU A  33
ASN A  44
 None
 0.85A 6nj9K-3c3yA:
11.5		 6nj9K-3c3yA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		3 THR A 119
GLU A 172
ASN A 195
 None
 0.85A 6nj9K-3eagA:
2.9		 6nj9K-3eagA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 THR A  25
GLU A  51
ASN A  21
 None
 0.77A 6nj9K-3fi9A:
5.4		 6nj9K-3fi9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		3 THR A 383
GLU A 358
ASN A  24
 None
 0.91A 6nj9K-3ik2A:
undetectable		 6nj9K-3ik2A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 THR A 176
GLU A 487
ASN A 708
 None
 0.86A 6nj9K-3j04A:
undetectable		 6nj9K-3j04A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		3 THR C 124
GLU C 168
ASN C 164
 None
 0.83A 6nj9K-3j7aC:
undetectable		 6nj9K-3j7aC:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 THR A 328
GLU A 419
ASN A 425
 None
 0.74A 6nj9K-3kl4A:
2.7		 6nj9K-3kl4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN ALPHA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		3 THR A 152
GLU A  39
ASN A 148
 None
None
BLA  B 555 (-4.2A)
 0.88A 6nj9K-3kvsA:
undetectable		 6nj9K-3kvsA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica) 		PF00923
(TAL_FSA) 		3 THR A 163
GLU A 154
ASN A 161
 None
 0.87A 6nj9K-3m16A:
undetectable		 6nj9K-3m16A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Encephalitozoon
cuniculi) 		PF00274
(Glycolytic) 		3 THR A 203
GLU A 113
ASN A 156
 None
 0.90A 6nj9K-3mbfA:
undetectable		 6nj9K-3mbfA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on6 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 THR A  87
GLU A  57
ASN A  82
 None
 0.73A 6nj9K-3on6A:
undetectable		 6nj9K-3on6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 THR A  89
GLU A  59
ASN A  84
 None
 0.72A 6nj9K-3p2cA:
undetectable		 6nj9K-3p2cA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 THR A1096
GLU A1076
ASN A1092
 None
 0.66A 6nj9K-3psiA:
undetectable		 6nj9K-3psiA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		3 THR B 191
GLU B 231
ASN B 224
 None
 0.76A 6nj9K-3s4wB:
undetectable		 6nj9K-3s4wB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		3 THR A 361
GLU A  77
ASN A  73
 None
 0.85A 6nj9K-3um1A:
undetectable		 6nj9K-3um1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 THR A  26
GLU A 113
ASN A 135
 None
 0.69A 6nj9K-3zzuA:
3.0		 6nj9K-3zzuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3

(Mus musculus) 		PF07528
(DZF) 		3 THR B 356
GLU B 252
ASN B 221
 None
 0.65A 6nj9K-4atbB:
undetectable		 6nj9K-4atbB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 3 THR A 213
GLU A 290
ASN A 222
 None
 0.66A 6nj9K-4bg2A:
undetectable		 6nj9K-4bg2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		3 THR A 324
GLU A 442
ASN A 266
 None
 0.86A 6nj9K-4e3cA:
undetectable		 6nj9K-4e3cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 THR A 466
GLU A 631
ASN A 409
 None
 0.91A 6nj9K-4g9iA:
undetectable		 6nj9K-4g9iA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf4 PORIN B

(Pseudomonas
putida) 		PF04966
(OprB) 		3 THR A 302
GLU A 236
ASN A 144
 None
 0.91A 6nj9K-4gf4A:
undetectable		 6nj9K-4gf4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 3 THR A  64
GLU A  74
ASN A 331
 None
 0.50A 6nj9K-4gjiA:
undetectable		 6nj9K-4gjiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		3 THR A1074
GLU A1563
ASN A1154
 SO4  A1703 (-4.3A)
None
SO4  A1703 (-3.7A)
 0.82A 6nj9K-4guaA:
5.7		 6nj9K-4guaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 THR A  13
GLU A 356
ASN A 109
 None
 0.88A 6nj9K-4jr7A:
undetectable		 6nj9K-4jr7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxu PUTATIVE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF01063
(Aminotran_4) 		3 THR A 192
GLU A 266
ASN A 179
 None
 0.88A 6nj9K-4jxuA:
undetectable		 6nj9K-4jxuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		3 THR A 440
GLU A 467
ASN A 464
 None
 0.86A 6nj9K-4kngA:
undetectable		 6nj9K-4kngA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 THR A 225
GLU A 138
ASN A 885
 None
NAG  A1002 (-3.7A)
None
 0.88A 6nj9K-4kxbA:
undetectable		 6nj9K-4kxbA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg3 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF16175
(DUF4875) 		3 THR A 119
GLU A 177
ASN A 198
 None
EDO  A 305 ( 4.5A)
None
 0.86A 6nj9K-4lg3A:
undetectable		 6nj9K-4lg3A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 THR A 129
GLU A 888
ASN A 521
 None
 0.64A 6nj9K-4lglA:
2.9		 6nj9K-4lglA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		3 THR A 479
GLU A 323
ASN A 327
 None
 0.85A 6nj9K-4m00A:
undetectable		 6nj9K-4m00A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 THR A 840
GLU A 858
ASN A 842
 None
 0.85A 6nj9K-4o9xA:
undetectable		 6nj9K-4o9xA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 THR A 217
GLU A 159
ASN A 238
 None
 0.87A 6nj9K-4ox2A:
undetectable		 6nj9K-4ox2A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 THR A1234
GLU A1456
ASN A1271
 None
 0.74A 6nj9K-4p1tA:
undetectable		 6nj9K-4p1tA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qcc 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CHIMERA

(Escherichia
coli) 		PF01081
(Aldolase)
PF01346
(FKBP_N) 		3 THR A  66
GLU A  46
ASN A  41
 None
 0.88A 6nj9K-4qccA:
undetectable		 6nj9K-4qccA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 THR A 174
GLU A 159
ASN A 474
 None
 0.88A 6nj9K-4w8bA:
undetectable		 6nj9K-4w8bA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wi0 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		3 THR A   6
GLU A  67
ASN A   8
 None
 0.91A 6nj9K-4wi0A:
undetectable		 6nj9K-4wi0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05845
(PhnH)
PF06007
(PhnJ) 		3 THR B 188
GLU D 148
ASN D 178
 None
 0.51A 6nj9K-4xb6B:
2.3		 6nj9K-4xb6B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 THR E 435
GLU E 422
ASN E 414
 None
 0.87A 6nj9K-4xgcE:
undetectable		 6nj9K-4xgcE:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		3 THR A 869
GLU A 944
ASN A1018
 None
 0.71A 6nj9K-4xqkA:
undetectable		 6nj9K-4xqkA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		3 THR B 344
GLU B 534
ASN B 376
 None
 0.78A 6nj9K-4yg8B:
undetectable		 6nj9K-4yg8B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 THR A 525
GLU A 534
ASN A 442
 None
 0.85A 6nj9K-4zmhA:
undetectable		 6nj9K-4zmhA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
4E-BINDING PROTEIN
MEXTLI

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF01652
(IF4E)
no annotation 		3 THR B 477
GLU A 130
ASN B 474
 None
 0.82A 6nj9K-5abyB:
undetectable		 6nj9K-5abyB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 THR A 238
GLU A 225
ASN A 391
 None
 0.79A 6nj9K-5aewA:
undetectable		 6nj9K-5aewA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d88 PREDICTED PROTEASE
OF THE COLLAGENASE
FAMILY

(Methanopyrus
kandleri) 		PF01136
(Peptidase_U32) 		3 THR A 168
GLU A 154
ASN A 149
 None
 0.78A 6nj9K-5d88A:
undetectable		 6nj9K-5d88A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 3 THR A 217
GLU A 267
ASN A  12
 None
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 0.88A 6nj9K-5ec0A:
undetectable		 6nj9K-5ec0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF08276
(PAN_2) 		3 THR A  87
GLU A  92
ASN A  73
 None
 0.85A 6nj9K-5gyyA:
undetectable		 6nj9K-5gyyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 THR A1870
GLU A1766
ASN A1808
 None
 0.91A 6nj9K-5h64A:
undetectable		 6nj9K-5h64A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9k LIPOCALIN AI-4

(Rhodnius
prolixus) 		PF03973
(Triabin) 		3 THR A 148
GLU A  99
ASN A 143
 None
 0.55A 6nj9K-5h9kA:
undetectable		 6nj9K-5h9kA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		3 THR A 349
GLU A 204
ASN A 211
 None
None
EDO  A 502 (-2.4A)
 0.80A 6nj9K-5i92A:
2.5		 6nj9K-5i92A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 THR A 102
GLU A  18
ASN A 135
 None
 0.64A 6nj9K-5iclA:
undetectable		 6nj9K-5iclA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 THR A 102
GLU A  18
ASN A 135
 None
 0.70A 6nj9K-5ij6A:
undetectable		 6nj9K-5ij6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1

(Homo sapiens) 		PF02002
(TFIIE_alpha)
PF08271
(TF_Zn_Ribbon) 		3 THR Q 137
GLU Q 165
ASN Q 123
 None
 0.54A 6nj9K-5iy7Q:
undetectable		 6nj9K-5iy7Q:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 THR A 155
GLU A  44
ASN A 113
 None
 0.92A 6nj9K-5khaA:
undetectable		 6nj9K-5khaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 THR A  22
GLU A 449
ASN A 366
 None
 0.83A 6nj9K-5ldfA:
undetectable		 6nj9K-5ldfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR A 131
GLU A 115
ASN A 121
 None
 0.89A 6nj9K-5udhA:
undetectable		 6nj9K-5udhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens;
Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14629
(ORC4_C) 		3 THR A 765
GLU A 774
ASN C 219
 None
 0.82A 6nj9K-5uj7A:
undetectable		 6nj9K-5uj7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 THR A 526
GLU A 298
ASN A 529
 None
 0.71A 6nj9K-5ujuA:
4.7		 6nj9K-5ujuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		3 THR A 456
GLU A 582
ASN A 604
 None
 0.77A 6nj9K-5w81A:
undetectable		 6nj9K-5w81A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 THR A 169
GLU A 115
ASN A 158
 None
 0.85A 6nj9K-5wvbA:
undetectable		 6nj9K-5wvbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 3 THR B 153
GLU B 138
ASN B 146
 None
 0.85A 6nj9K-5x1yB:
undetectable		 6nj9K-5x1yB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 3 THR A  47
GLU A 315
ASN A  45
 None
 0.86A 6nj9K-6ekvA:
undetectable		 6nj9K-6ekvA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 3 THR A 287
GLU A 281
ASN A 292
 None
None
DJE  A 504 ( 4.8A)
 0.88A 6nj9K-6fi2A:
undetectable		 6nj9K-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 3 THR A 343
GLU A 323
ASN A 418
 None
 0.85A 6nj9K-6fosA:
undetectable		 6nj9K-6fosA:
undetectable